Publication Type:

Journal Article

Source:

European Journal of Medicinal Chemistry, Volume 45, Number 1, p.106 - 113 (2010)

URL:

http://www.sciencedirect.com/science/article/pii/S0223523409004632

Keywords:

cytotoxicity

Abstract:

The novel glycosyl saccharide derivative, (d-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94×10−8 (LC50=2.76×10−8 for cisplatin) and so distinctly better than free ligand and other complexes.

Cite this Research Publication

M. P. Sathisha, Budagumpi, S., Dr. Naveen V. Kulkarni, Kurdekar, G. S., Revankar, V. K., and Pai, K. S. R., “Synthesis, structure, electrochemistry and spectral characterization of (d-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice”, European Journal of Medicinal Chemistry, vol. 45, pp. 106 - 113, 2010.

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