• One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems. Critical to this aim is the investigation of timing mechanisms in the cerebellar cortex.

    neurophysiological-recording-and-modeling-fast-response-timing-of-granule-and-golgi-cell-responses-for-cerebellar-function
  • Envenomation resulting from snake bite is a significant problem faced by both developed and developing countries. Within South Asia, India is quite heavily affected with an estimated 46,000 deaths per year. Currently available anti-venom therapy consists of polyvalent immunoglobulin fractions prepared from the plasma of donor animals, typically horses or sheep that were immunized with a mixture of venoms from different snake species.

    development-of-peptide-inhibitors-against-functional-components-of-snake-venom-a-new-approach
  • Anthracyclines are among the most effective anti-cancer treatments ever developed, but their clinical use is limited by their cumulative dose-related cardio-toxicity which may ultimately lead to a severe form of cardiomyopathy. A classical example is Doxorubicin (DOX) that is used for the treatment of a wide variety of cancers, including lymphoma, leukemia, and solid tumors.

    identification-of-molecular-mechanisms-of-action-of-the-cardioprotective-compound-arjunolic-acid
  • The research activity in our laboratory aims at the development of novel biopolymer matrices with potential applications in waste water management, drug delivery etc. For instance, the β-oxothioamide derivative of chitosan biopolymer was found to have potential applications as a metal chelator for waste water management. We have also successfully grafted analogues of drugs like bupropion onto the chitosan backbone which will facilitate the slow release of the drug into the biological system. The newly synthesized biopolymers are characterized by FT-IR spectroscopic as well as thermal studies like DSC, TGA, etc.

    chemically-modified-biopolymers-synthesis-characterization-amp-applications
  • There are reports on derivatives of azobenzene that exhibit light-triggered association of Bovine Serum Albumin. To this end, an azobenzene-triazine conjugate was prepared by reacting Disperse Orange 3 dye with trichlorotrizaine. This intermediate was then conjugated to the biopolymer chitosan by a facile nucleophilic substitution.

    photo-switchable-azobenzene-conjugated-matrices-for-affinity-chromatography-synthesis-characterization-and-studies
  • Flavanoids like naringin and naringenin are functional chemicals with important properties in the field of health care, cosmetics, food and agriculture. Naringin composed of aglycon naringenin and the disaccharide neohespiridose, is the principle bitter flavanone glycoside and the primary bitter component in citrus fruits. Enzymatic hydrolysis is a possibility to overcome the bitterness. This study aimed to isolate Aspergillus sp.

    production-purification-and-application-of-naringinase-from-aspergillus-sp-sec-nigri
  • The microorganisms in biofilms live in a self-produced matrix of hydrated extracellular polymeric substances (EPS) that mainly comprises of polysaccharides, proteins, nucleic acids and lipids and provide mechanical stability to the biofilms by mediating their adhesion to surfaces and forming a cohesive, three-dimensional polymer network that interconnects and transiently immobilizes biofilm cellsThe mainaim of this study was to analyse the potential use of fungal enzymes like polysaccharidase

    studies-on-the-effect-of-fungal-enzymes-on-bacterial-biofilm-inhibition
  • Pulmonary diseases are very common. The main causative agents of these diseases are Klebsiella pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa, haemophilus influenza etc. Medication is the most important treatment of most diseases of pulmonology. The essential oils produced by many plants have been traditionally used for curing respiratory tract infections and are used as ethical medicines for cold. These oils have antimicrobial activity.

    effect-of-volatile-compounds-on-pulmonary-pathogens
  • Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which originate from the intrinsic nature of the enzymes. This project aims at developing a commercially viable non-enzymatic glucose sensor strip and a glucometer. Electrode surface modified with transition metal and metal oxide nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. 

    development-of-non-enzymatic-electrochemical-glucose-biosensors-and-glucometer
  • The aim of this study was to determine the effects of environmental factors on the biofilm formation of Klebsiella pneumoniae , by allowing the organism to grow under different condition. The organism was grown in different media, pH, temperature, time, and substratum and in different body fluids. The amount of biofilm formed was determined using microtiter plate assay. Klebsiella showed more biofilm production in Tryptic soy broth than in Nutrient Borth, LB broth and BHI broth.

    effect-of-environmental-factors-on-klebsiella-biofilm-formation
  • Dental plaque is the community of microorganisms found on a tooth surface as a biofilm, embedded in a matrix of polymers of host and bacterial origin. Over 400 microbial
    species can be found in the typical adolescent human mouth. The most virulent of these species is Streptococcus mutans, which has been found to be the initiator of most dental caries. As a result, dental caries can be considered one of the most widespread and common infectious disease.

    studies-on-biofilm-inhibition-and-antibacterial-properties-of-selected-plant-extracts-against-s-mutans-a-dental-plaque-pathogen
  • Scientific understanding of probiotics and their potential for preventing and treating health conditions is at an early stage. Probiotics is rapidly gaining importance in medical science and food science. We created a review of literature on various aspects of probiotics including mechanism of action, health benefits, side effect, stability and antimicrobial activity.

    studies-on-binding-of-probiotic-strains-to-host-extracellular-matrix-protein-gelatin-and-analysis-of-its-stability-with-different-substrates

Pages