Publication Type:

Journal Article


International Journal of Pharmaceutical Sciences Review and Research, Volume 21, Number 1, p.64-69 (2013)



acetylsalicylic acid, adalimumab, adjuvant therapy, antiinflammatory activity, auranofin, azathioprine, celecoxib, chemiluminescence immunoassay, diclofenac, disease modifying antirheumatic drug, drug delivery system, drug dosage form comparison, drug efficacy, drug elimination, drug release, drug retention, drug targeting, emulsion, encapsulation, enzyme linked immunosorbent assay, erythrocyte sedimentation rate, etanercept, etodolac, etoricoxib, gastrointestinal symptom, gel, human, ibuprofen, indometacin, infliximab, ketoprofen, knee osteoarthritis, latex agglutination test, leflunomide, lipid vesicle, liposomal delivery, liposome, lumiracoxib, meloxicam, methotrexate, naproxen, niosome, nonsteroid antiinflammatory agent, piroxicam, prednisolone, recombinant interleukin 1 receptor blocking agent, review, rheumatoid arthritis, rofecoxib, salazosulfapyridine, suspension, tacrolimus, turbidimetry, unindexed drug, unspecified side effect, valdecoxib


Rheumatoid Arthritis is a chronic systemic, inflammatory disease that if untreated, results in joint destruction and disability, affecting the quality of life. Various diagnostic indicators are used to ascertain the presence of the chronic disorder. Current treatment strategies offer various side effects and decreased action at the target site. The therapeutic possibilities in the management of rheumatoid arthritis have changed with the advent of vesicular systems that can be used to target the inflammatory cascade seen in rheumatoid arthritis. Vesicular drug delivery has brought about breakthrough in improving the therapeutic efficacy of the drugs by controlling and sustaining the action while minimizing the side effects. The focus of this review is to explore the potential of various novel vesicular systems in targeting drug action, improving the bioavailability and in reducing the systemic sideeffects of anti-rheumatic drugs.


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Cite this Research Publication

S. Letha and Viswanad, V., “Vesicular systems in treatment of rheumatoid arthritis”, International Journal of Pharmaceutical Sciences Review and Research, vol. 21, pp. 64-69, 2013.