Publication Type:

Journal Article

Source:

International Journal of Biological Macromolecules, Volume 74, p.575-584 (2015)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921762619&partnerID=40&md5=438e77c2c443654c83f49d2622682957

Keywords:

Crosslinking-precipitation, Hemocompatibility, Hydroxyethyl starch, Nanoparticles, Parenteral drug delivery

Abstract:

Development of parenteral nanoformulations is highly challenging due to the stringent demands on stability, reproducibility and high drug loading with minimal excipients. This study focuses on the development of a pharmaceutically acceptable nanomatrix system for parenteral delivery based on Hydroxyethyl Starch (HES), a FDA approved polymer that is relatively unexplored in drug delivery research. HES nanoparticles were prepared through a simple, two-step crosslinking-precipitation route, yielding 160. ±. 5. nm, nearly monodispersed spherical particles with high colloidal stability. The utility of this nanocarrier for parenteral delivery was verified by a panel of hemo/cytocompatibility assays at high concentrations (0.05-1. mg/ml) in vitro and in vivo. HES nanomatrix was found effective in encapsulating two chemically distinct drugs having varying hydrophobicities, with the release behavior being influenced by their chemical nature and drug-matrix interactions. Better in vitro efficacy was measured for the nanoencapsulated drug than its bare form, establishing the potential of HES nanocarriers for controlled drug delivery. © 2014 Elsevier B.V.

Cite this Research Publication

D. Narayanan, Nair, S., and Menon, D., “A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery”, International Journal of Biological Macromolecules, vol. 74, pp. 575-584, 2015.