• The Project entitled "Development of Endogenous H2S Triggered Fluorescence Modulated Theranostic in Cancer Therapy and Imaging" is funded by CSIR (02(0386)/1 9/EMR-ll).

    development-of-endogenous-h2s-triggered-fluorescence-modulated-theranostic-in-cancer-therapy-and-imaging
  • WeNet will create a platform to enable people to support each other transcending geographical and cultural backgrounds.It is funded by Horizon 2020 (the biggest EU Research and Innovation program) and was launched at the Department of Information Engineering and Computer Science, University of Trento, Italy.

    wenet-the-internet-of-us
  • Blood Oxygen Level Dependent (BOLD) signals are the responses of functional magnetic resonance imaging techniques used to understand brain state and function in neurology.

    modeling-fmri-bold-correlates-of-neural-circuit-activity
  • In this project, we will use EEG recordings to control robotic arm by extracting left and right side motor imagery movement patterns. We will develop and use feature extraction methods to extract the required features from the pre-processed signal data.

    designing-a-bmi-based-robotic-arm-using-eeg-and-motor-articulation-control
  • Bacteriocins are antimicrobial peptides produced by bacteria that kill or inhibit the growth of other bacteria. Bacteriocins differ from most therapeutic antibiotics in being proteinaceous and generally express a narrow specificity of action against strains of the same or closely related species.

    studies-on-antagonistic-effects-of-partially-purified-bacteriocins-from-microflora-of-fermented-vegetables-against-enteric-pathogens
  • The exploration of endophytes is still an emerging field. Almost all plants seem to deliver endophytes with promising contents and activities. Simarouba glauca has a long history in herbal medicine as antiparasitic, antidysentric, antipyretic and anti cancerous agent in many countries.

    in-vitro-studies-on-pharmacological-potential-of-mycoendophyte-of-simarouba-glauca
  • This research project seeks to bring together biomass based biochars and hydrochars from rice husk waste product to remove heavy metals and other contaminants from industrial and domestic wastewater that makes its way untreated or only partially treated into rivers and streams.

    an-innovative-green-technology-for-treating-municipal-and-industrial-wastewater-entering-rivers-and-streams
  • In a unique partnership, Amrita Vishwa Vidyapeetham joined hands with Wipro Technologies, Bangalore to work on an end-to-end diabetes solution. The project entitled "Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care" is funded by DBT-BIRAC, Government of India.

    low-cost-device-and-cloud-enabled-smart-solution-for-diabetes-care
  • Viruses infecting the bacteria, called bacteriophage (phage), have been used for over 90 years as an alternative to antibiotics in Russia, east Europe and France.  They are currently being tried as a possible therapy against multi-drug-resistant strains of many bacteria. We are looking for potential application of bacteriophages and their parts or enzymes from kitchen waste in treating enteric infections and foul smell from domestic wastewater (toilet).

    viral-agents-to-target-and-kill-pathogens-and-odour-producing-bacteria-in-fecal-waste
  • A wide range of plants have been harnessed for the development of remedies under the Ayurvedic system of medicine. However, a comprehensive modern biological understanding regarding the factors that contribute to the physiology of these plants, the active metabolites and their production is largely lacking.

    identification-and-characterization-of-the-role-of-allium-sativum-microbiome-on-the-production-of-therapeutic-metabolites
  • When encountering a new host, every potential microbial pathogen can stay, acquire nutrients, colonize and then seek another host.  Alternatively the pathogen could express its full battery of virulence factors, and invade the host. The successful attack of a host is now understood to be a communal process called Quorum Sensing (QS).

    quorum-sensing-and-biofilm-formation-in-microbial-pathogenesis
  • The proposed work envisages the fabrication of microfluidic lab-on-a-chip (LOC) module for non-enzymatic sensing of glucose, cholesterol and creatinine using a single device.

    development-of-a-lab-on-a-chip-loc-for-detection-of-glucose-cholesterol-and-kidney-function
  • Traditional Indian medicine has always captivated Indian researchers and medical practitioners for its application in various pathological conditions. Natural products have been an invaluable repository for the discovery of novel drug candidates as a source of remedy for a number of ailments including cardiovascular diseases and cancers. Almost 60% of the approved anti-cancer drugs were known to be derived from natural sources.

    anacardic-acid-a-novel-template-for-cancer-therapy
  • Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries like India. An in-depth understanding of the molecular mechanisms involved in the progression of different forms of cancer has been the focus of drug discovery efforts.

