• Amrita Healthcare Informatics Suite is a demonstration of Amrita’s leadership in research and development of state-of-the- art technologies. Amrita HIS is a comprehensive software solution that allows a holistic approach within and across clinical segments, delivering solutions with the innovation and synergy necessary to help move forward in today’s changing healthcare environment.

    amrita-hospital-information-system-ahis-
  • Multidrug resistant microbial infections are difficult to treat with common antibiotics, and incidences of infections caused by such strains are increasing day by day. Therefore, there is a constant and urgent need for alternative and effective anti-microbial agents for treatment of poultry, cattle and humans.

    identification-and-characterization-of-anti-microbial-compounds-s-and-adhesins-produced-by-lactobacillus-fermentum-l-fermentum-
  • In collaboration with the Medical Informatics Group, CDAC Trivandrum, the MEDSIM project will design and develop Computer based Medical Simulations that will allow students pursuing medical sciences to visualize, learn, practise and experience a variety of medical skills and procedures in order to provide a simulated patient experience.

    computer-based-medical-simulation-medsim-
  • This study attempts to analyze, in a prospective manner, the psycho-social and economic impact of surgery for CHD on Indian families.

    psychological-and-economic-impact-of-surgery-for-congenital-heart-disease-chd-on-indian-families
  • Rheumatoid arthritis is a chronic, progressive systemic inflammatory disease of the synovium, a delicate membrane that lines the non-weight-bearing surfaces of the joint. Auto-immunity plays an important role in the development of RA and that increased antibody response has been shown to be a hallmark of RA. Presence of anti-CCP and anti-immunoglobulin reactivity indicates that antibody response is crucial in the development of RA.

    identification-of-new-autoantigens-in-rheumatold-arthritis-using-an-unbiased-clinical-proteomics-approach
  • Synthesis and preliminary evaluation of ring – A mono – substituted chalcones as potential anti-inflammatory agents ( funded by Kerala State Council for science, Technology and Environment (KSCSTE) for a period of one year from July 2012 to June 2013 to the extent of Rs. 10,000/-)

    synthesis-and-preliminary-evaluation-of-ring
  • Studies on structural modifications of antimicrobial chitosan (Rs. 10,000, funded by Kerala State Science, Technology and Environment for a period of one year from July 2012 to June 2013).

    structural-modifications-of-antimicrobial-chitosan
  • This project proposes to explore the utility of the autologous modified endothelial cells engrafted onto a nano scaffold framework as a novel therapeutic modality for optimising wound healing. This would lead to potential translational application in patients with diabetic foot ulcers and non-healing wounds.

    development-of-blood-outgrowth-endothelial-cell-and-nanofiber-scaffold-synergy-in-wound-healing
  • Staphylococcus aureus is the commonly found bacteria in septic arthritis. Methicillin resistant S.aureus (MRSA) is the most common cause of community-onset adult septic arthritis. It has been documented that S.aureus cell surface associated components can induce sepsis, organ injury, and septic arthritis. 

    role-of-staphylococcal-pathogen-associated-molecular-patterns-in-septic-arthritis
  • Endovascular stents, used commonly for the treatment of occlusive vascular diseases, have historically been manufactured using metals and metal composites. Although stents have reduced the restenosis rate from 40% to 20% compared to angioplasty alone, in-stent restenosis still remains a major limitation for this approach.

    nanosurface-engineering-of-bare-metallic-coronary-stents-for-combating-in-stent-restenosis
  • Lactobacillus fermentum, a probiotic strain, which the team isolated from human colonic mucosal biopsy samples, possesses anti-microbial activities and inhibits the adhesion of enteropathogens to intestinal epithelial cells. Isolated cell surface associated proteins from L. fermentum were sufficient for this adhesion exclusion. Identification and characterisation of these surface proteins from L.

    identification-and-functional-analysis-of-probiotic-bacterial-surface-associated-proteins-in-preventing-enteropathogenic-infections
  • Metformin is a frequently used medication for patients with type II diabetes mellitus (DM) that has received increased attention, because of a study from pharmacy and disease databases showing decreased cancer incidence in individuals taking metformin. Metformin inhibits the growth of breast and prostate cancer cell lines. 

    metformin-encapsulated-biodegradable-chitosan-nanoparticles-a-novel-strategy-for-pancreatic-cancer-therapy
  • This project deals with development of nanomedicine for the targeted photodynamic therapy of cancer. This project is done in collaboration with Erasmus Medical Centre, Netherlands, where pre-clinical evaluation will be done using the nanomedicine developed by the ACNS team.

    targeted-nanoparticle-photodynamic-therapy
  • The project aims at high through put screening of biological activity of extracts from deep sea marine organisms.The project is funded by MLR Technology Development (MLR-TD), Marine Living Resources Program (MLRP), Ministry of Earth Sciences.

    extracts-from-deep-sea-marine-organisms
  • Induced pluripotent stem cells (iPSc) are somatic cells that have been reprogrammed to a pluripotent state. These iPSc have similar characteristics to embryonic stem cells and hold great promise in various aspects of research. The aim of this study is to develop patient specific stem cells to understand disease mechanism and identify drugs that will prevent malignant transformation.

