A validated hptlc determination of an angiotensin receptor blocker Olmesartan Medoxomil from tablet dosage form

Publication Type:

Journal Article

Authors:

Parambi, D.G.T.a; Mathew Sr., M.b; Ganesan, V.c; Jose, A.d; Revikumar, K.G.d

Source:

International Journal of Pharmaceutical Sciences Review and Research, Volume 4, Number 3, p.36-39 (2010)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79952024428&partnerID=40&md5=141e7ee307d65f8cf8b918037a04a531

Keywords:

accuracy, Acetic acid, Acetonitrile, analytic method, article, chloroform, controlled study, drug determination, high performance thin layer chromatography, olmesartan, physical phase, quantitative analysis, sensitivity and specificity, silica gel, tablet formulation, toluene, validation process

Abstract:

{A quantitative HPTLC method for determination of Olmesartan Medoxomil in tablet dosage form has been established and validated. Olmesartan from formulations was separated and identified on silica gel 60 F 254. HPTLC plates with chloroform: acetonitrile: toluene: glacial acetic acid, in the ratio 1:8:1:0.1(v/v) was used as mobile phase. The plates were developed to a distance of 8 cm. Quantitation was performed at λ=301nm by reflectance scanning and well resolved results were obtained for Olmesartan medoxomil. The method was validated for precision, recovery, robustness, specificity and ruggedness. The calibration plot for olmesartan standard was linear with r =0.9991

Notes:

cited By (since 1996)3

Cite this Research Publication

D. G. Ta Parambi, Sr., MbMathew, Ganesan, Vc, Jose, Ad, and Revikumar, K. Gd, “A validated hptlc determination of an angiotensin receptor blocker Olmesartan Medoxomil from tablet dosage form”, International Journal of Pharmaceutical Sciences Review and Research, vol. 4, pp. 36-39, 2010.

 
          
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