    elucidating-the-molecular-mechanisms-of-anacardic-acid-and-biacacetin-mediated-regulation-of-matrix-metalloproteinases-in-cancer
  • Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth. Understanding the mis-regulation of molecular mechanisms leading to cancer has been the primary method of discovering new drug targets. MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis.

    role-of-mirnas-in-cancer-and-modulation-of-oncogenes-by-natural-products
  • Quantum dots, also known as nanocrystals, are a special class of materials known as semiconductors, which are crystals composed of periodic groups of II-VI, III-V, or IV-VI materials. Their size ranges from 2-10 nanaometers. At these small sizes materials behave differently, giving quantum dots unprecedented tunability and enabling never before seen applications to science and technology. They have properties that are between those of bulk semiconductors and those of discrete molecules.

    synthesis-and-characterization-of-lead-salt-based-linear-heterostructures-for-photovoltaic-applications
  • The role of various sugars on the surface glycans in bacterial /fungal pathogenesis of plants and animals is well known. The focus of our research group is to hit upon proteins which are capable of interacting with these sugars. A class of proteins called ‘’lectins” which are widely present in natural sources like plants, marine algae etc. are very specific in their interaction with various sugars/glycoproteins. The interactions will be studied by Isothermal Titration Calorimetry (ITC) and Surface Plasmon resonance (SPR). 

    marine-algae-an-important-source-for-lectins
  • Endophytes/ endosymbionts from marine micro algae have recently gained attention as potential sources of bioactive secondary metabolites. Our aim is to isolate and identify the endophytes by molecular biology methods. 

    identification-of-endophytes-from-marine-algae-by-16s-rrna-sequencing
  • Diabetes is a long term prevailing disease which affects millions of people worldwide. It is a condition where the body fails to utilize the ingested glucose. There has been a dire need for the development of low cost yet effective glucose sensing device. Present day devices are amperometric and works on generated electrochemical signals.

    escherichia-coli-based-microfluidic-whole-cell-glucose-biosensor
  • Cancer, which results from altered tissue growth regulation, is one of the leading causes of death worldwide.  Inflammation is the response of the immune system to infection and injury and has been implicated in the pathogeneses of arthritis and cancer. There are several interactions that occur within the tumor microenvironment that is dependent on various signaling pathways.

    cyclooxygenase-2-in-cancer-and-inflammatory-diseases
  • Nowadays researchers are interested in cell patterning and here is a method used for patterning mammalian cells that does not require access to photolithographic capabilities. This work describes a versatile process for forming microstructures of polymers, ceramics and metals.

    mimic-a-unique-approach-to-wound-healing-assays
  • Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.  It is one of the major steps in normal wound healing process with overlapping events such as formation of granulation tissue, angiogenesis, and tissue remodeling. However, chronic inflammation can also lead to a host of diseases.

    regulation-of-inflammasomes-by-natural-product-extracts-role-in-metabolic-disorders
  • MicroRNAs (miRNAs) are short double stranded RNAs that are produced endogenously in mammalian cells, and control the regulation of many target genes at the post-transcriptional level. There are many reports of the misregulation of these miRNAs in cancer. We will be studying the regulation of MMP-2 & MMP-9 by miRNAs, and the effect of natural products on the modulation of these miRNAs.

    the-discovery-of-micrornas-mirnas-that-regulate-the-expression-of-gelatinase-a-matrix-metalloproteinase-2-mmp-2-and-b-matrix-metalloproteinase-9-mmp-9-in-colon-cancer-cells
  • Investigating the organized activity of neuron ensembles is critical to understand how brain circuits work and is one main target of the project. Reconstruction of network activity has proved to be a hard task. This project will study cellular function using multi-scale models of single cells and networks will be developed with NEURON.

    computational-modelling-and-prediction-of-cerebellar-input-layer-function-timing-and-plasticity-for-understanding-neurophysiological-disorders
  • DNA microarrays have rapidly evolved to become one of the essential tools to examine expression or mutation of thousands of genes simultaneously. There is a need for alternative patterning methods that must be very simple, reproducible, cost-effective, and eventually transferable to any laboratories for their own problematic situations.

    benchtop-nanoscale-patterning-using-soft-lithography-for-the-printing-of-dna-molecules
  • India is rich in plant biodiversity, and that has been utilized extensively in traditional medicine. In collaboration with Dr. Asoke Banerji (Phytochemistry, Amrita School of Biotechnology) who is leading the efforts in the extraction and purification of natural products from various plant sources, we plan to test these compounds on the expression of gelatinases (MMP-2 and MMP-9); known to be up-regulated in majority of cancers including breast and colon cancers.

