Publications

Year of Publication Publication Type Title

2017

Journal Article

P. Shanavas Khan, J.b Thilak, George, M. J., Nair, A. V., and Madanan, A., “Tubercular infection after arthroscopic rotator cuff repair”, Knee Surg Sports Traumatol Arthrosc, vol. 25, no. 7, pp. 2205-2207, 2017.[Abstract]


Tubercular septic arthritis after shoulder arthroscopy has not been reported in the English literature to our knowledge. A case of Tubercular septic arthritis of the shoulder following arthroscopic rotator cuff repair is presented. The sinus and the wound healed well, and laboratory parameters returned to normal, which suggests that the infection was well controlled with the treatment follow-up of 1 year. But the functional score was poor due to repeated surgeries; long-standing infection and the arthritic changes developed. Tubercular infection can occur after arthroscopic shoulder surgery especially in healthcare workers in zones endemic for Tuberculosis. Level of evidence V.

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2017

Journal Article

K. Yokote, Chanprasert, S., Lee, L., Eirich, K., Takemoto, M., Watanabe, A., Koizumi, N., Lessel, D., Mori, T., Hisama, F. M., Ladd, P. D., Angle, B., Baris, H., Cefle, K., Palanduz, S., Ozturk, S., Chateau, A., Deguchi, K., Easwar, T. K. M., Federico, A., Fox, A., Grebe, T. A., Hay, B., Dr. Sheela Nampoothiri, Seiter, K., Streeten, E., Piña-Aguilar, R. E., Poke, G., Poot, M., Posmyk, R., Martin, G. M., Kubisch, C., Schindler, D., and Oshima, J., “WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.”, Hum Mutat, vol. 38, no. 1, pp. 7-15, 2017.[Abstract]


Werner syndrome (WS) is a rare autosomal recessive disorder characterized by a constellation of adult onset phenotypes consistent with an acceleration of intrinsic biological aging. It is caused by pathogenic variants in the WRN gene, which encodes a multifunctional nuclear protein with exonuclease and helicase activities. WRN protein is thought to be involved in optimization of various aspects of DNA metabolism, including DNA repair, recombination, replication, and transcription. In this update, we summarize a total of 83 different WRN mutations, including eight previously unpublished mutations identified by the International Registry of Werner Syndrome (Seattle, WA) and the Japanese Werner Consortium (Chiba, Japan), as well as 75 mutations already reported in the literature. The Seattle International Registry recruits patients from all over the world to investigate genetic causes of a wide variety of progeroid syndromes in order to contribute to the knowledge of basic mechanisms of human aging. Given the unusually high prevalence of WS patients and heterozygous carriers in Japan, the major goal of the Japanese Consortium is to develop effective therapies and to establish management guidelines for WS patients in Japan and elsewhere. This review will also discuss potential translational approaches to this disorder, including those currently under investigation.

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2017

Journal Article

V. V. Panicker, Riyaz, N., and Balachandran, P. K., “A clinical study of cutaneous changes in pregnancy.”, J Epidemiol Glob Health, vol. 7, no. 1, pp. 63-70, 2017.[Abstract]


BACKGROUND/OBJECTIVE: Pregnant women experience a myriad of physiological and metabolic changes that affect different organ systems in the body. Cutaneous and appendageal alterations that manifest during pregnancy are largely modulated by hormonal, immunologic, and metabolic factors. Detailed reports encompassing physiological changes and specific dermatoses of pregnancy and effects of various dermatoses on pregnant women are scanty in literature. This study was conducted to examine in detail both physiological changes and specific dermatoses. The cutaneous changes are divided into physiological changes, skin diseases aggravated by pregnancy, and specific dermatoses of pregnancy. The objectives were to study the various cutaneous changes of pregnancy and to know the proportion of these cutaneous manifestations in pregnant women.

METHODS: This study included 600 pregnant women attending the Obstetrics and Gynecology Department of a tertiary teaching hospital in Northern Kerala, India. Detailed history elicitation and complete physical and dermatological examination were performed. Skin biopsy was performed in relevant cases.

RESULTS: Cutaneous changes were seen in a majority of patients, of which physiological changes were the most common (99%). The most common cutaneous manifestation was hyperpigmentation (526; 87.6%), followed by striae gravidarum (72.8%). Other changes were vascular, including pedal edema (10%), pregnancy gingivitis (1.8%), and varicose veins (1%). Infections were the common dermatological problem in this study group. The most common infections were vulvovaginal candidiasis (21%), Tinea versicolor (6%), scabies (2.8%), dermatophytosis (1.5%), and sexually transmitted infection (0.5%). Specific dermatoses were seen in 12 cases (2%), with the most common being pruritic urticarial papules and plaques of pregnancy (1.3%).

CONCLUSION: Pregnant women are prone to suffer from a wide range of dermatological problems apart from specific dermatoses of pregnancy. The study emphasizes the need for a detailed and meticulous examination of these patients to detect these various disorders.

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2017

Journal Article

A. Sreedevi, Gopalakrishnan, U. Ambika, Kamalamma, La, and Prof. K. R. Sundaram, “A Randomized controlled trial of the effect of yoga and peer support on glycaemic outcomes in women with type 2 diabetes mellitus: a feasibility study.”, BMC Complement Altern Med, vol. 17, no. 1, p. 100, 2017.[Abstract]


BACKGROUND: Type two diabetes is a complex and demanding chronic disease and its impact in a state (Kerala) which leads India in terms of the number of people with Diabetes is profound. Though the male to female ratio among the people with diabetes is roughly equal, women are uniquely and more severely affected. Management of type two Diabetes requires considerable dexterity on the part of the patient to manage drugs, diet and exercise. Therefore, in a low middle-income country like India it is necessary to look at low cost interventions that can empower the patient and build on available resources to help manage diabetes. Hence, we studied the feasibility and effect of two low cost interventions; yoga and peer support on glycaemic and other outcomes among women with type two diabetes.

METHODS: An open label parallel three armed randomized control trial was conducted among 124 recruited women with Diabetes for three months. Block randomization with a block length of six was carried out with each group having at least 41 women. In the Yoga arm, sessions by an instructor, consisting of a group of postures coordinated with breathing were conducted for an hour, two days a week. In the peer support arm each peer mentor after training visited 13-14 women with diabetes every week followed by a phone call. The meeting was about applying disease management or prevention plans in daily life.

RESULTS: There was a trend in decline of fasting plasma glucose in the peer and yoga group and of glycosylated haemoglobin (HbA1c) in the yoga group only, though not significant. A significant decrease was observed in diastolic blood pressure and hip circumference in the yoga group. The process indicated that most (80%) of the women in the yoga group attended classes regularly and 90% of the women in the peer group reported that peer mentoring was useful.

CONCLUSION: The effect of yoga and peer support on glycaemic outcomes was incremental. Longer term studies are necessary to ascertain the benefits shown by this feasibility study.

TRIAL REGISTRATION: CTRI/2011/12/002227 dated 14/12/2011.

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2017

Journal Article

K. S Priya, Kumar, K., Hiran, K. R., Dr. Bindhu M. R., Nagare, R. P., Vijaykumar, D. K., and Ganesan, T. S., “Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance.”, Int J Clin Oncol, vol. 22, no. 1, pp. 107-117, 2017.[Abstract]


OBJECTIVE: The purpose of this study was to evaluate microvessel density (MVD) as assessed by C-type lectin 14A (CLEC14A), which is a new marker for endothelial cells, and compare its expression to CD31 and CD105 in epithelial ovarian cancer (EOC).

METHODS: MVD was evaluated in tumors (n = 50) from patients with EOC who underwent primary surgery and in patients with EOC who received preoperative chemotherapy (n = 49) using immunohistochemistry with antibodies to CLEC14A, CD31 and CD105. The median duration of follow-up was 24.5 months (range 1-101 months). The effect of prognostic factors on event-free survival (EFS) and overall survival (OS) was assessed using the Cox regression model.

RESULTS: The amount of residual disease was found to be an independent prognostic factor in multivariate analysis with respect to EFS (P = 0.009) and OS (P < 0.001). The mean MVD of CLEC14A (MVD = 6), in tumors from patients who underwent primary surgery, was significantly lower than that of CD31 (MVD = 25, P < 0.0001) and CD105 (MVD = 11, P = 0.018). However, there was no significant correlation between MVD as detected by these markers and clinical outcome. There was no expression of CLEC14A in tumors from patients who received preoperative chemotherapy and the MVD of CD31 and CD105 was significantly reduced (P = 0.001 and 0.006, respectively) in this set of patients.

CONCLUSION: This study demonstrates MVD as detected by CLEC14A in EOC. Treatment with chemotherapy reduces tumor blood vessels significantly. We suggest that CLEC14A may be a more specific endothelial marker to assess tumor angiogenesis.

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2017

Journal Article

La Kumar, Dominic, Mb, Rajan, Sa, and Dr. Sanjeev K. Singh, “Impact of modified quality control checklist on protocol adherence and outcomes in a post-surgical intensive care unit”, Indian Journal of Anaesthesia, vol. 61, pp. 29-35, 2017.[Abstract]


Background and Aims: Quality improvement (QI) is the sum of all activities that create desired changes in the quality. An effective QI system results in a stepwise increase in quality of care. The efficiency of any health-care unit is judged by its quality indicators. We aimed to evaluate the impact of QI initiatives on outcomes in a surgical Intensive Care Unit (ICU). Methods: This was an observational study carried out using a compliance checklist, developed from the combination of the World Health Organization surgery checklist and Society for Healthcare Epidemiology of America guidelines for the prevention of infections. A total of 170 patients were prospectively evaluated for adherence to the checklist and occurrence of infections. This was compared with a random retrospective analysis of 170 patients who had undergone similar surgeries in the previous 3 months. Results: Introduction and supervised documentation of comprehensive checklist brought out significant improvement in the documentation of quality indicators (98% vs. 32%) in the prospective samples. There was no difference in mortality, health-care-related infection rates or length of ICU stay. Conclusion: The introduction of comprehensive surgical checklist improved documentation of parameters for quality control but did not decrease the rates of infection in comparison to the control sample. © 2017 Indian Journal of Anaesthesia.

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2017

Journal Article

D. Harichandran and Dinesh, K. Radhakrish, “Antimicrobial susceptibility profile, treatment outcome and serotype distribution of clinical isolates of Salmonella enterica subspecies enterica: a 2-year study from Kerala, South India.”, Infect Drug Resist, vol. 10, pp. 97-101, 2017.[Abstract]


<p><strong>BACKGROUND/PURPOSE: </strong>Typhoid and paratyphoid fever continue to be important causes of illness and death in parts of Asia, being associated with poor sanitation and consumption of unsafe food and water. Antimicrobial resistance has emerged to traditional first-line drugs, namely, the fluoroquinolones, as well as to third-generation cephalosporins, posing challenges to treatment. Azithromycin has proven to be an effective alternative for treatment of uncomplicated typhoid fever. The purpose of this study was to determine the antimicrobial susceptibility, clinical outcome and serotype distribution pattern of clinical isolates belonging to Salmonella enterica subspecies enterica.</p>

<p><strong>METHODOLOGY: </strong>All clinical isolates of S. enterica obtained from blood, sterile body fluids, as well as stool and urine samples at Amrita Institute of Medical Sciences and Research Centre, Kerala, India, between August 2011 and July 2013 were included in the study and processed based on standard microbiology protocols.</p>

<p><strong>RESULTS: </strong>A total of 118 isolates of Salmonella were obtained during the study period. Out of these, 79 were of S. Typhi (66.95%), followed by isolates of S. Paratyphi A (22; 18.64%) and S. Typhimurium 12 (10.17%). Five isolates could not be identified further. There was 100% susceptibility to ceftriaxone in all S. enterica subspecies. Ciprofloxacin susceptibility was 32.91% for S. Typhi and 40.90% for S. Paratyphi A as determined by the disk diffusion method. The susceptibility profile of S. Typhi isolates to different antimicrobials was as follows: chloramphenicol (94.93%), ampicillin (77.21%), cotrimoxazole (75.94%) and azithromycin (78.48%). For S. Typhi, the minimum inhibitory concentration (MIC) of ciprofloxacin required to inhibit the growth of 50% of organisms was 0.5 μg/mL (intermediate) and MIC required to inhibit the growth of 90% of organisms was 1 μg/mL (resistant). S. Typhimurium was 100% susceptible to cotrimoxazole, ampicillin, ceftriaxone, chloramphenicol, ofloxacin and azithromycin. Susceptibility to ciprofloxacin was 66.66%. Patients from whom S. Typhimurium was isolated had comorbidities with documented risk. Of the 118 patients, 3 expired. Two had typhoid fever and were in sepsis at admission. One had S. Typhimurium and was suffering from multiple myeloma.</p>

<p><strong>CONCLUSION: </strong>S. Typhi was the predominant isolate. All isolates were susceptible to ceftriaxone. Chloramphenicol susceptibility was &gt;90%. No multidrug-resistant Salmonella strains were isolated. Susceptibility to ciprofloxacin for S. Typhi was 33%. Recovery rate was 97%.</p>

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2017

Journal Article

B. Palafox, Mocumbi, A. Olga, R Krishna Kumar, Ali, S. K. M., Kennedy, E., Haileamlak, A., Watkins, D., Petricca, K., Wyber, R., Timeon, P., and Mwangi, J., “The WHF Roadmap for Reducing CV Morbidity and Mortality Through Prevention and Control of Rheumatic Heart Disease.”, Glob Heart, 2017.[Abstract]


Rheumatic heart disease (RHD) is a preventable non-communicable condition that disproportionately affects the world's poorest and most vulnerable. The World Heart Federation Roadmap for improved RHD control is a resource designed to help a variety of stakeholders raise the profile of RHD nationally and globally, and provide a framework to guide and support the strengthening of national, regional and global RHD control efforts. The Roadmap identifies the barriers that limit access to and uptake of proven interventions for the prevention and control of RHD. It also highlights a variety of established and promising solutions that may be used to overcome these barriers. As a general guide, the Roadmap is meant to serve as the foundation for the development of tailored plans of action to improve RHD control in specific contexts.

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2017

Journal Article

M. Subramanian, Prabhu, M. A., Harikrishnan, M. S., Dr. Saritha Sekhar S., Pai, P. G., and Natarajan, K. Uma, “The Utility of Exercise Testing in Risk Stratification of Asymptomatic Patients with type 1 Brugada Pattern”, Journal of Cardiovascular Electrophysiology, vol. 28, no. 6, pp. 677-683, 2017.[Abstract]


INTRODUCTION: Risk stratification of asymptomatic patients with a Brugada type 1 ECG pattern remains an unresolved clinical conundrum. In contrast to provocative pharmacological testing in Brugada syndrome, there is limited data on the role of exercise stress testing as a risk stratification modality. The objective of this study was to evaluate the utility of exercise testing in asymptomatic patients with type 1 Brugada pattern to prognosticate major arrhythmic events(MAE) during follow-up.

METHODS AND RESULTS: Treadmill exercise testing was conducted for 75 asymptomatic patients with type 1 Brugada pattern and for 88 healthy control subjects. The clinical end point of MAE was defined as the occurrence of sudden cardiac death(SCD) or resuscitated ventricular fibrillation(VF). During a follow-up of 77.9±28.9 months, 8 MAE occurred(5 VF and 3 SCD). Multivariate Cox regression analysis showed that the following were independent predictors of MAE in asymptomatic patients with a type 1 Brugada pattern: increase in S wave upslope duration ratio &gt;30% at peak exercise(HR 1.35, 95% CI 1.08-10.97,p = 0.023),augmentation of J point elevation in lead aVR&gt; 2mm in late recovery(HR 1.88, 95% 1.21 - 15.67,p = 0.011) and delayed HR recovery(HR 1.14, 95% CI 1.06-18.22,p = 0.042). A high risk cohort was identified by the final step wise regression model with good accuracy (specificity = 98.4%,sensitivity = 62.5%) and discriminative power(AUC = 0.93,95%CI 0.89-0.96,p = 0.002). Kaplan Meier analysis revealed that there increasing MAE in subjects with one, two,or three predictors(log rank p&lt;0.001).

CONCLUSIONS: Exercise testing in asymptomatic patients with Type 1 Brugada pattern aids in identification of high risk patients and provides a unique window of opportunity for early intervention. This article is protected by copyright. All rights reserved.

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2017

Journal Article

L. Guo, Bobhate, P., Kumar, S., Vadlamudi, K., Kaddoura, T., Elgendi, M., Holinski, P., Coe, J. Y., Rutledge, J., and Adatia, I., “Hyperoxia Reduces Oxygen Consumption in Children with Pulmonary Hypertension.”, Pediatr Cardiol, 2017.[Abstract]


High inspired oxygen concentration (FiO2 > 0.85) is administered to test pulmonary vascular reactivity in children with pulmonary hypertension (PH). It is difficult to measure oxygen consumption (VO2) if the subject is breathing a hyperoxic gas mixture so the assumption is made that baseline VO2 does not change. We hypothesized that hyperoxia changes VO2. We sought to compare the VO2 measured by a thermodilution catheter in room air and hyperoxia. A retrospective review of the hemodynamic data obtained in children with PH who underwent cardiac catheterization was conducted between 2009 and 2014. Cardiac index (CI) was measured by a thermodilution catheter in room air and hyperoxia. VO2 was calculated using the equation CI = VO2/arterial-venous oxygen content difference. Data were available in 24 subjects (males = 10), with median age 8.3 years (0.8-17.6 years), weight 23.3 kg (7.5-95 kg), and body surface area 0.9 m(2) (0.4-2.0 m(2)). In hyperoxia compared with room air, we measured decreased VO2 (154 ± 38 to 136 ± 34 ml/min/m(2), p = 0.007), heart rate (91 [Formula: see text] 20 to 83 [Formula: see text] 21 beats/minute, p=0.005), mean pulmonary artery pressure (41 [Formula: see text] 16 to 35 [Formula: see text] 14 mmHg, p=0.024), CI (3.6 [Formula: see text] 0.8 to 3.3 [Formula: see text] 0.9 L/min/m(2), p = 0.03), pulmonary vascular resistance (9 [Formula: see text] 6 to 7 [Formula: see text] 3 WU m(2), p = 0.029), increased mean aortic (61 [Formula: see text] 11 to 67 [Formula: see text] 11 mmHg, p = 0.005), pulmonary artery wedge pressures (11 [Formula: see text] 8 to 13 [Formula: see text] 9 mmHg, p = 0.006), and systemic vascular resistance (12 [Formula: see text] 6 to 20 [Formula: see text] 7 WU m(2), p=0.001). Hyperoxia decreased VO2 and CI and caused pulmonary vasodilation and systemic vasoconstriction in children with PH. The assumption that VO2 remains unchanged in hyperoxia may be incorrect and, if the Fick equation is used, may lead to an overestimation of pulmonary blood flow and underestimation of PVRI.

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2017

Journal Article

S. Vijaykumar Patil and S Y Nanduri, L., “Interaction of Chitin/chitosan with Salivary and Other Epithelial Cells - An Overview”, Int J Biol Macromol, 2017.[Abstract]


Chitin and its deacetylated form, chitosan, have been widely used for tissue engineering of both epithelial and mesenchymal tissues. Epithelial cells characterised by their sheet-like tight cellular arrangement and polarised nature, constitute a major component in various organs and play a variety of roles including protection, secretion and maintenance of tissue homeostasis. Regeneration of damaged epithelial tissues has been studied using biomaterials such as chitin, chitosan, hyaluronan, gelatin and alginate. Chitin and chitosan are known to promote proliferation of various embryonic and adult epithelial cells. However it is not clearly understood how this activity is achieved or what are the mechanisms involved in the chitin/chitosan driven proliferation of epithelial cells. Mechanistic understanding of influence of chitin/chitosan on epithelial cells will guide us to develop more targeted regenerative scaffold/hydrogel systems. Therefore, current review attempts to elicit a mechanistic insight into how chitin and chitosan interact with salivary, mammary, skin, nasal, lung, intestinal and bladder epithelial cells.

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2017

Journal Article

P. S. Panicker, Melge, A. R., Biswas, L., Keechilat, P., and Dr. Gopi Mohan C., “Epidermal growth factor receptor (EGFR) structure-based bioactive pharmacophore models for identifying next-generation inhibitors against clinically relevant EGFR mutations.”, Chem Biol Drug Des, vol. 90, no. 4, pp. 629-636, 2017.[Abstract]


Present work elucidates identification of next generation inhibitors for clinically relevant mutations of epidermal growth factor receptor (EGFR) using structure-based bioactive pharmacophore modeling followed by virtual screening (VS) techniques. Three-dimensional (3D) pharmacophore models of EGFR and its different mutants were generated. This includes seven 3D pharmacophoric points with three different chemical features (descriptors), that is, one hydrogen bond donor, three hydrogen bond acceptors and three aromatic rings. Pharmacophore models were validated using decoy dataset, Receiver operating characteristic plot, and external dataset compounds. The robust, bioactive 3D e-pharmacophore models were then used for VS of four different small compound databases: FDA approved, investigational, anticancer, and bioactive compounds collections of Selleck Chemicals. CUDC101 a multitargeted kinase inhibitor showed highest binding free energy and 3D pharmacophore fit value than the well known EGFR inhibitors, Gefitinib and Erlotinib. Further, we obtained ML167 as the second best hit on VS from bioactive database showing high binding energy and pharmacophore fit value with respect to EGFR receptor and its mutants. Optimistically, presented drug discovery based on the computational study serves as a foundation in identifying and designing of more potent EGFR next-generation kinase inhibitors and warrants further experimental studies to fight against lung cancer.

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2017

Journal Article

S. T. Joseph, Dr. Krishnakumar T., and Iyer, S., “Reconstruction of a Combined Maxillectomy and Segmental Mandibulectomy Defect in a Seven-Year-Old with a Single Free Fibula Osteocutaneous Flap.”, Craniomaxillofac Trauma Reconstr, vol. 10, no. 1, pp. 73-76, 2017.[Abstract]


Combined upper alveolectomy and segmental mandibulectomy are complex defects. Reconstruction of these defects is usually suboptimal. We describe the case of a pediatric patient with vessel-depleted neck with recurrent vascular malformation involving the ramus and coronoid process of mandible and a previous history of maxillectomy and a reconstruction with anterolateral thigh flap. The patient underwent wide resection. The defects involving the upper alveolus and mandible were simultaneously reconstructed with a single free fibula flap.

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2017

Journal Article

K. V. Mankulangara, Sreekumar, A., and Vijayakumar, P., “Case report of warfarin induced upper gastrointestinal bleeding”, Journal of Applied Pharmaceutical Science, vol. 7, pp. 233-236, 2017.[Abstract]


Warfarin is an oral vitamin k antagonist prescribed to those patients for the treatment and prevention of venous thromboembolism. The major challenges to be faced during the therapy were a greater risk for both major as well as minor bleeding, which makes the regular monitoring of INR (international normalized ratio) mandatory. Here we report a case study of 80 year old male who presented to casualty with the complaints of vomiting fresh blood in large quantities due to consumption of warfarin three times in a day for past 2 weeks. Patient was on anticoagulation therapy for paroxysmal atrial fibrillation since 2012 and was taking all his medications alone, he was independent in activities of daily living and instrumental activities of daily living. The blood investigation revealed anemia (Hemoglobin:6.1g/dl). He was immediately transfused with packed RBC and fresh frozen plasma to replenish the body reserves. Prothrombin time (PT)/INR was reported undetectable and warfarin was withheld from the past medications and was restarted at INR 1.56. The overdose has led to additional monitoring and prolonged hospital stay. Furthermore this case highlights the need for a better communication by providing counselling regarding all aspects of medications as well as lifestyle modifications and also by giving patient information leaflets. © 2017 Kavya Vinod Mankulangara et al.

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2017

Journal Article

L. Sunny, Lakshmi R., and Vijayakumar, M., “Evaluation of Antimicrobial use in Ventilated Patients in Coronary Care Unit of a Tertiary Care Hospital”, Research Journal of Pharmacy and Technology , vol. 10, no. 1, pp. 05-10 , 2017.[Abstract]


In developing countries, excess and indiscriminate use of antibiotics in community and hospital settings can lead to adverse effects primary to prolongation of therapy, harbour antibiotic resistance bacteria, rise in health expenditures and decrease quality of life. Antimicrobial resistance in the intensive care unit (ICU) has emerged as an important problem in this scenario. Recent studies revealed that antibiotic use is roughly ten times larger in ICU than in general wards. Research studies are required to gain suitable information concerning the use of antimicrobials (AMA) in ventilated patients which helps in improving the prescribing pattern of antimicrobial and also in executing infection control strategies in the therapy modification of such patients. There is barely limited data on antibiotic prescribing pattern in ventilated patients from India hence this study was carried out with an objective to know more about the antibiotic prescribing pattern and to analyze rationality among the prescriptions. This retrospective study was conducted in the Coronary care unit (CCU) of tertiary care hospital in South India from June 2014 to December 2014. The prescribing pattern of antimicrobials in patients aged between 10-90 years was studied. Total 33 AMA preparations were used either single or in combination. In the study, the commonly used AMAs were beta-lactam antibiotics, particularly ceftriaxone, levofloxacin followed by piperacillin + tazobactam (extended –spectrum penicillins + ß-lactamase inhibitor) as single or combination therapy. Combination of AMAs was used in 54.3% of patients. In order to achieve good outcome right use of antibiotic at right time and right dose is required, based on general AMAs prescribing pattern and susceptibility pattern of pathogens, which aid to minimize the irrational employ of antibiotics and extra pressure for resistance.

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2017

Journal Article

A. C. Sen, Morrow, D. F., Balachandran, R., Du, X., Gauvreau, K., Jagannath, B. R., Kumar, R. K., Kupiec, J. K., Melgar, M. L., Chau, N. T., Potter-Bynoe, G., Tamariz-Cruz, O., and Jenkins, K. J., “Postoperative Infection in Developing World Congenital Heart Surgery Programs: Data from the International Quality Improvement Collaborative”, Circulation: Cardiovascular Quality and Outcomes, vol. 10, 2017.[Abstract]


Background - Postoperative infections contribute substantially to morbidity and mortality after congenital heart disease surgery and are often preventable. We sought to identify risk factors for postoperative infection and the impact on outcomes after congenital heart surgery, using data from the International Quality Improvement Collaborative for Congenital Heart Surgery in Developing World Countries. Methods and Results - Pediatric cardiac surgical cases performed between 2010 and 2012 at 27 participating sites in 16 developing countries were included. Key variables were audited during site visits. Demographics, preoperative, procedural, surgical complexity, and outcome data were analyzed. Univariate and multivariable logistic regression were used to identify risk factors for infection, including bacterial sepsis and surgical site infection, and other clinical outcomes. Standardized infection ratios were computed to track progress over time. Of 14 545 cases, 793 (5.5%) had bacterial sepsis and 306 (2.1%) had surgical site infection. In-hospital mortality was significantly higher among cases with infection than among those without infection (16.7% versus 5.3%; P<0.001), as were postoperative ventilation duration (80 versus 14 hours; P<0.001) and intensive care unit stay (216 versus 68 hours; P<0.001). Younger age at surgery, higher surgical complexity, lower oxygen saturation, and major medical illness were independent risk factors for infection. The overall standardized infection ratio was 0.65 (95% confidence interval, 0.58-0.73) in 2011 and 0.59 (95% confidence interval, 0.54-0.64) in 2012, compared with that in 2010. Conclusions - Postoperative infections contribute to mortality and morbidity after congenital heart surgery. Younger, more complex patients are at particular risk. Quality improvement targeted at infection risk may reduce morbidity and mortality in the developing world. © 2017 American Heart Association, Inc. More »»

2017

Journal Article

A. Sasidharan, John, A., and Prof. K. R. Sundaram, “Comparison of knowledge, attitude and practice FF self-learning among different levels of faculty members”, Journal of South India Medicolegal Association, vol. 9, pp. 18-25, 2017.[Abstract]


The teaching methodologies in medical colleges can be tilted towards teacher centric or learner centric kind of approach. Recently Medical Council of India has been mandating revised faculty training programmes and one of the objectives of such training programmes is to promote a learner-centred approach. Self-Learning is the vital component of a learner-centred approach in medical education. Through self-learning the learners assume responsibility for their learning thereby facilitating adult learning. However till date, there is no published literature on the existing knowledge, attitude and practice of self-learning among faculty members of a medical college. Unless the existing scenario is clear, it is not possible to decide on the emphasis of self-learning in the revised faculty training programmes across the country. Moreover unless the faculty members are trained adequately, it is near to impossible to promote self-learning in the learners. This pilot research work was chosen as a beginning to determine this gap of knowledge of existing scenario amongst the faculty members in medical colleges. 30 junior level and 30 senior level faculty members voluntarily participated in this study that lasted six months. The results have shown that the attitude and practice of self-learning in faculty members, especially juniors were disappointing and it is high time for research works relating to medical education to be taken up involving faculty members in order to understand the pitfalls in the existing system. © 2017 South India Medico-Legal Association. All rights reserved.

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2017

Journal Article

S. Rajan, Surendran, J., Paul, J., and Kumar, L., “Rapidity and efficacy of ultrasonographic sliding lung sign and auscultation in confirming endotracheal intubation in overweight and obese patients”, Indian Journal of Anaesthesia, vol. 61, pp. 230-234, 2017.[Abstract]


{Background and Aims: Obese individuals are predisposed to difficult airway and intubation. They usually yield confusing or misleading auscultatory findings. We aimed to assess the rapidity and efficacy of ultrasonographic (USG) sliding lung sign for confirming endotracheal intubation in normal as well as overweight and obese surgical patients. Methods: This prospective, observational study was performed in forty surgical patients. Twenty patients with body mass index (BMI) <25 were recruited to Group A, whereas twenty patients with BMI ≥25 constituted Group B. Following induction and intubation, appearance of end‑tidal carbon dioxide waveform was used to confirm endotracheal intubation. Presence of breath sounds bilaterally was sought by auscultation, and time taken for auscultatory confirmation was noted. The USG confirmation of air entry to the lung field as indicated by lung sliding was sought, and the time taken was noted. Chi‑square test, independent t‑test and paired t‑test were used as applicable. Results: Auscultatory confirmation was more rapid in Group A as compared to Group B (9.34 ± 2.43 s vs. 14.35 ± 5.53 s More »»

2017

Journal Article

Dr. Anil Kumar V., Sachu, A., Mohan, K., Vinod, V., Dinesh, K. Radhakrish, and Karim, S., “Simple low cost differentiation of Candida auris from Candida haemulonii complex using CHROMagar Candida medium supplemented with Pal's medium”, Revista Iberoamericana de Micologia, 2017.[Abstract]


Background: Candida auris is unique due to its multidrug resistance and misidentification as Candida haemulonii by commercial systems. Its correct identification is important to avoid inappropriate treatments. Aims: To develop a cheap method for differentiating C. auris from isolates identified as C. haemulonii by VITEK2. Methods: Fifteen C. auris isolates, six isolates each of C. haemulonii and Candida duobushaemulonii, and one isolate of Candida haemulonii var. vulnera were tested using CHROMagar Candida medium supplemented with Pal's agar for better differentiation. Results: On CHROMagar Candida medium supplemented with Pal's agar all C. auris strains showed confluent growth of white to cream colored smooth colonies at 37. °C and 42. °C after 24 and 48. h incubation and did not produce pseudohyphae. The isolates of the C. haemulonii complex, on the contrary, showed poor growth of smooth, light-pink colonies at 24. h while at 48. h the growth was semiconfluent with the production of pseudohyphae. C. haemulonii complex failed to grow at 42. °C. Conclusions: We report a rapid and cheap method using CHROMagar Candida medium supplemented with Pal's agar for differentiating C. auris from isolates identified as C. haemulonii by VITEK2. © 2017 Asociación Española de Micología.

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2017

Journal Article

G. Zaidi, Bhatia, V., Sahoo, S., Sarangi, A. Narayan, Bharti, N., Zhang, L., Yu, L., Eriksson, D., Bensing, S., Kämpe, O., Bhavani, N., Yachha, S. K., Bhansali, A., Sachan, A., Jain, V., Shah, N., Aggarwal, R., Aggarwal, A., Srinivasan, M., Agarwal, S., and Bhatia, E., “Autoimmune polyendocrine syndrome type 1 in an Indian cohort: a longitudinal study.”, Endocrine connection, 2017.[Abstract]


OBJECTIVE: Autoimmune polyendocrine syndrome type 1 (APS 1) is a rare autosomal recessive disorder characterized by progressive organ-specific autoimmunity. There is scant information on APS1 in ethnic groups other than European Caucasians. We studied clinical aspects and autoimmune regulator (AIRE) gene mutations in a cohort of Indian APS1 patients. DESIGN: Twenty-three patients (19 families) from six referral centres in India, diagnosed between 1996-2016, were followed for [median (range)] 4 (0.2-19) years. METHODS: Clinical features, mortality, organ-specific autoantibodies and AIRE gene mutations were studied. RESULTS: Patients varied widely in their age of presentation [3.5 (0.1-17) years] and number of clinical manifestations [5 (2-11)]. Despite genetic heterogeneity, the frequency of the major APS1 components (muco-cutaneous candidiasis: 96%; hypoparathyroidism: 91%; primary adrenal insufficiency: 55%) were similar to reports in European series. In contrast, primary hypothyroidism (23%) occurred more frequently and at an early age, while kerato-conjunctivitis, urticarial rash and autoimmune hepatitis were uncommon (9% each). Six (26%) patients died at a young age [5.8 (3-23) years] due to septicaemia, hepatic failure, adrenal/hypocalcaemic crisis from non-compliance/unexplained cause. Interferon-α and/or interleukin-22 antibodies were elevated in all 19 patients tested, including an asymptomatic infant. Eleven AIRE mutations were detected, the most common being p.C322fsX372 (haplotype frequency 37%). Four mutations were novel while others were previously described (European Caucasians:6, Arab:1). CONCLUSIONS: Indian APS1 patients exhibited considerable genetic heterogeneity and had highly variable clinical features. While the frequency of major manifestations was similar to European Caucasians, other features showed significant differences. A high mortality at a young age was observed. More »»

2017

Journal Article

M. Thillai, Sethi, P., Menon, R. Narayana, and Kader, N. Puthukudiy, “Cystic artery pseudoaneurysm following acute necrotising pancreatitis.”, BMJ Case Reports, vol. 2017, 2017.[Abstract]


Cystic artery pseudoaneurysm is a rare pathology. Of the 20 cases reported so far, chronic cholecystitis and iatrogenic biliary injury form the majority of causes. Currently, there is no published report of such pseudoaneurysms caused secondary to pancreatitis, hence the management in such a scenario is unclear. We hereby present the first such report of cystic artery pseudoaneurysm occurring as a sequel of acute necrotising pancreatitis. A 33-year-old man who recovered from a recent attack of acute pancreatitis was readmitted for melena and fever. Computed tomography of abdomen revealed blood in the gall bladder with pericholecystic blush and resolving pancreatic necrosis. Percutaneous transarterial embolisation of the cystic artery was done. This stabilised the patient but persistent sepsis and clinical deterioration warranted a surgical exploration and cholecystostomy. Hence, transarterial embolisation followed by surgery in selected cases can be an ideal management protocol. More »»

2017

Journal Article

R. Sarkar, Podder, I., Gokhale, N., Jagadeesan, S., and Garg, V. K., “Use of vegetable oils in dermatology: an overview.”, International journal of dermatology, 2017.[Abstract]


Vegetable oils have been used for a wide variety of purposes since time immemorial; however, their principle use remains as skin moisturizers, especially in neonates and children. Because of their considerable efficacy and a low side effect profile and bearable cost, these oils are hugely popular as moisturizers among the common people in countries such as India. A wide variety of oils have been used, and newer ones are coming up with each passing day. This article focuses on the different types of vegetable oils and their varied uses in dermatology. More »»

2017

Journal Article

P. S. Rakesh, Balakrishnan, S., Krishnaveni, V., Narayanan, V., Pillai, S., and Thomas, S. Merin, “Patients Perception Towards Directly Observed Treatment - A Qualitative Study from Kollam District, Kerala, Southern India.”, The Indian journal of tuberculosis, vol. 64, no. 2, pp. 93-98, 2017.[Abstract]


BACKGROUND: The Direct Observation of Treatment (DOT) is an important component of the country's TB Control strategy. Standards of TB care in India and the End TB strategy emphasised the importance of a patient-centered approach to foster adherence. A qualitative study was conducted to explore the perception of people with Tuberculosis in Kerala regarding DOT, mechanisms to make the treatment of TB more patients centered and to identify the preferable mechanisms to ensure adherence. METHODS:Six focus group discussions were conducted - two among people with TB from rural area, two among people with TB in urban area, one among multipurpose health workers of rural area and one among key field staff of TB control in urban area. RESULTS: Patients who were on a strict DOT were unhappy about the issues of confidentiality, patient inconvenience and provider centered approach. A flexible, patient centered approach were a family member can act as the DOT provider with guidance from a trained health worker was evolved as the most acceptable and comfortable mode of treatment to majority of the TB patients. They felt that a strict external monitor as a DOT provider was not a necessity in majority of the cases. Only practical way to effectively incorporate ICT in monitoring patient compliance in current scenario was identified as daily phone call reminders. Patients also expressed their concerns in keeping the medicines for entire duration at home. CONCLUSION: A flexible patient wise individualized system based on patient's behavior, literacy and awareness along with attitude of family members is needed to ensure adherence to anti TB drugs.

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2017

Journal Article

A. Chanchal Sen, Morrow, D. Forbes, Balachandran, R., Du, X., Gauvreau, K., Jagannath, B. R., R Krishna Kumar, Kupiec, J. Koch, Melgar, M. L., Chau, N. Tran, Potter-Bynoe, G., Tamariz-Cruz, O., and Jenkins, K. J., “Postoperative Infection in Developing World Congenital Heart Surgery Programs: Data From the International Quality Improvement Collaborative.”, Circulation. Cardivascular quality and outcomes, vol. 10, no. 4, 2017.[Abstract]


BACKGROUND:Postoperative infections contribute substantially to morbidity and mortality after congenital heart disease surgery and are often preventable. We sought to identify risk factors for postoperative infection and the impact on outcomes after congenital heart surgery, using data from the International Quality Improvement Collaborative for Congenital Heart Surgery in Developing World Countries. METHODS AND RESULTS: Pediatric cardiac surgical cases performed between 2010 and 2012 at 27 participating sites in 16 developing countries were included. Key variables were audited during site visits. Demographics, preoperative, procedural, surgical complexity, and outcome data were analyzed. Univariate and multivariable logistic regression were used to identify risk factors for infection, including bacterial sepsis and surgical site infection, and other clinical outcomes. Standardized infection ratios were computed to track progress over time. Of 14 545 cases, 793 (5.5%) had bacterial sepsis and 306 (2.1%) had surgical site infection. In-hospital mortality was significantly higher among cases with infection than among those without infection (16.7% versus 5.3%; P More »»

2017

Journal Article

B. Chandran, Bharathan, V. Kumar, Mathew, J. Shaji, Amma, B. Sivasankar, Gopalakrishnan, U., Balakrishnan, D., Menon, R. Narayana, Dhar, P., Vayoth, S. Othiyil, and Surendran, S., “Quality of life of liver donors following donor hepatectomy.”, Indian Journal of gastroenterology : official journal of the Indian society of Gastroenterology, 2017.[Abstract]


BACKGROUND: Although morbidity following living liver donation is well characterized, there is sparse data regarding health-related quality of life (HRQOL) of donors. METHODS: HRQOL of 200 consecutive live liver donors from 2011-2014 performed at an Indian center were prospectively collected using the SF-36 version 2, 1 year after surgery. The effect of donor demographics, operative details, post-operative complications (Clavien-Dindo and 50-50 criteria), and recipient mortality on the quality-of-life (QOL) scoring was analyzed. RESULTS: Among 200 donors (female/male=141:59), 77 (38.5%) had complications (14.5%, 16.5%, 4.5%, and 3.5%, Clavien-Dindo grades I-IV, respectively). The physical composite score (PCS) of donors 1year after surgery was less than ideal (48.75±9.5) while the mental composite score (MCS) was good (53.37±6.16). Recipient death was the only factor that showed a statistically significant correlation with both PCS (p More »»

2017

Journal Article

A. Kumar, Sachu, A., Mohan, K., Vinod, V., Dinesh, K., and Karim, S., “Simple low cost differentiation of Candida auris from Candida haemulonii complex using CHROMagar Candida medium supplemented with Pal's medium.”, Revista iberoamericana de micologia, 2017.[Abstract]


BACKGROUND: Candida auris is unique due to its multidrug resistance and misidentification as Candida haemulonii by commercial systems. Its correct identification is important to avoid inappropriate treatments. AIMS: To develop a cheap method for differentiating C. auris from isolates identified as C. haemulonii by VITEK2. METHODS: Fifteen C. auris isolates, six isolates each of C. haemulonii and Candida duobushaemulonii, and one isolate of Candida haemulonii var. vulnera were tested using CHROMagar Candida medium supplemented with Pal's agar for better differentiation. RESULTS:On CHROMagar Candida medium supplemented with Pal's agar all C. auris strains showed confluent growth of white to cream colored smooth colonies at 37°C and 42°C after 24 and 48h incubation and did not produce pseudohyphae. The isolates of the C. haemulonii complex, on the contrary, showed poor growth of smooth, light-pink colonies at 24h while at 48h the growth was semiconfluent with the production of pseudohyphae. C. haemulonii complex failed to grow at 42°C. CONCLUSIONS:We report a rapid and cheap method using CHROMagar Candida medium supplemented with Pal's agar for differentiating C. auris from isolates identified as C. haemulonii by VITEK2. More »»

2017

Journal Article

B. Ahrén, Masmiquel, L., Kumar, H., Sargin, M., Karsbøl, J. Derving, Jacobsen, S. Hald, and Chow, F., “Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial.”, The Lancet Diabetes & endocrinology, vol. 5, no. 5, pp. 341-354, 2017.[Abstract]


BACKGROUND: Semaglutide is a novel glucagon-like peptide-1 (GLP-1) analogue, suitable for once-weekly subcutaneous administration, in development for treatment of type 2 diabetes. We assessed the efficacy and safety of semaglutide versus the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin, thiazolidinediones, or both. METHODS:We did a 56-week, phase 3a, randomised, double-blind, double-dummy, active-controlled, parallel-group, multinational, multicentre trial (SUSTAIN 2) at 128 sites in 18 countries. Eligible patients were aged at least 18 years (or at least 20 years in Japan) and diagnosed with type 2 diabetes, with insufficient glycaemic control (HbA1c 7·0-10·5% [53·0-91·0 mmol/mol]) despite stable treatment with metformin, thiazolidinediones, or both. We randomly assigned participants (2:2:1:1) using an interactive voice or web response system to 56 weeks of treatment with subcutaneous semaglutide 0·5 mg once weekly plus oral sitagliptin placebo once daily, subcutaneous semaglutide 1·0 mg once weekly plus oral sitagliptin placebo once daily, oral sitagliptin 100 mg once daily plus subcutaneous semaglutide placebo 0·5 mg once weekly, or oral sitagliptin 100 mg once daily plus subcutaneous semaglutide placebo 1·0 mg once weekly. The two oral sitagliptin 100 mg groups (with semaglutide placebo 0·5 mg and 1·0 mg) were pooled for the analyses. The primary endpoint was change in HbA1c from baseline to week 56, assessed in the modified intention-to-treat population (all randomly assigned participants who received at least one dose of study drug); change in bodyweight from baseline to week 56 was the confirmatory secondary endpoint. Safety endpoints included adverse events and hypoglycaemic episodes. This trial is registered with ClinicalTrials.gov, number NCT01930188. FINDINGS: Between Dec 2, 2013, and Aug 5, 2015, we randomly assigned 1231 participants; of the 1225 included in the modified intention-to-treat analysis, 409 received semaglutide 0·5 mg, 409 received semaglutide 1·0 mg, and 407 received sitagliptin 100 mg. Mean baseline HbA1c was 8·1% (SD 0·93); at week 56, HbA1c was reduced by 1·3% in the semaglutide 0·5 mg group, 1·6% in the semaglutide 1·0 mg group, and 0·5% with sitagliptin (estimated treatment difference vs sitagliptin -0·77% [95% CI -0·92 to -0·62] with semaglutide 0·5 mg and -1·06% [-1·21 to -0·91] with semaglutide 1·0 mg; p<0·0001 for non-inferiority and for superiority, for both semaglutide doses vs sitagliptin). Mean baseline bodyweight was 89·5 kg (SD 20·3); at week 56, bodyweight reduced by 4·3 kg with semaglutide 0·5 mg, 6·1 kg with semaglutide 1·0 mg, and 1·9 kg with sitagliptin (estimated treatment difference vs sitagliptin -2·35 kg [95% CI -3·06 to -1·63] with semaglutide 0·5 mg and -4·20 kg [-4·91 to -3·49] with semaglutide 1·0 mg; p<0·0001 for superiority, for both semaglutide doses vs sitagliptin). The proportion of patients who discontinued treatment because of adverse events was 33 (8%) for semaglutide 0·5 mg, 39 (10%) for semaglutide 1·0 mg, and 12 (3%) for sitagliptin. The most frequently reported adverse events in both semaglutide groups were gastrointestinal in nature: nausea was reported in 73 (18%) who received semaglutide 0·5 mg, 72 (18%) who received semaglutide 1·0 mg, and 30 (7%) who received placebo, and diarrhoea was reported in 54 (13%) who received semaglutide 0·5 mg, 53 (13%) who received semaglutide 1·0 mg, and 29 (7%) who received placebo. Seven (2%) patients in the semaglutide 0·5 mg group, two (<1%) in the semaglutide 1·0 mg group, and five (1%) in the sitagliptin group had blood-glucose confirmed hypoglycaemia. There were six fatal events (two in the semaglutide 0·5 mg group, one in the semaglutide 1·0 mg group, and three in the sitagliptin group); none were considered likely to be related to the trial drugs. FUNDING: Novo Nordisk A/S More »»

2017

Journal Article

H. B. Rao, Ahamed, H., Panicker, S., Sudhindran, S., and Ramakrishna Venugopal, “Endoscopic therapy for biliary strictures complicating living donor liver transplantation: Factors predicting better outcome.”, World J Gastrointest Pathophysiol, vol. 8, no. 2, pp. 77-86, 2017.[Abstract]


AIM: To identify factors predicting outcome of endoscopic therapy in bile duct strictures (BDS) post living donor liver transplantation (LDLT).

