• In a unique partnership, Amrita Vishwa Vidyapeetham joined hands with Wipro Technologies, Bangalore to work on an end-to-end diabetes solution. The project entitled "Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care" is funded by DBT-BIRAC, Government of India.

    low-cost-device-and-cloud-enabled-smart-solution-for-diabetes-care
  • The project titled Multi-stimuli Responsive Polymeric Vehicle for Programmed Delivery of Chemotherapeutics to the Cancers, is funded by DBT. The investigator is Sankarprasad Bhuniya. 

    multi-stimuli-responsive-polymeric-vehicle-for-programmed-delivery-of-chemotherapeutics-to-the-cancers
  • Low-Cost Food Formulations Rich in Iron, Folic Acid, Calcium & Antioxidants for Rural Adolescent & Pregnant Women

    low-cost-food-formulations-rich-in-iron-folic-acid-calcium-amp-antioxidants-for-rural-adolescent-amp-pregnant-women
  • India is rich in plant biodiversity, and that has been utilized extensively in traditional medicine. In collaboration with Dr. Asoke Banerji (Phytochemistry, Amrita School of Biotechnology) who is leading the efforts in the extraction and purification of natural products from various plant sources, we plan to test these compounds on the expression of gelatinases (MMP-2 and MMP-9); known to be up-regulated in majority of cancers including breast and colon cancers.

    modulation-of-microrna-and-transcriptional-regulation-of-mmp-2-by-natural-products-in-human-breast-cancer-cells
  • Investigating the organized activity of neuron ensembles is critical to understand how brain circuits work and is one main target of the project. Reconstruction of network activity has proved to be a hard task. This project will study cellular function using multi-scale models of single cells and networks will be developed with NEURON.

    computational-modelling-and-prediction-of-cerebellar-input-layer-function-timing-and-plasticity-for-understanding-neurophysiological-disorders
  • Rheumatoid arthritis is a chronic, progressive systemic inflammatory disease of the synovium, a delicate membrane that lines the non-weight-bearing surfaces of the joint. Auto-immunity plays an important role in the development of RA and that increased antibody response has been shown to be a hallmark of RA. Presence of anti-CCP and anti-immunoglobulin reactivity indicates that antibody response is crucial in the development of RA.

    identification-of-new-autoantigens-in-rheumatold-arthritis-using-an-unbiased-clinical-proteomics-approach
  • Endovascular stents, used commonly for the treatment of occlusive vascular diseases, have historically been manufactured using metals and metal composites. Although stents have reduced the restenosis rate from 40% to 20% compared to angioplasty alone, in-stent restenosis still remains a major limitation for this approach.

    nanosurface-engineering-of-bare-metallic-coronary-stents-for-combating-in-stent-restenosis
  • Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which originate from the intrinsic nature of the enzymes. This project aims at developing a commercially viable non-enzymatic glucose sensor strip and a glucometer. Electrode surface modified with transition metal and metal oxide nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. 

    development-of-non-enzymatic-electrochemical-glucose-biosensors-and-glucometer
  • The project proposes to extend the nano-toxicological investigations of developed multifunctional NPs. It aims to extend the previous study to develop new theragnostic nanomedicines.

    nano-toxicology-and-nano-medicine-phase-ii
  • Induced pluripotent stem cells (iPSc) are somatic cells that have been reprogrammed to a pluripotent state. These iPSc have similar characteristics to embryonic stem cells and hold great promise in various aspects of research. The aim of this study is to develop patient specific stem cells to understand disease mechanism and identify drugs that will prevent malignant transformation.

    generation-of-induced-pluripotent-stem-ips-cells-from-genetically-altered-somatic-cells
  • This project proposes to develop novel natural biopolymeric composite hydrogel bandages based alginate, chitin and chitosan with antibacterial Herb Hemigraphis Ulternata/ZnO nanoparticles. This three-year project will involve preparation and characterization of nanostructured hydrogel bandages followed by in-vitro protein adsorption, antibacterial, blood clotting, cell attachment and proliferation.

    development-of-natural-biopolymeric-hydrogel-bandages-with-nanozno-nanosuspensions-of-herb-hemigraphis-ulternata-for-wound-dressing
  • This three-year project involves preparation of nanostructured scaffolds, plasma treatment of the scaffolds, followed by in-vitro protein adsorption, cell attachment and proliferation with and without plasma treatment.

