<p>The present study was designed to investigate the analgesic and antipyretic activity of methanol extract of aerial parts of Tabernaemontana divaricata in experimental animal models. The analgesic activity of T. divaricata at the doses of 100 and 200 mg/kg was assessed by various experimental models such as Acetic-acid and Hot-plate induced writhing and Hafner's Tail-clip method, by using indomethacin (10mg/kg) pentazocine (10mg/kg) as standard drugs, while Yeast-induced hyperpyrexia was used to evaluate the anti-pyretic activity using parecetamol(150 mg/kg) as standard. The methanol extract of T. divaricata (METD) at 200 mg/kg was found to be significantly (p < 0.001) reduced the Acetic-acid induced writhings in mice. Moreover in Hot-plate test, there was a significant dose dependent inhibition of pain (p < 0.01 & p < 0.001) at the doses of 100 and 200 mg/kg b.w. respectively. Also in the tail-clip test, METD caused a significant increase in the reaction time at both the doses used. METD significantly reversed the yeast induced hyperthermia in a dose dependent manner at different time of observation (1-4hr). The obtained results provide promising baseline information for the potential use of T. divaricata in the treatment of pain and pyrexia.</p>
S.K. Kanthlal, Suresh, V., Ganesan, A., P Frank, R., and Kameshwaran, S., “In vivo Evaluation of Analgesic and Antipyretic activity of Aerial parts of Tabernaemontana divaricata in Experimental Animal models”, Pharmacologyonline, vol. 3, p. 1127, 2011.