METHODS: Patients referred with BDS post LDLT, were retrospectively studied. Patient demographics, symptoms (Pruritus, Jaundice, cholangitis), intra-op variables (cold ischemia time, blood transfusions, number of ducts used, etc.), peri-op complications [hepatic artery thrombosis (HAT), bile leak, infections], stricture morphology (length, donor and recipient duct diameters) and relevant laboratory data both pre- and post-endotherapy were studied. Favourable response to endotherapy was defined as symptomatic relief with &gt; 80% reduction in total bilirubin/serum gamma glutamyl transferase. Statistical analysis was performed using SPSS 20.0.

RESULTS: Forty-one patients were included (age: 8-63 years). All had right lobe LDLT with duct-to-duct anastomosis. Twenty patients (48.7%) had favourable response to endotherapy. Patients with single duct anastomosis, aggressive stent therapy (multiple endoscopic retrograde cholagiography, upsizing of stents, dilatation and longer duration of stents) and an initial favourable response to endotherapy were independent predictors of good outcome (P &lt; 0.05). Older donor age, HAT, multiple ductal anastomosis and persistent bile leak (&gt; 4 wk post LT) were found to be significant predictors of poor response on multivariate analysis (P &lt; 0.05).

CONCLUSION: Endoscopic therapy with aggressive stent therapy especially in patients with single duct-to-duct anastomosis was associated with a better outcome. Multiple ductal anastomosis, older donor age, shorter duration of stent therapy, early bile leak and HAT were predictors of poor outcome with endotherapy in these patients.

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2017

Journal Article

Dr. Mahesh K., Koneti, N. Rao, Kannan, R. R., Kottayil, B. P., and Kumar, K., “Three-dimensional-printed cardiac prototypes aid surgical decision-making and preoperative planning in selected cases of complex congenital heart diseases: Early experience and proof of concept in a resource-limited environment.”, Ann Pediatr Cardiol, vol. 10, no. 2, pp. 117-125, 2017.[Abstract]


INTRODUCTION: Three-dimensional. (3D) printing is an innovative manufacturing process that allows computer-assisted conversion of 3D imaging data into physical "printouts" Healthcare applications are currently in evolution.

OBJECTIVE: The objective of this study was to explore the feasibility and impact of using patient-specific 3D-printed cardiac prototypes derived from high-resolution medical imaging data (cardiac magnetic resonance imaging/computed tomography [MRI/CT]) on surgical decision-making and preoperative planning in selected cases of complex congenital heart diseases (CHDs).

MATERIALS AND METHODS: </strong>Five patients with complex CHD with previously unresolved management decisions were chosen. These included two patients with complex double-outlet right ventricle, two patients with criss-cross atrioventricular connections, and one patient with congenitally corrected transposition of great arteries with pulmonary atresia. Cardiac MRI was done for all patients, cardiac CT for one; specific surgical challenges were identified. Volumetric data were used to generate patient-specific 3D models. All cases were reviewed along with their 3D models, and the impact on surgical decision-making and preoperative planning was assessed.

RESULTS: </strong>Accurate life-sized 3D cardiac prototypes were successfully created for all patients. The models enabled radically improved 3D understanding of anatomy, identification of specific technical challenges, and precise surgical planning. Augmentation of existing clinical and imaging data by 3D prototypes allowed successful execution of complex surgeries for all five patients, in accordance with the preoperative planning.

CONCLUSIONS: </strong>3D-printed cardiac prototypes can radically assist decision-making, planning, and safe execution of complex congenital heart surgery by improving understanding of 3D anatomy and allowing anticipation of technical challenges.

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2017

Journal Article

R Krishna Kumar, “A Roadmap for the Aspiring Interventional Pediatric Cardiologist.”, Ann Pediatr Cardiol, vol. 10, no. 2, pp. 109-113, 2017.

2017

Journal Article

K. G. Gopakumar, Thankamony, P., Dr. Sheela Nampoothiri, Bali, D., Raj, J., Vasudevan, J. A., and Nair, R. K., “Wolman Disease: A Mimic of Infant Leukemia.”, J Pediatr Hematol Oncol, 2017.[Abstract]


BACKGROUND: Infant leukemia most commonly present with pallor and hepatosplenomegaly. The possibility of other differential diagnosis also has to be kept in mind during evaluation, as identifying the precise etiology for this clinical presentation is crucial for management.

OBSERVATION: An infant, was referred to us with suspected infant leukemia and was subsequently diagnosed to have lysosomal acid lipase deficiency/Wolman disease with a novel 5 bp deletion "c.1180_1184del" in the last exon (exon 10) of the lipase A (LIPA) gene.

CONCLUSIONS: Hepatosplenomegaly and pallor resulting from nutritional deficiency or bone marrow involvement in Wolman disease can mimic infant leukemia.

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2017

Journal Article

B. Champaneri, Kappanayil, M., and Kumar, R. K., “Transcatheter closure of a membranous ventricular septal defect in a 1.8-kg infant using Amplatzer Duct Occluder II additional size device.”, Cardiol Young, vol. 27, no. 7, pp. 1437-1440, 2017.[Abstract]


Catheter closure of membranous ventricular septal defects is generally not considered feasible in small infants. We report the successful closure of a membranous ventricular septal defect in a 1.8-kg infant with bilateral femoral artery occlusion using Amplatzer Duct Occluder II additional size device. The ventricular septal defect was crossed from the right ventricle, and the device was deployed using transthoracic echocardiographic guidance.

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2017

Journal Article

V. K. Nambiar, Sajitha, S., Viswanath, N., Praveen, V. P., and Bindhu, M. R., “Cerebral venous thrombosis due to pheochromocytoma in a patient with Von Hippel Lindau mutation.”, Neurol India, vol. 65, no. 3, pp. 643-645, 2017.

2017

Journal Article

P. Shanavas Khan and Thilak, J., “Causes of Total Knee Revision in Emerging Economies: Is It Different from the Western World?”, J Knee Surg, vol. 30, no. 4, pp. 341-346, 2017.[Abstract]


There is limited information in English literature regarding the cause of revision total knee arthroplasty (TKA) in emerging economies. The purpose of this study is to report a detailed analysis of the TKA failure mechanisms from a referral hospital in India and to determine whether the failure mechanisms of primary TKA are different from that of the western world. A total of 53 revision TKAs performed at our institution over the past 5 years were identified. The revision TKA group was divided into subgroups according to the cause of failure, including infection, aseptic loosening, periprosthetic fracture, instability, extensor mechanism failure, and other causes. All revision TKA patients were subdivided into early (less than 2 years from primary) and late (more than 2 years from primary) failure groups depending upon the time interval between primary TKA and revision procedure. The overall common failure mechanisms were infection (73.58%), aseptic loosening (13.2%), and periprosthetic fracture (5.6%). Infection was the most common failure mechanism for early revision (< 2 years from primary) and aseptic loosening was the most common reason for late revision. Our study shows a pattern similar to the earliest trends of revision TKA in western literature reporting infection as the major cause for revision. The level of evidence for the study is Level 3.

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2017

Journal Article

Dr. Suhas Udayakumaran, Onyia, C. U., and Cherkil, S., “An Analysis of Outcome of Endoscopic Fenestration of Cavum Septum Pellucidum Cyst - More Grey than Black and White?”, Pediatr Neurosurg, 2017.[Abstract]


BACKGROUND: Cavum septum pellucidum (CSP) and cavum vergae are actually fluid-filled, generally communicating midline cavities located between the third ventricle and corpus callosum. There have been various reports of their association with many behavioral and psychiatric disorders. Infrequently, they have been associated with an obstructive hydrocephalus-like picture. Although the structure and management of CSP has long been known, it has been an enigma as far as functional significance and management indications are concerned. The authors of this article try to analyze the significance of a persistent cavum and involvement of the same entity in varied presentations ranging from an incidental imaging finding to acute hydrocephalus, and propose a possible implication on the present surgical intervention paradigm.

PURPOSE: To assess the surgical outcome of fenestration of a CSP cyst.

METHODS: Retrospective analysis of 3 patients who underwent endoscopic fenestration for CSP with obstructive hydrocephalus between 2012 and 2014 was done, and data were analyzed for symptomatic clinical improvement in particular behavior.

RESULTS: Pre- and postoperative brain MRI showed a significant decrease in the size of the cyst as well as the ventricles. There were no recurrences during follow-up. All of the patients improved.

CONCLUSIONS: (1) Endoscopic fenestration of symptomatic CSP cysts is a safe treatment option. (2) Neurocognitive assessment is essential in the evaluation and outcome assessment of CSP.

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2017

Journal Article

A. V. Balegadde, Vijan, V., and Rajesh Thachathodiyl, “A case series of young patients with completely reversed severe pulmonary hypertension”, Journal of Clinical and Diagnostic Research, vol. 11, pp. OR04-OR05, 2017.[Abstract]


Pulmonary Arterial Hypertension (PAH) is a progressive symptomatic disorder, which may ultimately lead to death if left untreated. Although majority of PAH cases are idiopathic, pulmonary hypertension resulting due to certain underlying conditions are also observed frequently. In such cases, it becomes essential to identify any potentially treatable or reversible causes for PAH. There have been significant advances in the medical management of PAH and various medicines have been approved by US Food and Drug Administration (FDA) for various stages of PAH. With these therapies, there can be varying degrees of improvement in the pulmonary artery pressures and hemodynamic profile. Therefore, physiologic reversal can and does occur, sometimes to the point of normalization. We hereby present three such cases of severe PAH in patients below 50 years of age due to various aetiologies like left heart disease, isolated unilateral absence of right pulmonary artery with hypoplastic right lung and factor V Leiden mutation associated pulmonary thromboembolism, all of whose pulmonary artery pressures are completely normalised with adequate treatment of the underlying disease and with optimised medications for PAH, ultimately leading to tapering and stoppage of PAH medications. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.

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2017

Journal Article

K. Surendran, Harilal, O. P., Hrudya, P., Poornachandran, P., and Suchetha, N. K., “Stylometry detection using deep learning”, Advances in Intelligent Systems and Computing, vol. 556, pp. 749-757, 2017.[Abstract]


Author profiling is one of the active researches in the field of data mining. Rather than only concentrated on the syntactic as well as stylometric features, this paper describes about more relevant features which will profile the authors more accurately. Readability metrics, vocabulary richness, and emotional status are the features which are taken into consideration. Age and gender are detected as the metrics for author profiling. Stylometry is defined by using deep learning algorithm. This approach has attained an accuracy of 97.7% for gender and 90.1% for age prediction. © Springer Nature Singapore Pte Ltd. 2017.

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2017

Journal Article

P. S. Rakesh, Lalu, J., and Leelamoni, K., “Prevalence of exposure to secondhand smoke among higher secondary school students in Ernakulam District, Kerala, Southern India”, Journal of Pharmacy and Bioallied Sciences, vol. 9, pp. 44-47, 2017.[Abstract]


Introduction: The association between secondhand smoke and health outcomes, such as frequent respiratory infections, ischemic heart disease, lung cancer, asthma, and stroke, has long been established. The study aimed to estimate the prevalence of secondhand smoking exposure among higher secondary school students in Ernakulam district, Kerala, Southern India. Materials and Methods: A structured questionnaire was administered to all students from four randomly selected higher secondary schools in Ernakulam district. Descriptive statistics was done using frequencies and percentages. Univariate and multivariate analyses were done for factors associated with household exposure to tobacco smoke generating odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 629 students participated in the study. The prevalence of ever smokers was 11.9% and of current smokers was 5.2%. Among the study participants, 23.2% were exposed to secondhand smoking from a family member and 18.8% from friends. Lower educational status of father was associated with the household exposure to secondhand smoke (adjusted OR 4.51 [95% CI 1.66-12.22]). More than half of the study participants (56.3%) reported that they were exposed to cigarette smoke in past 1 week in a public place and 10.2% in closed public places. Nearly one-third of the students reported that they have seen somebody smoking inside school campus in the past 30 days. Conclusion: Exposure to secondhand smoke at home, schools, and public places was higher among the late adolescent higher secondary school students in Ernakulam district. The findings underscore the urgent need for increased efforts to implement the strategies to reduce secondhand smoke exposure among adolescents.

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2017

Journal Article

R. Agarwal, Rajanbabu, A., Nair, I. R., Satish, C., Jose, G., and Unikrishnan, U. G., “Endometrial stromal sarcoma-A retropsective analysis of factors affecting recurrence.”, Eur J Obstet Gynecol Reprod Biol, vol. 216, pp. 92-97, 2017.[Abstract]


OBJECTIVE: To assess the factors associated with disease free survival and overall survival in endometrial stromal sarcoma (ESS).

METHODS: This was a single institution retrospective analysis done at Amrita Institute of Medical Sciences. Records from January 2005 to October 2016 were analysed and 42 patients with ESS were identified. Clinicopathological, surgical management, adjuvant treatment and outcome data were collected. Disease free and overall survivals were analysed using Kaplan-Meier method and compared using log rank test.

RESULTS: Out of 38 patients included in analysis 28 (73.7%) had low grade ESS (LGESS) and 10 (26.3%) had high grade ESS (HGESS). The median follow up period was 28 months (range 1-110 months). The 5year disease free survival (DFS) and overall survival (OS) for the entire cohort were 62.9 and 89.1% respectively. High grade ESS was significantly associated with recurrence on univariate analysis (p=0.045). Complete staging surgery in both HGESS and LGESS and adjuvant treatment in HGESS and advanced stage LGESS (cohort 1) were associated with improved 5-year DFS of 90.9% (p&lt;0.001). Completion staging surgery in patients with initial incomplete surgery (cohort 3) was associated with improved 5-year DFS of 100% (p&lt;0.001). Complete Staging surgery but no adjuvant treatment in HGESS and advanced stage LGESS (cohort 2) was associated with significantly poor 2-year DFS of 20% (5-year DFS rate 0%; as all patients recurred within 27 months) (P&lt;0.001). Significantly reduced 5-year DFS rate of 25% (p&lt;0.001) was also seen in cases where initial incomplete surgery was not followed by complete staging and adjuvant treatment (cohort 4). Adjuvant treatment in HGESS was associated with improved 5-year DFS of 66.7% (p=0.043). Resection of recurrent lesions were associated with improved mean survival of 41.2 months.

CONCLUSION: </strong>Incomplete surgery and no adjuvant treatment in ESS are associated with poor DFS. Complete staging surgery is associated with improved DFS. Resection of recurrent disease is associated with survival advantage.

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2017

Journal Article

P. Bijalwan, Kalavampara V Sanjeevan, Anil Mathew, and T Balagopal Nair, “Outcome and complications of living donor pediatric renal transplantation: Experience from a tertiary care center”, Indian J Urol, vol. 33, no. 3, pp. 221-225, 2017.[Abstract]


INTRODUCTION: We retrospectively reviewed the patient characteristics, outcome, and complications of renal transplantation in pediatric age group performed at our center and compared the results with various centers in India and other developed countries.

MATERIALS AND METHODS: Patients younger than eighteen years of age who underwent renal transplantation from 2003 to 2014 at our institute were reviewed. Demographic data of the transplant recipients and donors, etiology of ESRD, mode of dialysis, surgical details of renal transplantation, immunosuppression, medical and surgical complications, and post-transplant follow-up were assessed. Graft survival was determined at 1, 3 and 5 years post-transplant. All data collected were entered into Microsoft excel program and analyzed using SPSS 20. Kaplan-Meier method was applied to determine the graft survival at 1, 3, and 5 years. The log-rank test was applied to test the statistical significance of the difference in survival between groups.

RESULTS: Thirty-two children underwent transplantation comprising of 18 females and 14 males. The mean age was 14.5 years (range 10-17 years). The primary cause of renal failure was glomerular diseases in 53% (17/32) of patients. Seventeen postsurgical complications were noted in our series. Two grafts were lost over a follow-up of 5 years. The 1, 3, and 5 year graft survival rates were 96.7%, 92.9%, and 85%, respectively. There was no mortality.

CONCLUSION: The etiology of ESRD in our region is different from that of developed countries. The mean age at which children undergo renal transplantation is higher. Graft survival at our center is comparable to that of developed nations. Renal transplantation can be safely performed in children with ESRD.

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2017

Journal Article

D. Menon, Chelakkot, P. G., Sunil, D., and Lakshmaiah, A., “A cross sectional review of patient information available in the World Wide Web on CyberKnife: fallacies and pitfalls.”, Support Care Cancer, vol. 25, no. 12, pp. 3769-3773, 2017.[Abstract]


PURPOSE: The purpose of this study is to assess the quality of videos available in YouTube on CyberKnife.

METHODS: The term "CyberKnife" was input into the search window of www.youtube.com on a specific date and the first 50 videos were assessed for technical and content issues. The data was tabulated and analysed.

RESULTS: The search yielded 32,300 videos in 0.33 s. Among the first 50 analysed, most were professional videos, mostly on CyberKnife in general and for brain tumours. Most of the videos did not mention anything about patient selection or lesion size. The other technical details were covered by most although they seemed muffled by the animations. Many patient videos were recordings of one entire treatment, thus giving future patients an insight on what to expect. Almost half the videos projected glorified views about the treatment technique.

CONCLUSIONS: The company videos were reasonably accurate and well presented as were many institutional videos, although there was a tendency to gloss over a few points. The glorification of the treatment technique was a disturbing finding. The profound trust of the patients on the health care system is humbling.

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2017

Journal Article

S. Vijayrajratnam, Pushkaran, A. Choorakott, Balakrishnan, A., Dr. Anil Kumar V., Dr. Raja Biswas, and Dr. Gopi Mohan C., “Understanding the molecular differential recognition of muramyl peptide ligands by LRR domains of human NOD receptors”, Biochem J, vol. 474, no. 16, pp. 2691-2711, 2017.[Abstract]


Human nucleotide-binding oligomerization domain proteins, hNOD1 and hNOD2, are host intracellular receptors with C-terminal leucine-rich repeat (LRR) domains, which recognize specific bacterial peptidoglycan (PG) fragments as their ligands. The specificity of this recognition is dependent on the third amino acid of the stem peptide of the PG ligand, which is usually meso-diaminopimelic acid (mesoDAP) or l-lysine (l-Lys). Since the LRR domains of hNOD receptors had been experimentally shown to confer the PG ligand-sensing specificity, we developed three-dimensional structures of hNOD1-LRR and the hNOD2-LRR to understand the mechanism of differential recognition of muramyl peptide ligands by hNOD receptors. The hNOD1-LRR and hNOD2-LRR receptor models exhibited right-handed curved solenoid shape. The hot-spot residues experimentally proved to be critical for ligand recognition were located in the concavity of the NOD-LRR and formed the recognition site. Our molecular docking analyses and molecular electrostatic potential mapping studies explain the activation of hNOD-LRRs, in response to effective molecular interactions of PG ligands at the recognition site; and conversely, the inability of certain PG ligands to activate hNOD-LRRs, by deviations from the recognition site. Based on molecular docking studies using PG ligands, we propose few residues - G825, D826 and N850 in hNOD1-LRR and L904, G905, W931, L932 and S933 in hNOD2-LRR, evolutionarily conserved across different host species, which may play a major role in ligand recognition. Thus, our integrated experimental and computational approach elucidates the molecular basis underlying the differential recognition of PG ligands by hNOD receptors.

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2017

Journal Article

A. Kallikunne Mohamed, Mehta, A. Anilkumar, and James, P., “Predictors of Mortality of Severe Sepsis Among Adult Patients in the Medical Intensive Care Unit”, Lung India, vol. 34, no. 4, pp. 330-335, 2017.[Abstract]


BACKGROUND: Sepsis is an important cause of mortality in the Intensive Care Units (ICUs) worldwide. Information regarding early predictive factors for mortality and morbidity is limited.

AIMS AND OBJECTIVES: The primary objective of the study was to estimate the mortality of severe sepsis among adult patients admitted into the medical ICU. The secondary objective was to identify the predictors associated with mortality.

MATERIALS AND METHODS: Adult patients admitted with severe sepsis in the medical ICU were studied. The primary outcome was the mortality among the study population. Baseline demographic, clinical, and laboratory data were recorded upon inclusion into the study. Risk factors associated with mortality were studied by univariate analysis. The variables having statistical significance were further included in multivariate analysis to identify the independent predictors of mortality.
RESULTS: Out of eighty patients, 54 (67.5%) died. Univariate analysis showed that age &gt;60 years, tachycardia, hypotension, elevated C-reactive protein (CRP) and lactate, thrombocytopenia, need of mechanical ventilation, and high Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment scores were variables associated with high mortality. The independent predictors of mortality identified by multivariate regression analysis were platelet count below 1 lakhs, serum levels of CRP &gt;100, APACHE II score &gt;25 on the day of admission to the ICU with severe sepsis, and the need for invasive mechanical ventilation.

CONCLUSIONS: Low platelet count, elevated serum levels of CRP, APACHE score &gt;25, and the need for invasive mechanical ventilation were found to be independent predictors of mortality of severe sepsis among adult patients with severe sepsis in the medical ICU.

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2017

Journal Article

N. Subramaniam, Deepak Balasubramanian, Murthy, S., Limbachiya, S., Thankappan, K., and Dr. Subramania Iyer K., “Adverse pathologic features in early oral squamous cell carcinoma and the role of postoperative radiotherapy-a review”, Oral Surg Oral Med Oral Pathol Oral Radiol, vol. 124, no. 1, pp. 24-31, 2017.[Abstract]


The use of postoperative radiotherapy (PORT) in early stage oral cancer with adverse pathologic features (APFs) is controversial. Prognostically relevant APFs reviewed were perineural invasion, lymphovascular invasion, depth of invasion, worst pattern of invasion, and margin status. The current literature remains divided with regard to the benefit of treatment escalation in these patients; although these patients are at high risk for recurrence, the morbidity of PORT needs to be balanced against the likely benefit in disease control. A wide heterogeneity in the literature exists, likely as a result of differences in treatment protocols. We performed a literature review of the role of PORT in early-stage oral cancer with APFs. Based on the current evidence, the decision to administer adjuvant therapy needs to be made on an individual basis; patients with &gt;1 APF are likely to benefit from PORT, and the use of risk-scoring systems may help in decision making.

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2017

Journal Article

S. Singhal, N.K. Prabhu, Sethi, P., and S. Moorthy, “Role of multi detector computed tomography (MDCT) in preoperative staging of pancreatic carcinoma”, Journal of Clinical and Diagnostic Research, vol. 11, pp. TC01-TC05, 2017.[Abstract]


Introduction: Pancreatic carcinoma is one of the leading causes of cancer related death in advanced countries and has shown rising trends in developing countries like India. Increase in the incidence has been linked to risk factors like lifestyle modification associated with increased alcohol consumption and rapid urbanization. Most patients at the time of diagnosis present with an advanced condition. Surgical resection offers the only chance for cure in them and imaging plays a crucial role in the early diagnosis of the condition. Aim: To compare the staging of pancreatic carcinoma by MDCT (Multi Detector Computed Tomography) with surgery in a preoperative setting in a tertiary referral centre in Kerala. Materials and Methods: A cross sectional observational study was performed between November 2014 and October 2016, 25 patients (12 men, 13 women), with a mean age of 54.2 years, were evaluated. MDCT was performed using 16 slice, 64 slice and 256 slice multi detector CT machines. The gold standard for diagnosis was histopathology and operative data. All statistical analysis was done using IBM SPSS version 20.0. Validity parameters like sensitivity, specificity, accuracy and Positive Predictive Value (PPV)/Negative Predictive Value (NPV) were computed for MDCT with respect to surgery. Results: Of the 25 patients who were evaluated for surgery, 15 (60%) cases were classified as resectable tumours, 3 (12%) as borderline resectable and 7 (28%) as unresectable tumours. CT showed a sensitivity of 82.3% with a specificity of 87.5%. However, for assessing vascular invasion, CT showed sensitivity and specificity of 100% and 93.3% respectively. Three (12%) patients in the study who were classified as borderline resectable pancreatic tumours underwent surgery. Conclusion: Contrast-enhanced multiphase pancreatic imaging using MDCT plays a pivotal role in diagnosing and assessing resectability and vascular invasion of pancreatic tumours. It is very useful for determining borderline resectable tumours pre-operatively, which aids for better treatment planning. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.

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2017

Journal Article

G. P. Chelakkot, Ravind, R., Sruthi, K., Chigurupati, N., Kotne, S., Holla, R., R. Madhavan, and Dinesh, M., “Adjuvant hypofractionated radiation in carcinoma breast - Photon versus Electron: Comparison of treatment outcome”, Journal of Cancer Research and Therapeutics, vol. 13, pp. 262-267, 2017.[Abstract]


Background: Breast cancer tissue is sensitive to hypofractionation. This is an analysis of patients treated with hypofractionated protocols since 2009, at our tertiary cancer center. Methods: Details of breast cancer patients treated with adjuvant hypofractionated external beam radiation therapy (EBRT) from January 2009 to December 2014 were retrieved and analyzed. Results: One thousand seven hundred and eighty patients received adjuvant EBRT during this period. Three hundred and eight were offered hypofractionated schedule. One hundred and eighty-eight had modified radical mastectomy (MRM) and 120 had breast conservation surgery (BCS). Dose was 40 Gy in 15 fractions to chest wall/breast, and tumor bed boost of 10 Gy in 5 fractions, where indicated, using three-dimensional conformal radiotherapy (3DCRT). Electrons were used in 159 and photons in 149. Single en face electron field was used for chest wall in MRM patients, and tangential photon beams for the whole breast. Patients on follow-up were assessed for locoregional recurrence, chest wall, breast or ipsilateral upper limb edema, brachial neuralgia, local skeletal events, pulmonary and cardiac symptoms, and cosmetic results. Two developed chest wall recurrence, one each in electron and photon arms. No skeletal, cardiac, or pulmonary adverse events were recorded. About 13.6% had arm edema, which was staged according to the International Society of Lymphology lymphedema staging, as Stage I-7.8%, Stage II-3.9%, and Stage III-1.9%. Twenty-six treated with electrons had arm edema. Increased incidence of arm edema in MRM patients could be attributed to combined surgical and radiation morbidity. Five-year overall survival was 81.9%. Conclusion: Hypofractionation is an accepted cost-effective standard of care in adjuvant breast radiation. Single en face electron field is well tolerated, and 3DCRT planning ensures homogeneous chest wall coverage, respecting dose constraints to organs at risk. © 2017 Indian Journal of Ophthalmology | Published by Wolters Kluwer - Medknow.

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2017

Journal Article

S. Khan and Kumar, A., “Hepatitis B Vaccination for Healthcare Workers”, Indian Journal of Medical Microbiology, vol. 35, p. 315, 2017.

2017

Journal Article

P. Sethi, Thillai, M., Thankamonyamma, B. S., Mallick, S., Gopalakrishnan, U., Balakrishnan, D., Menon, R. N., S. Surendran, Dhar, P., and S. Vayoth, O., “Living Donor Liver Transplantation Using Small-for-Size Grafts: Does Size Really Matter?”, Journal of Clinical and Experimental Hepatology, 2017.[Abstract]


Background: In living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR). > 0.8% is perceived as the critical graft size. This lower limit of GRWR (0.8%) has been challenged over the last decade owing to the surgical refinements, especially related to inflow and outflow modulation techniques. Our aim was to compare the recipient outcome in small-for-size (GRWR. < 0.8) versus normal-sized grafts (GRWR. > 0.8) and to determine the risk factors for mortality when small-for-size grafts (SFSG) were used. Methods: Data of 200 transplant recipients and their donors were analyzed over a period of two years. Routine practice of harvesting middle hepatic vein (MHV) or reconstructing anterior sectoral veins into neo-MHV was followed during LDLT. Outcomes were compared in terms of mortality, hospital stay, ICU stay, and occurrence of various complications such as functional small-for-size syndrome (F-SFSS), hepatic artery thrombosis (HAT), early allograft dysfunction (EAD), portal vein thrombosis (PVT), and postoperative sepsis. A multivariate analysis was also done to determine the risk factors for mortality in both the groups. Results: Recipient and donor characteristics, intraoperative variables, and demographical data were comparable in both the groups (GRWR. < 0.8 and GRWR. ≥. 0.8). Postoperative 90-day mortality (15.5% vs. 22.85%), mean ICU stay (10 vs. 10.32 days), and mean hospital stay (21.4 vs. 20.76 days) were statistically similar in the groups. There was no difference in postoperative outcomes such as occurrence of SFSS, HAT, PVT, EAD, or sepsis between the groups. Thrombosis of MHV/reconstructed MHV was a risk factor for mortality in grafts with GRWR. <. 0.8 but not in those with GRWR. >. 0.8. Conclusion: Graft survival after LDLT using a small-for-size right lobe graft (GRWR. < 0.8%) is as good as with normal grafts. However, patency of anterior sectoral outflow by MHV or reconstructed MHV is crucial to maintain graft function when SFSG are used. © 2017 INASL.

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2017

Journal Article

C. U. Onyia and Menon, S. K., “The debate on most ideal technique for managing recurrent lumbar disc herniation: a short review.”, Br J Neurosurg, vol. 31, no. 6, pp. 701-708, 2017.[Abstract]


BACKGROUND: Though different techniques have been successfully employed in the treatment of recurrent lumbar disc herniation, the one which should be considered most ideal has remained a controversy, particularly since there are currently no generally accepted guidelines for surgical care.

OBJECTIVE: To review previous publications comparing the available operative options, with the aim of determining if any of the available interventions gives better outcomes compared to others.

METHODS: A systematic literature review of previous publications comparing various techniques employed in the surgical treatment of recurrent disc herniation.

RESULTS: All publications investigated in this review clearly demonstrated quite comparable outcomes, with no superiority of one method over the other.

CONCLUSION: In view of the currently available data and evidence, minimally invasive techniques for revision of recurrent disc herniation do not really appear to be superior to the conventional open surgical approaches and vice-versa. We suggest the management strategy for surgical treatment of each case of recurrence to be simply based on the experience of the surgeon, the available facilities and equipment. Fusion should not be undertaken in all recurrences but should only be considered as an option for revision when spinal instability, spinal deformity or associated radiculopathy is present.

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2017

Journal Article

S. Udayakumaran, Onyia, C. U., and Krishnakumar, R., “Forgotten? Not yet- Cardiogenic brain abscess in children - a case series based review.”, World Neurosurg, 2017.[Abstract]


INTRODUCTION: Brain abscess is a significant cause of morbidity in patients with uncorrected or partially palliated congenital cyanotic heart disease (CCHD). Unfortunately, in the developing world, the majority of the patients with CCHD remain either uncorrected or partially palliated. Furthermore, a risk of this feared complication also exists even among those undergoing staged corrective operations in the interval in between operations. There have been no recent articles in the literature on surgical outcomes of management of cardiogenic brain abscess in children.

OBJECTIVE: </strong>To describe the clinical and demographic profile of patients with cardiogenic cerebral abscess and to highlight the fact that uncorrected or palliated CCHD continue to be at risk for brain abscess.

MATERIAL AND METHODS: </strong>Retrospective analysis of 26 children (age below 19 years) being managed for CCHD who were diagnosed with cerebral abscess managed surgically (26/ 39 of cerebral abscess in children), at AIMS, Kochi, India from December 2000 to January of 2014 was done. Details of variables were retrospectively collected included demographics, modes of presentation, diagnosis, location of abscess, details of the underlying heart disease, management of the cerebral abscess and the outcome of the management.

RESULTS: Mean age for all 26 patients was 7.19 years, with a wide range of 1.5 years to 19 years. There were 16 males and 10 females. 10 of the 26 patients (38%) required reaspiration after the initial surgery. On follow up, all the patients improved symptomatically and were cured for the cerebral abscess.

CONCLUSIONS: </strong>Cardiogenic origin of cerebral abscess is the commonest cause of cerebral abscess amongst children. Unresolved cyanotic heart disease is a risk for occurrence, persistence and recurrence of cerebral abscess.

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2017

Journal Article

R. Antony, Krishna, S., James, J., Kunoor, A., and Vijayan, M., “Case report on docetaxel-induced interstitial lung disease”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 10-12, 2017.[Abstract]


Docetaxel belongs to taxane family of antineoplastic agents that are indicated for the treatment of locally advanced or metastatic non-small-cell lung cancer. Docetaxel is associated with many adverse effects, and pulmonary reaction has an incidence of 41%. However, interstitial pulmonary disease is found to occur only in &lt;1% of the population as per the post-marketing surveillance reports. Here, we report a case of docetaxel-induced interstitial lung disease (ILD). The patient information and details were collected using the hospital information system. The adverse drug reaction (ADR) of ILD occurred after 5 cycles of chemotherapy with docetaxel at a dose of 60 mg/m2 that is 80 mg IV. The causality of the event in our case was assessed using the Naranjo ADR probability scale which marked a score of 7 (probable). It is necessary that all physicians be aware of the reaction and to closely monitor clinicoradiological and functional status of the patients at regular intervals after administration of docetaxel.

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2017

Journal Article

M. S. M. Iype, Kunoor, A., and N, A. K., “A Treatment Dilemma Concerning Immunosuppressant Use: A Case Report”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 4-6, 2017.[Abstract]


Immunosuppressants including corticosteroids (prednisolone &gt;15 mg/day) are responsible for an increased risk of susceptibility to infections (especially pneumonia, tuberculosis [TB] including extra pulmonary TB), an important safety concern when providing immunosuppressive therapy. Anti-TB treatment (ATT) is medicines used to treat tuberculosis, an infectious disease which can affect lungs and other organs. Isoniazid, rifampicin, and pyrazinamide are known to cause ATT induced hepatitis. The prevalence of immunosuppressant induced TB and pyrazinamide induced hepatotoxicity during treatment for active TB ranges to about 0.6%-1% and &lt;1%, respectively. Here, we illustrate a typical case report of a 61-year-old woman who is a known case of interstitial lung disease and developed TB arthritis following therapy with the long-term use of immunosuppressants (prednisolone, azathioprine, leflunomide, and sulfasalazine). ATT regimen was started for TB arthritis which was later modified along with addition of liver protectant due to the development of hepatotoxicity. The causality of both the adverse drug reactions was confirmed to be probable via NARANJO causality assessment scale. This case highlights the incidence of infectious complications like TB which may be expected to be encountered more frequently in the future due to the increasing use of immunosuppressants for the treatment of allergic and inflammatory disorders.

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2017

Journal Article

J. Nayar, Nair, S. S., and George, N. A., “Is LNG-IUS the One-Stop Answer to AUB?”, Journal of Obstetrics and Gynecology of India, pp. 1-5, 2017.[Abstract]


A systematic search of the literature available on the use of Levonorgestrel intra-uterine system (LNG-IUS) in women with abnormal uterine bleeding was done. This included PubMed searches up to February 2017 as well as references available with the authors. LNG-IUS usage in other situations was not included in the study. Each relevant published article was evaluated as to whether it served the purpose of this review. Available data show that LNG-IUS is certainly the one-stop answer to AUB, providing a safe and cost-effective treatment and being a substitute for hysterectomy in most women with AUB. © 2017 Federation of Obstetric & Gynecological Societies of India

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2017

Journal Article

A. Vijay Kanetkar, Balakrishnan, D., Sudhindran, S., Dhar, P., Gopalakrishnan, U., Menon, R., and Sudheer, O. Vayoth, “Is Portal Venous Pressure or Porto-systemic Gradient Really A Harbinger of Poor Outcomes After Living Donor Liver Transplantation?”, J Clin Exp Hepatol, vol. 7, no. 3, pp. 235-246, 2017.[Abstract]


BACKGROUND:Portal hyperperfusion as a cause of small for size syndrome (SFSS) after living donor liver transplantation (LDLT) remains controversial. Portal venous pressure (PVP) is often measured indirectly and may be confounded by central venous pressure (CVP).

METHODS: In 42 adult cirrhotics undergoing elective LDLT, PVP was measured by direct canulation of portal vein and porto systemic gradient (PSG) was obtained after subtracting CVP from PVP. None underwent portal inflow modulation. SFSS was looked in 27 patients after excluding 15 with technical complications.

RESULTS:Clinical features of SFSS found in 6 patients, 5 with graft recipient weight ratio (GRWR)&nbsp;&gt;&nbsp;0.8% and PVP&nbsp;&lt;&nbsp;20&nbsp;mm of Hg. One with GRWR&nbsp;&lt;&nbsp;0.8% could truly be labeled as SFSS. Incidence of SFSS was not higher in patients with elevated PVP&nbsp;&gt;&nbsp;20&nbsp;mm of Hg (14.3% vs 0%, P&nbsp;=&nbsp;0.259) or PSG&nbsp;&gt;&nbsp;13&nbsp;mm of Hg (33.3% vs 0%, P&nbsp;=&nbsp;0.111). Intensive care unit (ICU) stay was longer in patients with elevated PVP (14.55 vs 9.13 days, P&nbsp;=&nbsp;0.007) and PSG (16.8 vs 9.72 days, P&nbsp;=&nbsp;0.009). There was no difference in graft functions, post-operative complications and mortality in first month post-LDLT.

CONCLUSION: </strong>Elevated PVP or PSG increased morbidity but neither predicted SFSS nor affected survival.

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2017

Journal Article

K. Y. Santosh Kumar, Mathew, J. Shaji, Balakrishnan, D., Bharathan, V. Kumar, Amma, B. Sivasankar, Gopalakrishnan, U., Menon, R. Narayana, Dhar, P., Vayoth, S. Othiyil, and Sudhindran, S., “Intraductal Transanastomotic Stenting in Duct-to-Duct Biliary Reconstruction after Living-Donor Liver Transplantation: A Randomized Trial.”, J Am Coll Surg, vol. 225, no. 6, pp. 747-754, 2017.[Abstract]


BACKGROUND: Biliary complications continue to be the "Achilles heel" of living-donor liver transplantation (LDLT). The use of biliary stents in LDLT to reduce biliary complications is a controversial issue. We performed a randomized trial to study the impact of intraductal biliary stents on postoperative biliary complications after LDLT.

STUDY DESIGN: Of the 94 LDLTs that were performed during a period of 16 months, ABO-incompatible transplants, left lobe grafts, 3 or more bile ducts on the graft, and those requiring bilioenteric drainage were excluded. Eligible patients were randomized to either a study arm (intraductal stent, n = 31) or a control arm (no stent, n = 33) by block randomization. Stratification was done, based on the number of ducts on the graft requiring anastomosis, into single (n = 20) or 2 ducts (n = 44). Ureteric stents of 3F to 5F placed across the biliary anastomosis and exiting into the duodenum for later endoscopic removal at 3 months were used. The primary end point was postoperative bile leak.

RESULTS: Bile leak occurred in 15 of 64 (23.4%), the incidence was higher in the stented group compared with the control group (35.5% vs 12.1%; p = 0.03). Multiplicity of bile ducts and stenting were identified as risk factors for bile leak on multivariate analysis (p = 0.031 and p = 0.032). During a median follow-up of 2 years, biliary stricture developed in 9 patients (14.1%). Postoperative bile leak is a significant risk factor for the development of biliary stricture (p = 0.003).

CONCLUSIONS: Intraductal transanastomotic biliary stenting and multiplicity of graft ducts were identified as independent risk factors for the development of postoperative biliary complications.

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2017

Journal Article

S. Nampoothiri, Hebbar, M., Roy, A. Grace, Kochumon, S. P., Bielas, S., Shukla, A., and Girisha, K. M., “Hyperphosphatasia with Mental Retardation Syndrome Due to a Novel Mutation in PGAP3.”, J Pediatr Genet, vol. 6, no. 3, pp. 191-193, 2017.[Abstract]


Hyperphosphatasia with mental retardation syndrome is a heterogeneous genetic condition. Two siblings aged 5 years and 3 years were evaluated for global development delay and facial dysmorphism. A novel missense variant, c.851A>G (p.H284R, NM_033419.3), in PGAP3 was identified using whole-exome sequencing. Assays for elevated alkaline phosphatase and exome sequencing can be useful for the diagnosis of hyperphosphatasia with mental retardation syndrome.

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2017

Journal Article

W. M. Jose, Pavithran, K., and Ganesan, T. S., “Short-course lenalidomide plus low-dose dexamethasone in the treatment of newly diagnosed multiple myeloma— A single-centre pragmatic study”, Current Oncology, vol. 24, pp. e361-e367, 2017.[Abstract]


Purpose We assessed response to treatment, toxicity, time to progression, progression-free survival, and overall survival in patients newly diagnosed with multiple myeloma who were ineligible for or unwilling to undergo transplantation and who were treated with a combination of lenalidomide and low-dose dexamethasone for a fixed 6 cycles in a resource-constrained environment. Methods This pragmatic study, conducted in a single tertiary cancer centre in South India, enrolled patients from May 2009 till April 2011. Treatment included lenalidomide 25 mg daily for 21 days, with dexamethasone 40 mg on days 1, 8, 15, and 22 of a 28-day cycle, for 6 cycles. Response was evaluated after the 3rd and 6th cycles of treatment. All patients were followed for 5 years. Results The study enrolled 51 patients. Median age in the group was 61 years (range: 38–76 years). Immunoglobulin G or A myeloma constituted 70.6% of the diagnoses, and light-chain myeloma constituted 29.4%. Stages i, ii, and iii (International Staging System) disease constituted 21.4%, 28.6%, and 50% of the diagnoses respectively. All patients were transplantation-eligible, but 34 (66.7%) refused for economic reasons. After treatment, 19.6% of the patients achieved a stringent complete response; 35.3%, a complete response; 5.9%, a very good partial response; and 29.4%, a partial response, for an overall response rate of 90.2%. Stable disease was seen in 3.9% of patients, and progressive disease, in 5.9%. Grade 3 or greater nonhematologic and hematologic toxicity occurred in 35.2% and 11.7% of patients respectively. Pulmonary embolism occurred in 1 patient. No patient experienced deep-vein thrombosis or peripheral neuropathy. The median follow-up duration was 66 months. All patients experienced disease progression. Median progression-free survival was 16 months. In 10 patients, re-challenge with lenalidomide and dexamethasone achieved a second complete response. At the time of writing, 19 patients had died. The overall survival rate at 5 years was 62.74%. Median overall survival is not yet reached. Conclusions In a resource-constrained setting, lenalidomide with low-dose dexamethasone is an effective treatment with acceptable toxicity in patients newly diagnosed with multiple myeloma and not planned for transplantation. Complete responses were significantly more frequent than reported in the Western literature. Occurrence of clinical deep-vein thrombosis was rare, but hyperglycemia was common. An abbreviated course of treatment is suboptimal in multiple myeloma. Maintenance regimens should be advocated.

