• One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems. Critical to this aim is the investigation of timing mechanisms in the cerebellar cortex.

    neurophysiological-recording-and-modeling-fast-response-timing-of-granule-and-golgi-cell-responses-for-cerebellar-function
  • Anthracyclines are among the most effective anti-cancer treatments ever developed, but their clinical use is limited by their cumulative dose-related cardio-toxicity which may ultimately lead to a severe form of cardiomyopathy. A classical example is Doxorubicin (DOX) that is used for the treatment of a wide variety of cancers, including lymphoma, leukemia, and solid tumors.

    identification-of-molecular-mechanisms-of-action-of-the-cardioprotective-compound-arjunolic-acid
  • Envenomation resulting from snake bite is a significant problem faced by both developed and developing countries. Within South Asia, India is quite heavily affected with an estimated 46,000 deaths per year. Currently available anti-venom therapy consists of polyvalent immunoglobulin fractions prepared from the plasma of donor animals, typically horses or sheep that were immunized with a mixture of venoms from different snake species.

    development-of-peptide-inhibitors-against-functional-components-of-snake-venom-a-new-approach
  • The research activity in our laboratory aims at the development of novel biopolymer matrices with potential applications in waste water management, drug delivery etc. For instance, the β-oxothioamide derivative of chitosan biopolymer was found to have potential applications as a metal chelator for waste water management. We have also successfully grafted analogues of drugs like bupropion onto the chitosan backbone which will facilitate the slow release of the drug into the biological system. The newly synthesized biopolymers are characterized by FT-IR spectroscopic as well as thermal studies like DSC, TGA, etc.

    chemically-modified-biopolymers-synthesis-characterization-amp-applications
  • Scientific understanding of probiotics and their potential for preventing and treating health conditions is at an early stage. Probiotics is rapidly gaining importance in medical science and food science. We created a review of literature on various aspects of probiotics including mechanism of action, health benefits, side effect, stability and antimicrobial activity.

    studies-on-binding-of-probiotic-strains-to-host-extracellular-matrix-protein-gelatin-and-analysis-of-its-stability-with-different-substrates
  • The requirement of energy in India has been growing exponentially over the years. Since conventional energy options are futile to tackle this raise, the needs for non-conventional energy sources have become essential. Solar Photovoltaic cell could be one such alternative energy source since solar energy is available abundantly in the world which is renewable, eco friendly and free from pollution.

    natural-dyes-as-efficient-candidate-for-enhancing-the-photovoltaic-properties-of-dye-sensitized-solar-cells
  • Klebsiella pneumonia is an opportunistic human pathogen that can cause acute ,life threatening infections.Part of the virulence repertoire of this microorganism includes the ability to sequeater iron from the host during infection by synthesis and secretion of siderophores..The aim of study was to determine the effect of Petroleum ether, chloroform, methanol and water extracts of eight traditional Indian medicinal plants Biophytum sensitivum, Leucus aspera, Aegle marmlos, Plectranthus amboini

    inhibitory-effect-of-plant-extracts-on-siderophore-production-in-klebsiella-pneumoniae
  • Mangroves have enormous ecological value. They protect and stabilize coastlines, enrich coastal waters, yield commercial forest products and support coastal fisheries. Mangroves are among the world’s most productive ecosystems, producing organic carbon well in excess of the ecosystem requirements and contributing significantly to the global carbon cycle. Extracts from mangroves and mangrove dependent species have proven activity against human, animal and plant pathogens.

    exploring-the-antipathogenic-potential-of-mangroves-and-mangrove-associate-plants-an-in-vitro-approach
  • Fibronectin, an extra cellular matrix glycoprotein was purified from human plasma obtained from Regional Cancer Centre Trivandrum. Gelatin based affinity chromatography was used for the purification of the protein. The usage of pressure was found to have prominent impact in the purification of the protein by reducing albumin contamination, which we suspect would have non specifically bound to the gelatin resin. The quality of the protein purified was analysed using SDS –PAGE.

    fibronectin-purification-and-fragmentation
  • As the importance of blood glucose control for both diabetic and non diabetic patients continues to increase, there is a need for advanced glucose sensing technologies. The low accuracy and sensor drift become major problems with in vivo environments especially for enzyme based electrochemical glucose sensors. This study dealt with the use of E.coli as an effective biorecognition element in a whole cell based biosensor. A lac operon based sensor has been decided to develop.

    studies-on-the-use-of-bacterial-cell-as-glucose-biosensor
  • The list of pollutants which pose environmental and health hazard are tough for biodegradation, is a long one and involves solvents, wood preservative chemicals, refrigerants, plasticizers, coal tar wastes, pesticides, biphenyls, synthetic fibers, plastics etc. The present study deals with the isolation of plastic degrading microorganisms from the plastic samples, analysis of physical or changes produced during biodegradation and the study of enzymes involved in biodegradation.

    biodegradation-of-plastics-using-fungal-isolates
  • Peptidoglycan (PG) hydrolases or autolysins are a group of enzymes which degrades bacterial cell wall at specific sites. Staphylococcus aureus produces two major PG hydrolases: major autolysin (AtlA) and Aaa, a autolysin/adhesin protein. Amidase are surface-associated proteins that have both enzymatic and adhesive functions. AtlA is the most predominant autolysin in Staphylococcus aureus. The AltA protein only with an amidase domain and the two repeat sequences R1 and R2 is 62 kDa.

    expression-and-refolding-of-recombinant-staphylococcal-amidases-in-e-coli

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