Publication Type:

Journal Article

Source:

Journal of Experimental Pathology, Volume 3, Number 3, p.295-304 (1987)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0023574829&partnerID=40&md5=4afb6fdff8e644e0774a57d8d3477037

Keywords:

Carcinoma, Diagnosis, Differential, Fabaceae, Fibrosis, histochemistry, horseradish peroxidase, human, human cell, lectin, Lectins, leukoplakia, Medicinal, mouth carcinoma, Mouth Mucosa, Mouth Neoplasms, Non-U.S. Gov't, Papillary, Plants, Squamous Cell, Support

Abstract:

Lectins from the seeds of Jackfruit (Artocarpus integrifolia) and winged bean (Psophocarpus tetragonolobus) were isolated using an immobilized N-acetyl-D-galactosamine column and conjugated to type VI horse radish peroxidase. The purified conjugate was used for the study of tissue specificities using diaminobenzidine as the substrate on dewaxed tissue sections of normal, oral leukoplakia, oral submucous fibrosis, verucous carcinoma and squamous cell carcinoma of the oral cavity. In spite of having a common inhibitory sugar, winged bean lectin did not bind to any lectins whereas Jackfruit lectin showed varying degrees of binding towards the above tissues. The difference in the nature and intensity of binding of the Jackfruit lectin suggest the utilizing this lectin in the differential diagnosis of the premalignant and malignant lesions of the oral cavity.

Notes:

cited By 10

Cite this Research Publication

D. M. Vasudevan, Vijayan, K. K., Remani, P., Beevi, V. M. Haseena, Ankathil, R., Vijayakumar, T., Rajendran, R., and Augustine, J., “Tissue binding patterns of lectins in premalignant and malignant lesions of the oral cavity”, Journal of Experimental Pathology, vol. 3, pp. 295-304, 1987.

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