    modulation-of-microrna-and-transcriptional-regulation-of-mmp-2-by-natural-products-in-human-breast-cancer-cells
  • One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems. Critical to this aim is the investigation of timing mechanisms in the cerebellar cortex.

    neurophysiological-recording-and-modeling-fast-response-timing-of-granule-and-golgi-cell-responses-for-cerebellar-function
  • Anthracyclines are among the most effective anti-cancer treatments ever developed, but their clinical use is limited by their cumulative dose-related cardio-toxicity which may ultimately lead to a severe form of cardiomyopathy. A classical example is Doxorubicin (DOX) that is used for the treatment of a wide variety of cancers, including lymphoma, leukemia, and solid tumors.

    identification-of-molecular-mechanisms-of-action-of-the-cardioprotective-compound-arjunolic-acid
  • A tropical forest, with its varied life forms, provides an array of resources and services, making life possible on earth. The major beneficial components include food, medicine, clothing and shelter. Plants used in medicine needs much attention as, on one side, they are not fully explored for their medicinal and curative properties, and on the other side, some of them are threatened by habitat loss and over exploitation.

    inventory-of-vegetation-with-special-reference-to-medicinal-and-aromatic-plants-and-documentation-of-traditional-knowledge-in-the-walayar-valley-western-ghats
  • The research activity in our laboratory aims at the development of novel biopolymer matrices with potential applications in waste water management, drug delivery etc. For instance, the β-oxothioamide derivative of chitosan biopolymer was found to have potential applications as a metal chelator for waste water management. We have also successfully grafted analogues of drugs like bupropion onto the chitosan backbone which will facilitate the slow release of the drug into the biological system. The newly synthesized biopolymers are characterized by FT-IR spectroscopic as well as thermal studies like DSC, TGA, etc.

    chemically-modified-biopolymers-synthesis-characterization-amp-applications
  • This project proposes to develop a cerebellum inspired pattern recognition algorithm for robotic data classification. The project aims to investigate the temporal and spatial dynamics in the cerebellar network models capable of predicting cerebellar input-output transformations by analyzing the mathematical and computational properties of the network. Both labs have been working together since 2004 on cerebellar models.

    cerebellum-inspired-approach-for-pattern-classification-in-robots
  • Lentiviral vectors are powerful tools to deliver genetic material into almost any cell or tissue, and are useful even in the creation of transgenic animals. They have been shown to deliver foreign genes not only to mammalian cells, but also in cells derived from fish, birds and amphibians. We are collaborating with InStem/NCBS to generate transgenic primitive metazoans.

    lentiviral-vectors-for-the-creation-of-transgenic-organisms
  • Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which originate from the intrinsic nature of the enzymes. This project aims at developing a commercially viable non-enzymatic glucose sensor strip and a glucometer. Electrode surface modified with transition metal and metal oxide nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. 

    development-of-non-enzymatic-electrochemical-glucose-biosensors-and-glucometer
  • Berberine, an isoquinoline alkaloid with a bright yellow color, is easily seen in most of the herb materials when found in significant amounts. Among Chinese herbs, the primary sources for berberine are phellodendron and coptis. Similar isoquinoline alkaloids (jateorrhizine, coptisine, palmatine, and columbamine) in these two herbs also have a yellowish color.

    synthesis-of-intermediate-analogues-for-biologically-active-molecules
  • The requirement of energy in India has been growing exponentially over the years. Since conventional energy options are futile to tackle this raise, the needs for non-conventional energy sources have become essential. Solar Photovoltaic cell could be one such alternative energy source since solar energy is available abundantly in the world which is renewable, eco friendly and free from pollution.

    natural-dyes-as-efficient-candidate-for-enhancing-the-photovoltaic-properties-of-dye-sensitized-solar-cells
  • The separation and characterization of bioactive compounds from plant extract is the crucial step in the study of phytochemicals. Over the past few years, the applications of Liquid Chromatography coupled with Mass Spectrometry (LC/MS) in natural product analysis have been dramatically growing because of the increasingly improved separation and detection capabilities of LC/MS instruments.

    development-of-chromatographic-separation-and-detection-techniques-for-natural-products-as-plant-extracts-peptides-proteins-and-carbohydrates
  • In contrast to other fields in biology, mathematical thinking and methodology have become entrenched in neuroscience since its very beginning, as witnessed by the classical work of Hodgkin and Huxley. One of the biggest open challenges mathematicians and engineers face is to understand the complex computation that takes place in our brain. Among the most interesting parts of the brain, is the ‘little brain’, otherwise known as the cerebellum.

