Meldrum’s acid has been reported to undergo a condensation reaction with aromatic aldehydes to afford adducts with a host of interesting chemical, physical as well as biological properties. In the present work we have prepared the Meldrum’s acid adduct of furfural which has been screened for antifungal activity. It has been reported that the Furfuryl adduct of Meldrum’s acid undergoes a ring opening reaction with secondary amines at room temperature to afford a new class of  donor-acceptor Stenhouse adducts (DASAs). Our group is trying to explore this property of the prepared derivative for trying out various biological applications.

Meldrum’s acid adduct of furfural

Furfural             Meldrum’s acid                Meldrum’s acid adduct of furfural

FTIR spectrum of Meldrum’s acid adduct of furfural

FTIR spectrum of Meldrum’s acid adduct of furfural

Project Details
PI: 
Dr. Sobha V. Nair
Co Pi: 
Aiswarya Soman
Ashwin Perumal
Athiralakshmi S.
Kalyani Ajayan
Ramya Raj
Start Date: 
Thursday, January 1, 2015 to Tuesday, May 12, 2015

School: