• Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries like India. An in-depth understanding of the molecular mechanisms involved in the progression of different forms of cancer has been the focus of drug discovery efforts.

    elucidating-the-molecular-mechanisms-of-anacardic-acid-and-biacacetin-mediated-regulation-of-matrix-metalloproteinases-in-cancer
  • Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth. Understanding the mis-regulation of molecular mechanisms leading to cancer has been the primary method of discovering new drug targets. MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis.

    role-of-mirnas-in-cancer-and-modulation-of-oncogenes-by-natural-products
  • Treatment of diabetes and its complications is a major challenge in India owing to several issues, including sociocultural factors, lack of appropriate facilities for diabetes care, an inadequate health system, poor monitoring and follow-up of patients, and problems in implementing effective management and educational strategies.

    escherichia-coli-based-microfluidic-whole-cell-glucose-biosensor
  • Antimicrobial resistance is increasing worldwide and is of particular concern in Gram-negative bacilli where there is a paucity of new and effective antimicrobial agents. Pseudomonas aeruginosa infections are associated with increased mortality and morbidity, especially in immunocompromised and burns patients respectively.

    tetracycline-augments-the-anti-biofilm-potential-of-essential-oils-and-d-amino-acids-against-pseudomonas-aeruginosa
  • Plant based biosynthesis of metal nanoparticles has proved to be an effective and novel method of synthesis. Various parts of plants have been investigated for the synthesis of metal nanoparticles. In our present work we present the synthesis of metal nanoparticles using the extract taken from the leaves such as Sesbania grandiflora (Agati), Morinda Citrifolia (Noni) and Tectona Grandis (Teak).

    green-synthesis-of-metal-nano-particles-like-gold-or-silver-and-its-application
  • DNA origami is the process in which long single-stranded DNA molecules are folded into arbitrary planar nanostructures with the aid of many short staple strands. DNA origami can be used to construct not only arbitrary two-dimensional nanostructures but also nano-sized breadboards for the arraying of nanomaterials or even complicated three-dimensional nano-objects.

    dna-origami-folding-of-the-vector-pcdh-cmv-mcs-ef1-puro-into-a-predefined-shape-using-18-20mer-staples
  • Carbohydrate binding proteins are one among the least exploited natural product that could be a promising remedy for many problems faced by mankind these days including tumour. Less exploited doesn’t mean it’s less accessible, it’s a kind of protein that we could find in almost every living form. Functions of these proteins include cell adhesion, cellular signalling, glycoprotein synthesis etc. and there are things yet unknown about the protein class, Lectins.

    isolation-of-carbohydrate-binding-proteins-lectins-from-natural-sources
  • The project titled "Use of viral agents, microbial fuel cell and effec tive recycling strategy to improve the economics of human waste disposal" is funded by BIRAC & DBT, Govt. of India and The Bill & Melinda Gates Foundation. Dr. Bipin Nair is the Principal investigator of the project.

    use-of-viral-agents-microbial-fuel-cell-and-effec-tive-recycling-strategy-to-improve-the-economics-of-human-waste-disposal
  • Over the years, conjugation of bioactive molecules onto polymer matrices has emerged as a versatile strategy for a wide spectrum of applications including protein purification, waste water management, drug delivery, etc. In this work, we have explored the scope of employing chitosan the second most abundant biopolymer for protein purification via a facile bioconjugation protocol.

    schiff-s-base-derivative-of-chitosan-a-potential-matrix-for-metalloprotein-enrichment
  • Incomparison to the traditional biochemical tests, Ribotyping is a high throughput method that enables rapid identification of microorganisms. For the isolation of genomic DNA, conventional method of DNA extraction is used. The DNA thus extracted is PCR ready genomic DNA. This could be directly used for PCR without any purification step. PCR is done to amplify the gene. One set of universal primers were used for the amplification. After amplification, the PCR product was run on agarose gel.

    ribotyping-ribotyping-of-bacterial-endophytes
  • Diabetes is a long term prevailing disease which affects millions of people worldwide. It is a condition where the body fails to utilize the ingested glucose. There has been a dire need for the development of low cost yet effective glucose sensing device.

    escherichia-coli-based-microfluidic-whole-cell-glucose-biosensor
  • A Microbial Fuel Cell(MFC) or Biological fuel cell is a bioelectrochemical system that drives a current by using bacteria and mimicking bacterial interactions found in nature.Usually a microbial cell consists of two electrodes separated by a semi permeable membrane. The main objective of the present study was to work on different exoelectrogen and electrodes that could be more efficient and could be more efficient and could be cheaper than the existing ones.

    mfc-caulobactercrescentus-as-an-electrogen-in-a-dual-chambered-microbial-fuel-cell-with-the-novel-proton-exchange-membrane

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