• This project aims at understanding cognitive functioning of cerebellar input layer and implement signal processing abilities into neural hardware using cerebellar architecture. The main goals include understanding cerebellum granule neuron’s role in signal propagation and information processing in a central neuronal network. The other major focus will be on the analysis of cerebellar microcircuits for designing electronic neural processors.

  • Composting is an aerobic microbiological process facilitated by diverse microbial groups supplementing significant fertilizer quality to soil. Our current society is faced with the problem of managing growing quantities of organic municipal waste. In order to increase the biodegradative rates and lower the emission of noxious gases, introduction of lignocelluloytic fungi and diazotropic microbes was found to be beneficial.

  • Biosurfactants are microbial metabolites with the typical amphiphilic structure of a surfactant, where the hydrophobic moiety is either a long-chain fatty acid, hydroxyl fatty acid, or α-alkyl-β-hydroxy fatty acid and the hydrophilic moiety can be a carbohydrate, an amino acid, a cyclic peptide, a phosphate, a carboxylic acid, or alcohol, among others.

  • Fibronectin is one of the extraceullar proteins in vertebrates generated by alternative splicing, with twenty more possible isoforms. This project involves a survey of current fibronectin literature, followed by an account of our experiments to purify fibronectin from plasma using gelatin affinity chromatography.

  • Probiotics has paved a new revolution in the field of medical and food sciences. We surveyed the literature on different aspects of probiotics. We explored the potential of different probiotics to control gut infection, combat malnutrition, prospects of personalization in view of the differential effects of probiotics on patients of different genetic make-up.

  • Matrix binding proteins from probiotics and viruses:

  • Chitosan is a natural based biopolymer, obtained by alkaline deacetylation of chitin, which presents excellent biological properties such as biodegradability and immunological, antibacterial and wound-healing activity. Recently, there has been a growing interest in the chemical modifification of chitosan in order to improve its solubility and widen its applications. The amino group of chitosan has been modified to assess its anti-microbial activity.

  • Characterization of Fibronectin isoforms and proteolytic fragments affecting cell behaviour (cell morphology, migration, proliferation)

    Factors affecting gelatinase (MMP-2) mediated fragmentation of fibronectin

  • Envenomation incapacitates the snake’s prey by interfering with specific aspects of physiological function such as nerve transmission and hemostasis.  Since the action of venom components is highly specific, many venom components may also have the potential of being employed pharmaceutically. Viper venom affects predominantly aspects of the coagulation pathway.  The conversion of fibrinogen to fibrin is a central part of the coagulation and clotting mechanism and hence another project in the lab is focusing on the isolation of proteases capable of altering or degrading fibrinogen and on the modulation of their proteolytic activity by small molecules and phytochemicals. 

  • Amrita Virtual Biotechnology laboratory is a new kind of experimental science that is being established as a virtual simulation based laboratory. These labs focus on helping students retain the real feel of a laboratory, while conducting the experiment from an internet-enabled computer terminal, much in the same way as is done, in a real lab.

  • Docking studies are computational techniques for the exploration of the possible binding modes of a substrate to a given receptor, enzyme or other binding site. The application of computational methods to study the formation of intermolecular complexes has been the subject of intensive research during the last decade.

  • From million doses of annual antibiotics consumption goes waste as these could not be utilized or targeted to the infective organisms effectively due to various factors like efficient absorption, transportation to the target site, retention time, operation of efflux pump, metabolism etc. Thus, large portions of the drugs we apply are wasted and only a miniscule percentage is being targeted to the infective microbes.