    plasma-surface-modification-of-nanostructured-surfaces-of-marine-based-scaffolds-and-membranes-for-enhanced-bioactivity
  • The tumour hierarchical model proposes origin of cancer from a small population of cells having properties of stemness like self renewal and pluripotency. Although, cancer stem cells (CSCs) have been identified in leukemia and solid tumours by surface markers, there is variability in their specificity for isolation of CSCs in a specific tumour.

    biology-of-cancer-stem-cells-2
  • Drug discovery is currently in an exciting phase where conventional methodologies are being ably complemented by ‘omics’ approaches due, in part, to the greater accessibility of the newest generation of high-throughput platforms and technologies. At the Cancer Discovery Biology Laboratory, work is done towards making the identification of oncology clinical biomarkers more feasible through state-of-the-art pharmacogenomic and proteomic techn

    cancer-discovery-biology
  • Fusion transcripts are known to occur in cancerous cells across a range of cancers and might play important roles in the pathophysiology of cancer. In developing newer strategies to combat cancer, therapeutic knock down of fusion transcripts by RNA interference technology is being considered for its potential benefits in targeting cancerous cells.

    fusion-transcripts-in-cancer-and-the-potential-to-inhibit-by-rna-interference
  • The project 'Oncogene Sensing and Finger Printing from Saliva Using Nanotechnology' deals with Raman spectroscopic detection of cancer biomarkers from human tissues and bio-fluids.

    oncogene-sensing-and-finger-printing-from-saliva-using-nanotechnology-enabled-using-raman-spectroscopy
  • The current study will enable the elucidation of global miRNA expression profiles and identification of miRNA targets in response to intervention with chemopreventive phytochemicals in liver cancer. This will enable a better understanding of miRNA dysregulation and identify novel biomarkers for preventive or therapeutic intervention in liver cancer.

    modulation-of-microrna-and-protein-signatures-in-hepatocellular-carcinoma-by-chemopreventive-phytochemicals
  • There are more than 2.5 million cancer patients in India at any given time, of which the frequency of breast and ovarian cancer cases has increased. Although there are many possible reasons, reversible phosphorylation of proteins, mediated by receptor tyrosine kinases (RTK) such as VEGF and HER2/neu receptors play a crucial role on different cellular processes associated with cancer pathogenesis.

    cancers-treated-with-vegf-and-her-2-neu-receptor-tyrosine-kinase-inhibitors
  • Seabuckthorn (SBT), (Hippophae L.) are deciduous shrubs in the genus Hippophae, family Elaeagnaceae. In addition to the nutritionally active constituents, many clinically important activities of seabuckthorn (SBT), such as beneficial effects on skin, cardiovascular diseases, diabetes, wound healing, cancer chemopreventive action, antiviral activity, sun screen and radioprotection have been established.

    seabuckthorn-a-repository-of-bioactive-phytochemicals
  • It is seen that therapies for diabetes and heart disease affects liver and these diseases are increasing in prevalence especially in developing countries. The liver metabolises and detoxifies drugs and substances that are harmful to the body as well as produces blood clotting factors, proteins, and enzymes and helps maintain hormone balances, and stores vitamins and minerals.

    affordable-paper-based-microfluidics-point-of-care-testing-device-for-liver-function
  • The joint effort by Amrita and Wipro has the goal of making diabetes care available, accessible and affordable for the Indian masses. Amrita and Wipro has envisaged a patient-centric solution wherein low cost diabetes care devices (glucose strips, glucometers & insulin pumps) will interact with users through mobile applications using the cloud gateway. Innovative features of the device will make diabetes management easier for Indian patients and physicians.

    cost-effective-device-and-cloud-enabled-smart-solution-for-diabetes-care
  • Tuberculosis (TB) is believed to affect nearly one third of the world population with approximately 9 million new cases detected every year. Current methods of diagnosis includes sputum smear microscopy, chest X-Ray and biopsy which are time consuming and expensive with a low level of accuracy.

    design-and-validation-of-point-of-care-disposable-sensor-strips-for-diagnosis-of-tuberculosis-from-urine-samples
  • A method that is specific and reliable for detecting cancers at early stages and at an affordable cost is of utmost importance as it can function as a first-line guidance. Due to the high prevalence of breast, cervical and ovarian cancer in Indian women our aim is to develop a device that can detect these three cancer’s at an early stage.

    development-of-lab-on-a-chip-for-the-early-detection-of-cancer-in-women
  • iabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has serious drawbacks like insufficient long-term stability, which originates from the intrinsic nature of the enzymes. This project aims at development and fabrication of non-enzymatic glucose sensor and a glucometer.

    development-and-fabrication-of-non-enzymatic-electrochemical-glucose-biosensor-and-fabrication-of-glucometer