• Improper sanitation and lack of drinking water ultimately results in the enteric infection and there by leads to huge malnutrition and other health problems in developing nations. Solving the sanitation challenge in the developing world will require radically new innovations that are deployable on a large scale. We aim to reduce the bacterial load of waste water by developing bacteriophages from sewage against the enteric pathogens.

    isolation-and-characterization-of-bacteriophage-against-enteric-pathogens-from-sewage
  • The technique of Electrospinning has been considered as the most promising approach for the large scale production of nanofibers of varying diameter. It is quite a simple and efficient method for the nanofiber production. When a viscous fluid is charged with a high voltage, the electrostatic force draws the fluid into a liquid jet.

    electrospun-tio2-nanofibers-as-a-matrix-to-enhance-the-drug-loading
  • Staphylococcus aureus is a gram-positive pathogen responsible for causing several infectious diseases and has been shown to be one of the leading causes of skin and soft tissue infections and bloodstream infections.

    novel-anti-mrsa-compounds-from-padina-tetrastromatica-identification-isolation-and-mass-spectrometric-characterization
  • Endothelium helps in maintaining vascular tone by regulating the vascular permeability. It selectively allows only certain molecules to cross the endothelial barrier. A large number of micro and macro vascular complications are associated with endothelial dysfunction in diabetes including cardiovascular disease, stroke and peripheral vascular diseases.

    natural-products-as-modulators-of-diabetes-associated-endothelial-dysfunctions
  • iabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has serious drawbacks like insufficient long-term stability, which originates from the intrinsic nature of the enzymes. This project aims at development and fabrication of non-enzymatic glucose sensor and a glucometer.

    development-and-fabrication-of-non-enzymatic-electrochemical-glucose-biosensor-and-fabrication-of-glucometer
  • Enteric bacteria found in sewage water cause many diseases throughout the world. Through our project, we proposed a recombinant DNA method as a solution to this problem. Many of the commonly found sewage pathogens can be degraded by autolysin/cell wall hydrolases such as amidase and glucosaminidase. The Atl is the most predominant autolysin/peptidoglycan hydrolase in staphylococci.

    transformation-expression-and-activity-analysis-of-recombinant-staphylococcus-autolysin-in-bacillus
  • Marine algae are rich sources of natural bioactive compounds. Out of the three important macoalgae, viz. red, brown and green, brown macroalgae are most commonly targeted for screening of antioxidant compounds.

    mass-spectrometry-assisted-identification-of-antioxidant-pigments-from-stoechospermum-polypodioides-a-marine-brown-macro-alga
  • Oxidative stress refers to the physiological stress caused by an imbalance between the systemic production of reactive oxygen species and the biological system's ability to detoxify the reactive intermediates. It is a condition where the system lacks its ability to repair the damage due to oxidative stress and thus leading to a number of diseases.

    mass-spectrometry-based-proteomic-characterization-of-carbonylated-proteins-as-indicators-of-oxidative-stress
  • Many cancer cells develop resistance to the apoptotic signals and flourish in the system. We are trying to target these defiant cells by inducing an alternative cell death pathway through natural products. One of the non-apoptotic mode of programmed cell death known as “paraptosis” or cytoplasmic vacuolation mediated cell death is one of our areas of interest.

    paraptosis-a-non-apoptotic-cell-death-pathway-to-target-cancer

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