Unusual presentation of Warthin variant of Papillary thyroid carcinoma with lymph nodal metastases in a patient of Graves' disease
Publication Type:Journal Article
Source:Journal of Cancer Research and Therapeutics, Medknow Publications, Volume 11, Number 3, p.652 (2015)
Keywords:adult, article, cancer prognosis, cancer surgery, case report, cervical lymphadenopathy, differentiated thyroid cancer, female, Graves disease, human, lymph node metastasis, thyroid carcinoma, thyroid scintiscanning, thyroidectomy, thyrotoxicosis, Warthin tumor, Young Adult
Warthin-like Papillary thyroid carcinoma (WPTC) is a rare variant of papillary carcinoma of thyroid, PTC which derives its name by closely resembling Warthin's tumor of salivary gland. Hallmark histological feature of this variant is papillary folding lined by oncocytic neoplastic cells with clear nuclei and nuclear pseudoinclusions, accompanied by prominent lymphocytic infiltrate in the papillary stalks. It is thought to be one of those differentiated thyroid cancers with favorable prognosis. We report a case of Graves' disease with a cold nodule harboring WPTC with initial presentation of lymph nodal metastases. It is important to identify this peculiar variant of PTC as 5 to 10% of them undergo dedifferentiation and 30% have the lymph nodal metastases and extra thyroidal extension.
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