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2017

Journal Article

G. Desai, G Kumar, S., Manoj, L., Gokul, G. R., Beena, K. V., Thennarasu, K., and Jaisoorya, T. S., “Prevalence & correlates of chronic perinatal pain - a study from India.”, J Psychosom Obstet Gynaecol, pp. 1-6, 2017.[Abstract]


OBJECTIVES: To study the prevalence of chronic perinatal pain among mothers who had infants between the ages of 13-25 months in the State of Kerala, India and to report its correlates in the socio-demographic, obstetric and psychological domains.

METHODS: A total of 9305 mothers selected by cluster random sampling were assessed cross-sectionally for chronic perinatal pain using a questionnaire by Junior Public Health Nurses (JPHNs). In addition, information regarding socio-demographic profile, obstetric history, infant details and perinatal depression were collected.

RESULTS: Of the 8302 (89.3%) valid responses, 552 (6.6%) mothers reported chronic perinatal pain. Among those with pain, 142 (25.6%) reported pain during pregnancy, 314 (56.7%) during postpartum and 96 (17.7%) during both periods. The commonest sites of pain reported were back 280 (51%) and pelvic region 110 (19%). Mothers with chronic perinatal pain were more likely to be younger, less educated, employed and from an urban background. Chronic perinatal pain was associated with obstetric complications, delivery by instrumental/caesarean section, non-exclusive breast feeding and higher maternal depression scores.

CONCLUSION: Chronic pain is common among mothers in India during the perinatal period and greater attention needs to be given for it to be recognised and treated early.

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2017

Journal Article

P. Makhija, Gopinath, S., Kannoth, S., and Radhakrishnan, K., “A case of post-leptospirosis autoimmune epilepsy presenting with sleep-related hypermotor seizures.”, Epileptic Disord, 2017.[Abstract]


This video-illustrated case report concerns a 49-year-old woman who presented with sleep-related hypermotor seizures. The antecedent history of leptospirosis, high frequency of new-onset seizures, presence of an unclassified anti-neuronal antibody, and dramatic response to steroids strongly supported post-infectious immune-mediated pathogenesis in our patient. To the best of our knowledge, post-leptospirosis autoimmune epilepsy presenting as sleep-related hypermotor seizures has not hitherto been reported. [Published with video sequences on www.epilepticdisorders.com].

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2017

Journal Article

S. Kuthiroly, Yesodharan, D., Ghosh, A., White, K. E., and Nampoothiri, S., “Osteoglophonic Dysplasia: Phenotypic and Radiological Clues.”, J Pediatr Genet, vol. 6, no. 4, pp. 247-251, 2017.[Abstract]


Osteoglophonic dysplasia (OD) is an extremely rare, skeletal dysplasia with an autosomal dominant mode of inheritance. Rhizomelic dwarfism, craniosynostosis, impacted teeth, hypodontia or anodontia, and multiple nonossifying bone lesions are the salient features of this condition. We report a 14-year-old girl with clinical and radiological features consistent with OD. She presented with disproportionate short stature, craniosynostosis, a prominent supraorbital ridge, delayed teeth eruption, hypodontia, and multiple nonossifying bone lesions in the femur, tibia, and fibula. She had hypophosphatemia, which is a known association in this dysplasia. She also had advanced bone age, which is an unreported feature of this dysplasia. This condition is caused by activating mutations in FGFR1 . A missense mutation was detected in the FGFR1 , NM_001174067 ( FGFR1 _v001):c.1115G > A [p.(Cys372Tyr)] confirming the diagnosis; this is the first mutation-proven case to be reported from India.

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2017

Journal Article

D. Yesodharan, Sudarsanan, B., Jojo, A., Abraham, M., Bhavani, N., Mathews, H., and Nampoothiri, S., “Plexiform Neurofibroma of Clitoris.”, J Pediatr Genet, vol. 6, no. 4, pp. 244-246, 2017.[Abstract]


The most frequent genital presentation of neurofibromatosis in females is clitoromegaly. We report a case of a 5-year-old girl with neurofibromatosis type 1 with clitoral plexiform neurofibromatosis. Clitoroplasty was done, and the histopathology confirmed the diagnosis. Though rare, plexiform neurofibroma of clitoris should always be considered as a differential diagnosis in children with clitoromegaly before embarking on detailed investigations.

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2017

Journal Article

S. Radhakrishnan, George, M., Dhar, M., Reny, N., Prathapan, M., and Anandkumar, A., “A longitudinal study of retinal nerve fibre layer profile in patients with multiple sclerosis and its significance.”, Neurol India, vol. 65, no. 6, pp. 1402-1403, 2017.

2017

Journal Article

L. Kumar, Balakrishnan, D., Varghese, R., and Surendran, S., “Extracorporeal membrane oxygenation for post-transplant hypoxaemia following very severe hepatopulmonary syndrome.”, BMJ Case Rep, vol. 2017, 2017.[Abstract]


Hepatopulmonary syndrome (HPS) associated with end-stage liver disease has a high morbidity when room air PaO2 is less than 50 mm Hg. Safe levels of oxygenation to facilitate transplantation have not been defined despite advancement in care. Postoperatively, hypoxaemia worsens due to ventilation perfusion mismatch contributed by postoperative pulmonary vasoconstriction and due to decrease in endogenous nitric oxide. A 16-year-old boy with cirrhosis presented with HPS and a PaO2 of 37 mm Hg on room air and underwent living donor liver transplant. Although stable intraoperatively, he desaturated on the second postoperative day. Despite a number of interventions, oxygenation remained critically low on 100% inspired oxygen. Extracorporeal membrane oxygenator (ECMO) was established with instant improvement in oxygenation (PaO268 mm Hg), and the patient was eventually salvaged. We suggest that ECMO could be a means of managing refractory post-transplant hypoxaemia in patients with HPS.

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2017

Journal Article

A. Keepanasseril, Keerthana, K., Keepanasseril, A., Maurya, D. K., Kadambari, D., and Sistla, S., “Pregnancy in women with Klippel-Trenaunay syndrome: Report of three pregnancies in a single patient and review of literature.”, Obstet Med, vol. 10, no. 4, pp. 177-182, 2017.[Abstract]


Klippel-Trenaunay syndrome is characterised by vascular abnormality which increases the risk of thromboembolism and haemorrhage. Physiological changes in pregnancy pose an increased risk to these complications. Being an uncommon disorder, there is limited literature about the management of women with pregnancy and Klippel-Trenaunay syndrome. We report in detail two of three pregnancies in a woman with Klippel-Trenaunay syndrome who had repeated episodes of haematochezia leading to anaemia, managed with Argon laser Photo-Coagulation in pregnancy and also reviewed the complications and the management of pregnant women with Klippel-Trenaunay syndrome.

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2017

Journal Article

P. Bijalwan, Bindhu, M. R., and Pooleri, G. Kumar, “Primary Mucin Secreting Adenocarcinoma Bladder: a Case Series.”, Indian J Surg Oncol, vol. 8, no. 4, pp. 634-636, 2017.[Abstract]


Primary mucinous adenocarcinoma is an extremely rare type of bladder cancer. These tumours may have varied presenting complains with isolated mucusuria in some patients. As it is difficult to differentiate primary from secondary tumours, it is often a diagnostic dilemma. We narrate three cases of primary mucinous adenocarcinoma bladder and try to bring out the clinical and pathological features unique to this tumour along with the diagnostic importance of immunohistochemistry.

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2017

Journal Article

A. Puneet, Balagopal, N., Ginil, K., Georgie, M., Sanjeevan, K. V., and Appu, T., “Correlation of Transabdominal Ultrasonography and Cystoscopy in Follow-up of Patients with Non-muscle Invasive Bladder Cancer.”, Indian J Surg Oncol, vol. 8, no. 4, pp. 548-553, 2017.[Abstract]


Cystoscopy (CS) is considered to be the gold standard in the follow-up of non-muscle invasive bladder cancer. However, CS is invasive, time-consuming, and expensive. On the other hand, modern sensitive transducers have improved the imaging of urinary tract rendering transabdominal ultrasonography (US) more effective in visualizing intraluminal filling defects in the bladder than it was in the past. Twenty-five follow-up patients of low-risk bladder cancer meeting the inclusion and exclusion criteria were included in study. Ultrasonography of the bladder was performed by a single senior radiologist, and subsequently, these patients were subjected to flexible cystoscopy under local anesthesia. Pain score was calculated for each of the cystoscopies done. Findings of transabdominal ultrasound of the bladder were correlated and compared with those of cystoscopy. Subjects with US and/or CS findings suggestive of recurrence underwent transurethral resection of bladder tumor (TURBT) under general anesthesia and confirmation of the bladder carcinoma was achieved by the histopathological examination. Mean patient age was 60.56 years with range of 29 to 77 years. The sensitivity of modern ultrasonographic techniques was found to be 84.61% with specificity of 91.7% taking flexible cystoscopy as the gold standard for detection of recurrence. The accuracy of US was 88% with positive predictive value of 91.7% and negative predictive value of 84.61%. Technological evolution has improved the accuracy of ultrasonography in diagnosis of bladder carcinoma. It represents a valuable surveillance tool in selected sub group of low risk non-muscle invasive bladder cancer patients.

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2017

Journal Article

A. C. Argent, Balachandran, R., Vaidyanathan, B., Khan, A., and R Kumar, K., “Management of Undernutrition and Failure to Thrive in Children with Congenital Heart Disease in Low- and Middle-income Countries”, Cardiol Young, vol. 27, no. S6, pp. S22-S30, 2017.[Abstract]


Poor growth with underweight for age, decreased length/height for age, and underweight-for-height are all relatively common in children with CHD. The underlying causes of this failure to thrive may be multifactorial, including innate growth potential, severity of cardiac disease, increased energy requirements, decreased nutritional intake, malabsorption, and poor utilisation of absorbed nutrition. These factors are particularly common and severe in low- and middle-income countries. Although nutrition should be carefully assessed in all patients, failure of growth is not a contraindication to surgical repair, and patients should receive surgical repair where indicated as soon as possible. Close attention should be paid to nutritional support - primarily enteral feeding, with particular use of breast milk in infancy - in the perioperative period and in the paediatric ICU. This nutritional support requires specific attention and allocation of resources, including appropriately skilled personnel. Thereafter, it is essential to monitor growth and development and to identify causes for failure to catch-up or grow appropriately.

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2017

Journal Article

R. A. Bronicki, Pollak, U., Argent, A. C., R Kumar, K., Balestrini, M., Cogo, P., Borim, B. Cury, De Costa, K., Beca, J., Shimizu, N., and Dominguez, T. E., “Global perspective on training and staffing for paediatric cardiac critical care.”, Cardiol Young, vol. 27, no. S6, pp. S9-S13, 2017.[Abstract]


This manuscript provides a global perspective on physician and nursing education and training in paediatric cardiac critical care, including available resources and delivery of care models with representatives from several regions of the world including Africa, Israel, Asia, Australasia, Europe, South America, and the United States of America.

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2017

Journal Article

A. Sreeja and Vinayan, K. P., “Multidimensional knowledge-based framework is an essential step in the categorization of gene sets in complex disorders.”, J Bioinform Comput Biol, vol. 15, no. 6, p. 1750022, 2017.[Abstract]


In complex disorders, collaborative role of several genes accounts for the multitude of symptoms and the discovery of molecular mechanisms requires proper understanding of pertinent genes. Majority of the recent techniques utilize either single information or consolidate the independent outlook from multiple knowledge sources for assisting the discovery of candidate genes. In any case, given that various sorts of heterogeneous sources are possibly significant for quality gene prioritization, every source bearing data not conveyed by another, we assert that a perfect strategy ought to give approaches to observe among them in a genuine integrative style that catches the degree of each, instead of utilizing a straightforward mix of sources. We propose a flexible approach that empowers multi-source information reconciliation for quality gene prioritization that augments the complementary nature of various learning sources so as to utilize the maximum information of aggregated data. To illustrate the proposed approach, we took Autism Spectrum Disorder (ASD) as a case study and validated the framework on benchmark studies. We observed that the combined ranking based on integrated knowledge reduces the false positive observations and boosts the performance when compared with individual rankings. The clinical phenotype validation for ASD shows that there is a significant linkage between top positioned genes and endophenotypes of ASD. Categorization of genes based on endophenotype associations by this method will be useful for further hypothesis generation leading to clinical and translational analysis. This approach may also be useful in other complex neurological and psychiatric disorders with a strong genetic component.

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2017

Journal Article

R. UK, Sasidharan, A., Pillay V. V., Ajid, A., and KR, S., “Role and Utility of Clinical Forensic Medicine unit (CFMU) in a Major Hospital - Part I”, J South India Medicolegal Assoc , vol. 9, no. 2, pp. 68 - 73, 2017.

2017

Journal Article

A. Sasidharan, UK, R., Pillay V. V., Ajid, A., and KR, S., “Role and utility of Clinical Forensic Medicine Unit (CFMU) in a major hospital – Part II”, J South India Medicolegal Assoc , vol. 9, no. 2, pp. 74 - 79, 2017.

2017

Journal Article

Pillay V. V., ,, TS, T., and Pillay, M., “Sexual Dimorphism of Complete and Incomplete metopic Suture: a Regional South Indian Study”, . Indian J Forensic Med Toxicol, 2017.

2017

Journal Article

P. T. Francis, “Is Social Distancing the Unvaccinated Justifiable?”, Res Pediatrics Neonatology, vol. 1, no. 3, p. 513, 2017.

2017

Journal Article

A. Sasidharan and Kumar, D., “An Unfortunate Infant: A Case Report”, The Indian Police Journal, vol. 64, no. 1, 2017.[Abstract]


The importance of a medico-legal case doesn't end by the conclusion of the autopsy examination. Medico-legal cases are unique and there are some important 'take home messages' to be taken from each case into the society for the benefit of the common man. Careful observations and inquisitive thinking can bring forth interesting as well as educative lessons. These lessons should be imbibed in the most effective manner not only by the doctors, police officers and judiciary but also by the society as a whole. We hereby present a case report of an infant who died due to injuries sustained to her head in the most unfortunate manner. We have presented the various medico-legal aspects and extenuating circumstances that are surrounding this case in adjunction with the existing literature. Thereby in this case scenario some light has been thrown upon those 'hard truths' that are commonly overlooked, in order to bring out the grey areas and moot points that can be involved in similar situations.

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2017

Journal Article

V. N. Laghima, Sobha George, and Paul, N., “Study on Lifestyle Risk Factors in School Children and its Relationship to their Mothers”, National Journal of Research in Community Medicine, vol. 6, p. 313, 2017.[Abstract]


Globally Non Communicable Diseases (NCDs) are a rnajor cause of morbidity and mortality. 1'hey occur atier exposure to a set of lifestyle risk factors. Obesity and hypertension among adults has its antecedents during childhood .When governments are assessing ways to generate finances for management of NCDs, it is worthwhile to give due irnportance to preventiveservices.Objectives:Tostudyrelationshipoflifestyleriskfactors(BMI&amp;BP)betweenschool childrenand their rnothers ald to study the factors associated with BMI&amp; BP. Methodology: School based cross sectiorral study done among 225 studelts and their mothers in three settings,rural,tribal and urban. Students and mothers were interviewed using questionnair-e in local language after obtaining consent. Height, Weight and BP measured using standardized instrurrretrts. Data tabulated usi6g MS excel , analyzed using SPSS version 20. Results: There was statistically sigrrificarrt associalion between BMI of rnother and student.Association between BP ol' mother arrd student was not statistically signilicarrt. Association betweep BMI and BP was statistically significant among rnothers and students. Considering BMl, statistically significarrt association was noted for physical activity, use of non-smokirrg tobacco and desire to change weight. Considering BP, desire to change weight, use of non-smoking tobacco and intake of food frotn outside showed statistically signilicant associatiorr. Conclusion:Maintaiuirrg normal BMI is important as it is found to affect next generatiotr. Incleased llMl is associatedwithabnormal Pvalues,whichisaprecursorforlifbstylediseases.Hencecotrtrol ofBMI andBPisessential ttr protect future generations from lifestyle diseases.

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2017

Journal Article

K. C. Ratha and Mahapatra, S. K., “Resolving the mahanadi water conflict”, Economic and Political Weekly, vol. 52, pp. 84-88, 2017.[Abstract]


To chalk out the future course of action in view of the disputes regarding the use of Mahanadi river water, a well-rounded strategy that includes both the people and policymakers is needed. The strategy must allow for dialogue by rebuilding trust and should look at arbitration and negotiation as methods of conflict resolution. It is necessary to evolve a strategy that optimises the rational usage of Mahanadi water to benefit people from both Chhattisgarh and Odisha, coupled with the implementation of a multi-stakeholder forum that finds peaceful solutions and minimises areas of contention in a negotiable and consensual manner.

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2017

Journal Article

S. S. Lekshmi, Antony, R., Sidharthan, N., Kammath, G., and Anila, K. N., “Methotrexate induced lung toxicity - A case report”, Research Journal of Pharmacy and Technology, vol. 10, pp. 3458-3460, 2017.[Abstract]


Methotrexate (MTX) belongs to a class of antimetabolites. It may cause serious side effects like lung problems, lung infections. Methotrexate-induced lung disease, as well as acute or chronic interstitial pneumonitis, is a potentially risky sore, which can happen intensely whenever, amid treatment and has been accounted for at low doses. The diagnosis of drug-induced pulmonary toxicity is generally settled in light of clinical discoveries. The present report describes a case of methotrexate-induced lung toxicity. Biopsy that had done reported as relapsed lymphoma. Then he got admitted for high dose methotrexate and rituximab followed by folinic acid rescue. He tolerated 2 chemotherapies well, without any major complications. He developed fever, cough with expectoration and breathlessness. In view of persisting high grade fever, associated with cough and breathing difficulty, pulmonology consultation was sought and CT done. In medication-induced lung toxicity, the radiologic patterns seen are exceeding factor and rely upon the kind of unfavorable response the patient is experiencing. One possibility in the clinical setting is methotrexate induced lung changes. Differential diagnosis (DD) is alveolitis due to infection. In view of suspected methotrexate induced lung toxicity, planned to withhold next dose of Methotrexate. He was started on high dose steroids. The patient symptomatically improved, fever subsided, counts improved. Prompt diagnosis is vital in light of the fact that early medication actuated lung harm will regularly relapse with cessation of treatment. It was found that the severity of the methotrexate induced lung toxicity is a probable adverse drug reaction (ADR) with Naranjo score of 7. © RJPT All right reserved.

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2017

Journal Article

S. Iyer, Sharma, M., Kishore, P., Mathew, J., Vijayaraghavan, S., Ramu, J., Wakure, A., Reddy, R., S. Chetan, M., Varma, V., Chaudhari, A., Dhake, S., Omkumar, A., and Prasad, V., “First two bilateral hand transplantations in India (Part 1): From vision to reality”, Indian Journal of Plastic Surgery, vol. 50, pp. 148-152, 2017.[Abstract]


Introduction: Vascularized composite tissue allotransplantation is a relatively new concept, which was unavailable in the Indian subcontinent till a bilateral hand transplant was carried out successfully in January 2015. Materials and Methods: The setting up of the transplant programme involved obtaining legal clearances, creating public awareness, harnessing the institutional facilities, drawing up protocols, assembling the surgical team, managing immunological issues, rehabilitation and preparing the ancillary services. Results: Both, the first and second bilateral hand transplants were resounding successes with both the recipients getting back to their original daily routines. Conclusions: The organisation of the hand transplant programme was a large task, which necessitated intensive planning, and cooperation from various teams within and outside the institution. Exemplary team-work was the key to the phenomenal success of these path breaking endeavors in the subcontinent. Iyer Subramania 1 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Sharma Mohit 2 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Kishore P 3 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Mathew Jimmy 4 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Vijayaraghavan Sundeep 5 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Ramu Janarthanan 6 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Wakure Abhijeet 7 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Reddy Raghuveer 8 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Mali Chetan S 9 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Varma Visakh 10 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Chaudhari Ashish 11 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Dhake Swapnil 12 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Omkumar Akshay 13 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala Prasad V 14 Department of Transplant co-ordinator, Amrita Institute of Medical Sciences, Kochi, Kerala Petruzzo P, Lanzetta M, Dubernard JM, Landin L, Cavadas P, Margreiter R, et al. The international registry on hand and composite tissue transplantation. Transplantation 2010;90:1590-4. Baumeister S, Kleist C, Döhler B, Bickert B, Germann G, Opelz G, et al. Risks of allogeneic hand transplantation. Microsurgery 2004;24:98-103. Landin L, Bonastre J, Casado-Sanchez C, Diez J, Ninkovic M, Lanzetta M, et al. Outcomes with respect to disabilities of the upper limb after hand allograft transplantation: A systematic review. Transpl Int 2012;25:424-32. Sandeep S, Srija M, Shilpa P, Mathew A, Rajesh R, Kurian G, et al. Kidney transplantation - Experience at Amrita hospital. Amrita J Med 2013;9:24-7. 325 Liver Transplants in Ten Years at Amrita Institute of Medical Sciences (AIMS), Kochi. Amrita Vishwa Vidyapeetham (Amrita University); c2017. Available from: https://www.amrita.edu/news/325-liver-transplants-ten-years-amrita-insti.... [Last accessed on 2017 Mar 11]. Kerala Network for Organ Sharing Mrithasanjeevani. MOHAN Foundation; c2016. Available from: http://www.knos.org.in/default.aspx. [Last accessed on 2017 Mar 11]. Amirlak B, Gonzalez R, Gorantla V, Breidenbach WC 3rd, Tobin GR. Creating a hand transplant program. Clin Plast Surg 2007;34:279-89, x. Cendales LC, Kanitakis J, Schneeberger S, Burns C, Ruiz P, Landin L, et al. The Banff 2007 working classification of skin-containing composite tissue allograft pathology. Am J Transplant 2008;8:1396-400.

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2017

Journal Article

D. Joseph, Varghese, D. R., Prabhu, R., and Anila, K. N., “Mechanism of resistance to tyrosine kinase inhibitors - A case report and review”, National Journal of Physiology, Pharmacy and Pharmacology, vol. 7, pp. 1444-1446, 2017.[Abstract]


This report aims to assess the viability of various challenging approaches such as tyrosine kinase inhibitors (TKIs) therapy, chemotherapy, and stem cell transplantation in patients with chronic myeloid leukemia (CML), especially for those in an advanced phase. Although standard treatments have been extremely effective in combating CML propagation and negating the disease symptoms along with an increased survival rate, these traditional treatment methods have experienced an increased failure rate due to TKI treatment resistance. A common mechanism that can be attributed to the increase in TKI resistance is the increasing mutations of the BCR-ABL 1 kinase domain. These mutations can be clearly observed in clinical trials. Currently, there are five BCR-ABL 1 kinase inhibitors that are approved for the safe treatment of CML. These are imatinib, dasatinib, nilotinib, bosutinib, and ponatinib. Mutational testing should be carried out on patients in such cases that show little response to traditional TKI therapy.In this report, we evaluate a patient who has been diagnosed with an accelerated phase CML and requires constant monitoring to tailor the treatment program to their requirements. © 2017 Dawnwin Joseph, et al.

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2017

Journal Article

P. T. James, Kunoor, A., and Rakesh, P. S., “Awareness of Health Care Workers, Patients and Visitors Regarding Air Borne Infection Control - A Descriptive Study from a Tertiary Care Centre in Kerala, Southern India.”, Indian J Tuberc, vol. 65, no. 2, pp. 168-171, 2017.[Abstract]


Airborne infections are major public health concern especially in hospitals and public spaces in a highly populated country like India. Generating awareness about good infection control practices among common man and health care workers are important steps in curtailing transmission of air borne infections. In this study we were trying to assess the awareness of airborne infection control measures among patients, bystanders and healthcare workers in a tertiary care hospital at Kochi, Kerala. Self-administered questionnaire which included 10 questions for health care staff and 12 questions for lay men prepared on the basis of NAIC and NCDC guideline were given to the study participants. 143 health care staff and 332 laymen were participated in the study. In both groups majority of the responses were correct. However, only a small proportion of health care staff correctly answered fast tracking of a patient with TB (14.7%) and minimum air exchanges in air-conditioned settings (15.4%). Among laymen only a few correctly identified ideal place for sputum collection (43.3%) and role of hand washing in preventing flu (36.4%). Overall more intervention needed in improving awareness about good infection control practices among both health care staff and laymen

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2017

Journal Article

A. Ramachandran, Rajanbabu, A., Bagul, K. Gulabrao, Pavithran, K., and Vijaykumar, D. K., “Correlation of Pattern of Spread and Outcomes in Advanced Epithelial Ovarian Cancers.”, Indian J Surg Oncol, vol. 9, no. 2, pp. 126-132, 2017.[Abstract]


The purpose of this study was to correlate the pattern of spread with oncological outcomes in advanced ovarian cancer patients. This is a retrospective analysis of 55 consecutive patients who had advanced epithelial ovarian cancer or primary peritoneal carcinomatosis (stages 3C and 4) with primary surgical intervention as the initial modality of treatment. Based on the spread of disease, they were further classified into class A: disease confined to the pelvis (excluded); class B: disease extending to the lower abdomen and omentum; class C: diffuse small-bowel disease with or without A, B, or D; and class D: disease in the upper abdomen. There were 17 patients (30.9%) in class B, 17 (30.9%) in class C, and 21 (38.2%) in class D. The number of patients with suboptimal cytoreduction was highest in class C (six patients). At the end of follow-up (median 38.6 months), 16 patients had no evidence of disease and 26 patients were alive with disease. The 3-year overall survival rates in classes B, C, and D were 94.1, 52.5, and 93.3%, respectively. The 3-year progression-free survival rates were 55.8, 11.8, and 41.9%, respectively. The rates were lowest for class C. The differences in the overall survival rate ( < 0.001) and progression-free survival rate ( = 0.001) were statistically significant. In advanced ovarian cancer patients, the presence of disease in the small-bowel serosa and mesentery results in poorer outcomes in terms of overall and progression-free survival. The number of patients with suboptimal cytoreduction was also highest in this group.

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2017

Journal Article

D. Deepa Devadas, “A Study of Variations in the Origin of Superior Laryngeal Artery and its Clinical Relevance”, Anatomy and cell biology, vol. 49, pp. 254-258, 2017.

2017

Journal Article

D. L. Kumar, R, P., BK, V., S, R., and SG, N., “Efficacy of Intranasal Dexmedetomidine Versus Oral Midazolam for Paediatric Premedication”, Indian J Anaesth, vol. 61, no. 2, pp. 125–130, 2017.[Abstract]


Premedication is an integral component of paediatric anaesthesia which, when optimal, allows comfortable separation of the child from the parent for induction and conduct of anaesthesia. Midazolam has been accepted as a safe and effective oral premedicant. Dexmedetomidine is a selective alpha-2 agonist with sedative and analgesic effects, which is effective through the transmucosal route. We compared the efficacy and safety of standard premedication with oral midazolam versus intranasal dexmedetomidine as premedication in children undergoing elective lower abdominal surgery.

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2017

Journal Article

D. A. Chanchal Sen, Rajan, S., Balachandran, R., Kumar, L., and Nair, S. G., “Comparison of Perioperative Thoracic epidural Fentanyl with Bupivacaine and Intravenous Fentanyl for Analgesia in Patients Undergoing Coronary Artery Bypass Grafting Surgery ”, Anesth Essays Res, vol. 11, no. 1, pp. 105-109, 2017.

2017

Journal Article

D. S. Rajan, Malayil, G. J., Varghese, R., and Kumar, L., “Comparison of Usefulness of Ketamine and Magnesium Sulphate Nebulisations for Attenuating Post Operative Sore Throat, Hoarseness of Voice and Cough”, 2017.

2017

Journal Article

D. Sunil Rajan, Sreekumar, S., and Kumar, L., “Effect of lactate Versus Acetate Based Intravenous Fluids on Acid Base Balance in Patients Undergoing Free Flap Reconstructive Surgeries”, J Anaesthesiol Clin Pharmacol, vol. 33, no. 4, pp. 514-519, 2017.

2017

Journal Article

D. Sunil Rajan, Surendran, J., Paul, J., and Kumar, L., “Rapidity and Efficacy of Ultrasonographic Sliding Lung Sign and Auscultation in Confirming Endotracheal Intubation in Overweight and Obese Patient ”, Ind J of Anaesth, vol. 61, no. 3, pp. 230–234, 2017.

2017

Journal Article

D. Sunil Rajan, Arora, V., Paul, J., and Kumar, L., “Effectiveness of Transtracheal Lidocaine as an Adjunct to General Anaesthesia in Providing Patient Immobility During Total Parotidectomy: A Comparison with Dex-Medetomidine Infusion ”, J Anaesthesiol Clin Pharmacol., vol. 33, no. 2, pp. 193-196, 2017.

2017

Journal Article

D. S. Rajan, Talukdar, R., Vasu, B. K., Paul, J., and Kumar, L., “Haemodynamic Responses and Safety of Sedation Following Premedication with Dexmedetomidine and Fentanyl During Fiberoptic Assisted Intubation in Patients with Predicted Difficult Airway”, Anesth Essays Res, vol. 12, no. 1, pp. 11-15, 2017.

2017

Journal Article

D. S. Rajan, Tosh, P., Puthenveettil, N., and Kumar, L., “Oral Clonidine Premedication for Attenuation of Haemodynamic Responses Following Ketamine Administration During Total Intravenous Anaesthesia ”, Ind J of Anaesth , 2017.

2017

Journal Article

D. G. Das and Rajgopal, R., “Comparison of 3% Hypertonic Saline and the Different Concentration of Manital for ICP Reduction in Elective Supra Tentoril Surgery”, Amrita Journal, 2017.

2017

Journal Article

D. Aveek Jayant, “Delirium After Cardiac Surgery: A Pilot Study from a Single Tertiary Referral Centre”, Ann Card Anaesth , pp. 76-82, 2017.

2017

Journal Article

D. Amitabh Ch Sen, B, D. R., and Krishnakumar, D. R., “Postoperative Infection in Developing world Congenital Heart surgery programme: Data from the International Quality Improvement Collaborative”, Circulation outcomes, 2017.

2017

Journal Article

D. M. Pillay, “Corona Mortis: An Indian Perspective.”, Italian Journal of Anatomy and Embryology, 2017.

2017

Journal Article

M. S. Farhan, Sudhakaran, R., and Thilak, J., “Solving the Mystery of the Anterolateral Ligament”, Journal of Clinical and diagnostic Research, 2017.

2017

Journal Article

D. S. Iyer, Minnie, P., Krishnakumar, T., and Raghuveer, R., “Soft Embalming of Cadavers for Training Purposes: Optimising for Long Term Use in Tropical Weather”, Indian Journal of Plastic Surgery, 2017.

2017

Journal Article

D. Paul T.Francis, “Utilization of Anganwadi Services in a Rural Population of Kerala”, Indian Pediatrics, vol. 54, pp. 65-66, 2017.[Abstract]


Integrated Child Developmental Services (ICDS) has played an important role in improving the health and education of children of India [1]. The state of Kerala has better health and socio-economic indicators compared to most other parts of the country. However, there are not many studies assessing the utilization of Anganwadi services in Kerala [2-4]. This study was done in a rural area near Kochi. In the first stage of sampling, we selected four wards randomly. In the selected wards, the investigators visited consecutive houses in all directions from the entry point to the ward. We collected data from 352 households regarding utilization of Anganwadi services in the past 1 year. The information was obtained from an adult member present at the time of visit, preferably a lady.

In our sampling frame, 136 families had children below 6 years, 66 families had adolescent girls (11-19), and 193 women were in reproductive age group out of which 26 were lactating or pregnant. All respondents knew about Anganwadi; 79% were aware of supplementary nutrition provided from there. Respondents had average (71.4%) or good (8.5%) knowledge about services provided to children below 3 years, but not to other age groups.

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2017

Journal Article

D. N. Mohan, “Mortality Predictors in Acute Coronary Syndrome Induced Ventricular Arrhythmias”, Amrita Journal, 2017.

2017

Journal Article

D. N. Mohan, “A Study on the Efficacy of Intravenous Labetalol in Hypertensive Urgency”, Int. J of Pharmaceutical Science and Research, 2017.

2017

Journal Article

D. A. Balasubramanian, “Adherence to Treatment Among Hypertensives of Rural Kerala, India”, Journal of Family Medicine and primary care, 2017.

2017

Journal Article

D. Beena kumari, D, V., and Anand R, “Adjuvant Treatment in Carcinoma of Endometrium: Where Do We Stand?”, Ind J of Gynec oncology, 2017.

2017

Journal Article

D. V. DK, “Predicting No-Shows for Breast Cancer Follow-Up Visits: An India Perspective Manuscript Number:  IJGO-D-17-00010”, International J of Medical Informatics, 2017.

2017

Journal Article

G. Goel, Janaki, P. D., Anupama, R., Agarwal, R., and Vijaykumar, D. K., “Predicting Nodal Burden in Clinically N0 Breast Cancer: A Comparison Between Ultrasound-Guided Fine Needle Aspiration Cytology (FNAC) and Sentinel Lymph Node Biopsy (SLNB)”, Indian Journal of Gynecologic Oncology, vol. 15, p. 33, 2017.[Abstract]


Post-Z0011 era there is much debate on omitting axillary clearance in select group of patients. However, there is difference in nodal burden in SLNB and FNAC positive group even though both are clinically N0. This study compares the nodal burden in SLNB and FNAC positive patients of clinically N0 breast cancer

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2017

Journal Article

D. V. DK, “Detection of EGFRvIII among Gynecological Cancers, Breast Cancers and HNSCC: A Study from a Single Indian Academic Institution".Laxmi Vijaychandran et al; The reference number for this manuscript is "IJC_57_17”, Ind J of Cancer, 2017.

2017

Journal Article

M. Sarika K. S, Balakrishnan, D. Vandana, Sundaram, D. K. R., and , “Physiological Impact of Integrated Amrita Meditation Technique in improving glycemic control in type 2 diabetes”, J of Physiological Sciences, 2017.

2017

Journal Article

B. R. J. Satishkumar, Mohan, T., Thirumalaisamy, S., sunil, A., Praveen, B. L., and Leo, B., “How Much Bone Cement is Utilized for Component Fixation in Primary Cemented Total knee Arthroplasty ?"”, J of Arthroplasty, p. -, 2017.[Abstract]


Purpose: No scientific evidence exists regarding the amount of bone cement used and discarded in primary cemented Total knee arthroplasty (TKA). The aim of this study was to identify the exact amount of bone cement utilized for component fixation in primary TKA. Methods: In a prospective study carried out at five centers, 133 primary cemented TKAs were performed. One pack of 40g Palacos bone cement ( PBC 40) was hand mixed and digitally applied during the surgery. After fixation of the TKA components, the remaining bone cement was methodically collected and weighed on a digital weighing scale. The actual quantity of cement utilized for component fixation was calculated. Results: On an average, 22.1 g of bone cement was utilized per joint, which accounted to 39 % of 57g , the solidified dry weight of PBC 40. Among 133 knees, the cement usage was 20 % to 50% in 109 knees, more than 50% in 20 knees and less than 20% in 4 knees. Knees which received larger sized femoral implant required more cement compared to medium and small sizes. Knees which had pulse lavage had more cement utilization compared to knees which had simple syringe lavage before implantation. Conclusion: Large quantity of bone cement was handled than actual requirements in primary TKA when a standard 40g pack was used with the digital application technique, resulting in sizeable discard of bone cement. Customizing cement pack according to the implant size can potentially avoid this cement wastage. Future research is required to study the utility and economic impact of smaller packs ( 20 g or 30 g) of bone cement in primary TKA.

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2017

Journal Article

R. Madhavan, P.K, B., Nithiya, A., Kani, J., mathi, M., P, B., and Kumar, S., “A Comparative study of radical radiotherapy with weekly paclitaxel versus radical radiotherapy with weekly cisplatin in the management of locally advanced squamous cell carcinomas of head and neck”, International Journal of Research in Medical Sciences, vol. 5, pp. 473–477} doi = {10.18203/2320-6012.ijrms20170135, 2017.[Abstract]


Background: Concurrent chemo radiation is standard of care in locally advanced squamous cell carcinomas of head and neck. Single agent Cisplatin either weekly or three weekly is commonly used concurrently with radiation. The present study aims to evaluate the response rate and toxicity of radical radiotherapy with weekly paclitaxel and cisplatin in head and neck cancers.Methods: This is a prospective double arm study in which sixty patients with histologically proved squamous cell carcinomas registered in our department were accrued into the study with thirty patients in each arm. All patients were treated using Theratron phoenix 780 cobalt unit with a dose of 66 Gy in 33 fractions. The patients were randomized to receive 40 mg/m2 of weekly cisplatin or 40 mg/m2 of weekly Paclitaxel concurrently with radiation. The response to the therapy was assessed six weeks after completion of treatment. The statistical analysis was done using SPSS software.Results: In cisplatin group 18 patients achieved complete response and 12 patients achieved partial response whereas in Paclitaxel group 21 patients achieved complete response and 9 patients achieved partial response. However in paclitaxel arm the incidence of radiation dermatitis, mucositis, dysphagia and laryngitis are slightly higher compared to cisplatin group.Conclusions: The weekly paclitaxel concurrent with radiation is a feasible alternative to weekly cisplatin in locally advanced squamous cell carcinomas of head and neck.

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2017

Journal Article

D. R. Madhavan, “Effect of Bladder Filling in Dosimetry in Intracavitary Brachytherapy Versus Vaginal Vault Brachytherapy”, J of contemporary brachytherapy, 2017.

2017

Journal Article

D. R. Madhavan, “Stereotactic Body Radiation Therapy, Ia An Active Breath Coordinator necessary?”, Lung India, 2017.

2017

Journal Article

D. R. Madhavan, “Pediatric Brain Tumors, An Analysis of Five Years of Data from a Tertiary Cancer Care Centre, India ”, Ind J of Cancer, 2017.[Abstract]


BACKGROUND: Pediatric brain tumors are the most common solid tumors in children and a leading cause of mortality and morbidity in children worldwide. Even though there are enough data about the epidemiology of pediatric brain tumors in western population, there are only a few reports from developing countries like India. AIMS: To study the epidemiological patterns of brain tumors in children, to study the patterns of care, and to assess the treatment response. MATERIALS AND METHODS: A retrospective epidemiological approach is used. The records of children <18 years registered in our department from August 2006 to July 2011 diagnosed as primary brain tumors are selected. Data regarding age, sex, site of the tumor, clinical features, histology, treatment plan, and treatment response are collected. The World Health Organization classification of neoplasms was adopted. RESULTS: Of 250 cases, females (57%) slightly outnumbered males. The present study revealed that astrocytoma (52%) is the most common brain tumor in childhood. Surgery was the main modality of treatment. Chemotherapy was given to 16% of patients. Even though radiation therapy was offered to 74% of patients, only 42% completed radiotherapy. There was subjective clinical improvement in 68% of patient population after treatment. CONCLUSIONS: This is the second study from Tamil Nadu that deals with epidemiology of brain tumors. Multimodality management including surgery, chemotherapy, and radiation therapy remains the cornerstone in the management of pediatric brain tumors.

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2017

Journal Article

A. Gopinathan, Mukhopadhyay, C., and E., V. K., “Characterization of Antimicrobial Resistance Mechanisms of Multidrug Resistant Gram Negative Bacterial Wound Infections and their Clinical Epidemiology from a Tertiary Care Hospital in Karnataka, India”, International Journal of Research in Medical Sciences, vol. 5, pp. 824–828} doi = {10.18203/2320-6012.ijrms20170535, 2017.[Abstract]


Background: Extended spectrum beta lactamases, AmpC and Metallo-betalactamases in GNB isolates are a common occurrence in most Indian hospitals. The presence of these antimicrobial resistance mechanisms contributes to prolonged hospital stay, poor quality of life, increased morbidity and mortality among patients with these infections. The aim of the study was to analyse the antimicrobial resistance mechanisms of multidrug resistant Gram negative bacterial wound infection and their clinical epidemiology.Methods: A prospective study was conducted for one year among 100 patients of Kasturba Medical College, Manipal admitted with MDR GNB wound infections. The antibiogram and phenotypic resistance mechanisms of the bacterial isolate from these infections were identified using phenyl boronic acid and ethyl diacetate. The empirical therapy, specific therapy and clinical outcome of the patients were also analyzed.Results: Out of 100 study patients, 152 MDR GNB isolates were obtained. 73% patients were admitted in the surgical wards. 43% patients had diabetes. Ulcers (27%) and abscess (25%) were the most common diagnosis. Escherichia coli (39%), Klebsiella pneumoniae (24%) and Pseudomonas aeruginosa (19%) were the most common isolates. Maximum number of ESBL was seen among Enteric Gram negative bacilli (36%), MBL was seen among Pseudomonas aeruginosa and Acinetobacter species (55% each), AmpC was seen among enteric GNB (10%) and Acinetobacter species (18%). Cefaperazone sulbactam, amikacin and meropenem were the most common antibiotics given as specific therapy. Clinical response was observed among 93% patients.Conclusions: The determination of the antimicrobial resistance mechanisms of GNB isolates from wound infections plays a major role in establishing an antibiotic policy for the treatment of these infections.

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2017

Journal Article

S. P and C, J., “ Erosive Esophagitis with Transient Respiratory Distress in Newborns: Case Reports”, J Pediatr Res, vol. 4, no. 1, pp. 48-52, 2017.

2017

Journal Article

N. Srinivasan, Chandramathi, J., Prabhu, A., and Ponthenkandath, S., “Vitamin D deficiency and morbidity among preterm infants in a developing country”, International Journal of Contemporary Pediatrics, vol. 4, pp. 499–502} doi = {10.18203/2349-3291.ijcp20170697, 2017.[Abstract]


Background: The association of serum vitamin D levels to clinical outcome in VLBW infants has not been studied. Our objective was to measure the cord blood levels, and the dose response for two doses of vitamin D in preterm infants and correlate the relationship of vitamin D levels to the clinical outcome.Methods: We prospectively obtained cord blood levels in 80 preterm infants under 34 weeks gestation (mean gestation age 29±2 weeks and BW: 1210±350 gms). Infants were supplemented with 400 IU or 800-1000 IU vitamin D daily. Serun vitamin D levels were obtained at 2 - 3 weeks after supplementation and levels were correlated to clinical outcome. Results: The mean cord blood vitamin D level was 12±8.5 ng/ml. Babies who developed sepsis and compared to those who did not develop these morbidities, ROP had vitamin D levels: 13.5±6 (ng/ml) versus 30.5±10 (ng/ml) (p &lt; 0.01) and 15.7±11 (ng/ml) versus 34±18 (ng/ml) (p &lt;0.03) respectively. Supplementation with 400 IU vitamin D resulted in levels of 17±8.6 (ng/ml) and infants given 800-1000 IU vitamin D had levels 46±17(ng/ml) (p &lt;0.001).Conclusions: These data suggest that cord blood vitamin D levels are low in preterm infants and 800-1000 IU vitamin D supplementation is advisable to achieve levels &gt;30 ng/ml. Infants with low levels of vitamin D have higher incidence of sepsis, and ROP.

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2017

Journal Article

A. Majeed, Chandramati, J., Prabhu, A., and Ponthenkandath, S., “PARADOXICAL VOCAL CORD MOTION (PVCM) IN VERY LOW BIRTH WEIGHT PRETERM INFANTS: CASE REPORTS AND A BRIEF REVIEW ”, International Journal of Pediatric Otorhinolaryngology, 2017.