    generation-of-induced-pluripotent-stem-ips-cells-from-genetically-altered-somatic-cells
  • The project proposes to extend the nano-toxicological investigations of developed multifunctional NPs. It aims to extend the previous study to develop new theragnostic nanomedicines.

    nano-toxicology-and-nano-medicine-phase-ii
  • This study involves the development of a nutraceutical product using coconut water as the main ingredient by incorporating some of the traditionally used natural antioxidants, such as, extracts from plants like Trichopus, Sp.Carrot, Grape seed. etc, without affecting stability. The research involves characterization of taste, anti-oxidant potential and stability of a variety of different formulations.

    nutraceutical-preparation-using-coconut-water
  • Several projects are focused on the development of nanomedicines for application in cancer therapeutics, drug delivery for infectious diseases and also for regeneration of tissues using nanostructured scaffolds. Some of the tissues studied are bone, cartilage, cardiac tissue, vascular tissue and liver tissue. A wide range of natural polymeric nanostructured materials and bioceramics are being investigated for such applications.

    nanomedicine-and-tissue-engineering
  • In 2011, Amrita Center for Nanosciences and Molecular Medicine was chosen for a TUE in Tissue Engineering and Medical Bio Nanotechnology by the Nanomission of the Government of India. The TUE focuses on translational biomedical products where nanomaterials play an enabling role. This includes nanomedicines using organic non-toxic encapsulants, surface modified products, multifunctional diagnostic nanoparticles, and tissue engineered implants.

    thematic-unit-of-excellence-tue-on-tissue-engineering-and-medical-bio-nanotechnology
  • This project deals with nano-toxicological evaluation of silica nano-particle based agricultural products such as neutraceuticals and pesticides.

    toxicology
  • This project is an observational, prospective and laboratory based retrospective multi-centre, national study of invasive disease caused by S.Pneumoniae or H.influenzae or N. meningitis in children < 5 years of age. Two aspects are covered: one, a study of disease burden indicators and, two, study of the organism characteristics covering a well defined population in a specific geographical area.

    population-survey-of-invasive-diseases-in-india-caused-by-s-pneumoniae-or-h-influenzae-or-n-meningitis-in-children-below-5-years-of-age
  • This project proposes to develop novel natural biopolymeric composite hydrogel bandages based alginate, chitin and chitosan with antibacterial Herb Hemigraphis Ulternata/ZnO nanoparticles. This three-year project will involve preparation and characterization of nanostructured hydrogel bandages followed by in-vitro protein adsorption, antibacterial, blood clotting, cell attachment and proliferation.

    development-of-natural-biopolymeric-hydrogel-bandages-with-nanozno-nanosuspensions-of-herb-hemigraphis-ulternata-for-wound-dressing
  • The project on novel target-specific multiplexed nanophytomedicines for cancer therapy, funded by ICMR, focuses on the importance of dietary phytochemicals in sensitizing breast cancers that are resistant to chemodrugs such as Paclitaxel in clinical use.

    novel-target-specific-multiplexed-nano-phytomedicines-for-cancer-therapy
  • This project aims to develop a synergistic collaboration between an active nanomedicine team from the Faculty of Pharmacy, University of Porto, Portugal and a strong nano medicine group at the Amrita Center for Nanosciences, AIMS, Kochi, India. The broad area of this targeted nanomedicine research is lung cancer, which is a very serious disease in both the collaborating countries.

    novel-targeted-chitosan-based-therapeutic-polymeric-nanomedicines-for-lung-cancer-applications
  • This three-year project involves preparation of nanostructured scaffolds, plasma treatment of the scaffolds, followed by in-vitro protein adsorption, cell attachment and proliferation with and without plasma treatment.

    plasma-surface-modification-of-nanostructured-surfaces-of-marine-based-scaffolds-and-membranes-for-enhanced-bioactivity
  • The tumour hierarchical model proposes origin of cancer from a small population of cells having properties of stemness like self renewal and pluripotency. Although, cancer stem cells (CSCs) have been identified in leukemia and solid tumours by surface markers, there is variability in their specificity for isolation of CSCs in a specific tumour.

    biology-of-cancer-stem-cells-2
  • This project provides mobility funding for joint facility utilisation visits between ACNS and University of Zurich on the project entitled, “Anti-cancer Applications of Chitosan and Polyoxometalate Nanocomplexes”.

    joint-utilization-of-advance-facility-juaf-program-isjrp-indo-swiss
  • Drug discovery is currently in an exciting phase where conventional methodologies are being ably complemented by ‘omics’ approaches due, in part, to the greater accessibility of the newest generation of high-throughput platforms and technologies. At the Cancer Discovery Biology Laboratory, work is done towards making the identification of oncology clinical biomarkers more feasible through state-of-the-art pharmacogenomic and proteomic techn

    cancer-discovery-biology
  • Asymptomatic hyperparathyroidism is not well recognized in Indian population and is considered rare. Estimation of serum calcium level is not part of routine comprehensive health checkup.

