Publication Type:

Journal Article

Source:

Sensors and Actuators B: Chemical, Volume 171–172, p.1292 - 1296 (2012)

URL:

http://www.sciencedirect.com/science/article/pii/S0925400512006569

Keywords:

MEMS

Abstract:

We have developed a novel, operator-friendly, nanothermite reaction actuator which generates transient pressures comprised of a shock wave superimposed on a broad pressure pulse to facilitate intranuclear molecular transport. The actuator demonstrates the delivery of ∼70 kDa FITC-Dextran into chicken cardiomyocytes with cytoplasmic delivery efficiency greater than 90%, maximum intranuclear delivery efficiency of 84%, and cell survival rates exceeding 95% in minimum operating pressure conditions. Tunable nanothermite reactions enable versatile pressure generating characteristics which can extend the technology to a spectrum of biomedical molecular delivery applications.

Cite this Research Publication

M. Korampally, Apperson, S. J., Staley, C. S., Castorena, J. A., Dr. T. Rajagopalan, Gangopadhyay, K., Mohan, R. R., Ghosh, A., Polo-Parada, L., and Gangopadhyay, S., “Transient pressure mediated intranuclear delivery of FITC-Dextran into chicken cardiomyocytes by MEMS-based nanothermite reaction actuator”, Sensors and Actuators B: Chemical, vol. 171–172, pp. 1292 - 1296, 2012.

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