Publication Type:

Journal Article

Source:

Pharma Times, Volume 42, Number 6, p.20-21 (2010)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77954463638&partnerID=40&md5=d932a5a6d36374c02267263c820b2c73

Keywords:

acquired immune deficiency syndrome, Alzheimer disease, amyloid beta protein[1-42], article, baboon, bone remodeling, chemokine, chimpanzee, clinical research, cytokine, disease model, drug efficacy, drug safety, experimental animal welfare, genetic marker, genetic polymorphism, human, human versus animal comparison, immunopathogenesis, insulin, intracellular signaling, monoclonal antibody, nonhuman, phylogeny, protein analysis, rhesus monkey, risk assessment, species comparison, streptozocin diabetes, tau protein, toxicity testing

Abstract:

Nonhuman primates (NHP) are the preferred animal models for pre-clinical research because they approximate humans in physiology and genetics more closely than any other animal species. Vital advances in immunologic research have been made through the use of the NHP model, most notably in AIDS pathogenesis, treatment, and vaccine development. Cytokines and chemokines are soluble mediators of the immune system that play a crucial role in intercellular signaling, and in the recruitment of cells to inflammation sites. Identification of these molecules in NHP is important for the understanding of complex physiological and pathological mechanisms that occur in these species, and to demonstrate whether these mechanisms function similarly in humans. Recently, several antibodies specific for human cytokines that have the capacity to recognize homologous chemokines and cytokines of NHP origin have been identified. Currently, a panel of reagents is available which allows the simultaneous identification of cytokines and chemokines from Chimpanzees, Old World Monkeys, Rhesus Macaques, Baboons, Cynomolgus Macaques, Pig-tailed Macaques, and African Green Monkeys.

Notes:

cited By (since 1996)0

Cite this Research Publication

S. M. Sonal, Aneesh, T. P., and Shenoy, P. O., “Use of nonhuman primates in developing monoclonal antibodies”, Pharma Times, vol. 42, pp. 20-21, 2010.