Acne vulgaris is a multifactorial disease affecting the pilosebaceous follicle characterized by comedones, papules, pustules, nodules and scars. Microorganism was isolated from facial swabs and the colonies developed on the plates were S.epidermidis. Biochemical tests carried out to confirm theorganism. Various topical agents were screened for efficiency to inhibition through disc and well diffusions. Clidamycin, Himalaya and lime gave positive for antibacterial activity. Among this Clidamycin showed the largest zone of inhibition.