    population-survey-of-asymptomatic-hyperparathyroidism-in-kerala
  • Application of nanomaterials to cell-based targeted diagnostics and regenerative medicine at a clinical level is an evolving domain that is of substantial interest to the medical scholars worldwide.

    cell-targeted-diagnostics-and-therapy-using-nanomaterials
  • This project deals with the development of a non-destructive technology for the detection of biological and chemical food toxins including bacteria, virus, small molecules toxins, and genetically modified foods using nanotechnology enabled Surface Enhanced Raman Scattering (SERS).

    chemical-and-biological-food-toxins-using-surface-enhanced-raman-scattering-sers-
  • Fusion transcripts are known to occur in cancerous cells across a range of cancers and might play important roles in the pathophysiology of cancer. In developing newer strategies to combat cancer, therapeutic knock down of fusion transcripts by RNA interference technology is being considered for its potential benefits in targeting cancerous cells.

    fusion-transcripts-in-cancer-and-the-potential-to-inhibit-by-rna-interference
  • The project 'Oncogene Sensing and Finger Printing from Saliva Using Nanotechnology' deals with Raman spectroscopic detection of cancer biomarkers from human tissues and bio-fluids.

    oncogene-sensing-and-finger-printing-from-saliva-using-nanotechnology-enabled-using-raman-spectroscopy
  • This project involves a controlled and well-characterized material process development for the preparation of carboxymethyl chitin and chitosan derivatives for applications in the biomedical area. Chitin and Chitosan are known to be natural biopolymers and are non-toxic, biodegradable and biocompatible. In the last decade, chitin and chitosan derivatives have become the focus of interest in biomedical and biopharmaceutical research.

    preparation-of-carboxymethyl-chitin-and-chitosan-derivatives
  • This project involves application of a new technique using a proteomics approach to sensitively identify molecules of therapeutic significance in Cerebral Spinal Fluid (CSF) samples.

    identification-of-novel-cell-surface-molecules-of-therapeutic-significance-in-central-nervous-system-leukemia
  • There are more than 2.5 million cancer patients in India at any given time, of which the frequency of breast and ovarian cancer cases has increased. Although there are many possible reasons, reversible phosphorylation of proteins, mediated by receptor tyrosine kinases (RTK) such as VEGF and HER2/neu receptors play a crucial role on different cellular processes associated with cancer pathogenesis.

    cancers-treated-with-vegf-and-her-2-neu-receptor-tyrosine-kinase-inhibitors
  • The objective of this study is to develop an epidemiological model for school-based interventions to modify cardiovascular risk profile. The study aims to identify ethical and practical issues with possible solutions in conducting such a study in an Indian setting.

    development-of-an-epidemiological-model-to-modify-cardiovascular-risk-profile-in-children
  • The basic methodology of this project envisages capturing core patient identifying information with details of clinical stage, types of treatment (with all particulars), and follow-up parameters as per standards specified. The results are evaluated at annual reviews by The National Cancer Registry Program, Indian Council of Medical Research.

    patterns-of-care-and-survival-studies-in-head-amp-neck-cancer-cancer-cervix-cancer-breast-all-india-study-national-cancer-registry-project
  • Amrita Research Labs has developed this integrated telemedicine solution for linking various clinics and hospitals located in the remote areas of India with Amrita Institute of Medical Sciences and Research Center (AIMS), Kochi. Telemedicine, reduced to its simplest form, is connecting geographically separate health care facilities via telecommunications, video, and information systems.

    center-for-digital-health-wireless-telemedicine-
  • In a synergistic combination arising out of its partnership with Media Lab Asia, Amrita has developed an innovative wireless telemedicine system and network for digital health at every doorstep. Amrita’s wireless telemedicine instantly enables a variety of common biomedical and public healthcare diagnostic devices to capture body parameters directly from people’s office or home and immediately transmit wirelessly through a combination of ultra high-speed WiFi and satellite networks to the 1450-bed all digital, super specialty hospital, AIMS, in Kochi.

    digital-health-at-every-doorstep-using-integrated-high-bandwidth-wireless-communication-networks
  • The principal investigator (PI) of the project titled "Evaluation and Promotion of Rational Drug Use in Primary Health Care Centres in Gassim Region" is Emmanuel James, Associate Professor at the Department of Pharmacy Practice, Amrita School of Pharmacy,Kochi. The project is funded by King Abdul Aziz City for Science and Technology, Riyadh, Saudi Arabia.

    evaluation-and-promotion-of-rational-drug-use-in-primary-health-care-centres-in-gassim-region
  • The major research objective of this unit/centre is the development of theragnostic nanoparticles with multi-functionality and characterisation of these theragnostic materials through preclinical trials.

    theragnostics-re-generative-medicine-and-stem-cell-using-cell-targeted-nano-material
  • Medical research is vital to advance the cause of medical science. However, there are increasing complexities in devices and therapeutics, and with this comes enhanced risk of patient harm.

    clinical-research-training-center-and-clinical-trials