2017

Journal Article

D. Madhumita Kumar, Sreeparvathi, A., Kalyanikuttyamma, L. Kumari, Sreekumar, N., and Veerasigamani, N., “Significance of Blood Eosinophil Count in Patients with Chronic Rhinosinusitis with Nasal Polyposis”, Journal of Clinical Diagnostic Research – JCDR, 2017.

2017

Journal Article

J. PT, .K, A., and .PS, R., “To Assess the Awareness of Airborne Infection Control Among Patients and Healthcare Workers in a Tertiary care Hospital in Cochin”, TB Association of India, 2017.

2017

Journal Article

Sobha George, Paul, N., Francis, P. T., and Leelamoni, K., “Prevalence of Domestic Accidents in a Rural Area of Kerala: A Cross Sectional Study”, International Journal Of Community Medicine And Public Health, vol. 4, pp. 949–953} doi = {10.18203/2394-6040.ijcmph20170949, 2017.[Abstract]


Background: Domestic accidents are important worldwide public health problems which require increased attention. A domestic accident means an accident that takes place at home or its immediate surroundings. Domestic accidents can result in disability and loss of productivity. The aim of the study was to find the prevalence of domestic accidents in a rural area and the various epidemiological factors associated with it. Methods: A community based cross sectional study was done in a rural area of Kerala. The study period was April-May 2016. Face to face interview with a responsible adult informant was done to collect information from 403 households consisting of 1826 individuals using a semi-structured questionnaire after getting consent. Data was tabulated using MS Excel and analysed using SPSS version 20. Qualitative variables expressed as percentages and association found out using Chi square test.Results: The prevalence of domestic accidents in the community was found to be 10.5% (9.14 – 11.95, 95% CI). Majority of the victims were females (66%). Falls were the most prevalent type of domestic accident (33.5%) and it was found to be significantly associated with age, educational status, place of occurrence and activity during accident. First aid kits were available only in 38.2% of houses. Conclusions: Increased awareness, specially among female population is needed to reduce domestic accidents. Take extra care of the extreme ages as they are more vulnerable to falls. It is essential that every house has a first aid kit.

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2017

Journal Article

L. George, S., A., Paul, N., and Leelamoni, K., “Community based interventional study on dengue awareness and vector control in a rural population in Ernakulam, Kerala”, International Journal Of Community Medicine And Public Health, vol. 4, pp. 962–967} doi = {10.18203/2394-6040.ijcmph20170984, 2017.[Abstract]


<p>Background: Dengue fever is an acute infectious disease for which there are currently no specific drugs or effective vaccines available. Therefore its prevention &amp; control solely rest on vector control strategies, for which behavioural change of the community is a requirement. Hence, the aim of our study was to implement a standardised behaviour change communication intervention strategy (BCC) and to measure its impact on the population in terms of awareness, attitude and practice regarding dengue and its vector control. Methods: This study was carried out in a ward in Njarackal Panchayath in Ernakulam district of Kerala. An initial baseline survey was conducted to assess the current awareness, attitude and practices of dengue &amp; its vector control among the residents of the ward. This was followed by the implementation of standardized BCC Intervention strategy. A post intervention survey was carried out two months later to analyze its impact. Results: This BCC strategy resulted in increasing the awareness regarding dengue and its vector control even though it was found not to be statistically significant. However, the strategy was able to bring about a significant change in the attitude and practice of the people with regard to dengue prevention and control strategies. Conclusions: This BCC strategy was successful in this population due to community acceptance, however it requires constant reinforcement for its sustainability.</p>

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2017

Journal Article

A. B, “Live donor liver transplantation for anti-tubular drug induced acute liver failure”, Indian Journal of Gastroenterology, 2017.

2017

Journal Article

R. A. Henry, Rao, G., and , “Determination and Validation of a Lower Cut off Value of Cerebrospinal Fluid - Adenosine Deaminase (CSF-ADA) Activity in Diagnosis of Tuberculous Meningitis.”, 2017.

2017

Journal Article

H. Ahamed, Henry, R., and Pai, R., “Association of mean platelet volume and acute coronary syndrome”, International Journal of Research in Medical Sciences, vol. 5, pp. 1217–1220} doi = {10.18203/2320-6012.ijrms20170968, 2017.[Abstract]


Background: Acute coronary syndrome (ACS) is a set of signs and symptoms due to rupture of a plaque and are a consequence of platelet rich coronary thrombus formation. Larger platelets are haemostatically more active and and hence carry risk for developing coronary thrombosis leading to ACS. Platelet parameters especially mean platelet volume (MPV) could be used as an important and reliable marker in early detection of ACS when the patients come to emergency department with chest pain. The primary objective is to study the association between mean platelet volume and acute coronary syndrome. The secondary objectives are to analyse if there is a statistically significant difference in mean platelet volume between Non-ST elevation (NSTEMI) and ST-elevation Myocardial Infarction (STEMI) and between double vessel disease (DVD) and triple vessel disease (TVD).Methods: A total of 260 patients were included in the study depending on the inclusion and exclusion criteria. After dividing the patients with chest pain into control (Non-cardiac chest pain) and study group (ACS) which contained 130 each, venous blood was drawn and taken to haematology laboratory for analysis of MPV within 2 hrs. The statistical analysis used were mean, median, test of significance in difference (t-test) and chi-square test.Results: Mean platelet volume (MPV) was found to be higher among ACS patients (9.4868±0.85270) as compared to control (7.430±0.72172) and it was significant with a P value &lt;0.05. It was also noticed that MPV was higher among patients with STEMI when compared to NSTEMI, 10.32±0.77932 and 9.22±0.52743 and it was statistically significant (P&lt;0.05). Similarly, MPV between patients with triple and double vessel disease were compared and the mean MPV of 10.04±0.88738 of TVD was greater than the mean MPV of 9.22±0.67438 in DVD and was statistically significant (P&lt;0.05).Conclusions: In this study the MPV was higher in patients with ACS than those in control group. The study also showed that there was significant difference in MPV values between people with STEMI and NSTEMI and between people with DVD and TVD. Hence it might be useful as an additional cost efficient test in conjunction with other markers in the early prediction of ACS in the emergency room. Larger platelets are haemostatically more active and hence carry risk for developing coronary thrombosis leading to ACS. Patients with increased MPV could be easily identified during routine haematological analysis and hence could play an important role in early detection of acute coronary syndrome (ACS).

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2017

Journal Article

D. Sajana Krishna, “Dermatological Problems in Geriatric Population”, Journal of medicine/ Amrita Viswa Vidyapeetham university, vol. 13, 2017.

2017

Journal Article

D. L. Susan George, “Utilization of health servicesand its determinants among elderly population of Raichur District, Karnataka”, National Journal of research in Community Medicine, 2017.[Abstract]


Introduction: Utilization of Health Services is a result of “Health Seeking Behavior” which in fact is an entity of a wider concept known as “Health Behavior”. Data regarding the utilization of health services by the elderly and the factors associated with it from the most rural and backward areas of Raichur district of Karnataka are lacking. Objectives: To assess the utilization of health services and the socio-demographic factors associated with it among the elderly population of the rural villages of Raichur district. Materials and Methods: This community based cross sectional study was carried out in the most rural and backward villages of Raichur District. Data was collected using a pre-designed and pre-tested questionnaire. 230 elderly were interviewed regarding their socio-demographic profile and utilization of health services. Results: It was observed that, 83% of the elderly used health services in the past year of which 78% utilized the allopathic health services. However, 16% of them still utilized the services of quacks. The average monthly expenditure of the elderly on health was Rs100/-. A higher level of education and social class were found to be significant factors favouring the utilization of healthcare services by the elderly. Recommendation: Integration of geriatric care into the primary healthcare system has become the need of the hour in order to make health services more accessible to the elderly

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2017

Journal Article

D. Ram Madhavan, Kunheri, D. B., .Haridas.M.Nair, D., and Holla, M. R., “Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma, Experience from a Tertiary Cancer Care Center in India”, vol. 54, no. 1, 2017.

2017

Journal Article

P. R. I. Y. A. N. K. BIJALWAN, ,, and Thomas, A., “COMPARISON OF STERILE WATER IRRIGATION VERSUS MMC IN NON MUSCLE INVASIVE BLADDER CANCER”, INDIAN JOURNAL OF UROLOGY, 2017.

2017

Journal Article

P. R. I. Y. A. N. K. BIJALWAN, SANJEEVAN, K. V., Anil Mathew, and NAIR, B. A. L. A. G. O. P. A. L., “OUTCOME AND COMPLICATIONS OF LIVING DONOR PEDIATRIC RENAL TRANSPLANTAION : EXPERIENCE FROM A TERTIARY CARE CENTRE IN SOUTH INDIA”, INDIAN JOURNAL OF UROLOGY, 2017.

2017

Journal Article

D. Nandu Mohan, K.P, D. Gireesh Ku, and T.P, S., “A Study on Efficacy of IV Labetalol in Hypertensive Urgency in Emergency room.”, 2017.

2017

Journal Article

D. Nandu Mohan, K.P, D. Gireesh Ku, T.P, S., Mohan, D. Naveen, and Prasad, D. Bharath, “ Mortality predictors in ACS induced Ventricular arrythmias”, Amrita Journal , 2017.

2017

Journal Article

D. Sreekrishn T.P and K.P, D. Gireesh Ku, “ Provenance of Vitamin D Deficiency in Patients coming to Emergency Room”, 2017.

2017

Journal Article

T. Joy, Paul, N., S., R. P., and Leelamoni, K., “High Prevalence of Dietary and Physical Activity Related Risk Factors for Non-communicable Diseases Among Apparently Healthy Urban Women in Kochi, Kerala, South India”, International Journal Of Community Medicine And Public Health, vol. 4, pp. 987–991} doi = {10.18203/2394-6040.ijcmph20171311, 2017.[Abstract]


Background: Non communicable diseases (NCDs) represent the biggest threat to women’s health worldwide. NCD is a leading cause of morbidity and premature mortality among women in Kerala. This study attempts to delineate the risk factors of NCDs among apparently healthy urban women in Kochi, Kerala. Methods: A cross sectional study was conducted among apparently healthy women of age 20-60 years in randomly selected wards of Eloor municipality, Kochi, Kerala. The minimum calculated sample size was 130. Houses were selected by systematic random sampling. A semi structured questionnaire based on the STEPS instrument was administered to eligible subjects. Their anthropometric measurements were also taken using standardised tools. Data were entered into Excel sheet and analysed using SPSS version 15. Results: The mean age of the women surveyed was 38.9 years (SD 10.2). Majority (71%) of the study participants were home makers. Majority (97.2%) consumed less than 5 servings of fruits and vegetables a day. Of them, 79.3% were in the low physical activity category. Around 55% of the women were either overweight or obese. Conclusions: The current study showed a high burden of risk factors for non-communicable diseases among women in urban area in Kerala. Considering the burden of NCD risk factors in the population, there is urgent need to plan and implement gender sensitive community-based interventions at different levels including health promotion, and prevention.

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2017

Journal Article

K. Kumar M. K. and George, L. Susan, “Pulmonary function of automobile repair workers in the informal sector of Raichur urban”, International Journal Of Community Medicine And Public Health, vol. 4, pp. 1510–1514} doi = {10.18203/2394-6040.ijcmph20171571, 2017.[Abstract]


Background: Automobile repair workers of the informal sector are exposed to dusts, toxic fumes and aerosols. Long term occupational exposure may lead to pulmonary function impairment. Hence, the objectives were to study the occurrence of obstructive and restrictive pulmonary impairment among the automobile repair workers by using pulmonary function test and the factors associated with it.Methods: A cross sectional study was carried out in automobile repair workers who work in informal sector in the urban area of Raichur in Karnataka. The pulmonary function tests viz. Forced Expiratory volume in one second, Forced vital capacity, Peak Expiratory Flow Rate per liter and FEV1/FVC ratio in percentage were measured for each worker in sitting posture using a digital spirometer. Data collected were analyzed in SPSS 16.0 software. Chi-square test and t test was used.Results: Out of the 97 automobile repair workers, 42 (43.3%) had normal pulmonary function. Among the abnormal PFT, 20 (20.6%) had obstructive lung function, 25 (25.8%) had restrictive lung function and 10 (10.3%) had mixed obstructive and restrictive lung function. The workers with abnormal PFT consisted of body repair workers (25.0%), mechanical workers (38.1%), spray painters (75.0%), battery repair workers (100.0%) and tyre retreading workers (88.9%).Conclusions: In this study, 56.7% of workers had some form of pulmonary function impairment. Smoking, increase in duration of work hours and years of work showed significant pulmonary impairment. The study highlights the need for creating awareness and encouraging the use of protective gears such as masks, early screening, diagnosis and treatment of respiratory diseases among the garage workers.

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2017

Journal Article

G. BN, G, R., K, V., and V, B., “ Zinc/copper Ratio: a Predictor of Pancreatic Function in Chronic Pancreatitis?”, 2017.[Abstract]


Background:&nbsp;The role of trace elements in the maintenance of normal pancreatic function is unclear.

Aim:&nbsp;To estimate trace elements (zinc and copper) in chronic pancreatitis (CP) patients and study their relationship with exocrine and endocrine insufficiency. Methods: The study involved 101 CP patients and 113 healthy controls. Disease characteristics and imaging features were recorded. Erythrocyte zinc (Zn) and copper (Cu) were estimated by flame atomic absorption spectrophotometry. Fecal pancreatic elastase1 was estimated by polyclonal antibody ELISA method as a marker of pancreatic exocrine function

Results:&nbsp;The mean erythrocyte Zn level and Zn/Cu ratio were significantly lower whereas the copper level was significantly higher in CP patients than controls. The mean Zn level and Zn/Cu ratio was significantly lower in CP patients with diabetes and those with low elastase1 as compared to non-diabetics and those with normal elastase1 respectively. Erythrocyte Cu level was significantly higher in CP patients with diabetes and with low elastase1 than those without diabetes and with normal elastase1 levels respectively. There was a significant positive correlation between elastase1 and Zn/Cu ratio (r = 0.396, p &lt; 0.001). Receiver operating characteristic curve (ROC) analysis was performed to predict the development of exocrine insufficiency and it indicated an area under curve (AUC) of 0.838 ± 0.047 (95% CI: 0.746-0.93). The optimal cutoff value was 9.03 (sensitivity 86.5%, specificity 73.5%). When the same was performed to predict the development of diabetes, the AUC was 0.710 ± 0.05 (95% CI: 0.607-0.812). The optimal cutoff value was 7.2 (sensitivity 69.1%, specificity 69.7%).

Conclusion:&nbsp;Low erythrocyte Zn/Cu ratio was found to be associated with exocrine and endocrine insufficiency in CP patients.

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2017

Journal Article

R. M, ,, R, R., ,, TM, J., and RK, K., “ Health Related Quality of Life (HRQL) in Indian children -A community based cross-sectional survey. ”, 2017.

2017

Journal Article

L. Feinberg, Menon, J., Smith, R., Rajeev, J. G., Kumar, R. Krishan, and Banerjee, A., “Potential for mobile health (mHealth) prevention of cardiovascular diseases in Kerala: A population-based survey”, Indian Heart Journal, vol. 69, pp. 182 - 199, 2017.[Abstract]


Background India's southern state of Kerala stands at the forefront of India's epidemic of cardiovascular disease (CVD), among other non-communicable diseases (NCDs). Mobile phone use in healthcare (mHealth) has shown promise in India, including NCDs. However, suitability and acceptability of m-Health interventions is poorly researched, particularly in rural settings. Objectives (1)To explore mobile phone usage patterns in rural Kerala (Ernakulam).(2)To explore acceptability of mHealth delivery of health promotion and CVD prevention. Methods A questionnaire regarding mobile phone usage and possible use in healthcare was verbally administered in five primary health centres and by home visits in five village councils (“panchayats”) of Ernakulam, Kerala. Adults who spoke Malayalam or English, with access to a mobile phone were recruited by convenience sampling in partnership with accredited social health activists (ASHAs). Quantitative data analysis was conducted using SPSS software. Results 262 participants were recruited. 87% routinely used and 88% owned a mobile phone. 92% were willing to receive mHealth advice, and 94% favoured mobile medication reminders. 70.3% and 73% preferred voice calls over short messaging service (SMS) for delivering health information and medication reminders, respectively. 85.9% would send home recorded information on their blood pressure, weight, medication use and lifestyle to a doctor or ASHA. 75.2% trusted the confidentiality of mHealth data, while 77.1% had no concerns about the privacy of their information. Conclusions The majority of this population approve mHealth interventions. While further investigation of mHealth as a health education tool is warranted, SMS interventions may fail to maximise equity and penetration across all patient groups.

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2017

Journal Article

V. S and RK, K., “Should we close small ventricular septal defects?”, 2017.

2017

Journal Article

R. ps, “Prevalence of Anemia in Kerala- A Review”, Journal of Clinical and Diagnostic Research, vol. 11, no. 5, 2017.[Abstract]


Introduction
Anaemia is the most common nutritional problem affecting children, adolescents and women. A systematic review was undertaken to find out the prevalence of anaemia and to identify the trend in the prevalence of anaemia in Kerala state, Southern India.

Aim
The aim of the review was to identify the prevalence of anaemia in Kerala and to comment on its trend across last 25 years.

Materials and Methods
PubMed and google scholar searches and scanning of reference lists were used to identify studies. All population based studies on anaemia from Kerala, irrespective of its designs, published between Jan 1st 1990 to Dec 31st 2015 were included. Data extraction and quality assessment were carried out using structured proformas. Due to the heterogeneity of reviewed studies, meta-analysis was not done. A narrative approach was used.

Results
A total of 10 studies in addition to two major survey reports- National Family Health Survey (NFHS) and District Level Household Survey (DLHS) were included in the final analysis. Prevalence of anaemia among adolescents from recent study reports was around 30% and prevalence of severe anaemia was less than 1% in all studies. Anaemia among tribal women and children were in the range of 78.3% to 96.5%. A key finding of this review was the paucity of data and inconsistency in haemoglobin estimation methods and population characteristics which made comparisons impossible.

Conclusion
The current prevalence of anaemia in Kerala is unclear. Though, there are many studies and reports regarding prevalence of anaemia in the state, those results could not be combined due to non uniform haemoglobin estimation methods. Standardised prospective study of general population including subgroups will be necessary.

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2017

Journal Article

S. N., R., S., V., N. Pillai, S., M., M., R., D., V., C., J., and A., S., “Low-dose prophylaxis for children with haemophilia in a resource-limited setting in south India—A clinical audit report”, Haemophilia, vol. 23, pp. e382-e384, 2017.

2017

Journal Article

C. Lyssikatos, Pavithran, P. V., Tirosh, A., R.Faucz, F., Vasukutty, J. R., Belyavskaya, E., Ahamed, A., Raygada, M., and Stratakis, C. A., “NEWLY DIAGNOSED CARNEY COMPLEX IN THREE YOUNG ADULTS WITH PRIMARY ADRENAL CUSHING SYNDROME”, 2017.

2017

Journal Article

D. .Aswathy.s, .K.N.Panicker, D., and Paul, N., “Targeting Infant and Young child feeding practices. An interventional behaviour change communicate approach”, 2017.

2017

Journal Article

T. Mary Joy, MK, S., Paul, N., and K, L., “Prevalence of Tobacco Use in an Urban Slum Population in Kochi, Kerala”, National Journal of Research in Community Medicine, 2017.

2017

Journal Article

R. Reddy, Iyer, S., Pillay, M., and Thankappan, K., “Soft emblaming of cadavers for training purposes:Optimising for long term use in tropical weather”, Indian Journal of Plastic Surgery, 2017.

2017

Journal Article

M. S. Dharmadas, Kumar, D. Harish, Pillay, D. M., .K.R.Sundaram, D., C.J, D. S., .Mangalanandhan, D., Lakshmanan, D. Vivek, .V.P.Praveen, D., and Bal, D. A., “Prevalence of Charcot Arthropathy in Type 2 Diabetes Patients Aged over 50 Years with Severe Peripheral Neuropathy: A Retrospective Study in a Tertiary Care South Indian Hospital”, Indian Journal of Endocrinology and Metabolism, 2017.

2017

Journal Article

K. B, G, A., PS, S., R, A., and KU, P., “ Nasopharyngeal Carcinoma:Experience and Treatment Outcome with Radical Conformal Radiotherapy from a Tertiary”, Indian Journal of Cancer, 2017.

2017

Journal Article

, Kumar, H., KR, S., and Menon, A. S., “GLYCEMIC RESPONSE AND SATIETY TO TRADITIONAL AND HIGH FIBER CEREAL PREPARATIONS OF KERALA CUISINE IN HEALTHY VOLUNTEER ”, Indian Journal of Nutrition, vol. 4, no. 1, 2017.

2017

Journal Article

S. .P, Menon.S, A., K.R, S., Menon.N, L., .M, G., and , “ CORRELATION BETWEEN BODY MASS INDEX (BMI) AND WAIST CIRCUMFERENCE (W.C) WITH URINE ALBUMIN EXCRETION IN NON-DIABETIC OBESE SUBJECTS - A CROSS SECTIONAL STUDY ”, IOSR Journal of Dental and Medical Sciences, 2017.

2017

Journal Article

M. T. Shenoy, Menon, A. S., Nazar, P. K., Moorthy, S., Kumar, H., Nair, V., Pavithran, P. Valiyapara, Bhavani, N., Menon, V. Usha, Abraham, N., and R. Jayakumar, V., “Radiofrequency Ablation Followed by Percutaneous Ethanol Ablation Leading to Long-Term Remission of Hyperparathyroidism”, Journal of the Endocrine Society, vol. 1, pp. 676-680, 2017.

2017

Journal Article

K. Jonnalagadda, Bhavani, N., Pavithran, P., Kumar, H., Menon, U., and R., C., “Spontaneous Bilateral Adrenal Hemorrhage of Pregnancy”, International Journal of Reproduction, Contraception, Obstetrics and Gynecology, vol. 6, pp. 772–775} doi = {10.18203/2320-1770.ijrcog20170423, 2017.[Abstract]


Spontaneous adrenal hemorrhage of pregnancy is an acute hemorrhage into the adrenal gland in pregnancy in the absence of trauma, tumor or decoagulant therapy. This can have catastrophic consequences on the mother and the baby and if the hemorrhage involves both the adrenal glands the risk is aggravated because of the high incidence of resulting adrenal insufficiency. We report a case of spontaneous bilateral adrenal hemorrhage in pregnancy resulting in adrenal crisis. A 26 year old primigravida presented at 32 weeks of gestation initially with right sided infrascapular pain and one month later with similar pain in the left side associated with high blood pressure. Imaging with ultrasound and MRI was suggestive of bilateral adrenal mass probably hemorrhage; 2 days following the second episode of pain she developed drowsiness and hypotension and a diagnosis of primary adrenal insufficiency was confirmed by a low serum cortisol and high ACTH. She stabilized with hydrocortisone therapy and the fetus was closely monitored. At 37 weeks she had a normal vaginal delivery under steroid cover. Repeat MRI abdomen 3 months after delivery showed resolution of the hemorrhage but biochemically she continued to be cortisol insufficient at 1 year of follow up. Prompt diagnosis of adrenal hemorrhage in pregnancy and treatment of adrenal insufficiency along with close fetal monitoring usually results in good perinatal outcome in spontaneous adrenal hemorrhage of pregnancy.

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2017

Journal Article

C. Lyssikatos, Pavithran, P. V., Tirosh, A., Faucz, F. R., Vasukutty, J. R., Belyavskaya, E., Ahamed, A., Raygada, M., and Stratakis, C. A., “NEWLY DIAGNOSED CARNEY COMPLEX IN 3 YOUNG ADULTS WITH PRIMARY ADRENAL CUSHING SYNDROME – A CASE SERIES AND REVIEW OF THE LITERATURE”, AACE Clinical Case Reports, vol. 3, pp. e326-e330, 2017.

2017

Journal Article

B. O. Aliren Lui Masmiquel, Kumar, H., Sargin, M., and Chow, J. Derving Ka, “Efficacy & Safety of Once Weekly Semaglutide Verses Once Daily Sitagliptin as an Add as to Metformin, Thiafolinediones, or both in Patients with Type 2 Diabetes (SUSTAIN 2) : a 56 Week, Double Blind Phase 3 a Randomized Trial”, 2017.

2017

Journal Article

J. R, T, G., JS, G., and al, et, “Efficacy of Stereotactic Conformal Radiotherapy vs Conventional Radiotherapy on Benign and Low-grade Brain tumors: A Randomized Clinical Trial”, JAMA Oncology, vol. 3, pp. 1368-1376, 2017.

2017

Journal Article

A. Sreedevi and Paul, N., “Prevalence and Social Determinants of Type 2 Diabetes in a Coastal Area of Kerala,India”, Journal of Endocrinology and metabolism, vol. 4, no. 3, 2017.

2017

Journal Article

D. Prem Nair, P.S, D. Rakesh ., and .James.P.T, D., “How We Achieved Hundred Percentage TB Notification Experiennces from a Private Territory Care Centre in India”, 2017.

2017

Journal Article

D. Prem Nair, Akhilesh, D., P.S, D. Rakesh ., and .James.P.T, D., “Outcome of Patients Treated with Private Anti TB Regiment”, 2017.

2017

Journal Article

S. Khan, Anil kumar, Kale, S., Kurkure, N., Nair, G., and Dinesh, K., “Multiple Cortical Brain Abscesses Due to Listeria Monocytogenes in an Immunocompetent Patient”, Tropical Doctor, vol. 48, pp. 160-163, 2017.[Abstract]


Listeria monocytogenes is an intracellular organism which is well recognised for its ability to cause meningeal infections in neonates, immunosuppressed, debilitated and elderly individuals.1 Other less common central nervous system (CNS) infections caused by Listeria spp. include rhomboencephalitis, cerebritis and abscesses in the brain, brain stem and spinal cord. The neuroradiological appearance of Listeria brain abscesses is similar to other types and may also mimic primary or metastatic brain tumours.2,3 We report a case of Listeria brain abscesses in a patient who was being treated for atypical parkinsonism. A good clinical outcome was achieved after appropriate antimicrobial therapy.

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2017

Journal Article

L. V.N, Sobha George, and Paul, N., “Study on Risk Factors Associated with Diabetic Retinopathy among the patients with Type II Diabetes Mellitus in South India: Hospital Based Cross Sectional Study ”, National Journal of research in Community Medicine, 2017.

2017

Journal Article

P. S. Rakesh, Balakrishnan, S., Jayasankar, S., and Asokan, R. V., “TB management by private practitioners – Is it bad everywhere?”, Indian Journal of Tuberculosis, vol. 63, pp. 251 - 254, 2017.[Abstract]


ntroduction Poor prescribing practice is alleged to be one of the major factors fuelling the drug-resistant tuberculosis (DR TB) emergence. A study in Mumbai revealed the extent of inappropriate tuberculosis (TB) management practices of private practitioners and discussed that with the context of high DR TB. Kerala is rated among the well performing States in India as far as TB control is concerned with evidences for a lower level of TB transmission and DR TB. The current study was done in Kerala State to assess the prescribing practices of private sector doctors in the treatment of TB. Methods Survey questionnaire to write a standard prescription for treating TB was administered to private practitioners dealing with TB, who attended continuing medical education programme on TB at two major cities in Kerala. Results Responses from a total of 124 questionnaires were studied. None of them prescribed anti-TB regimen for less than 6 months. Only 7 (5.6%) prescribed a regimen without complete four drugs (H, R, Z, E) in the intensive phase. Out of the 81 doctors who prescribed private anti-TB regimen, 67 (82.7%) had of the opinion that not less than 80% of their patients complete the treatment for the prescribed duration. Conclusion The current study reports a reasonable TB management practice among the private sector doctors from a State with a low prevalence of DR TB and compliments the argument that effective treatment of TB following the principles of standards for TB care can prevent the emergence of DR TB.

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2017

Journal Article

K. Viswanathan, Rakesh, P. S., Balakrishnan, S., and Kumar, A. S. Pradeep, “Health Benefits of Practical Approach to Lung Health (PAL) Experienced by Patients with Chronic Respiratory Diseases – Results from PAL Pilot Project in Primary Health Care Setting in Kerala, India”, Indian Journal of Tuberculosis, vol. 65, pp. 237 - 240, 2017.[Abstract]


Government of Kerala state had implemented a pilot project of the World Health Organisation recommended Practical Approach to Lung health (PAL) strategy, with an intention to improve the quality of diagnosis, treatment and management of common chronic respiratory diseases (CRD) in primary health care settings. The current study was done as a part of implementation of PAL pilot project and was intended to assess the benefits of PAL for the individual patients with CRDs accessing services from primary health institutions. Exit interviews were conducted at the baseline and for impact assessment after six months of pilot project by interviewing patients with CRD attending primary health institutions implementing PAL and control institutions. A total of 94 and 100 CRD patients were interviewed at baseline and after six months in the PAL implementing institutions, and 88 and 96 CRD patients were interviewed at the control institutions. Reduction in number of medical consultation, hospital admissions and exacerbations among CRD patients were 5.03, 3.20 and 2.24 times higher in PAL implementing institutions as compared to the control institutions. PAL pilot project in India implemented in an area with a reasonably sound primary health care system has proved that it might be beneficial for the patients with CRD as it reduces frequency of exacerbations, hospital visits and frequency of medical consultations.

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2017

Journal Article

V. nelson, Rakesh, P. S., and simon, S., “Work related health problems of female workers engaged in Cashew processing Industries- a cross-sectional study from Kollam district, Kerala, southern India”, Indian Journal of Community Health , vol. 28, no. 4, 2017.[Abstract]


Background: India accounted for one third of the global export market for cashew kernels. Unhealthy sitting posture, working near furnaces and contact with the cashew nut shell liquid may make the workers in the cashew sector vulnerable to many health issues Aims & Objectives: To identify the health related problems among female workers of cashew processing industries in Kollam district, southern Kerala, Setting and Design: A cross sectional study was conducted in selected cashew units of Kollam, Kerala. Material & Methods: An interviewer administered and structured questionnaire was used to collect health related issues from 301 female cashew processing workers. Statistical analysis: Descriptive statistics using frequencies was done and chi square test was used to detect difference between proportions. Results: Low back pain was the predominant problem (48.8%) followed by hand and wrist pain (46.6%), knee pain (37.8%) and neck pain (32.5%). Among the workers engaged in roasting, 86.6% had experienced a burn (p < 0.001). Workers engaged in roasting (53.3%) and shelling (43.7%) had blackish staining of their palms and fingers. Conclusion: Health related issues pertaining to musculoskeletal system, respiratory system, and skin conditions are highly prevalent among women engaged in cashew processing industry. A comprehensive programme to prevent health related issues may be considered to promote health of women engaged in cashew processing industries

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2017

Journal Article

S. TP, Raj, S., M, N., S, R., Jayakumar, A., Nair, P. G., and KP, G. Kumar, “Efficacy of Low Dose Fentanyl in the Treatment of Severe Pain”, 2017.

2017

Journal Article

A. Balachandran and Hussain, S. Shakeer, “Determination of stature from the length of middle finger – An autopsy Sudy”, 2017.

2017

Journal Article

M. Pillay, Sukumaran, T. T., and Mayilswamy, M., “Anatomical Considerations on Surgical Implications of Corona Mortis: an Indian Study”, Italian Journal of Anatomy and Embryology, vol. 122, 2017.[Abstract]


The blood vessels traversing the superior pubic ramus are usually vascular connections between obturator and external iliac systems of vessels. Dislocated fractures or iatrogenic injury can cause life threatening bleeding and hence these vascular anomalies are referred to as corona mortis meaning ‘crown of death’. Except for a case report, no study on corona mortis has been attempted in India so far and hence the present study was intended at exploring the possible variations, both morphological and topographical, of these vascular connections in Indian population through cadaveric dissection. 24 adult cadavers dissected bilaterally (48 hemipelves) and 19 random hemipelves available in the Department of Anatomy were considered for the study.The vascular connections observed were classified as arterial, venous or both (Types I, II and III). Type III was further classified into subtypes a, b, c, d and e based on various combinations of the first two types. In a total of 67 pelvic halves corona mortis was detected in 56 (83.58%) specimens: arterial 7/56 (12.5%), venous 34/56 (60.7%) and both arterial and venous in 15/56 (26.78%) specimens respectively. 22 hemipelves had an artery on the superior pubic ramus out of which in 7 cases there was only an artery whereas in 15 cases both an artery and a vein were present. Commonest source of obturator artery was inferior epigastric artery 15/22 (68.18%) followed by external iliac artery 4/22 (18.18%). 49 of the 56 corona mortis positive specimens had a vein on the superior pubic ramus. In 34/56 specimens only a vein was present.12/49 (24.48%) veins drained into external iliac vein, 3/49 (6.12%) into inferior epigastric vein. A venous anastamosis was found between obturator vein and external iliac vein in 21/49 (42.85%) cases and between obturator and inferior epigastric vein in 10/49% (20.40%) cases. Corona mortis was observed in a significant percentage of specimens, venous corona mortis being more common than arterial. Every surgeon dealing with hernias or fractures of the region needs to be aware of the possible variations and ligate vessels if corona mortis presents itself or else it becomes difficult to control bleeding if a cut vessel retracts into the pelvis.

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2017

Journal Article

S. Dharmadas, Kumar, D. H., Pillay, D. M., Jojo, D. A., and .Tessy.P.J, D., “Microarchitecture of Foot Bone of Diabetic Patients with Chronic Charcot arthopathy Gives Insight into Pathogenesis”, Conference -ESICON 2017 Indian Journal of Endocrinology and Metabolism, 2017.

2017

Journal Article

P. M, S, R., Tintu, T. S., A, J., and V, P. V., “Effect of Embalming Fluid on the Histological Appearance of Organs-A Cadaveric study”, Conference- 65th National Conference of Anatomical Society of India-2017,Chattisgarh, 2017.

2017

Journal Article

D. .Gopalan.M and Pillai, D. G. S., “Human Iris Patterns-Iridology-Applications”, Conference- 65th National Conference of Anatomical Society of India-2017,Chattisgarh, 2017.

2017

Journal Article

D. Sunil Rajan, “Effectiveness of transtracheal lidocaine as an adjunct to general anesthesia in providing patient immobility during total parotidectomy: A comparison with dexmedetomidine infusion”, Journal of Anaesthesiology Clinical Pharmacology, 2017.

2017

Journal Article

D. Pulak Tosh, “Oral Clonidine Premedication Attenuates Hemodynamic Responses of Ketamine During Total Intravenous Anesthesia.”, Anesthesia: Essays and Researches , 2017.

2017

Journal Article

D. Bindu K. Vasu, “Efficacy of Atomised Local Anaesthetic Versus Transtracheal Topical Anaesthesia for Awake Fibreoptic Intubation”, Indian J Anaesth, vol. 61, 2017.

2017

Journal Article

S. M. Zachariah, C., S., S., A., Kokkayil, P., and Mathews, A. A., “Investigation of Hepatitis A outbreak in Palakkad district”, International Journal Of Community Medicine And Public Health, vol. 4, pp. 4125–4130} doi = {10.18203/2394-6040.ijcmph20174630, 2017.[Abstract]


Background: A study was carried out to investigate an outbreak of viral hepatitis reported by district health authorities from a self-administrative unit, Koppam of Palakkad district in Kerala in the month of November 2016. Methods: An epidemiological investigation was carried out to investigate the outbreak, describe epidemiological features and recommend measures for control. An epidemiological case sheet was prepared, case definition formulated and blood samples were collected to confirm the diagnosis of hepatitis. Environmental samples were collected from wells, soil and tested for hepatitis A virus. Results: 15 blood samples taken from cases of jaundice tested positive for hepatitis A, IgM antibody by ELISA test. More than three fourths 39 (79.6%) of the cases gave a history of having attended the same wedding function prior to the occurrence of symptoms. Attack rate (6.14%) was highest among 15-25 year age group. The water analysis from 3 of the wells in the area showed presence of coliform bacteria. Hepatitis A virus IIIA genotype was isolated from the soil sample of the house of the index case. Consumption of welcome drink was found to be associated significantly with cases than controls (OR 2.77; 95% CI: 1.02-7.52, p&lt;0.05). Conclusions: The hepatitis A (type IIIA) outbreak in Koppam was associated with poor sanitation practices among the people. During a socio-cultural-demographic event like marriage this led to an explosive outbreak. Involving community organizations to generate awareness regarding food sanitation, supported by a system of registration of such events, certification of food handlers can help to prevent future outbreaks

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2017

Journal Article

A. Khot, Thomas, T. K., P, S., and N, R. A., “Analysis of the pattern of ADR's reported to an ADR monitoring Centre in South India: a prospective study”, International Journal  of Basic & Clinical Pharmacology, no. 10, pp. 2477-2481, 2017.

2017

Journal Article

S. T. P and KP, G. Kumar, “PREVELANCE OF VITAMIN D DEFICIENCY IN PATIENTS COMING TO A TERTIARY CARE HOSPITAL IN INDIA”, International Journal of Recent Scientific Research, 2017.

2017

Journal Article

A. A.K, Mohan, N., Prasad, B., C.U, K., and Kumar, G., “ETCO2: A NON INVASIVE GUIDE TO ARTERIAL PaCO2 IN THE EMERGENCY ROOM”, International Journal of Recent Scientific Research, 2017.

2017

Journal Article

E. Kuriakose, Cheppayil, S. Narayanan, Narayanan, S. Kuzhikanda, and Vasudevan, A., “A Study on Free Light Chain Assay and Serum Immunofixation Electrophoresis for the Diagnosis of Monoclonal Gammopathies”, Indian Journal of Clinical Biochemistry, 2017.[Abstract]


Demonstration of monoclonal immunoglobulin molecule in serum forms the mainstay in the diagnosis of monoclonal gammopathies. The major tests that help in this regard are serum protein electrophoresis (SPEP), serum immunofixation electrophoresis (sIFE) and serum free light chain assay (sFLC). Our objectives were to study the accuracy of sFLC and sIFE in the diagnosis of monoclonal gammopathies and also to study the role of combination of SPEP&nbsp;+&nbsp;sIFE&nbsp;+&nbsp;sFLC in the diagnosis of the same. 46 patients who attended the hemato-oncology clinic with signs and symptoms suggestive of monoclonal gammopathy were enrolled in this study. SPEP, sIFE, sFLC and pre-treatment serum beta-2 microglobulin levels were analysed among the study population. Both SPEP and sIFE were performed in the Interlab Genios fully automated machine. Serum beta-2 microglobulin and sFLC were estimated by immunoturbidimetry in Beckman Coulter AU 2700 analyzer. The accuracy of sIFE came to be 80{%} with respect to sFLC assay. Sensitivity, specificity, positive and negative predictive value of sIFE with respect to sFLC were 81.3, 78.6, 89.7 and 64.7{%} respectively. It was observed that a combination panel of SPEP&nbsp;+&nbsp;sIFE&nbsp;+&nbsp;sFLC could detect all the cases of myeloma included in this study. Further testing in large samples is required for generalising the findings of this study. The pre-treatment beta-2 microglobulin levels were significantly higher in the group which was positive for myeloma. A combination panel of SPEP&nbsp;+&nbsp;sIFE&nbsp;+&nbsp;sFLC prove to be more useful than individual tests for the detection of myeloma.

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2017

Journal Article

A. Nair, Haridas, N., Ahmed, S., and Eapen, M., “Radial Probe Endobronchial Ultrasound for Peripheral Pulmonary Lesions: Initial Experience in an Indian Tertiary Healthcare Centre”, Journal of Cardio-Thoracic Medicine, vol. 5, pp. 213-217, 2017.[Abstract]


Introduction : Diagnosis of peripheral pulmonary nodules is confusing; therefore, an accurate and safe lung biopsy can prevent unnecessary invasive diagnostic procedures. This study soughtto study the diagnostic yield, sensitivity, specificity, and negative and positive predictive values (NPV and PPV) of radial probe endobronchial ultrasound (EBUS)-guided biopsy for peripheral pulmonary lesions. Materials and Methods: Patients referred to the Division of Pulmonary Medicine for evaluation of peripheral pulmonary lesions were subjected to radial probe EBUS-guided transbronchial lung biopsy under conscious sedation after reviewing positron emission tomography scan/computed tomography results. The obtained specimens were considered diagnostic when the cytological, histopathological, or microbiological diagnosis was consistent with the clinical presentations. Results: Totally, 14 procedures were performed on 13 patients with mean lesion size of 30.42 mm. Mean distance between the lesion and pleura was 1.17±0.68 cm, and the diagnostic yield of this technique was 78.57%. Furthermore, the sensitivity, specificity, and NPV were 70% (range: 34.75 to 93.33), 100% (range: 39.76 to 100), and 57.14% (range: 18.41 to 90.10), respectively. This procedure was not associated with any major complications. Conclusion: Radial probe EBUS with satisfactory diagnostic yield and low complication rate is a promising tool for early diagnosis of lung cancer

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2017

Journal Article

Rakesh P S, “A Point Source Outbreak of Acute Gastroenteritis Among School Students in Kerala, India”, Indian J Public Health , vol. 61, pp. 302-4, 2017.

2017

Journal Article

D. Kotchuther Mathew, “ Lithium Induced Thyroiditis in a Subject Having Bipolar Affective Disorder”, 2017.

2017

Journal Article

D. Kotchuther Mathew, “ A Case Report of Phenytoin Toxicity in an Adolescent with Epilepsy Following Self Harm- Is Early Detection of Depression Imperative ?”, 2017.

2017

Journal Article

D. Prabhakaran, Anand, S., Watkins, D., Gaziano, T., Wu, Y., Mbanya, J. Claude, Nugent, R., Ajay, V. S., Afshin, A., Adler, A., Ali, M. K., Bateman, E., Bettger, J., Bonow, R. O., Brouwer, E., Bukhman, G., Bull, F., Burney, P., Capewell, S., Chan, J., Chandrasekar, E. K., Chen, J., Criqui, M. H., Dirks, J., Dugani, S. B., Engelgau, M., Nahas, M. El, Fall, C. H. D., Feigin, V., F Fowkes, G. R., Glassman, A., Goenka, S., Gupta, R., Hasan, B., Hersch, F., Hu, F., Huffman, M. D., Jabbour, S., Jarvis, D., Jeemon, P., Joshi, R., Kamano, J. H., Kengne, A. Pascal, Kudesia, P., R Krishna Kumar, Kumaran, K., Lambert, E. V., Lee, E. S., Li, C., Luo, R., Magee, M., Malik, V. S., J Marin-Neto, A., Marks, G., Mayosi, B., McGuire, H., Micha, R., J Miranda, J., Montoya, P. Aschner, Moran, A. E., Mozaffarian, D., Naicker, S., Naidoo, N. G., Narayan, K. M. Venkat, Nikolic, I., O'Donnell, M., Onen, C., Osmond, C., Patel, A., Perez-Padilla, R., Poulter, N., Pratt, M., Rabkin, M., Rajan, V., Rassi, A., Rassi, A., Rawal, I., Remuzzi, G., Riella, M., Roth, G. A., Roy, A., Rubinstein, A., Sakuma, Y., Sampson, U. K. A., Siegel, K. R., Sliwa, K., Suhrcke, M., Tandon, N., Thomas, B., Vaca, C., Vedanthan, R., Verguet, S., Webb, M., Weber, M. Beth, Whitsel, L., Wong, G., Yan, L. L., Yancy, C. W., Zhang, P., Zhao, D., and Zhu, Y., “Cardiovascular, Respiratory, and Related Disorders: key Messages from Disease Control Priorities, 3rd edition”, The Lancet, vol. 391, pp. 1224 - 1236, 2017.[Abstract]


Summary Cardiovascular, respiratory, and related disorders (CVRDs) are the leading causes of adult death worldwide, and substantial inequalities in care of patients with CVRDs exist between countries of high income and countries of low and middle income. Based on current trends, the UN Sustainable Development Goal to reduce premature mortality due to CVRDs by a third by 2030 will be challenging for many countries of low and middle income. We did systematic literature reviews of effectiveness and cost-effectiveness to identify priority interventions. We summarise the key findings and present a costed essential package of interventions to reduce risk of and manage CVRDs. On a population level, we recommend tobacco taxation, bans on trans fats, and compulsory reduction of salt in manufactured food products. We suggest primary health services be strengthened through the establishment of locally endorsed guidelines and ensured availability of essential medications. The policy interventions and health service delivery package we suggest could serve as the cornerstone for the management of CVRDs, and afford substantial financial risk protection for vulnerable households. We estimate that full implementation of the essential package would cost an additional US$21 per person in the average low-income country and $24 in the average lower-middle-income country. The essential package we describe could be a starting place for low-income and middle-income countries developing universal health coverage packages. Interventions could be rolled out as disease burden demands and budgets allow. Our outlined interventions provide a pathway for countries attempting to convert the UN Sustainable Development Goal commitments into tangible action.

