New transition metal complexes of quinoxaline–thiosemicarbazone ligands were prepared and characterised by spectroanalytical techniques. The ligands L1H2 and L2H2 were obtained by the reaction of quinoxaline-2.3(1,4H)-dione with methyl and phenyl thiosemicarbazide, respectively. All the complexes are found to be monomeric in nature and have tetrahedral geometry. The copper complexes have shown redox responses in the applied voltage range, whereas the ligands and other complexes are electrochemically innocent. The ligands, copper and zinc complexes are explored for antidiabetic activity in the diabetes-induced Wister rats. Evaluation of antidiabetic activity was done by blood-glucose test and oral glucose tolerance test; few compounds have exhibited significant antidiabetic activity and posses low toxicity with a high safety profile.
Dr. Naveen V. Kulkarni, Revankar, V. K., Kirasur, B. N., and Hugar, M. H., “Transition metal complexes of thiosemicarbazones with quinoxaline hub: an emphasis on antidiabetic property”, Medicinal Chemistry Research, vol. 21, pp. 663–671, 2012.