Publication Type:

Journal Article

Source:

International Journal of Biological Macromolecules, Volume 49, Number 1, p.20-31 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79953326236&partnerID=40&md5=262574b208655e129262169ac685fad0

Keywords:

adsorption, alpha chitin, animal cell, Animals, article, biocompatibility, biomineralization, cell adhesion, cell proliferation, cell spreading, Cell Survival, cell viability, Cercopithecus aethiops, chemical analysis, chitin, controlled study, Cytocompatibility, degradation, Durapatite, Electron, Fourier Transform Infrared, freeze drying, human, human cell, Humans, hydrogel, infrared spectroscopy, light scattering, Mice, microscopy, mouse, nanocomposite, nanofabrication, nanohydroxyapatite, Nanostructures, NIH 3T3 Cells, nonhuman, porosity, Scanning, scanning electron microscopy, Spectroscopy, Thermogravimetry, tissue engineering, Tissue Scaffolds, unclassified drug, Vero cells, Wound healing, X ray diffraction, X-Ray Diffraction

Abstract:

α-chitin hydrogel/nano hydroxyapatite (nHAp) composite scaffold have been synthesized by freeze-drying approach with nHAp and α-chitin hydrogel. The prepared nHAp and nanocomposite scaffolds were characterized using DLS, SEM, FT-IR, XRD and TGA studies. The porosity, swelling, degradation, protein adsorption and biomineralization (calcification) of the prepared nanocomposite scaffolds were evaluated. Cell viability, attachment and proliferation were investigated using MG 63, Vero, NIH 3T3 and nHDF cells to confirm that the nanocomposite scaffolds were cytocompatible and cells were found to attach and spread on the scaffolds. All the results suggested that these scaffolds can be used for bone and wound tissue engineering. © 2011 Elsevier B.V.

Notes:

cited By (since 1996)9

Cite this Research Publication

P. T. Sa Kumar, Srinivasan, Sa, Lakshmanan, V. - Ka, Tamura, Hb, Nair, S. Va, and Jayakumar, Ra, “Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds”, International Journal of Biological Macromolecules, vol. 49, pp. 20-31, 2011.