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2017

Journal Article

L. Dandona, Dandona, R., G Kumar, A., Shukla, D. K., Paul, V. K., Balakrishnan, K., Prabhakaran, D., Tandon, N., Salvi, S., Dash, A. P., Nandakumar, A., Patel, V., Agarwal, S. K., Gupta, P. C., Dhaliwal, R. S., Mathur, P., Laxmaiah, A., Dhillon, P. K., Dey, S., Mathur, M. R., Afshin, A., Fitzmaurice, C., Gakidou, E., Gething, P., Hay, S. I., Kassebaum, N. J., Kyu, H., Lim, S. S., Naghavi, M., Roth, G. A., Stanaway, J. D., Whiteford, H., Chadha, V. K., Khaparde, S. D., Rao, R., Rade, K., Dewan, P., Furtado, M., Dutta, E., Varghese, C. M., Mehrotra, R., Jambulingam, P., Kaur, T., Sharma, M., Singh, S., Arora, R., Rasaily, R., Anjana, R. M., Mohan, V., Agrawal, A., Chopra, A., Mathew, A. J., Bhardwaj, D., Muraleedharan, P., Mutreja, P., Bienhoff, K., Glenn, S., Abdulkader, R. S., Aggarwal, A. N., Aggarwal, R., Albert, S., Ambekar, A., Arora, M., Bachani, D., Bavdekar, A., Beig, G., Bhansali, A., Bhargava, A., Bhatia, E., Camara, B., Christopher, D. J., Das, S. K., Dave, P. V., Dey, S., Ghoshal, A. G., Gopalakrishnan, N., Guleria, R., Gupta, R., Gupta, S. S., Gupta, T., Gupte, M. D., Gururaj, G., Harikrishnan, S., Iyer, V., Jain, S. K., Jeemon, P., Joshua, V., Kant, R., Kar, A., Kataki, A. C., Katoch, K., Khanna, T., Khera, A., Kinra, S., Koul, P. A., Krishnan, A., Kumar, A., Kumar, R. K., Kumar, R., Kurpad, A., Ladusingh, L., Lodha, R., Mahesh, P. A., Malhotra, R., Mathai, M., Mavalankar, D., BV, M. Mohan, Mukhopadhyay, S., Murhekar, M., Murthy, G. V. S., Nair, S., Nair, S. A., Nanda, L., Nongmaithem, R. S., Oommen, A. M., Pandian, J. D., Pandya, S., Parameswaran, S., Pati, S., Prasad, K., Prasad, N., Purwar, M., Rahim, A., Raju, S., Ramji, S., Rangaswamy, T., Rath, G. K., Roy, A., Sabde, Y., Sachdeva, K. S., Sadhu, H., Sagar, R., Sankar, M. J., Sharma, R., Shet, A., Shirude, S., Shukla, R., Shukla, S. R., Singh, G., Singh, N. P., Singh, V., Sinha, A., Sinha, D. N., Srivastava, R. K., Srividya, A., Suri, V., Swaminathan, R., Sylaja, P. N., Tandale, B., Thakur, J. S., Thankappan, K. R., Thomas, N., Tripathy, S., Varghese, M., Varughese, S., Venkatesh, S., Venugopal, K., Vijayakumar, L., Xavier, D., Yajnik, C. S., Zachariah, G., Zodpey, S., Rao, J. V. R. Prasad, Vos, T., K Reddy, S., Murray, C. J. L., and Swaminathan, S., “Nations Within a Nation: Variations in Epidemiological Transition Across the States of India, 1990–2016 in the Global Burden of Disease Study”, The Lancet, vol. 390, pp. 2437 - 2460, 2017.[Abstract]


Summary Background 18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016. Methods Using all available data sources, the India State-Level Disease Burden Initiative estimated burden (metrics were deaths, disability-adjusted life-years [DALYs], prevalence, incidence, and life expectancy) from 333 disease conditions and injuries and 84 risk factors for each state of India from 1990 to 2016 as part of GBD 2016. We divided the states of India into four epidemiological transition level (ETL) groups on the basis of the ratio of DALYs from communicable, maternal, neonatal, and nutritional diseases (CMNNDs) to those from non-communicable diseases (NCDs) and injuries combined in 2016. We assessed variations in the burden of diseases and risk factors between ETL state groups and between states to inform a more specific health-system response in the states and for India as a whole. Findings DALYs due to NCDs and injuries exceeded those due to CMNNDs in 2003 for India, but this transition had a range of 24 years for the four ETL state groups. The age-standardised DALY rate dropped by 36·2% in India from 1990 to 2016. The numbers of DALYs and DALY rates dropped substantially for most CMNNDs between 1990 and 2016 across all ETL groups, but rates of reduction for CMNNDs were slowest in the low ETL state group. By contrast, numbers of DALYs increased substantially for NCDs in all ETL state groups, and increased significantly for injuries in all ETL state groups except the highest. The all-age prevalence of most leading NCDs increased substantially in India from 1990 to 2016, and a modest decrease was recorded in the age-standardised NCD DALY rates. The major risk factors for NCDs, including high systolic blood pressure, high fasting plasma glucose, high total cholesterol, and high body-mass index, increased from 1990 to 2016, with generally higher levels in higher ETL states; ambient air pollution also increased and was highest in the low ETL group. The incidence rate of the leading causes of injuries also increased from 1990 to 2016. The five leading individual causes of DALYs in India in 2016 were ischaemic heart disease, chronic obstructive pulmonary disease, diarrhoeal diseases, lower respiratory infections, and cerebrovascular disease; and the five leading risk factors for DALYs in 2016 were child and maternal malnutrition, air pollution, dietary risks, high systolic blood pressure, and high fasting plasma glucose. Behind these broad trends many variations existed between the ETL state groups and between states within the ETL groups. Of the ten leading causes of disease burden in India in 2016, five causes had at least a five-times difference between the highest and lowest state-specific DALY rates for individual causes. Interpretation Per capita disease burden measured as DALY rate has dropped by about a third in India over the past 26 years. However, the magnitude and causes of disease burden and the risk factors vary greatly between the states. The change to dominance of NCDs and injuries over CMNNDs occurred about a quarter century apart in the four ETL state groups. Nevertheless, the burden of some of the leading CMNNDs continues to be very high, especially in the lowest ETL states. This comprehensive mapping of inequalities in disease burden and its causes across the states of India can be a crucial input for more specific health planning for each state as is envisioned by the Government of India's premier think tank, the National Institution for Transforming India, and the National Health Policy 2017. Funding Bill &amp; Melinda Gates Foundation; Indian Council of Medical Research, Department of Health Research, Ministry of Health and Family Welfare, Government of India; and World Bank

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2017

Journal Article

D. Abdul Maje K and K, D. Pavithran, “Bence Jones Myeloma- An Analysis of 28 Cases ”, IJSR - INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2017.

2017

Journal Article

A. Bhardwaj, .S, A., Vasudevan, S., Paul, N., and Vidyadha, G., “Prevalence of Anaemic Among Tribal Adolescent Girls Attending a Primary Care Facility ,Wayanad, Kerala”, 2017.

2017

Journal Article

D. Sruthi C. Babu, “Postoperative Ultrasound Guided Continuous Femoral Nerve Blockade for Unilateral Total Knee Arthroplasty: A Comparison of 0.125% Bupivacaine and 0.2% Ropivacaine”, Anesthesia Essays and Researches Anesth Essays Res, vol. 11, 2017.

2017

Journal Article

D. Sunil Rajan, “Effect of Inhaled Budesonide Suspension, Administered Using a Metered Dose Inhaler, on Post Operative Sore Throat, Hoarseness of Voice and Cough”, Indian Journal of Anaesthesia, 2017.

2017

Journal Article

A. R. Nair, Ahmed, S., Kunoor, A., Salam, B., Ponneduthamkuzhi, J. P., and Ajith, A. M., “Reliability of Overnight Desaturation Index (ODI)in Suspected Obstructive Sleep Apnea”, European Respiratory Journal, vol. 50, 2017.[Abstract]


Background: A full polysomnography (PSG) is the gold standard for diagnosis of obstructive sleep apnea(OSA) and provides comprehensive data on the sleep stages, efficiency, apnea, hypopnea events, and overnight oximetry during supervised overnight sleep study.Aims: Overnight desaturation index (ODI) is a surrogate marker for diagnosis of OSA and can be easily recorded using portable standalone overnight oximetry devices which are considerably inexpensive when compared to the full PSG. There is limited data on comparisons between AHI &amp; ODI. There is a need to find out if ODI is a reliable measure when compared to the AHI, to guide its use for first line screening in patients who attend the sleep service.Methods: The study was conducted in a tertiary care university hospital in South India. 250 consecutive patients who underwent 22-channel full PSG were included. All subjects were included after full clinical evaluation in a dedicated sleep clinic. Demographic data including comorbidities, AHI and ODI were compared.Results: Fifty four%(n=135)of subjects were obese with a mean AHI of 35.8 and 46%(n=115) were non obese with an AHI of 26.95 respectively. Underlying asthma was identified in 19.6%(n=49) and they had statistically higher AHI when compared to non asthmatics ( 42.1 vs 29.2, p0.005). There was a linear significant correlation between AHI &amp; ODI (r 0.83, p&lt;0.001) and agreement between the two as determined by single measure intra class coefficient(ICC) 0.81(0.76-0.85, p&lt;0.001)Conclusion: Overnight oximetry based surrogates (ODI) have the potential for use as reliable first line screening tool in OSA

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2017

Journal Article

S. H. Advani, Malhotra, H., Chacko, R. Titus, Basade, M., Keechilat, P., Mahapatra, P. N., Goswami, C., Sahoo, T. P., and Shah, C., “ Advanced Therapeutic Options and Importance of Rebiopsy in Epidermal Growth factor Receptor‑Tyrosine Kinase Inhibitor‑Progressed Nonsmall Cell Lung Carcinoma Patients: An Expert Opinion”, Indian Journal of Cancer, 2017.

2017

Journal Article

N. Haridas, “Yooung Man with Non Resolving Pneumonia”, Egyptian journal of bronchology, 2017.

2017

Journal Article

D. .Rakesh.P.S, “Prevalence of Bronchial Asthma and Factors Associated with it Among Higher Secondary School Children in Ernakulam District, Kerala”, J Family Med Prim Care, vol. 6, no. 2, pp. 311-315, 2017.

2017

Journal Article

D. Leyanna Su George, “Morbidity Pattern and Socio Demographic Determinants Among Elderly Population of Raichur Dist, Karnataka, India”, 2017.

2017

Journal Article

D. R. P.S, “Outcome of Patients with TB Treated with Individualised Regiment from a Territory Care in India”, 2017.

2017

Journal Article

D. Kesavankut Nayar, “ A STUDY ON FIXED DOSE COMBINATIONS ( FDCS) AND RELATED ISSUES AND PROBLEMS IN INDIA”, 2017.

2017

Journal Article

G. K, Sandeep, S., Z, P., A, M., G, K., and R, N., “Profile of Pediatric Kidney Transplantation at a Tertiary Care Centre in Southern India”, J Ped. Nephrology , 2017.

2017

Journal Article

R. Abraham, Sreedharan, S., Paul, Z., Anil Mathew, Kurian, G., and Nair, R. R., “Structural and Functional Changes in the Heart in Patients with Chronic Kidney Disease on Hemodialysis”, Urology Nephrology Andrology International , vol. 2, no. 1, pp. 17-20, 2017.[Abstract]


Osteoarthrosis incidence among subjects above 65 is 60-70%, and arterial hypertension in the same age-related group occurs in 50% of the subjects. But the severity of arterial hypertension is determined not only by the degree of arterial pressure increase. Early diagnostics of disordering the structure and function of target organs, and, first of all, those of the heart is one of the important moments. 50 patients at the age above 50 with the knee and the hip osteoarthrosis have been examined. All of them had associated arterial hypertension of II-III stage. The patients were divided into groups depending on their age. ECG- and EchoCG-examination was performed in all of them. Left vetricular remodeling and hypertrophy progressing with age were observed in 82 % of cases. The higher values of wall thickness, myocardium mass, and myocardium mass index of the left ventricle, as well as the decreased values of ejection fraction and fractional shortening were observed in patients with the heart geometry changed in comparison with the patients with the heart normal geometry. High percentage of revealing the diastolic function disorder of both the left and the right ventricles was observed in all the groups.

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2017

Journal Article

A. K, Sreedharan, S., Nair, S. S., Paul, Z., Anil Mathew, Kurian, G., and Nair, R. R., “Comparison of Adequacy of Hemodialysis in Patients with Dual lumen Tunneled Catheter and Arteriovenous Fistula”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. Sreedharan, Anil Mathew, Paul, Z., Kurian, G., and Nair, R. R., “Changes In Left Ventricular Mass And Cardiac Function After Kidney Transplantation”, International Journal of Organ Transplantation Medicine, 2017.

2017

Journal Article

K. Ganesh, Nair, R. R., Seethalekshmy, N. V., Kurian, G., Mathew, A., Sreedharan, S., and Paul, Z., “A Study of Clinical Presentation and Correlative Histopathological Patterns in Renal Parenchymal Disease”, Indian Journal of Nephrology , 2017.[Abstract]


Suspicion and subsequent detection of renal disease is by an assessment of the urinalysis and renal function in the clinical context. Our attempt in this study is to correlate initial presenting features of urinalysis and renal function to the final histopathological diagnosis. A retrospective analysis of 1059 native kidney biopsies performed from January 2002 to June 2015 at Amrita Institute of Medical Sciences was conducted. Correlative patterns between urinalysis, renal function, and final histopathological diagnosis were studied. Five hundred and eleven (48%) patients had nephrotic syndrome. Out of these, 193 (38%) had pure: nephrotic syndrome, 181 (35.8%) had associated microhematuria, 110 (21.7%) had microhematuria and renal failure, and 27 (5.3%) had only associated renal failure. Minimal change disease (MCD) (30%), membranous nephropathy (30%), and IgA nephropathy (29%) were the major diseases in the respective groups. Five hundred and five (47.6%) patients had subnephrotic proteinuria. Out of these, 29 (5.6%) had only subnephrotic proteinuria, 134 (27%) had additional microhematuria, 300 (59%) had subnephrotic proteinuria, microhematuria, and renal failure, and 42 (8%) had subnephrotic proteinuria with renal failure. Lupus Nephritis (45% and 40%) and IgA Nephropathy (32% and 21%) were the major disorders in the subgroups respectively. Forty-two patients (3.7%) were biopsied for isolated renal failure with bland urinary sediment. Cast nephropathy and acute interstitial nephritis were the major diseases. Out of 89 patients with diabetes who were biopsied, 15 (16.8%) had diabetic nephropathy, 45 (50.5%) had no diabetic nephropathy, and 29 (32.5%) had diabetic nephropathy along with a non-diabetic renal disease. Postinfectious glomerulonephritis was the major glomerular disease. IgA nephropathy (22.2%) and membranous nephropathy (15.5%) were the major diseases in patients with diabetes with no diabetic nephropathy. In our population, MCD and membranous nephropathy formed the majority of diseases in biopsied nephrotic syndrome. Added microhematuria did not seem to decrease the incidence of either disease on the whole. We found a significant number of patients with membranous nephropathy with nephrotic syndrome, microhematuria, and additional renal failure. IgA nephropathy formed a majority of cases with nephrotic syndrome, microhematuria, and renal failure. The presence of renal failure regardless of other abnormalities in urinalysis showed a trend toward IgA nephropathy. Membranous nephropathy may have a more varied presentation than was originally thought and IgA nephropathy presenting as nephrotic syndrome may not be uncommon. MCD is the major subgroup of diseases in the pediatric population and presents both as nephrotic syndrome as well as nephrotic syndrome with microhematuria. Thus, urinalysis and renal failure may be a valuable tool in assessing renal disease.

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2017

Journal Article

M. Venkatesan, Sekhar, S., Nair, R., Kurian, G., Anil Mathew, Sreedharan, S., Paul, Z., and Joshy, P., “Role of Urinary NGAL at 4 Hours PostCoronary Angioplasty in Detecting Contrast Induced Acute Kidney Injury. Cardiorenal Medicine”, Cardiorenal Medicine , 2017.

2017

Journal Article

T. Joseph, “Prevalence of Tuberculosis Among Community Acquired Pneumonia Diagnosed Patients ”, Journal of Pulmonary and Respiratory Medicine , 2017.

2017

Journal Article

T. Joseph, Nair, S., and P.T., J., “Clinical-Radiaological , Pathological Profile and Treatment Outcome of Patients with Haemoptysis”, Journal of Pulmonary and Respiratory Medicine , 2017.

2017

Journal Article

S. Krishna, “Prevalence of Dermatological Problems in Indian Geriatric Population ”, Amrita Journal of Medicine, 2017.

2017

Journal Article

R. Raj, “Percentage Comparison and Evaluation of Curve of Spee and Overbite Among Class II division 1 and Class I Malocclusion Group”, Amrita Journal of Medicine. , 2017.

2017

Journal Article

U. K. Menon, “Perceptions of Students Towards a Change of Pattern in the Otorhinolaryngology (ENT) Question Paper”, Amrita Journal of Medicine, 2017.

2017

Journal Article

R. Rajagopal, “Comparison of 3% Hypertonic Saline with 20% Mannitol on Water - Electrolyte Balance and Brain Relaxation During Elective Supratentorial Tumour Surgeries ”, Amrita Journal of Medicine, 2017.

2017

Journal Article

B. Prasad S, “Factors Determining Immediate Mortality In Hospitalised Patients Suffering Cardio pulmonary Arrest – Observations From A Tertiary Care Center”, Amrita Journal of Medicine., 2017.

2017

Journal Article

F. Ali A. A, “Treatment Outcomes of Bicondylar Tibial Plateau Fractures by Hybrid Fixator and with open Reduction and Internal Fixation”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. Nair, “Myxoedema Madness”, Amrita Journal of Medicine, 2017.

2017

Journal Article

J. V. Chimmen, “Primary Urachal Mucinous Adenocarcinoma of the Urinary Bladder”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. Sasidharan, “Screening Tools for Assessment of Early Changes of Retinal Toxicity in Patients on Hydroxychloroquine Therapy”, Amrita Journal of Medicine, 2017.

2017

Journal Article

V. G, “A Prospective Comparative Study on the Outcome of Treatment with Gabapentin and Oxcarbazepine in Patients with Neuropathic Pain Due to Lumbosacral Radiculopathy”, Amrita Journal of Medicine, 2017.

2017

Journal Article

N. M, “Mortality Predictors In Acute Coronary Syndrome Induced Ventricular Arrhthymias”, Amrita Journal of Medicine, 2017.

2017

Journal Article

R. R, “Study of Accuracy of Clinical Examination in Comparison with MR Fistulogram in Fistula in Ano”, Amrita Journal of Medicine, 2017.

2017

Journal Article

R. A. K, “Outcome and Predictors of Outcome in Patients with Pathological Node Negative Status of Breast Carcinoma”, Amrita Journal of Medicine, 2017.

2017

Journal Article

V. Krishna S, “Clinical Spectrum of Lung Cancer and its Association with Smoking Habit”, Amrita Journal of Medicine., 2017.

2017

Journal Article

R. M. V, “A Study of Hand Deformities in Rheumatoid Arthritis”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. M Sankari, “Evaluation of Second Trimester Uterine Artery Doppler in Prognosticating the Outcome of Pregnancy”, Amrita Journal of Medicine, 2017.

2017

Journal Article

K. Nayar, “Urinary Retention Associated With Amisulpride”, Amrita Journal of Medicine, 2017.

2017

Journal Article

K. K. V, “Ergonomics in Dentistry”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. Haridasan, “A Prospective Randomized Cohort Study Compairing the Use of Topical Anaesthesia with Intracameral Lignocaine Versus Peribulbar Anaesthesia in Small Incision Cataract Surgery- A Surgeons View Point”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. Sharma, “Isolation and Quantitative Standardisation of Adipose Derived Stem Cells (ADSCs) in Stromal Vascular Fraction (SVF) for Improving Fat Graft Viability in Humans”, Amrita Journal of Medicine, 2017.

2017

Journal Article

H. Rao B, “Utility of Acoustic Radiation Force Impulse (ARFI) Imaging of Liver and Spleen in Predicting the Variceal Status in Chronic Liver Disease”, Amrita Journal of Medicine, 2017.

2017

Journal Article

R. Sudevan, “Sex Based Differences in Barriers to Health Care Seeking Behaviour and Treatment After Acute Myocardial Infarction Among Patients Attending a Tertiary Care Hospital”, Amrita Journal of Medicine, 2017.

2017

Journal Article

V. S. P, “Clinical Profile of Interstitial Lung Diseases at a Tertiary Referral Centre in South India”, Amrita Journal of Medicine, 2017.

2017

Journal Article

M. Rajagopal, “Effectiveness of Jacobson’s Progressive Muscle Relaxation (JPMR) on Hypertension among School going Adolescents”, Amrita Journal of Medicine, 2017.

2017

Journal Article

M. Shafiq U, “Procalcitonin Levels in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Admitted to the Hospital”, Amrita Journal of Medicine., 2017.

2017

Journal Article

S. M, “A Study of Psychiatric Comorbidities and Executive Function- Deficits in First Degree Relatives of Alcoholics”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. Narayanamoorthy, “Evaluation of Mid-trimester Amniocentesis Markers with Obstetric Outcomes”, Amrita Journal of Medicine., 2017.

2017

Journal Article

A. B, “Establishment of Reference Ranges of Hematological Parameters In a Tertiary Care Center”, Amrita Journal of Medicine, 2017.

2017

Journal Article

C. Anuj Singhal, “To Study The Prevalence of Various Risk Factors for OSA and Their Correlation With Severity of OSA in Indian Urban Population”, Amrita Journal of Medicine, 2017.

2017

Journal Article

A. Rajeev, “The study of incidence of post operative delirium in sensory impaired patients undergoing coronary artery bypass grafting procedure in a tertiary care hospital”, Amrita Journal of Medicine, 2017.

2017

Journal Article

A. A, “Common Errors of Insulin Injection in Patients with Diabetes”, Amrita Journal of Medicine, 2017.

2017

Journal Article

R. Savalgi, “Organic or Steroid-induced Mania with Psychotic Symptoms”, Amrita Journal of Medicine, 2017.

2017

Journal Article

Z. Mohamed, “Unrecognised Transfixion of Colon During Percutaneous Endoscopic Gastrostomy”, Amrita Journal of Medicine, 2017.

2017

Journal Article

J. Chandrasekhar, Varghese, T. Panikasser, Gopi, A., raj, M., Sudevan, R., and Jayakumar, H., “Treatment Effect of Probiotic Bacillus Clausii on Neonatal Jaundice in Late Preterm and Term Newborn Babies: An Experimental Study”, Pediatrics & Therapeutics, 2017.

2017

Journal Article

N. Sidharthan, Joseph, M. Varsha, Georgy, S. Ann, S, P., ,, ,, Sudevan, R., and Vijayakumar, G., “Clinical Profile and Treatment of Primary Myelofibrosis - An Observational study from a tertiary care centre in Kerala, South India”, Amrita Journal of Medicine, 2017.

2017

Journal Article

V. Nambiar, Das, J. S., MaryPhilip, J., RachelVargheese, D., AlexanderFernandez, A., P, U., .S, D. T., Sudevan, R., raj, M., Ajai, A., and Pulickal, G., “Age Influence on Clinical Profile and Outcome of Stroke –A Hospital Based Cohort Study from aComprehensive Stroke Care Centre in Kerala, South India ”, Amrita Journal of Medicine. , 2017.

2017

Journal Article

, Sudevan, R., and , “A Case Report on ALPS, An Experience from a Tertiary Care Centre”, Journal of pharmacy medicine, 2017.

2017

Journal Article

V. Anand Viswanathen, Sudevan, R., and Vijayakumar, G., “Need of Routine Upper GI Endoscopy in Renal Transplant Workup Patients in a Resource Limited Setting- A Cross Sectional Study from Kerala, South India”, Amrita Journal of Medicine, 2017.

2017

Journal Article

S. Ann Georgy, R, L., and Sudevan, R., “The Pattern of Antibiotic use in the Treatment of General Pediatric Conditions: A Descriptive Study from a Tertiary Care Centre, India”, Amrita Journal of Medicine, 2017.

2016

Journal Article

Ma Pillay, Yesodharan, Db, Narayanan, D. Lb, Jojo, Ac, Luiz, Nd, and Nampoothiri, Se, “Sirenomelia: Case reports and current concepts of pathogenesis”, Pediatric and Developmental Pathology, vol. 15, pp. 403-406, 2016.[Abstract]


We present 2 cases of sirenomelia and highlight the recent theories about its pathogenesis. Both cases had a large aberrant abdominal umbilical artery (AAUA) arising from the aorta, suggesting vascular steal as the pathophysiology. However, the bilateral upper limb defects noted in 1 case, the reported 10% association of holoprosencephaly and anencephaly, and the reports of sirenomelia with normal umbilical arteries point to the alternative caudal dysgenesis (CD) theory. This proposes that an insult at the early blastogenic stage interferes with the formation of the notochord, resulting in abnormal development of caudal structures, an AAUA, and occasional neural tube defects. We have also analyzed the implications of the similarities between sirenomelia/CD and the VATER association; the increased risk of CD but not sirenomelia in infants of diabetic mothers; the fact that sirenomelia, holoprosencephaly, and the VATER association are all more common in monozygotic twins; the experimental production of sirenomelia in mice; and the possible genetic implications of the co-occurrence of sirenomelia and CD. © 2012 Society for Pediatric Pathology.

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2016

Journal Article

J. M. Kanthi, Sumathy, S., Sreedhar, S., Rajammal, B., Usha, M. G., and Sheejamol, V. S., “Comparative Study of Cesarean Myomectomy with Abdominal Myomectomy in Terms of Blood Loss in Single Fibroid”, Journal of Obstetrics and Gynecology of India, vol. 66, pp. 287-291, 2016.[Abstract]


Objective: In this study, we evaluate the safety and feasibility of cesarean myomectomy and compare this procedure with abdominal myomectomy in single fibroid, in terms of blood loss and postoperative complications. Methods: Thirty-three patients who underwent cesarean myomectomy from June 2006 to 2012 in Amrita Institute of Medical Sciences, were included in the study. Almost an equal number of patients who underwent abdominal myomectomy (32) in the same period were included. Women are divided into two groups: group 1—cesarean myomectomy, group 2—abdominal myomectomy. Results: Mean age of the women was comparable; mean gestational age in group 1 was 37.97 +/− 1.57 weeks; and 60 % were primiparous. Hemoglobin (Hb) drop postoperatively was compared between the groups, and there was no significant difference. Though there was statistically significant difference among the groups regarding the size of fibroids, the main outcome measure of the study, the Hb drop was comparable between group 1 and 2. There is statistically significant difference in the Hb difference with increasing mean diameter of the fibroids. As the size increases, Hb drop also increases indicating the increasing blood loss. The measures used to reduce blood loss such as vasopressin instillation and stepwise devascularization influence the blood loss, and P value shows borderline significance. There was no difference in Hb drop among the groups according to the type of fibroids. But more subserous fibroids were removed in group 1, whereas more intramural fibroids were removed in group 2. Conclusion: Cesarean myomectomy can be safely done in single fibroids and is comparable to abdominal myomectomy in terms of blood loss. © 2015 Federation of Obstetric & Gynecological Societies of India

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2016

Journal Article

M. Chatterjee, Anju, C. P., Biswas, L., V. Kumar, A., Dr. Gopi Mohan C., and Biswas, R., “Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options”, International Journal of Medical Microbiology, vol. 306, pp. 48 - 58, 2016.[Abstract]


Pseudomonas aeruginosa is a leading cause of nosocomial infections and is responsible for ∼10% of all hospital-acquired infections worldwide. It continues to pose a therapeutic challenge because of the high rate of morbidity and mortality associated with it and the possibility of development of drug resistance during therapy. Standard antibiotic regimes against P. aeruginosa are increasingly becoming ineffective due to the rise in drug resistance. With the scope for developing new antibiotics being limited, alternative treatment options are gaining more and more attention. A number of recent studies reported complementary and alternative treatment options to combat P. aeruginosa infections. Quorum sensing inhibitors, phages, probiotics, anti-microbial peptides, vaccine antigens and antimicrobial nanoparticles have the potential to act against drug resistant strains. Unfortunately, most studies considering alternative treatment options are still confined in the pre-clinical stages, although some of these findings have tremendous potential to be turned into valuable therapeutics. This review is intended to raise awareness of several novel approaches that can be considered further for combating drug resistant P. aeruginosa infections. © 2015 Elsevier GmbH.

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2016

Journal Article

Chitra P. and Jeenu, K. M., “Perspectives of Strange Environmental Stressors among Hospitalized Children at AIMS, Kochi”, Indian Journal of Public Health Research & Development, vol. 7, pp. 266–270, 2016.[Abstract]


Introduction: Common fears of childhood which includes fear of separation, loss of control and bodily injury, mutilation or harm. Hospitalization does affect the child’s control over decisions related to his/her own body. Method: The qualitative approach, exploratory research design was chosen. The tools used were Dichotomous Questions, NAVAS (Noise Assessment Visual Analogue Scale), Photographs images, Rank Order and Forced Choice Questions. The study was conducted among 100 Hospitalized Children (HC) used non probability purposive sampling technique to select the children. Results: The children 49 of them had previous exposure and 51 of them were new experience of hospitalization. Researchers were asked the opinions about existing ventilation, all (100)of them preferred open ventilation in day time but nearly half of them (52) liked closed ventilation in night. Perspectives of Strange Environmental Stressors (SES)was assessed by the use of selected photographs images - to choose in color of the unit, bedding, uniform and light set up. Most of them have chosen blue color is their favorite. Procedure room and indoor play room they have selected fantasyimagery. Hospitalequipments, supplies and utensils they have chosen fashionable, picturized items. A question was asked regarding what causes fear and stress during their hospitalization, majority of them reported such a manner, afraid of strange of any equipment’s, threatened pain in invasive procedures, scared in white uniform nurses talk and touch. Conclusion: The study findings revealed that, children’s perspectives is different, and too depth to visualize in each and everything. Especially where they spend time even if it is hospital, they are expecting fantasy environment they didn’t think as adult about the importance of hospital, treatment, health..

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2016

Journal Article

S. Rajan, Paul, J., and Kumar, L., “Spontaneous Repositioning of a Malpositioned Peripherally Inserted Central Catheter”, Indian Journal of Anaesthesia, vol. 60, pp. 148-149, 2016.

2016

Journal Article

Dr. Asha J. Mathew, Dr. Geetha S.G., and Sukumaran, T. T., “A study of the supratrochlear foramen of the humerus: Anatomical and clinical perspective”, Journal of Clinical and Diagnostic Research, vol. 10, pp. AC05-AC08, 2016.[Abstract]


Introduction: The Supratrochlear Foramen (STF) is a variably shaped perforation present in the bony septum that separates the olecranon and coronoid fossae at the distal end of the humerus, between the two epicondyles. Its incidence varies widely from 0.3% to 58% in different races. Aim: This study aims to describe its prevalence and morphometry in relation to its shape and size and distance from the epicondyles. Materials and Methods: A prospective study of 244 unpaired humerii, 130 of the left side and 114 of the right side of unknown age and sex were examined for the presence of STF and prevalence stated. The STF was classified according to shape and their metric assessment was carried out, along with measures of its distance from the epicodyles and trochlear margin. Results: Of the 244 humeri studied 60 showed presence of the foramen, 45 were opaque and 139 showed translucent septum. The sidewise prevalence of opacity, translucent septum and foraminae were tabulated. The commonest shape noted was oval. Other shapes such as round, triangular, rectangular, sieve and reniform were visualised. In the oval STF, transverse and vertical diameters were measured. The transverse and vertical diameters on the left were 4.9 and 3.27 mm and on the right it was 5.12 and 3.48mm respectively. The distance from the medial epicondyle, lateral epicondyle and trochlea to the STF margins was measured and the mean values were calculated separately for right and left sides. The mean diameter of the round foramen was 3.23 and 4.89mm for left and right sides respectively. In the triangular type the maximum vertical and transverse diameters were recorded. There was only one sample of the rectangular type. Its length was 4.1mm and the breadth was 2.27mm and it belonged to the right side. The reniform type totalled 7 of which 6 were of the left side. The average vertical length at the hilum was 4.52 mm and the transverse measurement was 7.44 mm. The foraminae of the right side were found to be larger, regardless of shape. Conclusion: Its existence is important to the orthopaedician in the preoperative planning of nailing fractures of the distal humerus and to the radiologist for differentiating it from an osteolytic or cystic lesion. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.

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2016

Journal Article

K. L, S, S., R, K., and N, M. R., “Simultaneous Pancreas–kidney Transplant for Type I Diabetes with Renal Failure: Anaesthetic Considerations”, Indian J Anaesth, vol. 60, no. 2, pp. 131 - 4, 2016.[Abstract]


Pancreatic grafts have been successfully used in patients with diabetes and are combined with kidney transplantation in patients with renal failure. The propagation of awareness in organ donation in India has increased the donor pool of transplantable organs in the last few years making multi visceral transplants feasible in our country. We present the anaesthetic management of a 32-year-old male with diabetes mellitus and end-stage renal failure who was successfully managed with a combined pancreas and kidney transplantation.

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2016

Journal Article

Dr. Chandrashekar Janakiram, Venkitachalam, R., and Joseph, J., “Profile of Institutional Ethics Committees in Dental Teaching Institutions in Kerala, India”, Accountability in Research, vol. 23, pp. 219-229, 2016.[Abstract]


<p>Objectives: To assess the existence, structure, and functioning of Institutional Ethics Committees (IECs) in dental teaching institutions in Kerala. Methodology: A cross-sectional questionnaire-based survey was conducted by personally approaching Heads of Institutions/Ethics Committee (EC) in-charge of all dental colleges (23) in Kerala. The validated questionnaire consisted of two parts. The first part pertained to details of institutions, and the second part assessed the structure and functioning of the IEC. The data obtained was tabulated and analyzed using descriptive statistics. Results: Of the participating 17 colleges, 13 colleges had a functioning IEC. Only four of these IECs were accredited to a central agency. Only one among the 12 colleges completely adhered to recommended structure. Regarding the functioning of IECs, 69% of the IECs had neither a separate application form for ethical review of proposals nor a proforma for its evaluation. On average, more than ten proposals were reviewed in a single EC meeting in 54% of the colleges. Nearly 40% of the IECs had no representation of a lay person. Conclusion: The absence of IEC in four colleges and non-accreditation to a central agency was a matter of concern. Enforced accreditation is the need of the hour to ensure ethical protection to human participants. © 2016 Taylor &amp; Francis.</p>

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2016

Journal Article

Dr. Subramania Iyer K., Thankappan, K., and Balasubramanian, D., “Early detection of oral cancers: Current status and future prospects”, Current Opinion in Otolaryngology and Head and Neck Surgery, vol. 24, pp. 110-114, 2016.[Abstract]


Purpose of review: This article reviews the current literature and summarizes the latest developments in screening and early detection of oral cancers and looks at the future possibilities. Recent findings: Oral cancer is the best model for screening and prevention. The screening for oral cancer can be population based, opportunistic, or targeted. A long-term 15-year follow-up data of a randomized controlled study from a developing country setting indicated a sustained reduction in oral cancer mortality in high-risk individuals. Visual oral examination remains the mainstay in the screening. Several adjunctive techniques have been described to aid in the clinical examination of these lesions. A Cochrane review revealed that there is no evidence to recommend these adjuncts in clinically visible lesions. Salivary biomarkers seem to be promising as a tool for screening in the future. A Targeted Evidence Update for the US Preventive Services Task Force found no evidence on screening either in the general or selected high-risk population for oral cancer in the United States or on benefit of any adjunctive device affecting the performance of the screening examination. Summary: Current evidence shows that community based screening has a value in reducing the oral cancer mortality in high-risk group of population. But this evidence may not be universally applicable. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

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2016

Journal Article

S. Rajan, Paul, J., and Kumar, L., “Carbon dioxide embolism during endoscopic thyroidectomy”, Indian Journal of Anaesthesia, vol. 60, pp. 65-66, 2016.

2016

Journal Article

D. Joseph and Kumar, S., “Identifying clues to molecular etiology of multiple sclerosis in South Indian patients”, Multiple Sclerosis and Related Disorders, vol. 5, pp. 7-11, 2016.[Abstract]


Background: Environmental risk factors have a dominant role in the pathogenesis of multiple sclerosis (MS). Unhealthy lifestyle can predispose people to autoimmune diseases. MS was a rare disease in Kerala, but now, we notice frequent cases of MS at the city neurology clinic. Changing lifestyle and associated changes in the level of proinflammatory biomolecules like: leptin, soluble leptin receptor (SLR) and free fatty acids (FA) could be contributing to rise in MS incidence. Objective: To identify variations in the levels of bio-molecules: leptin, SLR and FA, between MS patients and matched healthy control. Method: Leptin and SLR levels in the blood serum, were estimated using ELISA, while total FA levels, were estimated using an enzyme based calorimetric assay. Result: Mean serum FA levels in MS patients (31.39±4.83 nmole/100 μl) were 2.7 fold higher than controls (11.54±2.66 nmoles/100 μl) at more than 99% CI. The differences in mean leptin and SLR levels were not statistically significant. Conclusion: MS patients had high level of total FA in their blood. High FA in blood may have a role in MS pathogenesis. More in-depth study is required to understand the precise mechanism by which FA rise in MS blood sample can contribute to pathogenesis. © 2015 Elsevier B.V. All rights reserved.

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2016

Journal Article

G. Madhu S, Emmanuel James, and Ramakrishna Venugopal, “Appropriateness of antibiotic usage for gastrointestinal disorders in a tertiary care hospital”, European Journal of Hospital Pharmacy, 2016.[Abstract]


Objective To assess antibiotic usage in gastrointestinal disorders with respect to appropriateness, pattern of resistance, and incidence of adverse drug reactions (ADRs).Methodology Antibiotic prescribing in the gastroenterology department of a tertiary care hospital was evaluated using the Gyssens criteria and also by assessing drug related problems (DRPs) using the Pharmaceutical Care Network Europe V.6.2. A total of 173 patients were studied prospectively by a team of clinical pharmacists. Antibiotic susceptibility was prospectively studied; in addition, retrospective data on culture and sensitivity reports of commonly isolated organisms from 1 October 2012 to 30 September 2014 were collected to determine the resistance pattern in previous years. ADRs were evaluated using the Naranjo scale.Results Antibiotic therapy was appropriate in 60% of patients and inappropriate in the remaining patients due to incorrect decision, choice, and use. A total of 184 DRPs and 30 ADRs of antibiotics were identified. In the study patients, the most commonly isolated organism was Escherichia coli (27.3%) followed by Klebsiella pneumoniae (16.7%). Both E coli and K pneumoniae exhibited 100% resistance towards cefotaxime. There was an increase in the resistance of E coli and K pneumoniae against various antibiotics tested in 2013–2014 as compared to the previous year. An empirical antibiotic policy was developed which was endorsed by the gastroenterology department.Conclusions Although antibiotic therapy was appropriate in the majority of patients, irrational use occurred due to incorrect choice, improper dosage, and improper duration of therapy. E coli and K pneumoniae isolates showed an increase in resistance towards various antibiotics tested.

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2016

Journal Article

M. Vijayakumar, Vasudevan, D. M., Sundaram, K. R., Krishnan, S., Vaidyanathan, K., Nandakumar, S., Chandrasekhar, iv, R., and Mathew, N., “A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease”, Indian Heart Journal, 2016.[Abstract]


Coronary artery disease (CAD) and its pathological atherosclerotic process are closely related to lipids. Lipids levels are in turn influenced by dietary oils and fats. Saturated fatty acids increase the risk for atherosclerosis by increasing the cholesterol level. This study was conducted to investigate the impact of cooking oil media (coconut oil and sunflower oil) on lipid profile, antioxidant mechanism, and endothelial function in patients with established CAD. More »»

2016

Journal Article

A. Pillai, “Gamma Knife Surgery for Metastatic Brain Tumors from Gynecologic Cancer: Time for What Saves Time, Grants Time, and Is Tested By Time?”, World Neurosurg, vol. 91, pp. 597-9, 2016.

2016

Journal Article

V. Vijan, Vupputuri, A., and Nair, iv, R. Chandrasek, “An Unusual Case of Biatrial Myxoma in a Young Female”, Case Reports in Cardiology, vol. 2016, 2016.[Abstract]


Myxoma, a rare type of intracardiac tumor, forms a very small percentage of the cardiac cases. Reports of biatrial myxoma are rarer, with cases of single tumor reaching both atria being more common. Here, we present an unusual case of two independently growing atrial myxoma in a 29-year-old female. We emphasize that early recognition of symptoms, confirmation of diagnosis by transesophageal echocardiography, and prompt surgical excision remain vital in the management of such patients. The patient in the present case was managed successfully with no evidences of recurrence at the last follow-up.

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2016

Journal Article

M. Pillay, Ramakrishnan, S., and Mayilswamy, M., “Two Cases of Rectus Sternalis Muscle”, Journal of Clinical and Diagnostic Research, vol. 10, pp. AD01-AD03, 2016.[Abstract]


The sternalis muscle, an uncommon anatomical variant of the chest wall musculature, though perhaps well known to anatomists, is quite unfamiliar to clinicians and radiologists despite attempts to highlight its clinical importance in recent years. During routine dissection for undergraduate medical teaching, in the department of anatomy, we came across two cases of sternalis muscle. The first was a unique case of unilateral right sternalis with contralateral insertion on the left sternocleidomastoid, and the second case where bilateral presence of the muscle was noted with ipsilateral insertion. The former was supplied by medial pectoral nerve and the latter by lower intercostal nerves. Usually present between the pectoral and superficial fasciae, wide ranging prevalence and morphology have been attributed to this muscular variant. Opinions differ on its development and nerve supply. Its presence can be misdiagnosed as a wide range of benign and malignant anterior chest wall lesions and tumours, but it is also of great use as a pedicle flap or flap microvascular anastomosis in reconstructive surgeries of anterior chest wall, head and neck and breast. In this paper, two cases of sternalis muscle which presented very differently from each other are discussed. © 2015, Journal of Clinical and Diagnostic Research. All rights Reserved.

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2016

Journal Article

L. Kumar, Ramamurthi, P., Rajan, S., and S. Surendran, “Post–Operative Myocardial Infarction Complicating Donor Hepatectomy: Implications for Donor Safety”, Indian Journal of Anaesthesia, vol. 60, pp. 433-435, 2016.

