• MicroRNAs (miRNAs) are short double stranded RNAs that are produced endogenously in mammalian cells, and control the regulation of many target genes at the post-transcriptional level. There are many reports of the misregulation of these miRNAs in cancer. We will be studying the regulation of MMP-2 & MMP-9 by miRNAs, and the effect of natural products on the modulation of these miRNAs.

    the-discovery-of-micrornas-mirnas-that-regulate-the-expression-of-gelatinase-a-matrix-metalloproteinase-2-mmp-2-and-b-matrix-metalloproteinase-9-mmp-9-in-colon-cancer-cells
  • India is rich in plant biodiversity, and that has been utilized extensively in traditional medicine. In collaboration with Dr. Asoke Banerji (Phytochemistry, Amrita School of Biotechnology) who is leading the efforts in the extraction and purification of natural products from various plant sources, we plan to test these compounds on the expression of gelatinases (MMP-2 and MMP-9); known to be up-regulated in majority of cancers including breast and colon cancers.

    modulation-of-microrna-and-transcriptional-regulation-of-mmp-2-by-natural-products-in-human-breast-cancer-cells
  • One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems. Critical to this aim is the investigation of timing mechanisms in the cerebellar cortex.

    neurophysiological-recording-and-modeling-fast-response-timing-of-granule-and-golgi-cell-responses-for-cerebellar-function
  • A tropical forest, with its varied life forms, provides an array of resources and services, making life possible on earth. The major beneficial components include food, medicine, clothing and shelter. Plants used in medicine needs much attention as, on one side, they are not fully explored for their medicinal and curative properties, and on the other side, some of them are threatened by habitat loss and over exploitation.

    inventory-of-vegetation-with-special-reference-to-medicinal-and-aromatic-plants-and-documentation-of-traditional-knowledge-in-the-walayar-valley-western-ghats
  • This project proposes to develop a cerebellum inspired pattern recognition algorithm for robotic data classification. The project aims to investigate the temporal and spatial dynamics in the cerebellar network models capable of predicting cerebellar input-output transformations by analyzing the mathematical and computational properties of the network. Both labs have been working together since 2004 on cerebellar models.

    cerebellum-inspired-approach-for-pattern-classification-in-robots
  • Berberine, an isoquinoline alkaloid with a bright yellow color, is easily seen in most of the herb materials when found in significant amounts. Among Chinese herbs, the primary sources for berberine are phellodendron and coptis. Similar isoquinoline alkaloids (jateorrhizine, coptisine, palmatine, and columbamine) in these two herbs also have a yellowish color.

    synthesis-of-intermediate-analogues-for-biologically-active-molecules
  • Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which originate from the intrinsic nature of the enzymes. This project aims at developing a commercially viable non-enzymatic glucose sensor strip and a glucometer. Electrode surface modified with transition metal and metal oxide nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. 

    development-of-non-enzymatic-electrochemical-glucose-biosensors-and-glucometer
  • Lentiviral vectors are powerful tools to deliver genetic material into almost any cell or tissue, and are useful even in the creation of transgenic animals. They have been shown to deliver foreign genes not only to mammalian cells, but also in cells derived from fish, birds and amphibians. We are collaborating with InStem/NCBS to generate transgenic primitive metazoans.

    lentiviral-vectors-for-the-creation-of-transgenic-organisms
  • In contrast to other fields in biology, mathematical thinking and methodology have become entrenched in neuroscience since its very beginning, as witnessed by the classical work of Hodgkin and Huxley. One of the biggest open challenges mathematicians and engineers face is to understand the complex computation that takes place in our brain. Among the most interesting parts of the brain, is the ‘little brain’, otherwise known as the cerebellum.

    computational-neuroscience-and-cognitive-modeling
  • This project aims at understanding cognitive functioning of cerebellar input layer and implement signal processing abilities into neural hardware using cerebellar architecture. The main goals include understanding cerebellum granule neuron’s role in signal propagation and information processing in a central neuronal network. The other major focus will be on the analysis of cerebellar microcircuits for designing electronic neural processors.

    bio-inspired-processor-design-for-cognitive-functions-via-detailed-computational-modeling-of-cerebellar-granular-layer
  • Amrita Virtual Biotechnology laboratory is a new kind of experimental science that is being established as a virtual simulation based laboratory. These labs focus on helping students retain the real feel of a laboratory, while conducting the experiment from an internet-enabled computer terminal, much in the same way as is done, in a real lab.

    virtual-amrita-laboratories-in-biotechnology
  • The current study will enable the elucidation of global miRNA expression profiles and identification of miRNA targets in response to intervention with chemopreventive phytochemicals in liver cancer. This will enable a better understanding of miRNA dysregulation and identify novel biomarkers for preventive or therapeutic intervention in liver cancer.

    modulation-of-microrna-and-protein-signatures-in-hepatocellular-carcinoma-by-chemopreventive-phytochemicals
  • The dynamics of spatially structured populations (metapopulations) have been widely studied over the last few decades. For the sake of simplicity, most of these studies assume that all the constituent local populations (subpopulations) experience similar rates of migration (immigration and emigration). Although it is intuitively obvious that nothing in nature constrains the migration rates to be symmetric, i.e.

    theoretical-and-empirical-investigations-on-the-interaction-of-asymmetric-migration-and-intrinsic-growth-rate-on-the-dynamics-of-laboratory-metapopulations-of-drosophila-melanogaster
  • Seabuckthorn (SBT), (Hippophae L.) are deciduous shrubs in the genus Hippophae, family Elaeagnaceae. In addition to the nutritionally active constituents, many clinically important activities of seabuckthorn (SBT), such as beneficial effects on skin, cardiovascular diseases, diabetes, wound healing, cancer chemopreventive action, antiviral activity, sun screen and radioprotection have been established.

    seabuckthorn-a-repository-of-bioactive-phytochemicals
  • Diabetic wound healing is a challenging problem to solve as it requires the integration of interdependent processes that involve signal transduction input from inflammation, cell migration, cell proliferation, cell differentiation and production of extracellular protein components.

    molecular-mechanisms-in-impaired-wound-healing
  • Benzophenanthridines, naturally occurring isoquinoline alkaloids with various biological activities, are known to exist in five plant families, namely, the Fumariaceae (Genera Corydalis, Dicentra and Fumaria), the Papaveraceae, and the Rutaceae. Members of this family are generally investigated for potential biological activities.

    synthesis-of-modified-benzophenanthridine-a-preliminary-anti-cancer-study
  • Plant diseases caused by bacteria and fungi are the major reasons for significant loss in crop yields. To address this issue, many strategies have been developed and new bioanalytical tools have been utilized with an aim to control microbe derived diseases.

    mass-spectrometric-characterization-of-bioactive-peptides-and-proteins
  • The focus of the project is to screen molecules with anti-cancer properties and understand their mode of action with respect to cell death. Many cancer cells are apoptosis resistant; we are trying to target them by an alternative cell death pathway known as “paraptosis” or cytoplasmic vacuolation mediated cell death.

    paraptosis-a-newer-approach-to-target-cancer
  • Typically, a snake bite is treated with polyclonal antibody preparations obtained from immunized animals. This method is suboptimal because the neutralizing agents are not tailored towards specific venom components and because of batch variability due to turnover of venom donor and antivenom donor animals.

    peptide-based-anti-snake-venom-therapy