• Lectins are proteins, ubiquitous in nature and have garnered much attention due to specificity of its interaction with the carbohydrates. Glycosylation is a key step in many cellular processes and with more reports about the change in cell surface carbohydrates in different pathological conditions are more evident, research about exploiting lectins as a therapeutic tool is now at the forefront.

    isolation-of-lectins-and-colored-proteins-from-marine-algae
  • Endophytes/ endosymbionts from marine micro algae have recently gained attention as potential sources of bioactive secondary metabolites. In the present study we could isolate and then identify the endophytes by molecular biology methods. The isolation procedure included sterilization (ethanol and sodium hypochlorite) followed by plating on to a medium made in artificial sea water. Different media were used to isolate bacteria and fungus.

    isolation-and-identification-of-endophytes-from-marine-algae
  • Natural products play a key role in meeting the global demand for new pharmacologically active substances. Endophytes, which live asymptomatically within living plant tissues, are an under explored group of microorganisms and hence studies on these microbes from unique ecosystems offer resources with immense biotechnological potential. In the present study an attempt was made to explore the bioactive potential of the endophytes residing in mangrove plants. These plants have already been reported to have bioactivities against different ailments. Among the 16 endophytic isolates screened, three bacterial and four fungal isolates showed antibacterial activity comparable to that of standard antibiotics. 3 fungal endophytes showed strong antioxidant activity compared to bacterial endophytes. Seven bacterial isolates and one fungal isolate were found to produce glutaminase free L-Asparaginase. One fungal isolate and three bacterial isolates showed significantly higher thrombolytic activity. Isolate RM-S-01 an endophytic  bacteria isolated from the stem of the mangrove Rhizophora mucronata was found to be positive for all the four activities screened in the study.  Therefore we conclude that these endophytes represent new sources of bioactive metabolites. Characterization of these endophytes and purification of active compound in the crude extracts need to be further researched on.

    pharmacological-potential-of-endophytes-from-mangrove-plants-in-south-west-coast-of-kerala
  • Meldrum’s acid has been reported to undergo a condensation reaction with aromatic aldehydes to afford adducts with a host of interesting chemical, physical as well as biological properties. In the present work we have prepared the Meldrum’s acid adduct of furfural which has been screened for antifungal activity. It has been reported that the Furfuryl adduct of Meldrum’s acid undergoes a ring opening reaction with secondary amines at room temperature to afford a new class of  donor-acceptor Stenhouse adducts (DASAs). Our group is trying to explore this property of the prepared derivative for trying out various biological applications.

    furfuryl-derivatives-of-meldrum-s-acid-synthesis-characterisation-and-biological-studies
  • Pectinases and Xylanases are group of enzymes which cause degradation of pectin and xylan respectively. In the present study micro organisms were screened for pectinolytic and xylanolytic properties, their enzyme activity were compared and degumming (bio bleaching) of bio fibre (banana fibre) was carried out with crude enzyme.

    biofibre-from-agricultural-wastes-bio-bleaching-of-banana-fibre-using-microbial-enzymes
  • The use of micro organisms as soil inoculants to promote plant growth and to protect the plant from pests and diseases is an emerging area in sustainable agricultural practices. Plant Growth Promoting Bacteria (PGPB) may promote plant growth directly by facilitating nutrient acquisition or modulating plant hormone levels and indirectly by decreasing the inhibitory effects of various pathogenic agents.

    plant-growth-promoting-endophytic-bacteria-from-mangrove-plants-in-south-west-coast-of-kerala
  • Chitin, a linear polymer of β-1,4 linked N-acetylglucosamine is a major structural component of fungal cell wall, exoskeletons of arthropods, internal structures of cephalopods, protozoan cyst walls and helminth eggs. Chitinases  are glycosyl hydrolases that cleaves the β-1,4-glycosidic bonds of chitin. It is present in a wide range of organisms, such as bacteria, viruses, higher plants and animals including mammals and play an important physiological and ecological role.

    production-optimization-and-characterization-of-chitinase-enzyme-produced-by-aspergillus-sp
  • Viruses infecting the bacteria, called bacteriophage (phage), have been used for over 90 years as an alternative to antibiotics in Russia, east Europe and France.  They are currently being tried as a possible therapy against multi-drug-resistant strains of many bacteria. We are looking for potential application of bacteriophages and their parts or enzymes from kitchen waste in treating enteric infections and foul smell from domestic wastewater (toilet).

    viral-agents-to-target-and-kill-pathogens-and-odour-producing-bacteria-in-fecal-waste
  • A wide range of plants have been harnessed for the development of remedies under the Ayurvedic system of medicine. However, a comprehensive modern biological understanding regarding the factors that contribute to the physiology of these plants, the active metabolites and their production is largely lacking.

    identification-and-characterization-of-the-role-of-allium-sativum-microbiome-on-the-production-of-therapeutic-metabolites
  • The proposed work envisages the fabrication of microfluidic lab-on-a-chip (LOC) module for non-enzymatic sensing of glucose, cholesterol and creatinine using a single device.

    development-of-a-lab-on-a-chip-loc-for-detection-of-glucose-cholesterol-and-kidney-function
  • Traditional Indian medicine has always captivated Indian researchers and medical practitioners for its application in various pathological conditions. Natural products have been an invaluable repository for the discovery of novel drug candidates as a source of remedy for a number of ailments including cardiovascular diseases and cancers. Almost 60% of the approved anti-cancer drugs were known to be derived from natural sources.

    anacardic-acid-a-novel-template-for-cancer-therapy
  • The departments of Mechanical Engineering and Chemical Engineering, Amrita School of Engineering, and Amrita School of Biotechnology, along with Dartmouth College, USA, set up bio-filters in the tribal villages.

    bio-water-filtration-unit-for-improved-access-to-clean-water-communication-for-sustainable-change

Pages