2016

Journal Article

S. Va Nair, Baranwal, Ga, Chatterjee, Ma, Sachu, Ac, Dr. Anil Kumar V., Bose, C., Dr. Asoke Banerji, and Dr. Raja Biswas, “Antimicrobial activity of plumbagin, a naturally occurring naphthoquinone from Plumbago rosea, against Staphylococcus aureus and Candida albicans”, International Journal of Medical Microbiology, vol. 306, pp. 237-248, 2016.[Abstract]


Candida albicans and Staphylococcus aureus are opportunistic pathogens. Despite causing a number of independent infections, both pathogens can co-infect to cause urinary tract infections, skin infections, biofilm associated infections, sepsis and pneumonia. Infections of these two pathogens especially their biofilm associated infections are often difficult to treat using currently available anti-bacterial and anti-fungal agents. In order to identify a common anti-microbial agent which could confer a broad range of protection against their infections, we screened several phytochemicals and identified plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a phytochemical from Plumbago species as a potent antimicrobial agent against S. aureus and C. albicans, with a minimum inhibitory concentration of 5 μg/ml. Antimicrobial activity of plumbagin was validated using an ex-vivo porcine skin model. For better understanding of the antimicrobial activity of plumbagin, a Drosophila melanogaster infection model was used, where D. melanogaster was infected using S. aureus and C. albicans, or with both organisms. The fly's survival rate was dramatically increased when infected flies were treated using plumbagin. Further, plumbagin was effective in preventing and dispersing catheter associated biofilms formed by these pathogens. The overall results of this work provides evidence that plumbagin, possesses an excellent antimicrobial activity which should be explored further for the treatment of S. aureus and C. albicans infections. © 2016 Elsevier GmbH.

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2016

Journal Article

Ja Toledo, George, Lb, Martinez, Ec, Lazaro, Ad, Han, W. We, Coelho, G. Ef, Ranzinger, SgRunge, and Horstick, Oh, “Relevance of Non-communicable Comorbidities for the Development of the Severe Forms of Dengue: A Systematic Literature Review”, PLoS Neglected Tropical Diseases, vol. 10, 2016.[Abstract]


Patients with dengue fever and comorbidities seem to be at higher risk of developing complications and/or severe dengue compared to healthier individuals. This study systematically reviews the evidence related to comorbidities and dengue. A systematic literature review was performed in five databases (EMBASE, PUBMED, Global Health, SciELO, Cochrane) and grey literature for full-text articles since its inceptions until October 10, 2015. A total of 230 articles were retrieved. Sixteen studies were analysed after applying all inclusion and exclusion criteria. Seven case control studies and nine retrospective cohort studies showed that comorbidities may contribute to severe dengue, especially 1) cardiovascular disease, 2) stroke, 3) diabetes, 4) respiratory disease and 5) renal disease, as well as old age. However, due to heterogeneity in studies, the real estimate effect of comorbidities as modifiers of dengue severity could not be established. Further research in regions with high prevalence of dengue infection would contribute to a better understanding of the relevance of comorbidities in severe dengue, especially with a standardised protocol, for outcomes, specific comorbidities, study design—best using prospective designs—and sample sizes.

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2016

Journal Article

Dr. Suhas Udayakumaran and Onyia, C. U., “Customizable rigid head fixation for infants: technical note.”, Childs Nerv Syst, vol. 32, no. 1, pp. 159-61, 2016.[Abstract]


<p><b>INTRODUCTION: </b>The need and advantages of rigid fixation of the head in cranial surgeries are well documented (Berryhill et al., Otolaryngol Head Neck Surg 121:269-273, 1999). Head fixation for neurosurgical procedures in infants and in early years has been a challenge and is fraught with risk. Despite the fact that pediatric pins are designed, rigid head fixation involving direct application of pins to the head of infants and slightly older children is still generally not safe (Agrawal and Steinbok, Childs Nerv Syst 22:1473-1474, 2006). Yet, there are some surgeries in which some form of rigid fixation is required (Agrawal and Steinbok, Childs Nerv Syst 22:1473-1474, 2006). We describe a simple technique to achieve rigid fixation of the head in infants for neurosurgical procedures.</p><p><b>TECHNICAL NOTE: </b>This involves applying a head band made of Plaster of Paris (POP) around the head and then applying the fixation pins of the fixation frame directly on to the POP.</p><p><b>CONCLUSION: </b>We have used this technique of head fixation successfully for infants with no complications.</p>

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2016

Journal Article

A. Christabel, Anantanarayanan, P., Subash, P., Soh, C. L., Ramanathan, M., Muthusekhar, M. R., and Narayanan, V., “Comparison of pterygomaxillary dysjunction with tuberosity separation in isolated Le Fort I osteotomies: a prospective, multi-centre, triple-blind, randomized controlled trial.”, Int J Oral Maxillofac Surg, vol. 45, no. 2, pp. 180-5, 2016.[Abstract]


<p>The aim of this trial was to compare two techniques of maxillary dysjunction, with 10mg/kg tranexamic acid as an adjuvant, in isolated non-segmented Le Fort I procedures. Two hundred patients were randomized to one of four groups: group A, pterygomaxillary dysjunction+saline; group B, tuberosity separation+saline; group C, pterygomaxillary dysjunction+tranexamic acid; and group D, tuberosity separation+tranexamic acid. Primary outcome measures were intraoperative blood loss and operating time, while the secondary outcome measures were surgical field assessment, need for blood transfusion, and duration of hospitalization. The data were analyzed using one-way analysis of variance (SPSS v. 17.0), and the level of significance was set at P<0.05. Results revealed that group D (tuberosity separation+tranexamic acid) had the least blood loss (mean 172 ml) and shortest operating times (mean 49 min), with the best surgical field. This group also exhibited the lowest drop in postoperative haemoglobin concentration (Hbgm/dl) and packed cell volume (PCV). Five patients, all in group A, required a blood transfusion and had an extra 24h of hospitalization. This trial revealed that the tuberosity separation technique with the use of tranexamic acid was the best protocol in producing the least blood loss, minimizing the operating time, and providing the best surgical field.</p>

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2016

Journal Article

M. John Kuzhimattam and Krishnakumar, R., “Naked facet sign in a case of traumatic injury to the thoracic vertebra.”, Spine J, vol. 16, no. 2, pp. e37-8, 2016.

2016

Journal Article

A. Prakash, Sharma, C., Singh, A., P Singh, K., Kumar, A., Hagen, F., Govender, N. P., Colombo, A. L., Meis, J. F., and Chowdhary, A., “Evidence of genotypic diversity among Candida auris isolates by multilocus sequence typing, matrix-assisted laser desorption ionization time-of-flight mass spectrometry and amplified fragment length polymorphism.”, Clin Microbiol Infect, vol. 22, no. 3, pp. 277.e1-9, 2016.[Abstract]


<p>Candida auris is a multidrug-resistant nosocomial bloodstream pathogen that has been reported from Asian countries and South Africa. Herein, we studied the population structure and genetic relatedness among 104 global C. auris isolates from India, South Africa and Brazil using multilocus sequence typing (MLST), amplified fragment length polymorphism (AFLP) fingerprinting and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). RPB1, RPB2 and internal transcribed spacer (ITS) and D1/D2 regions of the ribosomal DNA were sequenced for MLST. Further, genetic variation and proteomic assessment was carried out using AFLP and MALDI-TOF MS, respectively. Both MLST and AFLP typing clearly demarcated two major clusters comprising Indian and Brazilian isolates. However, the South African isolates were randomly distributed, suggesting different genotypes. MALDI-TOF MS spectral profiling also revealed evidence of geographical clustering but did not correlate fully with the genotyping methods. Notably, overall the population structure of C. auris showed evidence of geographical clustering by all the three techniques analysed. Antifungal susceptibility testing by the CLSI microbroth dilution method revealed that fluconazole had limited activity against 87% of isolates (MIC90, 64 mg/L). Also, MIC90 of AMB was 4 mg/L. Candida auris is emerging as an important yeast pathogen globally and requires reproducible laboratory methods for identification and typing. Evaluation of MALDI-TOF MS as a typing method for this yeast is warranted.</p>

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2016

Journal Article

R. Sankaran, Shah, R., Menon, S., and Pillai, A., “Congenital Subaxial Cervical Subluxation Presenting as a Bilateral Erb's Palsy: Surgical Management, Rehabilitation, and Outcome.”, Childs Nerv Syst, vol. 32, no. 5, pp. 849-55, 2016.[Abstract]


<p><b>INTRODUCTION: </b>Subaxial spine injuries during infancy are uncommon.</p><p><b>CASE REPORT: </b>We present the case of an infant referred to our brachial plexus clinic with proximal weakness of both arms noted immediately following a complicated breech delivery. Nerve conduction studies were consistent with bilateral proximal upper plexus injury; however, radiological evaluation revealed a C4-C5 subluxation and MRI features of bilateral C5 root avulsions. He was immobilized in a cervical-body orthosis and underwent open reduction and posterior C4-C5-C6 fixation at 10 weeks age using luque rods, sublaminar wires, and rib graft. The spine was immobilized in a custom molded cervicothoracic brace for a total of 3 months, and a home exercise program prescribed. Follow-up radiographic evaluation showed good posterior bony fusion by 2 months but persistent bilateral proximal upper limb weakness with reduced compound motor action potential (CMAP) amplitudes of the axillary and musculocutaneous nerves. Bilateral supraclavicular exploration and C5 root neurotization using the ipsilateral C7 nerve roots were performed at 7 months of age. Voluntary biceps activity followed by voluntary external rotation with gravity eliminated was noted within the next 2-3 months. He progressed to develop near normal motor control of bilateral upper limbs within 1 year.</p><p><b>CONCLUSIONS: </b>We wish to report this rare entity and our favorable outcome using a strategy of early spinal stabilization and neurotization repair to restore function following proximal nerve root injury.</p>

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2016

Journal Article

V. M Priya, Dr. Sabitha M., and Dr. Jayakumar Rangasamy, “Colloidal chitin nanogels: A plethora of applications under one shell.”, Carbohydr Polym, vol. 136, pp. 609-17, 2016.[Abstract]


Chitin nanogels (CNGs) are a relatively new class of natural polymeric nanomaterials which have a large potential in the field of drug delivery and nanotherapeutics. These nanogels being very biocompatible are non-toxic when internalized by cells. In this review various properties, preparation techniques and applications of CNGs have been described. CNGs because of their nano-size possess certain unique properties which enable them to be used in a number of biomedical applications. CNGs are prepared by simple regeneration technique without using any cross-linkers. Various polymers, drugs and fluorescent dyes can be blended or incorporated or labelled with the chitin hydrogel network. Drugs and molecules encapsulated within CNGs can be used for targeted delivery, in vivo monitoring or even for therapeutic purposes. Here various applications of CNGs in the field of drug delivery, imaging, sensing and therapeutics have been discussed.

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2016

Journal Article

R. Gupta, Gupta, N., Dr. Sheela Nampoothiri, Mandal, K., Kishore, Y., Sharma, P., Kabra, M., and Phadke, S. R., “Smith-Magenis Syndrome: Face Speaks.”, Indian J Pediatr, vol. 83, no. 6, pp. 589-93, 2016.[Abstract]


<p>Smith-Magenis syndrome is a well delineated microdeletion syndrome with characteristic facial and behavioral phenotype. With the availability of the multi-targeted molecular cytogenetic techniques like Multiplex Ligation Probe Amplification and cytogenetic microarray, the cases are diagnosed even without clinical suspicion. Here, the authors present clinical features of nine Indian cases of Smith-Magenis syndrome. Characteristic facial phenotype including tented upper lip, broad forehead, midface hypoplasia, short philtrum and upslant of palpebral fissure is obvious in the photographs. The behavioral variations were seen in some of the cases but were not the presenting features. The characteristic facial phenotype can be an important clinical guide to the diagnosis.</p>

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2016

Journal Article

S. Balan, “Approach to Joint Pain in Children.”, Indian J Pediatr, vol. 83, no. 2, pp. 135-9, 2016.[Abstract]


It is not uncommon in pediatric clinical practice to encounter children with musculoskeletal symptoms. A number of disparate conditions can present with joint complaints in children. In this article, the author describes the clinical approach to a child presenting with joint complaints. A detailed clinical history, including the family history, along with a complete physical examination can provide vital clues to the underlying condition in most cases. A structured screening examination of the musculoskeletal system that has been recently developed (i.e., pGALS) is also discussed. It is also pointed out that the pattern of joint involvement gives us one of the most important clues to the etiology of arthritis. The pediatrician has to be aware of the conditions that can have arthritis as one of the manifestations so as to investigate and treat the child accordingly.

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2016

Journal Article

J. Urquhart, Roberts, R., de Silva, D., Shalev, S., Chervinsky, E., Dr. Sheela Nampoothiri, Sznajer, Y., Revencu, N., Gunasekera, R., Suri, M., Ellingford, J., Williams, S., Bhaskar, S., and Clayton-Smith, J., “Exploring the genetic basis of 3MC syndrome: Findings in 12 further families.”, Am J Med Genet A, vol. 170A, no. 5, pp. 1216-24, 2016.[Abstract]


<p>The 3MC syndromes are a group of rare autosomal recessive disorders where the main clinical features are cleft lip and palate, hypertelorism, highly arched eyebrows, caudal appendage, postnatal growth deficiency, and genitourinary tract anomalies. Ophthalmological abnormalities, most notably anterior chamber defects may also be seen. We describe the clinical and molecular findings in 13 individuals with suspected 3MC syndrome from 12 previously unreported families. The exclusion of the MASP1 and COLEC11 Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome.</p>

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2016

Journal Article

P. Sethi, Balakrishnan, D., Surendran, S., and Mohamed, Z. Umer, “Fulminant zygomycosis of graft liver following liver transplantation.”, BMJ Case Rep, vol. 2016, 2016.[Abstract]


<p>A 44-year-old man with hepatitis B virus (HBV)-related cirrhosis underwent living donor liver transplantation at our institute. Induction of immunosuppression was achieved with basiliximab, due to deranged renal function, and maintained with prednisolone, tacrolimus and mycophenolate mofetil. The intraoperative and immediate postoperative periods were fairly uneventful. A duplex scan, taken during the third week post-transplantation due to sudden rise in liver enzymes, revealed multifocal hypoechoic lesions in the graft liver with normal Doppler parameters. Multidetecor computed tomography (MDCT) showed multiple hypodense vessel-sparing lesions in the graft liver. Cultures from the aspirate grew filamentous fungi identified as Basidiobolus ranarum species. Despite multiple broad spectrum antifungal infusions including liposomal amphotericin, itraconazole, caspofungin and posaconazole, serial sonography showed the hepatic lesions increasing in size, and involving segments V, VI and VII. The patient developed severe liver dysfunction ultimately progressing to sepsis, multiorgan dysfunction and death.</p>

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2016

Journal Article

D. Khadakban, Kudpaje, A., Dr. Krishnakumar T., Jayaprasad, K., Gorasia, T., Vidhyadharan, S., Mathew, J., Sharma, M., and Iyer, S., “Reconstructive Indications of Anterolateral Thigh Free Flaps in Head and Neck Reconstruction.”, Craniomaxillofac Trauma Reconstr, vol. 9, no. 1, pp. 40-5, 2016.[Abstract]


Anterolateral thigh (ALT) free flap is a common flap with multitude of indications. The purpose of this article is to review the reconstructive indications of the flap in head and neck defects. This is a retrospective study of 194 consecutive ALT flaps. Data including patient characteristics (age, sex, comorbidities), disease characteristics (histology, T stage), and flap characteristics (size of the flap, type of closure of ALT donor site) were collected. The outcome in terms of flap success rate, surgical, and donor site morbidity were studied. A total of 194 flaps were performed in 193 patients over a period of 10 years. Mean age of the patients was 55 years (range 16-80 years). Out of the 193 patients, 91 (47.1%) patients had oromandibular defects, 52 (26.9%) had tongue defects, 15 (7.7%) had pharyngeal defects, 17 (8.8%) had skull base defects, 4 (2%) had scalp defects, and 14 (7.2%) had contour defects of the neck. The overall flap success rate was 95.8% (8 total flap loss out of 194). Hypertrophic scar was the commonest donor site problem seen in 20 (10.3%) patients. This study shows the versatility of free ALT flap in head and neck reconstruction. It is a reliable and safe. Donor site morbidity is minimal.

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2016

Journal Article

G. Divya, Rajitha Panonnummal, Swati P. Gupta, Jayakumar, R., and Sabitha, M., “Acitretin and Aloe-Emodin Loaded Chitin Nanogel for the Treatment of Psoriasis”, European Journal of Pharmaceutics and Biopharmaceutics, vol. 107, pp. 97-109, 2016.[Abstract]


he present study focuses on the development of an effective topical nanogel formulation of two anti-psoriatic drugs; Acitretin (Act) and Aloe-emodin (AE) using natural polymer chitin. Simple regeneration chemistry was used to prepare Chitin Nanogel Systems (CNGs). The developed control chitin (CNGs) nanogels, acitretin loaded chitin nanogels (ActCNGs) and aloe-emodin loaded chitin nanogels (AECNGs) were characterized by DLS, SEM, FTIR, XRD and TG-DTA. The systems were found to be spherical in shape with a size range of 98&nbsp;±&nbsp;10, 138&nbsp;±&nbsp;8 and 238&nbsp;±&nbsp;6&nbsp;nm having zeta potential values of +28&nbsp;±&nbsp;3, +27&nbsp;±&nbsp;3 and +25&nbsp;±&nbsp;6&nbsp;mV for CNGs, ActCNGs and AECNGs respectively. The in vitro haemolysis assay revealed that all the nanogel systems are blood compatible. The systems exhibited higher swelling and release at acidic pH. The ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging. The in vivo anti-psoriatic activity study using Perry's mouse tail model and skin safety studies confirmed the potential benefit of the system for topical delivery of acitretin and aloe-emodin in psoriasis. © 2016 Elsevier B.V.

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2016

Journal Article

Dr. Sheela Nampoothiri, Fernández-Rebollo, E., Yesodharan, D., Gardella, T. J., Rush, E. T., Langman, C. B., and Jüppner, H., “Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutations With or Without Overt Hypercalcemia.”, J Clin Endocrinol Metab, vol. 101, no. 11, pp. 4283-4289, 2016.[Abstract]


CONTEXT: Jansen's metaphyseal chondrodysplasia (JMC) is a rare skeletal dysplasia characterized by abnormal endochondral bone formation and typically severe hypercalcemia despite normal/low levels of PTH. Five different heterozygous activating PTH/PTHrP receptor (PTH1R) mutations that change one of three different amino acid residues are known to cause JMC. OBJECTIVES: Establishing the diagnosis of JMC during infancy or early childhood can be challenging, especially in the absence of family history and/or overt hypercalcemia. We therefore sought to provide radiographic findings supporting this diagnosis early in life. PATIENTS AND METHODS: Three patients, a mother and her two sons, had radiographic evidence for JMC. However, obvious hypercalcemia and suppressed PTH levels were encountered only in both affected children. Sanger sequencing and endonuclease (SphI) digestion of PCR-amplified genomic DNA were performed to search for the H223R-PTH1R mutation. RESULTS: The heterozygous H223R mutation was identified in all three affected individuals. Surprisingly, however, the now 38-year-old mother was never overtly hypercalcemic and was therefore not diagnosed until her sons were found to be affected by JMC at the ages of 28 months and 40 days, respectively. The presented radiographic findings at different ages will help diagnose other infants/toddlers suspected of having JMC. CONCLUSION: The H223R mutation is typically associated with profound hypercalcemia despite low/normal PTH levels. However, the findings presented herein show that overt hypercalcemia is not always encountered in JMC, even if caused by this relatively frequent mutation, which is similar to observations with other PTH1R mutations that show less constitutive activity. More »»

2016

Journal Article

S. Korula, Balakrishnan, S., Sundar, S., Paul, V., and Balagopal, A., “Acute kidney injury-incidence, prognostic factors, and outcome of patients in an Intensive Care Unit in a tertiary center: A prospective observational study.”, Indian J Crit Care Med, vol. 20, no. 6, pp. 332-6, 2016.[Abstract]


<p><b>BACKGROUND AND AIMS: </b>The information regarding the incidence of acute kidney injury (AKI) in medical Intensive Care Units (ICUs) in South India is limited. The aim of the study was to find the incidence, prognostic factors, and outcome of patients with AKI. We also assessed whether only urine output criteria of risk, injury, failure, loss, end (RIFLE) classification can be used to look at the outcome of AKI.</p><p><b>PATIENTS AND METHODS: </b>This was a prospective, cross-sectional study of 6 months duration in a 28 bedded medical ICU of a tertiary center. AKI was defined as an absolute creatinine value of>1.6 mg/dl or a 25% increase from baseline creatinine values.</p><p><b>RESULTS: </b>The incidence of AKI was 16.1%, and mortality was 7.8% in our study population. Among patients with AKI 87 (75.7%) patients had sepsis. 71.3% patients had metabolic acidosis on admission, and 47.8% patients were in shock. 57.4% of patient's required mechanical ventilation (MV). 39.1% of AKI patients required renal replacement therapy (RRT). Requirement of RRT was significantly affected by increasing age, Acute Physiology and Chronic Health Evaluation II and sequential organ failure assessment scores on admission, serum creatinine, and use of vasopressors. 49.5% of patients with AKI died within 28 days. Increasing age, MV, hemodialysis (HD), hypertension, chronic kidney disease, and requirement of noradrenaline support were associated with increasing 28 days mortality. The maximum RIFLE score with urine output criteria showed association to the requirement of HD in univariate analysis but did not show relation to mortality.</p><p><b>CONCLUSION: </b>The incidence of AKI was 16.1% in critically ill patients. In patients with AKI, 39.1% patients required HD and 28 days mortality was 49.5%. The study also showed good univariate association of urine output criteria of RIFLE classification to the requirement of HD in AKI patients.</p>

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2016

Journal Article

R. Prabhu, Bhaskaran, R., Shenoy, V., G, R., and Sidharthan, N., “Clinical characteristics and treatment outcomes of primary autoimmune hemolytic anemia: a single center study from South India.”, Blood Res, vol. 51, no. 2, pp. 88-94, 2016.[Abstract]


<p><b>BACKGROUND: </b>Autoimmune hemolytic anemia (AIHA) is a less recognized, potentially fatal condition. There is a scarcity of data on clinicoserological characteristics and response to therapy concerning this disease from South India.</p><p><b>METHODS: </b>Data for 33 patients with primary AIHA recorded from July 2009 to June 2015 were retrospectively analyzed for clinical presentation, response to frontline therapy, durability of response, time to next treatment (TTNT), and response to second-line agents.</p><p><b>RESULTS: </b>The median follow-up period was 50 months. Among 33 patients, 48% of the cases were warm autoimmune hemolytic anemia (WAIHA), 46% were cold agglutinin disease (CAD), and 6% were atypical. Three-fourth of patients had severe anemia (<8 g/dL hemoglobin [Hb]) at onset; younger patients (age <40 yr) had more severe anemia. All of the patients who required treatment received oral prednisolone at 1.5 mg/kg/d as a frontline therapy, and the response rate was 90% (62% complete response [CR] and 28% partial response [PR]). The overall response to corticosteroids in WAIHA and CAD was 87% and 92%, respectively. The median corticosteroid duration was 14 months, and 50% of the patients required second-line agents. Fourteen patients received azathioprine as a second-line agent, and 11 of these patients responded well, with half of them not requiring a third agent. Four patients developed severe infections (pneumonia, sepsis, and soft tissue abscess) and two had life-threatening venous thrombosis. One case of death was recorded.</p><p><b>CONCLUSION: </b>AIHA is a heterogeneous disease that requires care by physicians experienced in treating these patients.</p>

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2016

Journal Article

G. C Nair, Babu, M. J. C., Jacob, P., Menon, R., and Mathew, J., “Is intraoperative parathyroid hormone monitoring necessary in symptomatic primary hyperparathyroidism with concordant imaging?”, Indian J Endocrinol Metab, vol. 20, no. 4, pp. 512-6, 2016.[Abstract]


<p><b>INTRODUCTION: </b>Symptomatic primary hyperparathyroidism (PHPT) is still seen frequently in referral centers all over India. These patients require parathyroidectomy and this study aimed to assess the roll of intraoperative parathyroid hormone (PTH) assay when concordant results of two localization studies were available.</p><p><b>STUDY DESIGN: </b>We analyzed the case records of patients who underwent parathyroidectomy for PHPT from January 2005 to June 2015.</p><p><b>RESULTS: </b>Of 143 patients included in the study, technetium 99m methoxyisobutylisonitrate dual phase scintigraphy showed true positive images in 93.7% and high definition ultrasonography in 84.6% of patients. Concordance in localization studies was observed in 121 (84.6%) patients, successful parathyroidectomy was done in 117 (96.7%) patients with concordant localization studies. Intraoperative PTH monitoring showed 97.84% sensitivity and 75% specificity and predicted failure in 2 patients with concordant imaging. However, re-exploration was not successful in these patients.</p><p><b>CONCLUSION: </b>When concordant result is available between parathyroid scintigraphy and anatomical imaging surgical cure rate is high in trained hands. Re-exploration is unlikely to be successful since these patients require higher imaging.</p>

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2016

Journal Article

S. Boby Thomas, Balasubramaniam, D., Hiran, K. R., Dinesh, M., and Pavithran, K., “Esthesioneuroblastoma with Intracranial Extension: A Non-surgical Approach”, Asian J Neurosurg, vol. 11, no. 3, p. 313, 2016.[Abstract]


<p>Esthesioneuroblastoma is a rare tumor arising from the olfactory mucosa of upper respiratory tract. The primary modality of treatment has been surgery with craniofacial resection followed by post-operative radiotherapy. There are only a few reported cases of non-surgical approaches. We report a case of esthesioneuroblastoma with intracranial extension treated with Vincristine, Adriamycin, Cyclophosphamide, Ifosfamide, Etoposide protocol followed by radiation with 5 years of follow-up. This is the first reported case using this chemotherapy schedule.</p>

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2016

Journal Article

S. B. Patil, Roy, A. Grace, and Vinayan, K. Puthenveet, “Clinical profile and treatment outcome of febrile infection-related epilepsy syndrome in South Indian children.”, Ann Indian Acad Neurol, vol. 19, no. 2, pp. 188-94, 2016.[Abstract]


<p><b>PURPOSE: </b>To describe the clinical features and outcome of febrile infection-related epilepsy syndrome (FIRES), a catastrophic epileptic encephalopathy, in a cohort of South Indian children.</p><p><b>MATERIALS AND METHODS: </b>We performed a retrospective chart review of a cohort of children with previously normal development who presented with status epilepticus or encephalopathy with recurrent seizures following a nonspecific febrile illness during the period between January 2007 and January 2012. They were divided into two groups super refractory status epilepticus (SRSE) and refractory status epilepticus (RSE) depending on the duration and severity of the seizures.</p><p><b>KEY FINDINGS: </b>Fifteen children who met the inclusion criteria were included for the final analysis. The age of the children at presentation ranged 3-15 years (median 6.3 years). All the children presented with prolonged or recurrent seizures occurring 1-12 days (median 4 days) after the onset of fever. Eight children had SRSE while seven children had refractory seizures with encephalopathy. Cerebrospinal fluid (CSF) analysis was done in all the children in the acute phase, and the cell count ranged 0-12 cells/μL (median 2 cells/μL) with normal sugar and protein levels. Initial neuroimaging done in all children (MRI in 10 and CT in 5), and it was normal in 13 children. Treatment modalities included multiple antiepileptic drugs (AEDs) (4-9 drugs) (median 5 drugs). Midazolam (MDZ) infusion was administered in seven patients. Eight patients required barbiturate coma to suppress the seizure activity. The duration of the barbiturate coma ranged 2-90 days (median 3 days). Steroids were used in 14 children and intravenous immunoglobulin (2 g/kg) in 7 children. Three children died in the acute phase. All children were maintained on multiple AEDs till the last follow-up, the number of AEDs ranged 1-6 (median 5 AEDs). The patients with super refractory status in the acute phase were found to be more severely disabled at the follow-up; the median score of these patients on the Glasgow Outcome Scale (GOS) was 2 compared to 5 in the RSE group.</p><p><b>SIGNIFICANCE: </b>This study reports one of the largest single center cohorts from India, with an adverse long-term developmental and seizure outcome. The duration and severity of seizures in the acute period correlated directly with the short-term and long-term clinical outcomes. There is an urgent need for developing new effective therapeutic strategies to treat this acute catastrophic epileptic syndrome.</p>

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2016

Journal Article

M. Kumar, Thilak, J., Zahoor, A., and Jyothi, A., “Septic arthritis due to tubercular and Aspergillus co-infection.”, Indian J Orthop, vol. 50, no. 3, pp. 327-30, 2016.[Abstract]


<p>Aspergillus septic arthritis is a rare and serious medical and surgical problem. It occurs mainly in immunocompromised patients. Aspergillus fumigatus is the most common causative organism followed by Aspergillus flavus. The most common site affected is knee followed by shoulder, ankle, wrist, hip and sacroiliac joint. Debridement and voriconazole are primary treatment of articular aspergilosis. To the best of our knowledge, there are no reported cases of co-infection of tuberculosis (TB) and Aspergillus infecting joints. We report a case of co-infection of TB and A. flavus of hip and knee of a 60-year-old male, with type 2 diabetes mellitus. He was treated with debridement, intravenous voriconazole, and antitubercular drugs.</p>

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2016

Journal Article

L. Kumar, Rajan, S., and Baalachandran, R., “Outcomes Associated with Stroke Volume Variation Versus Central Venous Pressure Guided Fluid Replacements during Major Abdominal Surgery”, J Anaesthesiol Clin Pharmacol, vol. 32, no. 2, pp. 182-6, 2016.[Abstract]


<p><b>BACKGROUND AND AIMS: </b>There is limited data on the impact of perioperative fluid therapy guided by dynamic preload variables like stroke volume variation (SVV) on outcomes after abdominal surgery. We studied the effect of SVV guided versus central venous pressure (CVP) guided perioperative fluid administration on outcomes after major abdominal surgery.</p><p><b>MATERIAL AND METHODS: </b>Sixty patients undergoing major abdominal surgeries were randomized into two equal groups in this prospective single blind randomized study. In the standard care group, the CVP was maintained at 10-12 mmHg while in the intervention group a SVV of 10% was achieved by the administration of fluids. The primary end-points were the length of Intensive Care Unit (ICU) and hospital stay. The secondary end points were intraoperative lactate, intravenous fluid use, requirement for inotropes, postoperative ventilation and return of bowel function.</p><p><b>RESULTS: </b>The ICU stay was significantly shorter in the intervention group as compared to the control group (2.9 ± 1.15 vs. 5.4 ± 2.71 days). The length of hospital stay was also shorter in the intervention group, (9.9 ± 2.68 vs. 11.96 ± 5.15 days) though not statistically significant. The use of intraoperative fluids was significantly lower in the intervention group than the control group (7721.5 ± 4138.9 vs. 9216.33 ± 2821.38 ml). Other secondary outcomes were comparable between the two groups.</p><p><b>CONCLUSION: </b>Implementation of fluid replacement guided by a dynamic preload variable (SVV) versus conventional static variables (CVP) is associated with lesser postoperative ICU stay and reduced fluid requirements in major abdominal surgery.</p>

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2016

Journal Article

L. Kumar, “Brain Death and Care of the Organ Donor”, J Anaesthesiol Clin Pharmacol, vol. 32, no. 2, pp. 146-52, 2016.[Abstract]


<p>Brain death has specific implications for organ donation with the potential for saving several lives. Awareness on maintenance of the brain dead has increased over the last decade with the progress in the field of transplant. The diagnosis of brain death is clinical and can be confirmed by apnea testing. Ancillary tests can be considered when the apnea test cannot be completed or is inconclusive. Reflexes of spinal origin may be present and should not be confused against the diagnosis of brain death. Adequate care for the donor targeting hemodynamic indices and lung protective ventilator strategies can improve graft quality for donation. Hormone supplementation using thyroxine, antidiuretic hormone, corticosteroid and insulin has shown to improve outcomes following transplant. India still ranks low compared to the rest of the world in deceased donation. The formation of organ sharing networks supported by state governments has shown a substantial increase in the numbers of deceased donors primarily by creating awareness and ensuring protocols in caring for the donor. This review describes the steps in the establishment of brain death and the management of the organ donor. Material for the review was collected through a Medline search, and the search terms included were brain death and organ donation.</p>

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2016

Journal Article

M. Sathiyasekaran, Biradar, V., Ramaswamy, G., Srinivas, S., Ashish, B., Sumathi, B., Nirmala, D., and Geetha, M., “Pancreatitis in Children.”, Indian J Pediatr, vol. 83, no. 12-13, pp. 1459-1472, 2016.[Abstract]


Pancreatic disease in children has a wide clinical spectrum and may present as Acute pancreatitis (AP), Acute recurrent pancreatitis (ARP), Chronic pancreatitis (CP) and Pancreatic disease without pancreatitis. This article highlights the etiopathogenesis and management of pancreatitis in children along with clinical data from five tertiary care hospitals in south India [Chennai (3), Cochin and Pune]. More »»

2016

Journal Article

M. Abraham Kuriakose, Ramdas, K., Dey, B., Iyer, S., Rajan, G., Elango, K. K., Suresh, A., Ravindran, D., Kumar, R. R., R, P., Ramachandran, S., Kumar, N. Asok, Thomas, G., Somanathan, T., Ravindran, H. K., Ranganathan, K., Katakam, S. Babu, Parashuram, S., Jayaprakash, V., and M Pillai, R., “A Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia.”, Cancer Prev Res (Phila), vol. 9, no. 8, pp. 683-91, 2016.[Abstract]


<p>Oral leukoplakia is a potentially malignant lesion of the oral cavity, for which no effective treatment is available. We investigated the effectiveness of curcumin, a potent inhibitor of NF-κB/COX-2, molecules perturbed in oral carcinogenesis, to treat leukoplakia. Subjects with oral leukoplakia (n = 223) were randomized (1:1 ratio) to receive orally, either 3.6 g/day of curcumin (n = 111) or placebo (n = 112), for 6 months. The primary endpoint was clinical response obtained by bi-dimensional measurement of leukoplakia size at recruitment and 6 months. Histologic response, combined clinical and histologic response, durability and effect of long-term therapy for an additional six months in partial responders, safety and compliance were the secondary endpoints. Clinical response was observed in 75 (67.5%) subjects [95% confidence interval (CI), 58.4-75.6] in the curcumin and 62 (55.3%; 95% CI, 46.1-64.2) in placebo arm (P = 0.03). This response was durable, with 16 of the 18 (88.9%; 95% CI, 67.2-96.9) subjects with complete response in curcumin and 7 of 8 subjects (87.5%) in placebo arm, demonstrating no relapse after 6 months follow-up. Difference in histologic response between curcumin and placebo was not significant (HR, 0.88, 95% CI, 0.45-1.71; P = 0.71). Combined clinical and histologic response assessment indicated a significantly better response with curcumin (HR, 0.50; 95% CI, 0.27-0.92; P = 0.02). Continued therapy, in subjects with partial response at 6 months, did not yield additional benefit. The treatment did not raise any safety concerns. Treatment of oral leukoplakia with curcumin (3.6 g for six months), thus was well tolerated and demonstrated significant and durable clinical response for 6 months. Cancer Prev Res; 9(8); 683-91. ©2016 AACR.</p>

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2016

Journal Article

P. D. Shenoy, Bavaliya, M., Sashidharan, S., Nalianda, K., and Sreenath, S., “Cyclophosphamide versus mycophenolate mofetil in scleroderma interstitial lung disease (SSc-ILD) as induction therapy: a single-centre, retrospective analysis.”, Arthritis Res Ther, vol. 18, no. 1, p. 123, 2016.[Abstract]


BACKGROUND: Scleroderma is a systemic autoimmune disease characterized mainly by skin manifestations and involvement of various visceral organs, especially the lungs. Lung involvement is the leading cause of mortality in patients with scleroderma. There are data to suggest that cyclophosphamide (CYC) and mycophenolate mofetil (MMF) are effective in the management of scleroderma interstitial lung disease (SSc-ILD) but no head to head comparative data are available to date.METHODS:For the last 3 years, patients with SSc-ILD have been treated at our centre by protocol-based administration of intravenous CYC and MMF. Results of lung function tests (spirometry) were recorded at baseline, 3 months and 6 months in every patient. The clinical records of patients with systemic sclerosis and significant ILD, who were not previously exposed to any immunosuppressant and were treated with MMF OR CYC, were reviewed. The efficacy of treatment was assessed by the change in forced vital capacity on spirometry.</p><p><b>RESULTS: </b>Of the total 57 patients included in the analysis, 34 were treated with MMF and 23 were treated with CYC. Mean duration of illness was 4.19 ± 2.82 years in the MMF and 6.04 ± 5.96 years in the CYC group. After 6 months of therapy, FVC increased by 10.84 ± 13.81 % in the CYC group and by 6.07 ± 11.92 % in the MMF group. This improvement from baseline was statistically significant in both groups (P < 0.01). The improvement was comparable with no statistically significant differences between groups (P = 0.373). There were no major adverse events reported in either arm.</p><p><b>CONCLUSION: </b>Both MMF and CYC were equally effective in stabilizing lung function in patients with scleroderma and ILD.

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2016

Journal Article

A. Kumar, Prakash, A., Singh, A., Kumar, H., Hagen, F., Meis, J. F., and Chowdhary, A., “Candida haemulonii species complex: an emerging species in India and its genetic diversity assessed with multilocus sequence and amplified fragment-length polymorphism analyses.”, Emerg Microbes Infect, vol. 5, p. e49, 2016.

2016

Journal Article

A. Kalantre, Sunil, G. S., and Kumar, R. Krishna, “Pulmonary venous hypertension may allow delayed palliation of single ventricle physiology with pulmonary hypertension.”, Ann Pediatr Cardiol, vol. 9, no. 2, pp. 147-52, 2016.[Abstract]


<p>Pulmonary vascular disease develops early in untreated single ventricle patients with increased pulmonary flow. Pulmonary artery (PA) banding is done at a young age in these patients in order to protect the lung vasculature and maintain low pulmonary artery pressures (PAP) and pulmonary vascular resistance (PVR). This also enables future completion of the single ventricle palliation. Pulmonary venous hypertension (PVH) secondary to left sided obstruction if present in addition in this setting contributes to the pulmonary arterial hypertension (PAH) but involves an element of reversibility of the PAH if the obstruction is relieved. We present two cases of single ventricle both of who re-presented late with PAH and PVH (secondary to mitral valve obstruction) and underwent delayed PA banding at 9.5 and 4.5 years of age respectively. Both patients however had different outcomes. The patient undergoing PA banding at 9.5 years successfully underwent a cavo-pulmonary shunt at the age of 12 years. The patient with PA banding at 4.5 years however, has residual PAH that presently precludes a cavo-pulmonary shunt.</p>

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2016

Journal Article

A. Chauhan and Sharma, M. Mathur, “Evaluation of Surgical Outcomes Following Oncoplastic Breast Surgery in Early Breast Cancer and Comparison with Conventional Breast Conservation Surgery”, Med J Armed Forces India, vol. 72, no. 1, pp. 12-8, 2016.[Abstract]


<p><b>BACKGROUND: </b>The aim of this study was to determine whether oncoplastic breast surgery (OBS) ensures better tumour resection than conventional breast conservation surgery (BCS).</p><p><b>METHODS: </b>A prospective comparative study, conducted over a 3-year period, enrolled patients with early breast cancer who underwent OBS. The total volume of glandular resection, tumour volume resection and width of the margins obtained were noted. The incidence of complications, requirement of revision surgery and locoregional recurrence during follow-up period were also noted. The data were compared with matched controls who had undergone convention BCS in the past.</p><p><b>RESULTS: </b>Thirty-three patients underwent oncoplastic surgery and the data was compared with 46 patients of conventional breast conservation. The mean volume of specimen was higher in the oncoplastic group (173.5 cm(3) vs 101.4 cm(3), p = 0.03) though the tumour volume excised was similar (43.2 cm(3) vs 36.4 cm(3), p = 0.14). The mean margin widths were larger in the oncoplastic group (14 mm vs 6 mm, p = 0.01). There were more instances of close and positive margins seen in conventional BCS groups. The incidence of complication rate was similar. Median follow-up 18 months for oncoplasty group showed no cases of locoregional recurrence while in median follow-up of 38 months for conventional BCS group, six cases of locoregional relapse were noted.</p><p><b>CONCLUSIONS: </b>Oncoplastic surgery results in excision of larger volume of breast tissue and correspondingly obtain wider surgical margins as compared to conventional BCS. Longer follow-up is required to determine if wider resection translates into better locoregional control.</p>

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2016

Journal Article

S. L. Staveski, Parveen, V. P., Madathil, S. B., Kools, S., and Franck, L. S., “Parent education discharge instruction program for care of children at home after cardiac surgery in Southern India.”, Cardiol Young, vol. 26, no. 6, pp. 1213-20, 2016.[Abstract]


<p><b>UNLABELLED: </b>Introduction In many developing countries, children with CHD are now receiving surgical repair or palliation for their complex medical condition. Consequently, parents require more in-depth discharge education programmes to enable them to recognise complications and manage their children's care after hospital discharge. This investigation evaluated the effectiveness of a structured nurse-led parent discharge teaching programme on nurse, parent, and child outcomes in India. Materials and methods A quasi-experimental investigation compared nurse and parent home care knowledge before and at two time points after the parent education discharge instruction program's implementation. Child surgical-site infections and hospital costs were compared for 6 months before and after the discharge programme's implementation.</p><p><b>RESULTS: </b>Both nurses (n=63) and parents (n=68) participated in this study. Records of 195 children who had undergone cardiac surgery were reviewed. Nurses had a high-level baseline home care knowledge that increased immediately after the discharge programme's implementation (T1=24.4±2.89; T2=27.4±1.55; p0.05) after the programme's implementation.</p><p><b>CONCLUSION: </b>Nurse, parent, and child outcomes were improved after implementation of the structured nurse-led parent discharge programme for parents in India. Structured nurse-led parent discharge programmes may help prepare parents to provide better home care for their children after cardiac surgery. Further investigation of causality and influencing factors is warranted.</p>

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2016

Journal Article

Y. Singh Sudan, Dr. Vinayan K. P., Roy, A. Grace, Wagh, A., Dr. Sudheeran Kannoth, and Patil, S., “Clinical Characteristics and Follow-up of South Indian Children with Autoimmune Encephalopathy.”, Indian J Pediatr, vol. 83, no. 12-13, pp. 1367-1373, 2016.[Abstract]


OBJECTIVE: To describe the clinical characteristics of a cohort of south Indian children with probable autoimmune encephalopathy from a tertiary care academic hospital and to compare this data with the existing literature. METHODS: Patients with encephalopathy plus one or more of neuropsychiatric symptoms, seizures, movement disorder or cognitive dysfunction were identified. Common infectious causes were excluded. Clinical characteristics, investigations, management and outcome were analyzed. RESULTS: Thirteen patients were included in the study; 12 were females (92.3 %) and mean age was 9.6 y. Most common presentation was behavior change (13 patients) followed by seizures (11 patients). Three patients showed lymphocytic pleocytosis in CSF and one patient had oligoclonal bands. Initial MRI was normal in all patients except in one. Most common EEG abnormality was mild background slowing. Only one child had ovarian tumor. S.NMDA receptor antibody was positive in 10 patients (83 %), and all of them received immunotherapy. Six out of 13 children were followed up for more than 1 y (mean - 21 mo). Recurrence was noted in 4 out of 6 patients (66 %). On last follow-up, good recovery was seen in 2 children (33 %), moderate disability in 3 (50 %) and severe disability in 1 (16 %). CONCLUSIONS: The clinical characteristics and outcome of one of the largest single center cohort of Indian children with autoimmune encephalopathy is reported. Autoimmune encephalopathy should be considered as a differential diagnosis in the acute and subacute encephalopathies of childhood and treating pediatrician should be aware of this entity. More »»

2016

Journal Article

R. Chandrasekharan, Pullara, S. K., Thomas, T., Kader, N. Puthukudiy, and Moorthy, S., “Congenital Intrahepatic Portosystemic Shunts: Imaging Findings and Endovascular Management.”, Indian J Radiol Imaging, vol. 26, no. 1, pp. 92-4, 2016.[Abstract]


We present two cases of congenital intrahepatic portosystemic shunts in which the right portal vein directly communicated with the inferior venacava (IVC) in one patient and with the hepatic vein in the other. Multiple hepatic nodules consistent with focal nodular hyperplasia (FNH) were seen in the first patient. The second patient presented with recurrent history of hepatic encephalopathy. Percutaneous transhepatic embolization was performed using coils and Amplatz device following which she completely recovered

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2016

Journal Article

L. Devi Padmanabhan and Dr. Sheela Nampoothiri, “Prenatal detection of congenital high airway obstruction syndrome with encephalocele.”, Indian J Radiol Imaging, vol. 26, no. 1, pp. 70-2, 2016.[Abstract]


<p>Congenital high airway obstruction syndrome (CHAOS) causes secondary morphological changes which can be detected on ultrasound. Here we report a case of congenital high airway obstruction with an occipital encephalocele detected at 23 weeks of gestation.</p>

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2016

Journal Article

L. Devi Padmanabhan, Hamza, Z. V., Thampi, M. Venugopala, and Dr. Sheela Nampoothiri, “Prenatal diagnosis of amniotic band syndrome.”, Indian J Radiol Imaging, vol. 26, no. 1, pp. 63-6, 2016.[Abstract]


<p>Amniotic band can cause a broad spectrum of anomalies ranging from simple band constrictions to major craniofacial and visceral defects. It can cause significant neonatal morbidity. Accurate diagnosis will help in the management of the present pregnancy and in counseling with regard to future pregnancies. Here we report three cases of amniotic band syndrome detected in the prenatal period.</p>

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2016

Journal Article

S. Khan and Kumar, A., “Microbial identification systems: Making us tilt at windmills?”, Indian J Med Microbiol, vol. 34, no. 2, pp. 260-1, 2016.