    computational-neuroscience-and-cognitive-modeling
  • This project aims at understanding cognitive functioning of cerebellar input layer and implement signal processing abilities into neural hardware using cerebellar architecture. The main goals include understanding cerebellum granule neuron’s role in signal propagation and information processing in a central neuronal network. The other major focus will be on the analysis of cerebellar microcircuits for designing electronic neural processors.

    bio-inspired-processor-design-for-cognitive-functions-via-detailed-computational-modeling-of-cerebellar-granular-layer
  • Matrix binding proteins from probiotics and viruses:

    matrix-binding-microbes-and-bacteriophages-to-counter-infection
  • Amrita Virtual Biotechnology laboratory is a new kind of experimental science that is being established as a virtual simulation based laboratory. These labs focus on helping students retain the real feel of a laboratory, while conducting the experiment from an internet-enabled computer terminal, much in the same way as is done, in a real lab.

    virtual-amrita-laboratories-in-biotechnology
  • The current study will enable the elucidation of global miRNA expression profiles and identification of miRNA targets in response to intervention with chemopreventive phytochemicals in liver cancer. This will enable a better understanding of miRNA dysregulation and identify novel biomarkers for preventive or therapeutic intervention in liver cancer.

    modulation-of-microrna-and-protein-signatures-in-hepatocellular-carcinoma-by-chemopreventive-phytochemicals
  • Docking studies are computational techniques for the exploration of the possible binding modes of a substrate to a given receptor, enzyme or other binding site. The application of computational methods to study the formation of intermolecular complexes has been the subject of intensive research during the last decade.

    computational-chemistry-amp-molecular-docking-studies
  • Virtual Lab: Amrita Vishwa Vidyapeetham is transforming the face of higher education and research, through a revolutionary new educational tool – virtual labs. The VALUE Initiative is a project dedicated to developing these virtual labs in various science and engineering disciplines. Virtual labs are media-rich online learning environments, which allow users to conduct physical laboratory experiments in a computer-simulated environment. This innovative new educational technique is enabling experimentation beyond the boundaries of traditional laboratories

    value-virtual-simulation-labs
  • The dynamics of spatially structured populations (metapopulations) have been widely studied over the last few decades. For the sake of simplicity, most of these studies assume that all the constituent local populations (subpopulations) experience similar rates of migration (immigration and emigration). Although it is intuitively obvious that nothing in nature constrains the migration rates to be symmetric, i.e.

    theoretical-and-empirical-investigations-on-the-interaction-of-asymmetric-migration-and-intrinsic-growth-rate-on-the-dynamics-of-laboratory-metapopulations-of-drosophila-melanogaster
  • This study proposes the investigation of “Bulk Heterojunction” solar cells consisting of different types of p-type (donor) and n-type (acceptor) network. The various chemicals proposed to be used in this study are metal phthalocyanines, polypyrrole, polythiophene, azo dyes, etc.

    organic-bulk-heterojunction-devices-for-photovoltaic-solar-cell-applications
  • Divergent oriented synthesis is a strategy which aims to the synthesis of compounds with diverse chemical structures. It is often an alternative to convergent synthesis or linear synthesis.

    diversity-oriented-synthesis-applications-to-flavonols-flavones-isoflavones-and-biflavones
  • In the Phytochemistry laboratory, development, analysis, and optimization of technical processes for target dependent bioactive compound isolations and assays are carried out. A brief account is given below.

    process-development-for-isolation-and-characterization-of-phytochemicals
  • Seabuckthorn (SBT), (Hippophae L.) are deciduous shrubs in the genus Hippophae, family Elaeagnaceae. In addition to the nutritionally active constituents, many clinically important activities of seabuckthorn (SBT), such as beneficial effects on skin, cardiovascular diseases, diabetes, wound healing, cancer chemopreventive action, antiviral activity, sun screen and radioprotection have been established.

    seabuckthorn-a-repository-of-bioactive-phytochemicals
  • There are a wide range of underutilized plants with well known nutritional and medicinal properties. They have the potential for further promotion as they are locally available or are byproducts or waste materials. They are culturally accepted and often well established component of life systems and diets. Some of the isolated phytochemicals from them have commercial value.

    Seabuckthorn

    value-addition-to-underutilized-biosources
  • Diabetic wound healing is a challenging problem to solve as it requires the integration of interdependent processes that involve signal transduction input from inflammation, cell migration, cell proliferation, cell differentiation and production of extracellular protein components.

    molecular-mechanisms-in-impaired-wound-healing

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