Publication Type:

Journal Article


Indian J Dent Res, Volume 27, Issue 3, p.230-5 (2016)



<p><b>CONTEXT: </b>Topical corticosteroids are the treatment of choice for oral lichen planus (OLP) due to its potential anti-inflammatory effect. However, chronic nature of OLP often requires long-term and frequent applications, exposing patients to local and systemic side effects.</p><p><b>AIM: </b>To detect the systemic absorption of 0.1% triamcinolone acetonide (TAC) through the oral mucosa of patients with OLP.</p><p><b>SUBJECTS AND METHODS: </b>This was a pilot pharmacokinetic study carried out in the Department of Oral Medicine and Radiology in collaboration with the Department of Toxicology, over 10 months. A total of twenty patients with OLP were included and advised to apply 0.1% TAC 3 times/day for 2 weeks and 2 times/day for next 2 weeks. Blood samples were obtained on the first and second visits and analyzed for triamcinolone using High pressure liquid chromatography (HPLC).</p><p><b>STATISTICAL ANALYSIS USED: </b>Paired t-test was done to compare visual analog scale (VAS) score for burning sensation at the first and second visits, statistically significant if P < 0.05. The baseline demographic data were analyzed using descriptive statistics.</p><p><b>RESULTS: </b>Paired t-test was done to compare VAS score for burning sensation at the first and second visits, which turned to being statistically significant (P = 0.001). Although HPLC is an established method for the detection of TAC, none of the study populations showed evidence of steroid (TAC) in the blood sample during 4 weeks of treatment duration.</p><p><b>CONCLUSIONS: </b>0.1% triamcinolone is a relatively safe drug to be used with no systemic absorption in the standard dose regimen for oral lichen palnus.</p>

Cite this Research Publication

A. Aruna Ramadas, Jose, R., Arathy, S. L., Kurup, S., Chandy, M. Lazar, and Kumar, S. P., “Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus.”, Indian J Dent Res, vol. 27, no. 3, pp. 230-5, 2016.