2016

Journal Article

S. Mohan, Dr. Sheela Nampoothiri, Yesodharan, D., Venkatesan, V., Koshy, T., Paul, S. F. D., and Perumal, V., “Reciprocal Microduplication of the Williams-Beuren Syndrome Chromosome Region in a 9-Year-Old Omani Boy.”, Lab Med, vol. 47, no. 2, pp. 171-5, 2016.[Abstract]


<p><b>BACKGROUND: </b>Microdeletions of the 7q11.23 Williams-Beuren syndrome chromosome region (WBSCR) are reported with a frequency of 1 in 10,000, whereas microduplications of the region, although expected to occur at the same frequency, are not widely reported.</p><p><b>METHOD: </b>We evaluated a 9-year old Omani boy for idiopathic intellectual disability using genetic methods, including multiplex ligation-dependent probe amplification (MLPA), for detection of microdeletions (P064-B3).</p><p><b>RESULTS: </b>MLPA analysis revealed that the boy has a rare microduplication of the WBSCR. Prominent clinical features include global developmental delay with pronounced speech delay, dysmorphic facies, and autistic features.</p><p><b>CONCLUSION: </b>Microduplications, in general, are reported at a lesser frequency, perhaps owing to their milder phenotype. Complete genetic assessment in children with idiopathic intellectual disability would help in identifying rare conditions such as duplication of the WBSCR.</p>

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2016

Journal Article

G. Anjaneyan, Jagadeesan, S., and Thomas, J., “Cytodiagnostic copper pennies in chromoblastomycosis.”, Indian Dermatol Online J, vol. 7, no. 2, pp. 145-6, 2016.

2016

Journal Article

K. George, Abdulkader, J. Kulapurath, Sugumar, M., and Rajagopal, G. Kalarikkal, “Prevalence of MRSA Nasal Carriage in Patients Admitted to a Tertiary Care Hospital in Southern India.”, J Clin Diagn Res, vol. 10, no. 2, pp. DC11-3, 2016.[Abstract]


<p><b>INTRODUCTION: </b>Infections with MRSA, both community and hospital acquired, are well established and the source of infection is often a carrier. There are very few studies showing the magnitude of MRSA nasal colonization among healthy persons from the community. This study was conducted to detect the prevalence of MRSA nasal carriage in patients who did not have any known risk factors associated with HA- MRSA colonization, admitted to a tertiary care centre in Kerala.</p><p><b>MATERIALS AND METHODS: </b>Nasal swabs were collected from patients within 24 hours of admission. Specimen were inoculated on chromogenic agar (HiCrome MeReSa agar-HiMedia) for MRSA screening. Isolates were then subjected to antibiotic sensitivity tests, SCCmec typing and PVL gene detection.</p><p><b>RESULTS: </b>Out of 683 patients, 16 carried MRSA in their nares (2.3%). Of the 16 strains 13 (81.25 %) strain were SCCmec type III and one belonged to SCCmec type IV (6.25 %). Two strains failed to amplify SCCmec genes. Three strains carried genes for PVL toxin (18.75%).</p><p><b>CONCLUSION: </b>With a better understanding of the complex epidemiology of MRSA it is increasingly apparent that demarcations between the HA and CA phenotypes are not as clear cut as previously thought. In this study of nasal carriage of MRSA in the community we have demonstrated prevalence consistent with published data. Most isolates however were shown to belong to the type conventionally assigned to HA-MRSA.</p>

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2016

Journal Article

N. Singhal, Praveen, V. P., Bhavani, N., Menon, A. S., Menon, U., Abraham, N., Kumar, H., JayKumar, R. V., Nair, V., Sundaram, S., and Sundaram, P., “Technetium uptake predicts remission and relapse in Grave's disease patients on antithyroid drugs for at least 1 year in South Indian subjects.”, Indian J Endocrinol Metab, vol. 20, no. 2, pp. 157-61, 2016.[Abstract]


<p><b>CONTEXT: </b>Most of the information on remission related factors in Grave's disease are derived from Western literature. It is likely that there may be additional prognostic factors and differences in the postdrug treatment course of Grave's disease in India.</p><p><b>AIM: </b>To study factors which predict remission/relapse in Grave's disease patients from South India. Also to establish if technetium (Tc) uptake has a role in predicting remission.</p><p><b>SUBJECTS AND METHODS: </b>Records of 174 patients with clinical, biochemical, and scintigraphic criteria consistent with Grave's disease, seen in our Institution between January 2006 and 2014 were analyzed. Patient factors, drug-related factors, Tc-99m uptake and other clinical factors were compared between the remission and nonremission groups.</p><p><b>STATISTICAL ANALYSIS USED: </b>Mann-Whitney U-test and Chi-square tests were used when appropriate to compare the groups.</p><p><b>RESULTS: </b>Fifty-seven (32.7%) patients attained remission after at least 1 year of thionamide therapy. Of these, 11 (19.2%) patients relapsed within 1 year. Age, gender, goiter, and presence of extrathyroidal manifestations were not associated with remission. Higher values of Tc uptake were positively associated with remission (P- 0.02). Time to achievement of normal thyroid function and composite dose: Time scores were significantly associated with remission (P - 0.05 and P - 0.01, respectively). Patients with lower FT4 at presentation had a higher chance of remission (P - 0.01). The relapse rates were lower than previously reported in the literature. A higher Tc uptake was found to be significantly associated with relapse also (P - 0.009).</p><p><b>CONCLUSION: </b>The prognostic factors associated with remission in Graves's disease in this South Indian study are not the same as that reported in Western literature. Tc scintigraphy may have an additional role in identifying people who are likely to undergo remission and thus predict the outcome of Grave's disease.</p>

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2016

Journal Article

A. Putoux, Alqahtani, A., Pinson, L., Paulussen, A. D. C., Michel, J., Besson, A., Mazoyer, S., Borg, I., Nampoothiri, S., Vasiljevic, A., Uwineza, A., Boggio, D., Champion, F., de Die-Smulders, C. E., Gardeitchik, T., van Putten, W. K., Perez, M. J., Musizzano, Y., Razavi, F., Drunat, S., Verloes, A., Hennekam, R., Guibaud, L., Alix, E., Sanlaville, D., Lesca, G., and Edery, P., “Refining the phenotypical and mutational spectrum of Taybi-Linder syndrome.”, Clin Genet, vol. 90, no. 6, pp. 550-555, 2016.[Abstract]


Taybi-Linder syndrome (TALS, OMIM 210710) is a rare autosomal recessive disorder belonging to the group of microcephalic osteodysplastic primordial dwarfisms (MOPD). This syndrome is characterized by short stature, skeletal anomalies, severe microcephaly with brain malformations and facial dysmorphism, and is caused by mutations in RNU4ATAC. RNU4ATAC is transcribed into a non-coding small nuclear RNA which is a critical component of the minor spliceosome. We report here four foetuses and four unrelated patients with RNU4ATAC mutations. We provide antenatal descriptions of this rare syndrome including unusual features found in two twin foetuses with compound heterozygosity for two rare mutations who presented with mild intrauterine growth retardation and atypical dysmorphic facial features. We also carried out a literature review of the patients described up to now with RNU4ATAC mutations, affected either with TALS or Roifman syndrome, a recently described allelic disorder.

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2016

Journal Article

M. Pandey, Vidhyadharan, S., Puthalath, U., Veeraraghavan, R., Sukumaran, S. V., Prasad, C., Iyer, S., and Thankappan, K., “Macroscopic technique for the evaluation of oral tongue tumour thickness: a reliable intraoperative method.”, Int J Oral Maxillofac Surg, vol. 45, no. 8, pp. 933-7, 2016.[Abstract]


<p>There is no reliable method to assess tumour thickness preoperatively or intraoperatively in cases of oral tongue squamous cell carcinoma (SCC). The purpose of this study was to evaluate the efficacy of a macroscopic technique to measure tumour thickness. This was a prospective study of 51 consecutive patients with T1/T2 primary SCC of the oral tongue. All patients underwent primary resection with ipsilateral neck dissection. Thickness measurements were obtained using Vernier calipers on the fresh specimen. The technique was correlated with the microscopic evaluation statistically using (1) Pearson's correlation coefficient, (2) intra-class correlation, and (3) Bland-Altman plot with 95% confidence intervals. On comparing the macroscopic technique to the microscopic evaluation, Pearson's correlation (r) was 0.915 (P<0.001). The inter-rater reliability using the intra-class correlation coefficient was 0.955. The Bland-Altman plot to test the agreement between the techniques showed the average difference between macroscopic thickness and microscopic thickness (bias) to be -0.421, with 95% limits of agreement of -3.166 and 2.82. There was a significant correlation and agreement between the macroscopic and microscopic measures of tumour thickness. The macroscopic technique could be used as a reliable tool to measure tumour thickness intraoperatively, prior to neck dissection.</p>

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2016

Journal Article

S. Viswanathan, Singhi, A. K., and Kumar, R. Krishna, “Pediatric Cardiac Sciences 2015: A Summary of Significant Publications”, Ann Pediatr Cardiol, vol. 9, no. 1, pp. 96-107, 2016.

2016

Journal Article

R. Aghoram, Srijithesh, P. R., and Dr. Sudheeran Kannoth, “Adult-onset Satoyoshi syndrome and response to plasmapheresis.”, Ann Indian Acad Neurol, vol. 19, no. 1, pp. 131-3, 2016.[Abstract]


<p>Satoyoshi syndrome is a rare disease characterized by alopecia, recurrent muscle spasms, diarrhea, and skeletal abnormalities Adult-onset disease is reported only in five patients. Most of the reports have not characterized the nature of muscle spasm in the disease. In this paper, we report the first case of adult-onset Satoyoshi syndrome from India and the clinical and electrophysiological response to plasmapheresis.</p>

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2016

Journal Article

A. V Kumar, “Comments on "Impact of bronchoalveolar lavage multiplex polymerase chain reaction on microbiological yield and therapeutic decisions in severe pneumonia in intensive care unit".”, J Crit Care, vol. 33, p. 274, 2016.

2016

Journal Article

F. Moreau, Yang, R., Nambiar, V., Demchuk, A. M., and Dunn, J. F., “Near-infrared measurements of brain oxygenation in stroke.”, Neurophotonics, vol. 3, no. 3, p. 031403, 2016.[Abstract]


<p>We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS(®) fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and [Formula: see text] in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. [Formula: see text] values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced [Formula: see text] on the stroke side compared to the contralateral side. The evolution of tHb and [Formula: see text] at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.</p>

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2016

Journal Article

R. Yadav, Jaswal, A., Chennapragada, S., Kamath, P., Hiremath, S. M. S., Kahali, D., Anand, S., Sood, N. K., Mishra, A., Makkar, J. S., and Kaul, U., “Effectiveness of Ventricular Intrinsic Preference (VIP™) and Ventricular AutoCapture (VAC) algorithms in pacemaker patients: Results of the validate study.”, J Arrhythm, vol. 32, no. 1, pp. 29-35, 2016.[Abstract]


<p><b>BACKGROUND: </b>Several past clinical studies have demonstrated that frequent and unnecessary right ventricular pacing in patients with sick sinus syndrome and compromised atrio-ventricular conduction (AVC) produces long-term adverse effects. The safety and efficacy of two pacemaker algorithms, Ventricular Intrinsic Preference™ (VIP) and Ventricular AutoCapture (VAC), were evaluated in a multi-center study in pacemaker patients.</p><p><b>METHODS: </b>We evaluated 80 patients across 10 centers in India. Patients were enrolled within 15 days of dual chamber pacemaker (DDDR) implantation, and within 45 days thereafter were classified to either a compromised AVC (cAVC) arm or an intact AVC (iAVC) arm based on intrinsic paced/sensed (AV/PV) delays. In each arm, patients were then randomized (1:1) into the following groups: VIP OFF and VAC OFF (Control group; CG), or VIP ON and VAC ON (Treatment Group; TG). Subsequently, the AV/PV delays in the CG groups were mandatorily programmed at 180/150 ms, and to up to 350 ms in the TG groups. The percentage of right ventricular pacing (%RVp) evaluated at 12-month post-implantation follow-ups were compared between the two groups in each arm. Additionally, in-clinic time required for collecting device data was compared between patients programmed with the automated AutoCapture algorithm activated (VAC ON) vs. the manually programmed method (VAC OFF).</p><p><b>RESULTS: </b>Patients randomized to the TG with the VIP algorithm activated exhibited a significantly lower %RVp at 12 months than those in the CG in both the cAVC arm (39±41% vs. 97±3%; p=0.0004) and the iAVC arm (15±25% vs. 68±39%; p=0.0067). In-clinic time required to collect device data was less in patients with the VAC algorithm activated. No device-related adverse events were reported during the year-long study period.</p><p><b>CONCLUSIONS: </b>In our study cohort, the use of the VIP algorithm significantly reduced the %RVp, while the VAC algorithm reduced in-clinic time needed to collect device data.</p>

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2016

Journal Article

L. Bonafé, Kariminejad, A., Li, J., Royer-Bertrand, B., Garcia, V., Mahdavi, S., Bozorgmehr, B., Lachman, R. L., Mittaz-Crettol, L., Campos-Xavier, B., Dr. Sheela Nampoothiri, Unger, S., Rivolta, C., Levade, T., and Superti-Furga, A., “Brief Report: Peripheral Osteolysis in Adults Linked to ASAH1 (Acid Ceramidase) Mutations: A New Presentation of Farber's Disease.”, Arthritis Rheumatol, vol. 68, no. 9, pp. 2323-7, 2016.[Abstract]


<p><b>OBJECTIVE: </b>To establish a diagnosis and provide counseling and treatment for 3 adult patients from one family presenting with peripheral osteolysis.</p><p><b>METHODS: </b>Following clinical and radiographic assessment, exome sequencing, targeted gene resequencing, and determination of enzyme activity in cultured fibroblasts were performed.</p><p><b>RESULTS: </b>The proband (age 40 years) had a history of episodic fever and pain in childhood that subsided around puberty. He and 2 of his older sisters (ages 58 and 60 years, respectively) showed adult-onset progressive shortening of fingers and toes with redundancy of the overlying skin. Radiographs showed severe osteolysis of the distal radius and ulna, carpal bones, metacarpal bones, and phalanges. Sequencing of the known genes for recessively inherited osteolysis, MMP2 and MMP14, failed to show pathogenic mutations. Exome sequencing revealed compound heterozygosity for mutations c.505T>C (p.Trp169Arg) and c.760A>G (p.Arg254Gly) in ASAH1, the gene coding for acid ceramidase. Sanger sequencing confirmed correct segregation in the family, and enzyme activity in fibroblast cultures from the patients was reduced to ∼8% of that in controls, confirming a diagnosis of Farber's disease.</p><p><b>CONCLUSION: </b>Our findings indicate that hypomorphic mutations in ASAH1 may result in an osteoarticular phenotype with a juvenile phase resembling rheumatoid arthritis that evolves to osteolysis as the final stage in the absence of neurologic signs. This observation delineates a novel type of recessively inherited peripheral osteolysis and illustrates the long-term skeletal manifestations of acid ceramidase deficiency (Farber's disease) in what appear to be the oldest affected individuals known so far.</p>

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2016

Journal Article

Dr. Sudheeran Kannoth, Anandakkuttan, A., Mathai, A., Sasikumar, A. Nirmala, and Nambiar, V., “Autoimmune atypical parkinsonism - A group of treatable parkinsonism.”, J Neurol Sci, vol. 362, pp. 40-6, 2016.[Abstract]


<p><b>BACKGROUND: </b>Immunological causes of atypical parkinsonism/Parkinson plus syndromes are rare.</p><p><b>OBJECTIVE: </b>To study the clinical and laboratory features and treatment outcome of autoimmune atypical parkinsonism.</p><p><b>METHODS: </b>Retrospective case series. Patients with atypical parkinsonism and positive antibodies were identified retrospectively. Those who received immunotherapy (intravenous methyl prednisolone 1g daily for five days followed by mycophenylate mofetil 2g daily or azathioprine 2-3mg/kg/day) and consented for publication of non-anonymized videos were included.</p><p><b>RESULTS: </b>There were ten cases (nine males, age range 49-75years, disease duration 2months to 13years, follow-up 1-7months) of atypical parkinsonism [probable multiple system atrophy (MSA)-2, possible progressive supranuclear palsy (PSP)-1, probable PSP-3]. Eight had new uncharacterized neuronal antibodies, leucine rich glioma associated protein 1 (LGI1) antibody in one, and the other had another uncharacterized neuronal antibody along with LGI1 antibody. Four had abnormal CSF. There was a prompt, dramatic improvement in terms of Unified Parkinson Disease Rating Scale motor scale and or modified Rankin Scale as well as improvement in eye movement, postural instability, cerebellar, autonomic and non-motor symptoms. Two had reappearance of symptoms on discontinuing steroids and improvement on restarting. One died of infection despite good recovery of encephalopathy and parkinsonism.</p><p><b>CONCLUSION: </b>Autoimmune atypical parkinsonism is characterized by atypical parkinsonism with neuronal specific antibodies, sometimes associated with abnormal CSF and significant response to immunotherapy.</p>

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2016

Journal Article

S. J. Gandhi, Satish, C., Sundaram, P. Shanmuga, Subramanyam, P., and Vijaykumar, D. K., “Feasibility Study of Axillary Reverse Mapping Lymphoscintigraphy in carcinoma Breast: A Concept toward preventing Lymphedema.”, Indian J Nucl Med, vol. 31, no. 1, pp. 9-13, 2016.[Abstract]


OBJECTIVE: In the surgery of breast cancer, axillary reverse mapping (ARM) is the identification and preservation of arm draining lymph node (ARM node) during an axillary dissection. The assumption is that the ARM node is different from node draining breast and is unlikely to be involved even in the patients with axillary nodal metastases. If we can identify and preserve ARM node using lymphoscintigraphy; morbidity of lymphedema, as seen with axillary dissection, may be avoided.MATERIALS AND METHODS: </b>Pathologically proven 50 breast cancer patients undergoing initial surgery (cTx-4, cN0-2, and Mx-0) were included in this study. Less than 37 MBq, 0.5 ml in equally divided doses of filtered 99mTc sulfur colloid was injected intradermally into the second and third web spaces. ARM nodes in the axilla were identified with the help of Gamma Probe intraoperatively; however, their location was noted with the reference to specific anatomical landmarks and sent for histopathological examination after excision.</p><p><b>RESULTS: </b>The ARM node was successfully identified in 47/50 cases (sensitivity - 94%). In 40 out of 47 cases (85%), the location of the ARM node was found to lateral to the subscapular pedicle, above the second intercostobrachial nerve and just below the axillary vein. Of the 47 patients in whom ARM node/s were identified, metastasis was noted in 5 of them (10%). Four out of these 5 patients had the pN3 disease CONCLUSION: ARM node exists, and it is feasible to identify ARM node using radio isotope technique with an excellent sensitivity. ARM node seems to have a fairly constant location in more than 80% cases. It is involved with metastasis (10% cases) only when there are multiple lymph nodal metastases in the axilla.

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2016

Journal Article

P. Georgeena, Rajanbabu, A., Vijaykumar, D. K., Pavithran, K., Sundaram, K. R., Deepak, K. S., and Sanal, M. R., “Surgical treatment pattern and outcomes in epithelial ovarian cancer patients from a cancer institute in Kerala, India.”, Ecancermedicalscience, vol. 10, p. 619, 2016.[Abstract]


<p><b>OBJECTIVE: </b>To evaluate the treatment and survival pattern of patients with advanced epithelial ovarian cancer.</p><p><b>METHODS AND RESULTS: </b>Retrospective study of all advanced epithelial ovarian cancer patients treated in the department of gynaecologic oncology from an academic centre, in a four year period from 1 January 2008-31 December 2011.</p><p><b>SELECTION CRITERIA: </b>All patients with advanced epithelial ovarian cancer (stage III and IV) who underwent surgery from 2008-2011and had a follow-up of at least three months after completion of treatment were included. The decision on whether primary surgery or neoadjuvant chemotherapy (NACT) in advanced ovarian cancer was based on age, performance status, clinical and imaging findings.</p><p><b>RESULTS: </b>A total of 178 cases of epithelial ovarian cancer were operated on during this four year period. Among them 28 patients were recurrent cases, 22 had early stages of ovarian cancer, and the rest 128 had stage III and IV ovarian cancer. In these 128 patients, 50(39.1%) underwent primary surgery and 78(60.9%) had NACT followed by surgery. In the primary surgery group 36(72.0%) patients had optimal debulking while in the NACT group 59(75.6%) patient had optimal debulking. With a median follow-up of 34 months, the median overall survival (OS) and progression free survival (PFS) was 53 and 49 months respectively. Patients who underwent primary surgery had better median PFS than patients who had NACT (56 months versus 39 months, p = 0.002). In stage III C the difference median PFS was significant for those treated with primary surgery when compared with NACT (55 months versus 39 months, p = 0.012). In patients who had optimal debulking to no residual disease (n = 90), primary surgery gave a significant improved PFS (59 months versus 38 months, p = 0.001) when compared with NACT. In univariate analysis, NACT was associated with increased risk of death (HR: 0.350; CI: 0.177-0.693).</p><p><b>CONCLUSION: </b>In advanced epithelial ovarian cancer, primary surgery seems to have a definite survival advantage over NACT in patients who can be optimally debulked to no residual disease.</p>

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2016

Journal Article

K. Kouz, Lissewski, C., Spranger, S., Mitter, D., Riess, A., Lopez-Gonzalez, V., Lüttgen, S., Aydin, H., von Deimling, F., Evers, C., Hahn, A., Hempel, M., Issa, U., Kahlert, A. - K., Lieb, A., Villavicencio-Lorini, P., Ballesta-Martinez, M. Juliana, Dr. Sheela Nampoothiri, Ovens-Raeder, A., Puchmajerová, A., Satanovskij, R., Seidel, H., Unkelbach, S., Zabel, B., Kutsche, K., and Zenker, M., “Genotype and phenotype in patients with Noonan syndrome and a RIT1 mutation.”, Genet Med, vol. 18, no. 12, pp. 1226-1234, 2016.[Abstract]


PURPOSE: Noonan syndrome (NS) is an autosomal-dominant disorder characterized by craniofacial dysmorphism, growth retardation, cardiac abnormalities, and learning difficulties. It belongs to the RASopathies, which are caused by germ-line mutations in genes encoding components of the RAS mitogen-activated protein kinase (MAPK) pathway. RIT1 was recently reported as a disease gene for NS, but the number of published cases is still limited

METHODS: </strong>We sequenced RIT1 in 310 mutation-negative individuals with a suspected RASopathy and prospectively in individuals who underwent genetic testing for NS. Using a standardized form, we recorded clinical features of all RIT1 mutation-positive patients. Clinical and genotype data from 36 individuals with RIT1 mutation reported previously were reviewed.

RESULTS:Eleven different RIT1 missense mutations, three of which were novel, were identified in 33 subjects from 28 families; codons 57, 82, and 95 represent mutation hotspots. In relation to NS of other genetic etiologies, prenatal abnormalities, cardiovascular disease, and lymphatic abnormalities were common in individuals with RIT1 mutation, whereas short stature, intellectual problems, pectus anomalies, and ectodermal findings were less frequent.

CONCLUSION: RIT1 is one of the major genes for NS. The RIT1-associated phenotype differs gradually from other NS subtypes, with a high prevalence of cardiovascular manifestations, especially hypertrophic cardiomyopathy, and lymphatic problems.Genet Med 18 12, 1226-1234.

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2016

Journal Article

R. Krishna Kumar, “Screening for Congenital Heart Disease in India: Rationale, Practical Challenges, and Pragmatic Strategies.”, Ann Pediatr Cardiol, vol. 9, no. 2, pp. 111-4, 2016.

2016

Journal Article

R. Kannan Suppiah, Rajan, S., Paul, J., and Kumar, L., “Respiratory and Hemodynamic Outcomes Following Exchange Extubation with Laryngeal Mask Airway as Compared to Traditional Awake Extubation”, Anesth Essays Res, vol. 10, no. 2, pp. 212-7, 2016.[Abstract]


<p><b>BACKGROUND: </b>Traditional awake extubation leads to respiratory complications and hemodynamic response which are detrimental in neurosurgery, ENT surgery and patients with comorbidities.</p><p><b>AIMS: </b>The primary objective was to compare the respiratory complications and hemodynamic stress response between traditional awake extubation of a endotracheal tube (ETT) and that following exchange extubation of ETT by using a laryngeal mask airway (LMA).</p><p><b>SETTINGS AND DESIGN: </b>This prospective randomized study was conducted in a Tertiary Care Centre in 60 American Society of Anesthesiologists I and II patients coming for general surgery.</p><p><b>MATERIALS AND METHODS: </b>Patients were randomized by permuted blocks into traditional awake extubation group and exchange extubation group. At the end of surgery in traditional group, awake extubation of ETT was done. In exchange group, 0.3 mg/kg propofol was administered, and the ETT was exchanged for a LMA. Awake extubation of LMA was then performed. Respiratory complications such as bucking, coughing, desaturation and the need for airway maneuvers and hemodynamic response were noted in both groups.</p><p><b>ANALYSIS TOOLS: </b>Chi-square test, independent sample t- and paired t-tests were used as applicable.</p><p><b>RESULTS: </b>Incidence of respiratory complication was 93.3% in traditional extubation while it was only 36.7% in exchange extubation group (P < 0.001). Hemodynamic response measured immediately at extubation in terms of heart rate, systolic blood pressure (BP), diastolic BP, mean arterial pressure, and rate pressure product were all significantly lesser in exchange group when compared to traditional extubation.</p><p><b>CONCLUSION: </b>Exchange extubation with LMA decreases respiratory complications and hemodynamic stress response when compared to traditional awake extubation.</p>

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2016

Journal Article

A. N. Madkaiker, Krishna, N., Jose, R., Balasubramoniam, K. R., Murukan, P., Baquero, L., and Varma, P. Kerala, “Superior Vena Cava Syndrome Caused by Pacemaker Leads.”, Ann Thorac Surg, vol. 101, no. 6, pp. 2358-61, 2016.[Abstract]


Superior vena cava syndrome is one of the rare adverse events associated with pacemaker leads. We describe a 47-year-old woman with a pacemaker implanted 10 years earlier who presented to us with superior vena cava syndrome managed surgically. We report the presentation, diagnosis, and treatment of this patient and the causes and management options of superior vena cava obstruction associated with pacemaker leads

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2016

Journal Article

S. Valsala Krishnankutty and Rajan, S., “The Effect of Intravenous Conivaptan on Intraocular Pressure.”, J Ophthalmic Vis Res, vol. 11, no. 1, pp. 126-7, 2016.

2016

Journal Article

S. S. Nair and Nayar, J., “Thoracic Endometriosis Syndrome: A Veritable Pandora's Box.”, J Clin Diagn Res, vol. 10, no. 4, pp. QR04-8, 2016.[Abstract]


<p>Thoracic endometriosis syndrome is a rare disorder characterised by the presence of functioning endometrial tissue in pleura, lung parenchyma, airways, and/or encompasses mainly four clinical entities-catamenial pneumothorax, catamenial haemothorax, catamenial haemoptysis and lung nodules. The cases were studied retrospectively by reviewing the records at Amrita Institute of Medical Sciences, for duration of five years i.e., form March 2010-2014 and analysed for the clinical presentation and management of thoracic endometriosis syndrome. Catamenial breathlessness was the main symptom. Pneumothorax and pleural effusion were the findings on investigations. Histopathology report of endometriosis was present in three cases (50%). Conditions with excess oestrogen like endometriosis, fibroid, adenomyosis were diagnosed in these patients by pelvic scan. After the initial supportive treatment with hormones, pleurodesis, hysterectomy and lung decortication were the treatment modalities. Two cases that had multiple recurrences were diagnosed as disseminated TES. They underwent combined treatment of surgery and hormones.</p>

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2016

Journal Article

A. Gopinathan, Kumar, A., Rao, S. Nagaraja, Kumar, K., and Karim, S., “Candidal Vertebral Osteomyelitis in the Midst of Renal Disorders.”, J Clin Diagn Res, vol. 10, no. 4, pp. DD03-5, 2016.[Abstract]


<p>Vertebral osteomyelitis also known as discitis/pyogenic spondylitis refers to inflammation of the vertebral disc space. It is commonly seen in men and adults more than 50 years of age. Fungal osteomyelitis is a rare scenario compared to its bacterial counterpart. Spinal epidural abscess is a dangerous complication associated with vertebral osteomyelitis. Here, we report two cases of vertebral osteomyelitis caused by Candida tropicalis in patients with renal disorders (stage 5 chronic kidney disease and nephropathy). One of the case discussed here presented with spinal epidural abscess. Both the patients were started on antifungal therapy. One patient responded to treatment while the other was lost to follow up.</p>

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2016

Journal Article

S. Bhattacharya, Vidhyadharan, S., Dr. Krishnakumar T., and Dr. Subramania Iyer K., “Cross-Cheek Dumbbell-Shaped Radial Forearm Flap for Simultaneous Correction of Oral Cancer and Submucous Fibrosis”, Craniomaxillofac Trauma Reconstr, vol. 9, no. 2, pp. 162-5, 2016.[Abstract]


Simultaneous occurrence of oral submucous fibrosis along with carcinoma of the buccal mucosa is common. We report a novel technique of a single dumbbell-shaped, cross-cheek radial forearm free flap to repair bilateral defects caused by oral cancer resection on one side and the release of fibrosis on the other side in two patients. The dumbbell-shaped flap provided tissue for both the buccal mucosa defects and central released soft palate preventing fibrosis and reapproximation. The interincisor distance improved in both the patients.

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2016

Journal Article

A. Uttarilli, Ranganath, P., Matta, D., J Jain, M. Nurul, Prasad, K., Babu, A. S., Girisha, K. M., Verma, I. C., Phadke, S. R., Mandal, K., Puri, R. D., Aggarwal, S., Danda, S., Sankar, V. H., Kapoor, S., Bhat, M., Gowrishankar, K., Hasan, A. Q., Nair, M., Nampoothiri, S., and Dalal, A., “Identification and characterization of 20 novel pathogenic variants in 60 unrelated Indian patients with mucopolysaccharidoses type I and type II.”, Clin Genet, vol. 90, no. 6, pp. 496-508, 2016.[Abstract]


Mucopolysaccharidoses (MPS), a subgroup of lysosomal storage disorders, are caused due to deficiency of specific lysosomal enzyme involved in catabolism of glycosaminoglycans. To date more than 200 pathogenic variants in the alpha-l-iduronidase (IDUA) for MPS I and ∼500 pathogenic variants in the iduronate-2-sulphatase (IDS) for MPS II have been reported worldwide. The mutation spectrum of MPS type I and MPS type II disorders in Indian population is not characterized yet. In this study, we carried out clinical, biochemical, molecular and in silico analyses to establish the mutation spectrum of MPS I and MPS II in the Indian population. We conducted molecular analysis for 60 MPS-affected patients [MPS I (n = 30) (Hurler syndrome = 17, Hurler-Scheie syndrome = 13), and MPS II (n = 30) (severe = 18, attenuated = 12)] and identified a total of 44 [MPS I (n = 22) and MPS II (n = 22)] different pathogenic variants comprising missense, nonsense, frameshift, gross deletions and splice site variants. A total of 20 [MPS I (n = 14), and MPS II (n = 6)] novel pathogenic sequence variants were identified in our patient cohort. We found that 32% of pathogenic variants detected in IDUA were recurrent and 25% in MPS II. This is the first study revealing the mutation spectrum of MPS I and MPS II patients in the Indian population.

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2016

Journal Article

Dr. Saritha Sekhar S., Vupputuri, A., Nair, R. Chandrasek, Palaniswamy, S. Sundaram, and Natarajan, K. Uma, “Coronary Stent Infection Successfully Diagnosed Using 18F-Flurodeoxyglucose Positron Emission Tomography Computed Tomography.”, The Canadian Journal of Cardiology, vol. 32, no. 12, pp. 1575.e1-1575.e3, 2016.[Abstract]


Infection of coronary stents is extremely rare. We report a case of a 60-year-old gentleman with recurrent fever after acute stent occlusion and reintervention. A coronary angiogram showed an occluded stented segment and the blood cultures were positive for infection. The presence of inflammation in the stented region was confirmed using 18F-flurodeoxyglucose positron emission tomography computed tomography. The patient underwent surgery and the diagnosis was proven by examination of the surgical material. This article highlights the need to have a high index of suspicion of stent infection, and the use of 18F-flurodeoxyglucose positron emission tomography computed tomography along with coronary angiogram in aiding the diagnosis.

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2016

Journal Article

J. Joy, Thampi, S., Kumar, G., Sreekrishnan, T. P., and Ajith, V., “A case report on enteric fever induced hypophosphatemia”, Asian Journal of Pharmaceutical and Clinical Research, vol. 9, pp. 3-4, 2016.[Abstract]


Hypophosphatemia is critical ill patients are a common entity which causes unnoticed most of the time. This can lead to considerable morbidity and in some cases contribute to mortality. A 20-year-old female patient presented to Emergency Medicine with complaints of diarrhea, breathing difficulty, and tachypnea. Her routine electrolyte investigation showed low phosphate level. Once hypophosphatemia was corrected with intravenous phosphorous, patient became symptomatically better. In this study, we encounter that enteric fever can also be a factor for symptomatic hypophosphatemia and it should be corrected even if it is mild. Therefore, this case emphasis on importance of correcting symptomatic hypophosphatemia in critically ill patients. More »»

2016

Journal Article

M. Aggarwal, Vijan, V., Vupputuri, A., Nandakumar, S., and Navin Mathew, “A rare case of fatal endocarditis and sepsis caused by Pseudomonas aeruginosa in a patient with chronic renal failure”, Journal of Clinical and Diagnostic Research, vol. 10, pp. OD12-OD13, 2016.[Abstract]


Nosocomial catheter-related and Arteriovenous fistula (AV)-related infections are significant concern in patients undergoing haemodialysis. These infections are associated with multiple complications as well as mortality and demands immediate and appropriate management. While coagulase-negative staphylococci, S.aureus, and Escherichia coli are the most common causes of catheter-related infections in haemodialysis patients, such infections caused by Pseudomonas aeruginosa are relatively rare. Here, we present an unusual case of 36-year-old male patient with chronic renal failure, who developed endocarditis and sepsis from Pseudomonas aeruginosa infection of the left hand arteriovenous fistula. The bacteraemia in the present case caused multiple complications including dry gangrene of bilateral lower limbs, stroke, endophthalmitis, left brachial artery thrombosis and vegetations on the interventricular septum and aortic wall. Despite antibiotic treatment, the patient suffered a cardiac arrest and could not be revived. More »»

2016

Journal Article

Chitra P. and Nair, B. B., “Awareness Regarding Management and Preventive measures of Dog bite among parents in selected wards of Nayarambalam Panchayat, Ernakulam, Kerala”, Indian Journal of Public Health Research Development, vol. 7, pp. 310-316, 2016.[Abstract]


Introduction
The children below the age group younger than 10 years represent the high risk group for dog attacks. Studies revealed that boys between the ages of 5 to 9 are bitten five times more by dogs than any other group of people. Rabies, a disease of antiquity continues to be a major public health problem in India1. With around 1.06 lakh canine bite cases being reported in 2014–2015 and 40,000 in 2015 alone2.

Methods
The study design was descriptive research design. The study was conducted among 100 parents of children who met with the eligibility criteria following non probability convenience sampling technique.

Results
None of the parents exhibits adequate knowledge on dog behaviors towards child, 56(56%) are unaware about the dog behaviors, 44(44%) had average knowledge. Nearly 47(47%) of the subjects had inadequate knowledge regarding management of dog bite and 41(41%) had inadequate knowledge regarding the prevention of dog bite. Even though the incidence of dog bite is tremendously increasing in the country, awareness regarding child behaviors towards dog among parents was found to be poor, only 10(10%) had adequate knowledge, 58 (58%) had average knowledge, 32(32%) had inadequate knowledge. Regarding the misbeliefs related to dog bite, 41% of the subjects had misbeliefs related to dog bite.

Conclusion
The study findings revealed that fact most of the dog bite incidents are occurring due to the children are unaware of dog behaviors and not taught by parents or school how to behave or avoid such a situation. Dogs are understanding mostly by nonverbal cues, body language and previous exposure or treatment by humans based on exhibiting their behaviors.

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2016

Journal Article

M. K. Ali, Singh, K., Kondal, D., Devarajan, R., Patel, S. A., Shivashankar, R., Ajay, V. S., Unnikrishnan, A. G., V Menon, U., Varthakavi, P. K., Viswanathan, V., Dharmalingam, M., Bantwal, G., Sahay, R. Kumar, Masood, M. Qamar, Khadgawat, R., Desai, A., Sethi, B., Prabhakaran, D., Narayan, K. M. Venkat, and Tandon, N., “Effectiveness of a Multicomponent Quality Improvement Strategy to Improve Achievement of Diabetes Care Goals: A Randomized, Controlled Trial.”, Ann Intern Med, vol. 165, no. 6, pp. 399-408, 2016.[Abstract]


<p><b>BACKGROUND: </b>Achievement of diabetes care goals is suboptimal globally. Diabetes-focused quality improvement (QI) is effective but remains untested in South Asia.</p><p><b>OBJECTIVE: </b>To compare the effect of a multicomponent QI strategy versus usual care on cardiometabolic profiles in patients with poorly controlled diabetes.</p><p><b>DESIGN: </b>Parallel, open-label, pragmatic randomized, controlled trial. (ClinicalTrials.gov: NCT01212328).</p><p><b>SETTING: </b>Diabetes clinics in India and Pakistan.</p><p><b>PATIENTS: </b>1146 patients (575 in the intervention group and 571 in the usual care group) with type 2 diabetes and poor cardiometabolic profiles (glycated hemoglobin [HbA1c] level ≥8% plus systolic blood pressure [BP] ≥140 mm Hg and/or low-density lipoprotein cholesterol [LDLc] level ≥130 mg/dL).</p><p><b>INTERVENTION: </b>Multicomponent QI strategy comprising nonphysician care coordinators and decision-support electronic health records.</p><p><b>MEASUREMENTS: </b>Proportions achieving HbA1c level less than 7% plus BP less than 130/80 mm Hg and/or LDLc level less than 100 mg/dL (primary outcome); mean risk factor reductions, health-related quality of life (HRQL), and treatment satisfaction (secondary outcomes).</p><p><b>RESULTS: </b>Baseline characteristics were similar between groups. Median diabetes duration was 7.0 years; 6.8% and 39.4% of participants had preexisting cardiovascular and microvascular disease, respectively; mean HbA1c level was 9.9%; mean BP was 143.3/81.7 mm Hg; and mean LDLc level was 122.4 mg/dL. Over a median of 28 months, a greater percentage of intervention participants achieved the primary outcome (18.2% vs. 8.1%; relative risk, 2.24 [95% CI, 1.71 to 2.92]). Compared with usual care, intervention participants achieved larger reductions in HbA1c level (-0.50% [CI, -0.69% to -0.32%]), systolic BP (-4.04 mm Hg [CI, -5.85 to -2.22 mm Hg]), diastolic BP (-2.03 mm Hg [CI, -3.00 to -1.05 mm Hg]), and LDLc level (-7.86 mg/dL [CI, -10.90 to -4.81 mg/dL]) and reported higher HRQL and treatment satisfaction.</p><p><b>LIMITATION: </b>Findings were confined to urban specialist diabetes clinics.</p><p><b>CONCLUSION: </b>Multicomponent QI improves achievement of diabetes care goals, even in resource-challenged clinics.</p><p><b>PRIMARY FUNDING SOURCE: </b>National Heart, Lung, and Blood Institute and UnitedHealth Group.</p>

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2016

Journal Article

S. Vijayrajratnam, Pushkaran, A. Choorakott, Balakrishnan, A., Dr. Anil Kumar V., Dr. Raja Biswas, and Dr. Gopi Mohan C., “Bacterial peptidoglycan with amidated meso-diaminopimelic acid evades NOD1 recognition: an insight into NOD1 structure-recognition.”, Biochem J, vol. 473, no. 24, pp. 4573-4592, 2016.[Abstract]


Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is an intracellular pattern recognition receptor that recognizes bacterial peptidoglycan (PG) containing meso-diaminopimelic acid (mesoDAP) and activates the innate immune system. Interestingly, a few pathogenic and commensal bacteria modify their PG stem peptide by amidation of mesoDAP (mesoDAPNH2). In the present study, NOD1 stimulation assays were performed using bacterial PG containing mesoDAP (PGDAP) and mesoDAPNH2 (PGDAPNH2) to understand the differences in their biomolecular recognition mechanism. PGDAP was effectively recognized, whereas PGDAPNH2 showed reduced recognition by the NOD1 receptor. Restimulation of the NOD1 receptor, which was initially stimulated with PGDAP using PGDAPNH2, did not show any further NOD1 activation levels than with PGDAP alone. But the NOD1 receptor initially stimulated with PGDAPNH2 responded effectively to restimulation with PGDAP The biomolecular structure-recognition relationship of the ligand-sensing leucine-rich repeat (LRR) domain of human NOD1 (NOD1-LRR) with PGDAP and PGDAPNH2 was studied by different computational techniques to further understand the molecular basis of our experimental observations. The d-Glu-mesoDAP motif of GMTPDAP, which is the minimum essential motif for NOD1 activation, was found involved in specific interactions at the recognition site, but the interactions of the corresponding d-Glu-mesoDAP motif of PGDAPNH2 occur away from the recognition site of the NOD1 receptor. Hot-spot residues identified for effective PG recognition by NOD1-LRR include W820, G821, D826 and N850, which are evolutionarily conserved across different host species. These integrated results thus successfully provided the atomic level and biochemical insights on how PGs containing mesoDAPNH2 evade NOD1-LRR receptor recognition.

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2016

Journal Article

S. Narayanamoorthy and Ramanan, R., “Pulseless Disease in Pregnancy: A Rare Case.”, J Obstet Gynaecol India, vol. 66, no. 5, pp. 391-3, 2016.

