• One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems. Critical to this aim is the investigation of timing mechanisms in the cerebellar cortex.

    neurophysiological-recording-and-modeling-fast-response-timing-of-granule-and-golgi-cell-responses-for-cerebellar-function
  • Envenomation resulting from snake bite is a significant problem faced by both developed and developing countries. Within South Asia, India is quite heavily affected with an estimated 46,000 deaths per year. Currently available anti-venom therapy consists of polyvalent immunoglobulin fractions prepared from the plasma of donor animals, typically horses or sheep that were immunized with a mixture of venoms from different snake species.

    development-of-peptide-inhibitors-against-functional-components-of-snake-venom-a-new-approach
  • Anthracyclines are among the most effective anti-cancer treatments ever developed, but their clinical use is limited by their cumulative dose-related cardio-toxicity which may ultimately lead to a severe form of cardiomyopathy. A classical example is Doxorubicin (DOX) that is used for the treatment of a wide variety of cancers, including lymphoma, leukemia, and solid tumors.

    identification-of-molecular-mechanisms-of-action-of-the-cardioprotective-compound-arjunolic-acid
  • The research activity in our laboratory aims at the development of novel biopolymer matrices with potential applications in waste water management, drug delivery etc. For instance, the β-oxothioamide derivative of chitosan biopolymer was found to have potential applications as a metal chelator for waste water management. We have also successfully grafted analogues of drugs like bupropion onto the chitosan backbone which will facilitate the slow release of the drug into the biological system. The newly synthesized biopolymers are characterized by FT-IR spectroscopic as well as thermal studies like DSC, TGA, etc.

    chemically-modified-biopolymers-synthesis-characterization-amp-applications
  • The current studies provided a direct illustration that electrical power can be generated economically in a two chambered microbial fuel cell. Under the anaerobic condition at the anode, the electrons released by the Proteus vulgaris are directed towards the cathodic chamber through an external circuit. Low cost and less oligodynamicity encouraged the use aluminium as anode. Anaerobic condition of the anodic chamber is achieved by using an air-tight rubber suction outer lid.

    design-construction-and-operation-of-a-prototypes-of-phototrophic-microbial-fuel-cells
  • This project proposes to develop a cerebellum inspired pattern recognition algorithm for robotic data classification. The project aims to investigate the temporal and spatial dynamics in the cerebellar network models capable of predicting cerebellar input-output transformations by analyzing the mathematical and computational properties of the network. Both labs have been working together since 2004 on cerebellar models.

    cerebellum-inspired-approach-for-pattern-classification-in-robots
  • The project titled "Lab-on-a-chip(LOC) for the monitoring of diabetes, cholesterol and kidney function" is funded by DBT, Govt. of India. Dr. Bipin Nair is the Principal Investigator of the project.

    lab-on-a-chip-loc-for-the-monitoring-of-diabetes-cholesterol-and-kidney-function
  • Bacillus clausii, a gram positive, spore forming bacteria is widely used a probiotic in preventing and treating various gastrointestinal disorders. In order to understand the functioning of this strain as a probiotic, one needs to study the molecular level of interaction of this strain with host systems. Considering the fact that the first level of interaction can happen at the extracellular level, the project aims to characterize extracellular matrix proteins of Bacillus calusii.

    isolation-and-characterization-of-host-binding-proteins-from-bacillus-clausii-using-mass-spectrometry-a-proteomic-approach
  • There are reports on derivatives of azobenzene that exhibit light-triggered association of Bovine Serum Albumin. To this end, an azobenzene-triazine conjugate was prepared by reacting Disperse Orange 3 dye with trichlorotrizaine. This intermediate was then conjugated to the biopolymer chitosan by a facile nucleophilic substitution.

    photo-switchable-azobenzene-conjugated-matrices-for-affinity-chromatography-synthesis-characterization-and-studies
  • Flavanoids like naringin and naringenin are functional chemicals with important properties in the field of health care, cosmetics, food and agriculture. Naringin composed of aglycon naringenin and the disaccharide neohespiridose, is the principle bitter flavanone glycoside and the primary bitter component in citrus fruits. Enzymatic hydrolysis is a possibility to overcome the bitterness. This study aimed to isolate Aspergillus sp.

    production-purification-and-application-of-naringinase-from-aspergillus-sp-sec-nigri
  • The microorganisms in biofilms live in a self-produced matrix of hydrated extracellular polymeric substances (EPS) that mainly comprises of polysaccharides, proteins, nucleic acids and lipids and provide mechanical stability to the biofilms by mediating their adhesion to surfaces and forming a cohesive, three-dimensional polymer network that interconnects and transiently immobilizes biofilm cellsThe mainaim of this study was to analyse the potential use of fungal enzymes like polysaccharidase

    studies-on-the-effect-of-fungal-enzymes-on-bacterial-biofilm-inhibition
  • Pulmonary diseases are very common. The main causative agents of these diseases are Klebsiella pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa, haemophilus influenza etc. Medication is the most important treatment of most diseases of pulmonology. The essential oils produced by many plants have been traditionally used for curing respiratory tract infections and are used as ethical medicines for cold. These oils have antimicrobial activity.

    effect-of-volatile-compounds-on-pulmonary-pathogens

Pages