Furfuryl Derivatives of Meldrum’s Acid: Synthesis, Characterisation and Biological Studies
Meldrum’s acid has been reported to undergo a condensation reaction with aromatic aldehydes to afford adducts with a host of interesting chemical, physical as well as biological properties. In the present work we have prepared the Meldrum’s acid adduct of furfural which has been screened for antifungal activity. It has been reported that the Furfuryl adduct of Meldrum’s acid undergoes a ring opening reaction with secondary amines at room temperature to afford a new class of donor-acceptor Stenhouse adducts (DASAs). Our group is trying to explore this property of the prepared derivative for trying out various biological applications.
Furfural Meldrum’s acid Meldrum’s acid adduct of furfural
FTIR spectrum of Meldrum’s acid adduct of furfural