2016

Journal Article

C. G. Prameela, Ravind, R., Gurram, B. C., Sheejamol, V. S., and Dinesh, M., “Prognostic Factors in Primary Vaginal Cancer: A Single Institute Experience and Review of Literature.”, J Obstet Gynaecol India, vol. 66, no. 5, pp. 363-71, 2016.[Abstract]


BACKGROUND: Primary vaginal carcinoma is rare, accounting for 1-2&nbsp;% of all gynecological malignancies. Being rare, most observations are based on retrospective and comparative analyses. This study was aimed to retrospectively analyze the prognostic factors and its relevance in the outcomes of primary vaginal cancers

MATERIALS: Medical records of all cases of primary vaginal cancers, presented to Department of Oncology, from 2004 to 2012, at a tertiary care center in southern India, were retrieved from electronic medical records, and were analyzed.</p>

RESULTS: The total number of cases was 32. Median age at presentation was 64.28&nbsp;years. Squamous histology accounted for 84.4&nbsp;%, with the rest being adenocarcinoma. Surgery was offered for five (15.6&nbsp;%), and concurrent chemotherapy for 14 (43.8&nbsp;%) patients. Three patients had only surgery. All others received radiotherapy. Twenty received external beam radiation (EBRT) and vaginal brachytherapy (VBT); seven only EBRT and two, adjuvant radiation. Five patients had residual disease; two, stage III, and three stage IV. Median follow-up was 55.83&nbsp;months. Twelve patients were alive at last follow-up (37.5&nbsp;%), while 14 were dead (43.8&nbsp;%-8 of disease and 6 of other causes). Six patients were lost to follow-up (18.8&nbsp;%). Twenty patients were disease free. Seven had recurrence, three loco-regional and four distant. Median overall survival (OS) was 86.1&nbsp;months, disease-free survival (DFS) 90.17&nbsp;months, and disease-specific survival (DSS) 97.13&nbsp;months. When well and moderately differentiated tumors were taken together, the 5-year OS, DFS, and DSS rates were, 56.6, 64.3, and 82.3&nbsp;%. For poorly differentiated tumors, median OS, DFS, and DSS were, 20.9, 14.6, and 20.9&nbsp;months, with statistically significant advantage for better grade tumors, for DSS (p 0.050). Better 5-year OS, DFS, and DSS rates were observed for stage I&nbsp;+&nbsp;II group, with 54.9, 79.8, and 78.9&nbsp;%, compared with advanced stage where the same were 54.8, 38.2, and 68.6&nbsp;% (DFS-p 0.003, DSS-p 0.009). Grade and stage of tumor had statistically significant predictive value over the outcomes, while tumor size showed a significant trend. Patients treated with combination of EBRT and VBT fared well.

<p><strong>CONCLUSION: </strong>Our study could conclude that grade of differentiation was a significant predictor of poor survival as was stage of disease. Combination of VBT and external beam radiotherapy provides good DFS.</p>

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2016

Journal Article

S. Harikrishnan, Sanjay, G., Ashishkumar, M., Menon, J., Rajesh, G., and R Krishna Kumar, “Pulmonary Hypertension Registry of Kerala (PROKERALA) - Rationale, design and methods”, Indian Heart J, vol. 68, no. 5, pp. 709-715, 2016.[Abstract]


BACKGROUND: Pulmonary hypertension (PH) is a disease associated with a high morbidity and mortality. There is paucity of data regarding PH from the developing countries including India. Idiopathic pulmonary arterial hypertension is the most important etiological factor in the western world, but PH secondary to rheumatic heart disease, chronic obstructive pulmonary disease and untreated congenital heart disease could well be the predominant causes in developing countries like India. The main objective of the PROKERALA study - Pulmonary hypertension Registry Of Kerala is to collect data regarding the etiology, practice patterns and one-year outcomes of patients diagnosed to have PH.

METHODS: The study is a hospital-based registry in the state of Kerala supported and funded by the Cardiological Society of India, Kerala Chapter. A total of 77 hospitals have agreed to participate in the registry. PH was defined as systolic pulmonary artery pressure derived by echocardiography of more than 50mmHg (by tricuspid regurgitation jet) or mean PA pressure more than 25mmHg obtained at cardiac catheterization. A detailed questionnaire is administered which includes the demographic characteristics, risk factors, family history, ECG data, 6 minute walk test distance, chest X ray findings and echocardiographic data. Details of PH specific therapy and one-year follow-up data are collected. From a preliminary survey in the region, we estimated that we will be able to collect 2000 cases over a period of one year.

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2016

Journal Article

A. Vijayachan Nair, Rao, S. Nagaraja, Kumaran, C. Kadassery, and Kochukunju, B. Vadakkekot, “Clinico-Radiological Correlation of Subcoracoid Impingement with Reduced Coracohumeral Interval and its Relation to Subscapularis Tears in Indian Patients.”, J Clin Diagn Res, vol. 10, no. 9, pp. RC17-RC20, 2016.[Abstract]


INTRODUCTION: Clinically, subcoracoid impingement is characterized by pain at the anterior aspect of the shoulder that is induced by adduction, internal rotation and forward flexion. This position leads to narrowing of the Coraco-Humeral Interval (CHI)-that is, the space between the coracoid process and the lesser tuberosity of the humerus. Structures in the rotator interval are at greatest risk for impingement which includes the Subscorapularis tendon, tendon of the long head of the biceps, and the middle gleno-humeral ligament. This may result in Rotator interval pathologies such as subscapularis tear and long head of biceps tendon subluxation or fraying.
AIM: To study the prevalence of radiological evidence of reduced Coraco-Humeral Interval (CHI) in patients with clinically evident Subcoracoid impingement and to examine the presence of Subscapularis tears in these patients.

MATERIALS AND METHODS: </strong>Twenty four patients (6 males, 18 females, average age 52.83 years) were included in this prospective study who were diagnosed to have rotator cuff tears clinically. Nine of these patients were clinically found to have concomitant subcracoid impingement. All patients were subjected to MRI of shoulder. Measurement of the CHI was done in images with humerus in maximal internal rotation. Presence of subscapularis tear was examined intraoperatively. Statistical evaluation of the data was performed using Student's t-test and Fisher's exact test and the results were applied to two cohorts of patients. One cohort consisted of patients who had a CHI value of less than 5.5mm and the other cohort had a CHI value greater than 5.5mm. Average CHI values in patients with and without a subscapularis tear were determined

RESULTS: </strong>Nine patients who had clinical subcoracoid impingement were found to have an average CHI of 5.33mm. All nine of them had an associated tear of subscapularis with long head of Biceps tendon subluxation and/or fraying. Remaining 15 patients had an average CHI of 10.48 and they did not have either signs of Subcracoid impingement or subscapularis tear but had a tear elsewhere (Supraspinatus or Infraspinatus). Difference between these two groups was found highly significant (p-value&lt;0.001). All patients with a CHI value of equal to, or less than 5.5mm had a subscapularis tear, whereas only 11% of patients with a CHI value more than 5.5mm had a tear (p-value&lt;0.001, highly significant).

CONCLUSION: </strong>Reduction in the CHI has a significant association with rotator interval pathologies such as subscapularis tears and subluxation or fraying of long head of biceps tendon. Treatment of such patients should include modalities such as coracoplasty or anterior shoulder stabilisation. We recommend that clinical evidence of subcoracoid impingement should lead to further Investigation in the form of MRI and estimation of CHI. A CHI of less than 5.5 mm may indicate subscapulais tear in Indian patients.

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2016

Journal Article

L. Kumar, Seetharaman, M., Rajmohan, N., Ramamurthi, P., Rajan, S., and Varghese, R., “Metabolic Profile in Right lobe Living Donor Hepatectomy: Comparison of Lactated Ringer’s Solution and Normal Saline Versus Acetate Based Balanced Salt Solution – A Pilot Study”, Indian Journal of Anaesthesia, vol. 60, pp. 719-725, 2016.[Abstract]


{Background and Aims: Lactate levels predict outcomes after hepatectomy. We compared metabolic effects of lactated versus lactate free solutions in living donor hepatectomy. Methods: Consecutive right lobe donors (n = 53) were alternatively allotted to lactated Ringer’s solution and normal saline (Group L‑control) or acetated crystalloid (Sterofundin B Braun ® Group S ‑study group) in an observational prospective randomised study. The primary outcome measure was lactate level, and secondary outcomes were base excess, bicarbonate, glucose and chloride intra‑ and post‑operatively. Mann–Whitney and Chi‑square tests were used for analysis. Results: The intraoperative, post‑operative lactate levels and the time for normalisation were comparable. Group L had significantly lower intraoperative bicarbonate levels (mmol/L) at 6 and 8 h (20.0 ± 2.14 vs. 21.3 ± 1.6

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2016

Journal Article

A. Thampi, Joy, J., Kumar, G., Sreekrishnan, T. P., and Ajith, V., “Asian journal of pharmaceutical and clinical research: A case report on role of N-acetylcysteine in non-acetaminophen-related acute liver injury”, Asian Journal of Pharmaceutical and Clinical Research, vol. 9, pp. 7-8, 2016.[Abstract]


Acute liver failure (ALF) is a clinical entity associated with a high mortality rate, and the majority of these patients may require liver transplantation. N-Acetylcysteine (NAC), an antioxidant agent that replenishes mitochondrial and cytosolic glutathione stores, is an antidote for acetaminophen poisoning. However, their role in non-acetaminophen-related ALF is still not proven. Here, we discuss a 67-year-old male patient diagnosed with hepatitis with an acute liver injury who was admitted to Emergency Medicine. He was treated with NAC infusion for an average of 48 hrs, and later, it was found that his liver function tests improved. In this study, we could find that NAC plays a major role in improving the liver function test of patients with non-acetaminophen-related ALF. More »»

2016

Journal Article

C. S. Keechilot, Shenoy, V., Kumar, A., Dr. Lalitha Biswas, Vijayrajratnam, S., Dinesh, K., and Dr. Prem Kumar Nair, “Detection of Occult Hepatitis B and Window Period Infection Among Blood Donors by Individual donation Nucleic Acid Testing in a Tertiary Care Center in South India”, Pathogens and Global Health, pp. 1-5, 2016.[Abstract]


With the introduction of highly sensitive hepatitis B surface antigen immunoassay, transfusion associated HBV infection have reduced drastically but they still tend to occur due to blood donors with occult hepatitis B infection (OBI) and window period (WP) infection. Sera from, 24338 healthy voluntary blood donors were screened for HBsAg, HIV and HCV antibody using Vitros Enhanced Chemiluminescent Immunoassay. The median age of the donor population was 30 (range 18–54) with male preponderance (98%). All serologically negative samples were screened by nucleic acid testing (NAT) for viral DNA and RNA. NAT-positive samples were subjected to discriminatory NAT for HBV, HCV, and HIV and all samples positive for HBV DNA were tested for anti-HBc, anti-HBs, HBeAg. Viral load was determined using artus HBV RG PCR Kit. Of the 24,338 donors screened, 99.81% (24292/24338) were HBsAg negative of which NAT was positive for HBV DNA in 0.0205% (5/24292) donors. Four NAT positive donors had viral load of &lt;200&nbsp;IU/ml making them true cases of OBI. One NAT positive donor was negative for all antibodies making it a case of WP infection. Among OBI donors, 75% (3/4) were immune and all were negative for HBeAg. Precise HBV viral load could not be determined in all (5/5) NAT positive donors due to viral loads below the detection limit of the artus HBV RG PCR Kit. The overall incidence of OBI and WP infections was found to be low at 1 in 6503 and 1 in 24214 donations, respectively. More studies are needed to determine the actual burden of WP infections in Indian blood donors.

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2016

Journal Article

A. Vupputuri, Vijan, V., Prabhu, M. A., Rajesh Thachathodiyl, and R. Nair, C., “Isolated rheumatic severe tricuspid regurgitation”, Echocardiography, vol. 33, pp. 1769-1770, 2016.[Abstract]


Severe isolated tricuspid regurgitation (TR) is very rare, with most cases of TR being functional and secondary to pulmonary hypertension from left heart pathologies. We report an unusual case of a young Nigerian male, who presented to us with dyspnea, repeated hospital admissions for heart failure, and a childhood history of rheumatic fever. Echocardiogram showed massively dilated right atrium and ventricle, noncoaptation of thickened tricuspid valve with torrential free tricuspid regurgitation. Other valves were normal. Cardiac MRI showed normal right ventricular function and viability. Patient underwent tricuspid valve replacement with 35-mm St. Jude valve. © 2016, Wiley Periodicals, Inc.

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2016

Journal Article

A. Vijay B, Vijan, V., and Mathew, N., “Surviving All Odds: A Unique Case of Multiple Congenital Unruptured Sinus of Valsalva Aneurysms Involving Both Left and Right Coronary Sinuses with Biventricular Dysfunction and Heart Block.”, Case Rep Cardiol, vol. 2016, p. 4654031, 2016.[Abstract]


Aneurysms of the sinus of Valsalva are very uncommon, with an incidence ranging from 0.1 to 3.5% of all congenital heart defects. Very few cases have been reported in the literature that presented with involvement of two or more sinuses. We report a case of 27-year-old male with a history of exertional breathlessness of one-month duration. After complete evaluation using transesophageal echocardiography (TEE) and multiple detector computed tomography (MDCT) scanning, the patient was diagnosed to have large congenital unruptured sinus of Valsalva aneurysms involving both left and right coronary sinuses with extension into the interventricular septum. The patient also displayed second-degree heart block (Mobitz type 2) and biventricular dysfunction. The patient was managed successfully. We present the case with an aim to highlight the management challenges including intraoperative and postoperative complications that are associated with unruptured sinus of Valsalva aneurysms of ≥2 sinuses. More »»

2016

Journal Article

A. Pillai, Mathew, G., Nachimuthu, S., and Kalavampara, S. Vasudevan, “Ventriculo-ureteral shunt insertion using percutaneous nephrostomy: a novel minimally invasive option in a patient with chronic hydrocephalus complicated by multiple distal ventriculoperitoneal shunt failures.”, J Neurosurg, pp. 1-5, 2016.[Abstract]


The management of ventriculoperitoneal (VP) shunt failure is a common problem in neurosurgical practice. On occasion, extraperitoneal sites for CSF diversion are required when shunting to the peritoneal cavity has failed after multiple attempts. The authors report a novel minimally invasive procedure allowing cannulation of the ureter for the purpose of ventriculo-ureteral (VU) shunting. Sixteen years prior to presentation, this 46-year-old woman had contracted tuberculous meningitis and had chronic hydrocephalus, with multiple distal shunt failures in recent months. A percutaneous nephrostomy was used to pass the distal catheter based on intraoperative retrograde pyelography. Following successful placement of the VU shunt, the patient's hydrocephalus stabilized and she returned to her regular functional status. The only long-term complication noted within 36 months of follow-up was a transient episode of electrolyte disturbance and dehydration associated with a diarrheal illness that responded to adequate hydration and salt supplementation. By its minimally invasive nature, this approach offers a reasonable extraperitoneal alternative after multiple distal shunt catheter failures have occurred. More »»

2016

Journal Article

C. G. Nair, Babu, M., Jacob, P., Menon, R., and Mathew, J., “Renal dysfunction in primary hyperparathyroidism; effect of Parathyroidectomy: A retrospective Cohort Study.”, Int J Surg, vol. 36, no. Pt A, pp. 383-387, 2016.[Abstract]


INTRODUCTION: Renal dysfunction associated with primary hyperparathyroidism was studied mostly in patients with mildly asymptomatic or asymptomatic parathyroid disorders. Clinical and biochemical profile of asymptomatic and symptomatic disease vary grossly. The present study analyzed renal function in patients with primary hyperparathyroidism and the relation with clinical features, biochemical features and sonologic changes of kidneys in a cohort of primary symptomatic hyperparathyroidism.

STUDY DESIGN: Cross-sectional study was done in a cohort of surgically proven patients of primary symptomatic hyperparathyroidism. Urinary tract was evaluated with high definition Ultrasonography and renal function was estimated using Modification of Diet in Renal disease (MDRD) Study equation before and after parathyroidectomy.

RESULT: Case records 145 patients were studied and there were 44 patients (30.4%) with estimated Glomerular Filtration Rate (eGFR) less than 60&nbsp;mL/min/1.73&nbsp;m(2). Associated renal complications, coincident hypertension and high serum level of calcium were strongly associated with renal dysfunction. Renal dysfunction marginally improved after 1 year following surgical cure of hyperparathyroidism in 25% of patients with renal dysfunction. There was no detectable change in renal function during the follow up period

CONCLUSION:There was high prevalence of renal dysfunction among symptomatic hyperparathyroidism. Patients with primary hyperparathyroidism should undergo complete sonological assessment of kidneys which may include presence of nephrocalcinosis and cortical echogenicity. Successful parathyroidectomy prevented deterioration of renal function in most of patients and a significant subset with renal dysfunction showed improvement of functional status.

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2016

Journal Article

A. Madkaiker, Krishna, N., Kumaraswamy, N., and Dr. Praveen Varma, “Infected pseudoaneurysm of the left anterior descending artery.”, BMJ Case Rep, vol. 2016, 2016.[Abstract]


Primary percutaneous transluminal coronary angioplasty (PTCA) with the insertion of a stent is a well-established procedure for management of coronary artery disease. Infected pseudoaneurysms following PTCA and stenting are very rare and have poor outcomes if not managed properly. We are presenting a case of a man aged 50 years with infected pseudoaneurysm of the left anterior descending artery following multiple percutaneous interventions for coronary artery disease. In this paper, we have described the presentation, diagnosis and management of this patient and have discussed the aetiology and management options of infected pseudoaneurysm affecting coronary arteries. More »»

2016

Journal Article

A. Vupputuri, Vijan, V., Prabhu, M. A., Thachathodiyl, R., and Nair, iv, R. Chandrasek, “Isolated rheumatic severe tricuspid regurgitation.”, Echocardiography, vol. 33, no. 11, pp. 1769-1770, 2016.[Abstract]


Severe isolated tricuspid regurgitation (TR) is very rare, with most cases of TR being functional and secondary to pulmonary hypertension from left heart pathologies. We report an unusual case of a young Nigerian male, who presented to us with dyspnea, repeated hospital admissions for heart failure, and a childhood history of rheumatic fever. Echocardiogram showed massively dilated right atrium and ventricle, noncoaptation of thickened tricuspid valve with torrential free tricuspid regurgitation. Other valves were normal. Cardiac MRI showed normal right ventricular function and viability. Patient underwent tricuspid valve replacement with 35-mm St. Jude valve. More »»

2016

Journal Article

S. Sumathy, Mangalakanthi, J., Purushothaman, K., Sharma, D., Remadevi, C., and Sreedhar, S., “Symptomatology and Surgical Perspective of Scar Endometriosis: A Case Series of 16 Women”, Journal of Obstetrics and Gynecology of India, pp. 1-6, 2016.[Abstract]


Aim: The prevalence of scar endometriosis is increasing with the increasing caesarean deliveries and laparoscopic procedures done for pelvic endometriosis. To analyse the symptomatology and surgical perspective of scar endometriosis. Materials and methods: Retrospective review of 16 women who underwent surgery for scar endometriosis in the period of 4 years in Amrita institute of medical sciences. Results: Mean age of the patients is 35.19 years. Mean interval from the index surgery to the presentation is 4.56 years. Mean size of the swelling is 2.84 cm. In 68.8% of the patients, caesarean section was the inciting surgery. 18.7% had port site endometriosis. Cyclical pain and swelling at the scar site was present in 93.8% of the women. 18.9% had concurrent pelvic endometriosis. All women had involvement of the subcutaneous tissue followed by 11 women with the involvement of rectus sheath. There was no recurrence of the lesion in the operated patients in the mean follow-up period of 11.91 months. Conclusion: In all women presenting with cyclical scar site pain and swelling, scar endometriosis should be considered. It commonly follows caesarean section and laparoscopic surgeries done for endometriosis. Wide local excision with or without reconstruction is the method of choice for this condition. Role of tumescent solution during surgery and postoperative medical management to reduce recurrence needs further prospective studies.

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2016

Journal Article

T. R. Katapally, Goenka, S., Bhawra, J., Mani, S., Krishnaveni, G. V., Kehoe, S. H., Lamkang, A. S., Raj, M., and McNutt, K., “Results from India's 2016 report card on physical activity for children and youth”, Journal of Physical Activity and Health, vol. 13, pp. S176-S182, 2016.[Abstract]


Background: Physical inactivity in children and youth in India is a major public health problem. The 2016 Indian Report Card on Physical Activity for Children and Youth has been conceptualized to highlight this epidemic by appraising behaviors, contexts, strategies, and investments related to physical activity of Indian children and youth. Methods: An international research collaboration resulted in the formation of a Research Working Group (RWG). RWG determined key indicators; identified, synthesized, and analyzed existing evidence; developed criteria for assigning grades; and, finally, assigned grades to indicators based on consensus. Results: Overall Physical Activity Levels were assigned a grade of C-. Active Transportation and Sedentary Behaviors were both assigned a grade of C. Government Strategies and Investments was assigned a grade of D. Six other indicators, including the country-specific indicator Physical Fitness, were graded as INC (incomplete) due to the lack of nationally representative evidence. Conclusions: Based on existing evidence, it appears that most Indian children do not achieve recommended levels of physical activity and spend most of their day in sedentary pursuits. The report card identifies gaps in both investments and research that need to be addressed before understanding the complete picture of active living in children and youth in India.

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2016

Journal Article

M. A. Prabhu, Shekhar, S., and Natarajan, K. Uma, “An under-recognized cause for syncope.”, European Journal of Internal Medicine, vol. 42, pp. e3-e4, 2016.

2016

Journal Article

M. Aravind Prabhu, Pai, P. Gopalakris, Vupputuri, A., Shekhar, S., Harikrishnan, M. Santhakuma, and Natarajan, K. Umayammal, “Supra-Hisian Conduction Block As An Unusual Presenting Feature of Takotsubo Cardiomyopathy.”, Pacing Clin Electrophysiol, 2016.[Abstract]


INTRODUCTION: Atrioventricular (AV) block is rare in Takotsubo cardiomyopathy (TC).
CASE REPORT: A 66 years old woman presented with fatigue. Her electrocardiogram revealed 3:2 Mobitz Type II AV block, confirmed to be suprahisian by electrophysiological study. Echocardiogram and left ventricular angiogram showed moderate left ventricular dysfunction and apical ballooning, whereas coronary angiogram revealed mildly ectatic coronaries. At 2 weeks AV block persisted, needing permanent pacemaker implantation. At one-month follow-up, she had normal ventricular function and no AV block.

CONCLUSION: Delayed recovery of AV conduction is possible in TC, thus implying to wait for a longer period before implanting a pacemaker. This article is protected by copyright. All rights reserved.

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2016

Journal Article

V. P. Menon, Edathadathil, F., Sathyapalan, D., Moni, M., Don, A., Balachandran, S., Pushpa, B., Prasanna, P., Sivaram, N., Nair, A., Vinod, N., Jayaprasad, R., and Menon, V., “Assessment of 2013 AHA/ACC ASCVD risk scores with behavioral characteristics of an urban cohort in India: Preliminary analysis of Noncommunicable disease Initiatives and Research at AMrita (NIRAM) study.”, Medicine (Baltimore), vol. 95, no. 49, p. e5542, 2016.[Abstract]


Cardiovascular diseases (CVDs) are the leading cause of death and disability in India. Early and sustained exposure to behavioral risk factors leads to development of CVDs.The aim of this study was to determine the baseline risk of a "hard CVD event" in subjects attending comprehensive health clinic and assess behavioral characteristics in "at risk" population.Using WHO STEPwise approach to Surveillance modified questionnaire, prevalence of noncommunicable diseases (NCDs) and risk factors was estimated in this cross-sectional study of 4507 subjects. Baseline cardiovascular risk was determined using Framingham risk score (FRS) and American College of Cardiology (ACC)/American Heart Association (AHA) atherosclerotic cardiovascular disease (ASCVD) algorithms. Modifiable behavior associated with high CVD risk was assessed. Among 40 to 59-year olds, ASCVD risk tool derived both a 10-year and lifetime risk score, which were used to stratify the cohort into 3 risk groups, namely, a high 10-year and high lifetime, a low 10-year and high lifetime, and a low 10-year and low lifetime risks.Dyslipidemia (30.6%), hypertension (25.5%), diabetes mellitus (20%), and obstructive airway disorders (17.6%) were most prevalent NCDs in our cohort. The ASCVD score stratified 26.1% subjects into high 10-yr and 59.5% into high lifetime risk while FRS classified 17.2% into high 10-year risk. Compared with FRS, the ASCVD risk estimator identified a larger proportion of subjects "at risk" of developing CVD. A high prevalence of alcohol use (38.4%), decreased intake of fruits and vegetables (96.2%) and low physical activity (58%) were observed in "at risk" population. Logistic regression analysis showed that in 40 to 59-year group, regular and occasional drinkers were 8.5- and 3.1-fold more likely to be in high 10-year and high lifetime ASCVD risk category than in low 10-year and low lifetime risk group. Similarly, regular drinkers and occasional drinkers were 2.1 and 1.3 times more likely to be in low 10-year and high lifetime risk than in low 10-year and low lifetime risk category. Subjects with inadequate intake of fruits and vegetables were 1.59 times more likely to be in low 10-year and high lifetime risk than the lower 10-year and lifetime risk group. Obese participants were 2.3-fold more likely to be in low 10-year and high lifetime risk.Identification of "at risk" subjects from seemingly healthy population will allow sustainable primary prevention strategies to reduce CVD. More »»

2016

Journal Article

G. Goel, Janaki, P. D., Dr. Smitha N. V., Anupama, R., P Sundaram, S., Nataraj, Y. S., and Vijaykumar, D. K., “Role of Axillary Ultrasound, Fine Needle Aspiration Cytology and Sentinel Lymph Node Biopsy in clinically N0 Breast Cancer.”, Indian Journal of Surgical Oncology, vol. 7, no. 4, pp. 407-412, 2016.[Abstract]


This study evaluates the combined role of axillary ultrasound, fine needle aspiration cytology and sentinel lymph node biopsy in clinically N0 axilla. Between January 2014 and June 2015, 150 women with early breast cancer underwent axillary ultrasound as a first investigation for nodal status. Suspicious nodes were subjected to image guided fine needle aspiration cytology. Non-suspicious and fine needle aspiration cytology negative axillary nodes proceeded to sentinel lymph node biopsy at time of primary breast surgery. All confirmed positive (cytology and frozen) cases proceeded to axillary lymph node dissection. 52 women had positive axillary nodes at final histology. Axillary ultrasound with fine needle aspiration cytology identified 27 patients with positive axillary nodal status and had a sensitivity of 84.36&nbsp;% (27/32) and specificity of 87.5&nbsp;% (14/16). Intraoperative frozen analysis identified a further 13 cases with sensitivity of 56.52&nbsp;% (13/23) and specificity of 97.56&nbsp;% (80/82). Overall 76.92&nbsp;% (40/52) patients with positive axillary metastasis were identified peri-operatively using combination of axillary ultrasound, cytology and sentinel lymph node biopsy.

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2016

Journal Article

S. Gopinath, Roy, A. Grace, Dr. Vinayan K. P., Kumar, A., Sarma, M., Dr. Rajesh kannan, and Pillai, A., “Seizure outcome following primary motor cortex-sparing resective surgery for perirolandic focal cortical dysplasia.”, International Journal of Surgery, vol. 36, no. Pt B, pp. 466-476, 2016.[Abstract]


OBJECTIVES: We present a case series of patients who underwent perirolandic resection for medically refractory focal epilepsy due to focal cortical dysplasia (FCD). Our aim was to specifically evaluate the outcome of a surgical strategy intended for seizure freedom while preserving primary motor cortex function. MATERIALS AND METHODS: Thirteen patients undergoing perirolandic resection for pharmacoresistant focal epilepsy between 2010 and 2015 who demonstrated histological evidence of FCD were selected from a prospectively maintained database. Presurgical evaluation included video EEG telemetry and 3T MRI brain for all patients. Eight patients underwent interictal FDG PET scan. Intracranial EEG monitoring was done for 8 patients - six by conventional subdural grid and depth electrodes and two by Stereo EEG. Additional techniques included extraoperative cortical stimulation mapping, intraoperative electrocorticography (ECoG), intraoperative motor cortex mapping and awake surgery in various combinations. In all cases (lesional and nonlesional), resection was intentionally limited for anatomic preservation of the primary motor cortex. RESULTS: Amongst the thirteen patients with age ranging 14-44 years (mean 26.8 ± 9.2) 62% of them had daily seizures. MRI abnormalities were identified in 8 patients (62%), PET showed concordant findings in 7 patients (88%). When utilized, the mean duration of intracranial EEG recordings was 8.0 ± 7.2 days (range 2-23 days). All patients underwent a primary motor cortex-sparing resection of the suspected epileptogenic cortex. The mean postoperative follow up period was 23 months (range 7.5-62 months). Twelve out of 13 (92%) were seizure free (Engel 1) outcome at the last follow-up assessment; one patient had Engel 2a outcome at 28 months. Six patients (46%) had immediate new focal neurological deficits, however all six patients had recovered completely within three months. CONCLUSION: The surgical strategy of a primary motor cortex-sparing resective surgery for perirolandic FCD is associated with an excellent early seizure-freedom rate and no permanent neurological deficits. Since the ultimate goal of resective epilepsy surgery is seizure freedom with simultaneous functional preservation, similar long term outcome studies should ultimately guide the resection strategy. More »»

2016

Journal Article

Pillay V. V., ,, and UK, R., “Decontamination Methods in Poisoning Revisited”, J Indian Soc Toxicol, vol. 12, no. 1, pp. 22 - 28, 2016.

2016

Journal Article

M. JC, JK, J., MP, J., D, P., DB, M., HS, B., Pillay V. V., BN, M., C, R., PD, T., S, R., S, R., and S., T., “Management Protocol of Venomous Snakebite in India: a Consensus Statement”, Toxin Rev , vol. 35, no. 3 - 4, pp. 147 - 151, 2016.

2016

Journal Article

J. Venkatesan, Jayakumar, R., Anil, S., and Kim, S. - K., “7 - Chitosan–Nanohydroxyapatite Nanocomposite for Bone-Tissue Regeneration”, Nanocomposites for Musculoskeletal Tissue Regeneration, pp. 161 - 174, 2016.[Abstract]


In the past two decades, significant research has been conducted to make artificial bone with the use of metals, ceramics, and polymers. Composite of biopolymer (chitosan) and bioceramic (nanohydroxyapatite—nHA) is a promising approach and these are widely studied biomaterials for bone-graft substitution. In the present review, we discussed the preparative method, mechanical properties, cell proliferation, alkaline phosphatase activity, mineralization effect and in&nbsp;vivo study of chitosan–nHA composite for bone-tissue regeneration. Chitosan–nHA composites containing third-component systems (synthetic polymers, growth factors, and stem cells) were discussed for better bone formation. Hence, the composite of chitosan–nHA will be a promising biomaterial for bone-tissue engineering

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2016

Journal Article

R. S, Moorthy S, J, P., and L, K., “Effect of Dexmedetomidine on Postoperative Hemodynamics, Re-exploration Rates and Outcome of Free Flaps in Head and Neck Reconstructive Surgeries”, 2016.

2016

Journal Article

R. sunil, pillai, Svijayakris, and lakshmi, kumar, “Effect of Nitrous Oxide Inhalation on Induction Dose of Propofol, Induction time, Oxygen saturation, and Hemodynamic Responses to Laryngoscopy and Intubation”, 2016.

2016

Journal Article

S. S. Nair and Nitu, P., “Acute Fatty Liver of Pregnancy. Our Experience with Six Cases”, Annals of woman and child health, vol. 2, no. 3, 2016.

2016

Journal Article

R. S, V, N., and L, K., “Correlation Between Central Venous and PeripheralVenous Pressures in Surgical Patients”, Ain-Shams Journal of Anesthesiology , vol. 9, no. 1, pp. 52-56, 2016.[Abstract]


Introduction
The central venous pressure (CVP) measurement is important in assessing right ventricular function and systemic fluid status, and the venous pressures measured from peripheral venous catheters closely correlate with CVP and/or CVP trends. The correlation between CVP and peripheral venous pressure (PVP) in patients undergoing major surgical procedures under mechanical ventilation during normotension, hypotension, in the presence of inotropes, and postoperatively during spontaneous respiration was studied in this study.
Materials and methods
In this prospective, observational study, 40 adult patients undergoing surgical procedures lasting for more than 5 h, where a major blood loss was expected, were studied. The CVP and PVP were recorded simultaneously at a 15 min interval until 4 h intraoperatively, followed by hourly during the postoperative period for 4 h. Statistical analysis used Student's t-test to analyze statistical significance of difference in mean, Pearson's product moment correlation coefficient to assess correlation, and paired t-test to assess changes in mean arterial pressure.
Results
Throughout the study period, PVP persistently showed a positive trend with a significantly higher value than CVP (P < 0.001), but a statistically significant correlation could not be demonstrated persistently.
Conclusion
Hence, it is concluded that measurement of PVP can be considered as an alternative to CVP monitoring, when conditions are impractical for central venous catheterization.

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2016

Journal Article

T. Thottiyil S, “Pozzi”, International Journal of anatomical variations , 2016.

2016

Journal Article

T. Thottiyil S, “A New Technique of Tracing Intra Temporal Course of the Facial Nerve”, Journal of Biocommunications, 2016.

2016

Journal Article

G. .M, “Construction of a 3D model of Epitympanic folds & Spaces”, JBC, vol. 40, no. 1, pp. 26-31, 2016.

2016

Journal Article

B. Raj and Pillay, M., “Thymic Artery: Uncommon Origin from Proximal Aortic Arch or Distal Ascending Aorta”, Italian Journal of Anatomy and Embryology, vol. 120, 2016.[Abstract]


Internal thoracic and inferior thyroid arteries mainly supply the thymus. However, very few studies have been reported on the arterial variations of the thymus. The first author, a cardiac surgeon, happened upon a thymic artery arising from either proximal aortic arch or distal ascending aorta in a few cases during routine cardiac surgery in infants and neonates. Hence a study on the prevalence of the variant thymic artery during open heart surgery was contemplated, as knowledge of its presence could avoid its injury during surgical and diagnostic procedures of the region. The prevalence of the variant thymic artery was observed during 100 consecutive cardiac surgeries in infants and neonates. In addition to two branches from internal thoracic and inferior thyroid arteries, a thymic artery originating from the distal ascending aorta or proximal arch was found in 15 (15%) out of 100 patients who underwent open heart surgery for the correction of congenital heart defects. The artery took origin from the anterior surface of aorta, a little to the left. These were small arteries, single in origin, which started at right angles from the aorta and pierced the pericardium at its reflection, from visceral to parietal, to reach the posterior surface of the thymus where they divided into two branches, one for each lobe. Since this variant artery was present in 15% cases, being aware of its presence can help prevent troublesome bleeding during surgical thymectomy, and more importantly, during surgical and diagnostic interventions in the mediastinum.

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2016

Journal Article

S. N Kumar and N., S. K., “Role of anti-GAD, anti-IA2 antibodies and C-peptide in differentiating latent autoimmune diabetes in adults from type 2 diabetes mellitus”, International Journal of Diabetes in Developing Countries, vol. 36, pp. 313–319, 2016.[Abstract]


Latent autoimmune diabetes in adults (LADA) is a form of autoimmune diabetes affecting adult patients who do not require insulin at diagnosis, positive for circulating islet autoantibodies and characterized by slower beta cell destruction. The study was aimed to identify and characterize LADA patients from clinically diagnosed type 2 diabetes mellitus (DM). We estimated anti-glutamic acid decarboxylase (anti-GAD), anti-tyrosine phosphatase-like insulinoma antigen 2 (anti-IA2) antibodies, fasting connecting peptide (C-peptide) and other clinical and biochemical parameters in 297 clinically diagnosed type 2 DM patients. The diagnosis of LADA was made by the presence of at least one pancreatic autoantibody, and thereafter LADA groups were compared with those of autoantibody-negative type 2 DM groups. The prevalence of LADA was found to be 15.2&nbsp;{%} among patients presumed to have type 2 DM. There was significant difference concerning age of patients (pþinspace}&lt;þinspace}0.001), body mass index (pþinspace}&lt;þinspace}0.001), serum levels of C-peptide (pþinspace}&lt;þinspace}0.001), insulin (pþinspace}&lt;þinspace}0.001), total cholesterol (pþinspace}&lt;þinspace}0.001), triglycerides (pþinspace}=þinspace}0.025), high-density lipoprotein cholesterol (HDL-C; pþinspace}=þinspace}0.004), low-density lipoprotein cholesterol (LDL-C; pþinspace}=þinspace}0.001) as well as insulin resistance (pþinspace}&lt;þinspace}0.001) between LADA group and type 2 DM patients. In conclusion, anti-GAD antibody and C-peptide level determination can be considered as confirmatory diagnostic markers for LADA, along with anti-IA2 assay, while other clinical and biochemical parameters can be useful for further characterizing LADA patients.

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2016

Journal Article

A. A, S, R., G., R. K., Mattumal, S., and G, U. U., “Prevalence and Correlation of Risk Factors with Serum Lipoprotein Levels in Hyperlipidemia Patients”, vol. 8, no. 2, pp. 268-276, 2016.

2016

Journal Article

R. M., S, K., A, M., G, S., A, K., E, D., S, J., A, M., and P, G., “Rare Postoperative Delayed Malignant Hyperthermia After Off-Pump Coronary Bypass Surgery and Brief Review of Literature”, Annals of Cardiac Anaesthesia, vol. 19, no. 2, pp. 357-362., 2016.

2016

Journal Article

D. Natarajan KU, “Coronary Stent Infection Successfully Diagnosed with FDG- PET CT”, 2016.

2016

Journal Article

S. L. Staveski, Parveen, V. P., Madathil, S. B., Kools, S., and Franck, L. S., “Nurse and Parent Perceptions Associated with the Parent Education Discharge Instruction Programme in Southern India”, Cardiology in the Young, vol. 26, pp. 1168–1175, 2016.

2016

Journal Article

M. Aggarwal, Vijan, V., Vupputuri, A., Nandakumar, S., and Navin Mathew, “A Rare Case of Fatal Endocarditis and sepsis caused by Pseudomonas aeruginoda in a patient with chronic renal failure”, JCDR, vol. 10, 2016.

2016

Journal Article

J. C. Menon, Joseph, J. K., Jose, M. P., Dhananjaya, B. L., and Oommen, O. V., “Clinical Profile and Laboratory Parameters in 1051 Victims of Snakebite from a Single Centre in Kerala, South India ”, vol. 64, pp. 18-26, 2016.

2016

Journal Article

R. ps, “The Epidemic Diseases Act of 1897: Public Health Relevance in the Current Scenario”, Indian J Med Ethics, vol. 1, no. 3, 2016.

2016

Journal Article

D. Sreejith S. Nair, Paul, N., Amritesh, D., Joy, D. Teena Mary, and Leelamoni, D. K., “Prevalence of Stress and Coping Mechanisms AmongMedical Students in A Private Medical College,Kochi,Kerala”, International Journal of Scientific Research, vol. 5, pp. 229-230, 2016.

2016

Journal Article

L. Susan George and Paul, N., “Awareness and Social Stigma Associated with HIV/AIDS and TB Among Students: A Comparative Study”, Journal of Evidence Based Medicine and Healthcare, vol. 2, no. 51, 2016.

2016

Journal Article

Sobha George, Francis, P. T., Paul, N., and Leelamoni, K., “Depression Among Elderly :A Comparative Study Among the Elderly Living In Old Age Homes In Ernakulam ,Kerala State,India”, Internatinal Journal of Emerging Technology & Research, vol. 2, no. 4, pp. 62-66, 2016.

2016

Journal Article

J. Toledo, George, L., Martinez, E., Lazaro, A., Han, W. Wai, Coelho, G. E., Ranzinger, S., and Horstick, O., “Relevance of Non –communicable Comorbidities for the development of the severe forms of Dengue: A systematic literature review”, PLoS Negl Trop Dis , vol. 10, no. 1, 2016.

2016

Journal Article

A. Mary Thomas, John, A., Patki, S., Singh, R. Kumar, and CH, H., “Utilization of Eye Care Services Among Primary School Children in Urban Kerala”, 2016.

2016

Journal Article

Sobha George, Leelamoni, K., and Paul, N., “Determinants of Quality of Life of Elderly in a Rural Population of Kerala, India”, NJRCM, vol. 5, no. 1, pp. 46-51, 2016.

2016

Journal Article

L. Susan George, Balasubramanian, A., Paul, N., and Leelamoni, K., “A Study on Perceived Stress and Coping Mechanisms among Students of a Medical School in South India”, J. Evid. Based Med. Healthc, vol. 3, no. 38, 2016.

2016

Journal Article

S. Jagadeesan, Eapen, M., and Thomas, J., “Asymptomatic Hypopigmented Macules on the Trunk and Limbs of a Young Male”, Pigment Int [serial online], vol. 3, pp. 52-3, 2016.

2016

Journal Article

F. Kaliyadan, Ashique, K. T., Jagadeesan, S., and Krishna, B., “What's up Dermatology? A Pilot Survey of the uUse of WhatsApp in Dermatology Practice and Case Discussion Among Members of WhatsApp Dermatology Groups”, WhatsApp dermatology groups. Indian J Dermatol Venereol Leprol , 2016.

2016

Journal Article

A. Kumar Krishnan, KS, G. Kumar, TS, S. Kumar, TP, S., Kumar, V., and Soman, S., “Prevalence and Post-exposure Prophylaxis use for Needlestick Injuries among Health Care Providers in a Tertiary Care Hospital in Kochi, India”, Eurasian J Emerg Med , vol. 15, pp. 73-7, 2016.

2016

Journal Article

M. N, P, G. Kumar K., R, M. P., P, S. T., S, B. Prasad, V, A., K, A., K, K., M, N., V, M., I, K., and A, A. Kumar, “Antibiogram for a Teritiary Care Hospital in Kerala”, vol. 39, no. 2, pp. 198-201, 2016.

2016

Journal Article

G. Kumar KP, “Textbook”, 2nd edition 2016, 2016.

2016

Journal Article

P. VV, “Textbook of Forensic Medicine and Toxicology (2016)”, 17th edition of the Textbook, 2016.

2016

Journal Article

P. VV, Sasidharan, A., and UK, R., “Decontamination methods in Poisoning -Revisited”, In Press, vol. 12, 2016.

2016

Journal Article

R. S, T, P., B, U., M, G., and N, J., “Cheiloscopy- A study of lip prints for personl identification”, vol. 15, no. 2, 2016.

2016

Journal Article

S. Bajaj, Nampoothiri, S., Yesodharan, D., Gambhir, P., and Ranade, S., “Heterozygous Complete NIPBL Gene Deletion in Cornelia de Lange Syndrome: First Case Report from India”, International Journal of Human Genetics, vol. 16, pp. 61-69, 2016.[Abstract]


AbstractCornelia de Lange Syndrome-1 (CdLS; OMIM \# 122470) is a multisystem, congenital, developmental disorder caused by heterozygous mutation in NIPBL gene on chromosome 5p13. CdLS is characterized by growth and developmental delay, facial dysmorphism, limb abnormality and other organ defects. The condition is mainly caused due to mutation in one of the cohesin ring forming genes. Among NIPBL, SMC1A and SMC3; NIPBL is mainly responsible for causing CdLS. To date molecular data for Indian CdLS patients is not available. Entire NIPBL gene has been screened in 12 children showing CdLS using MLPA in this study. The study reports entire gene deletion in one proband and partial gene deletion in the second proband. The observed deletion was in heterozygous condition in both the cases. The finding was validated by real time PCR

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2016

Journal Article

J. Nayar and Nair, S. S., “Broad Ligament Pregnancy – Success Story of a Laparoscopically Managed Case”, Journal of Clinical and Diagnostic Research, vol. 10, no. 7, 2016.[Abstract]


Abdominal pregnancies constitute 1% of ectopic pregnancies, among which broad ligament pregnancy is a rare form. The maternal mortality rate has been reported to be as high as 20%. The diagnosis is seldom established before surgery. Laparoscopic management of broad ligament ectopic pregnancy is the ideal form of treatment in appropriately selected patients.

We present the case report of successful laparoscopic treatment of a 3x3.5cm broad ligament pregnancy. A search of literature shows that ours is the 6th case report of such a rare ectopic pregnancy managed endoscopically successfully.

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2016

Journal Article

D. Sobha S. Nair, K, D. Radhamany, and Nayar, D. Jayashree, “Morbidly Adherent Placenta: a 7 year experience”, Annals of Woman and Child Health, vol. 2, 2016.[Abstract]


Morbidly adherent placenta is a life threatening obstetric emergency. There is an increase in the incidence of adherent placenta . An important risk factor is the placenta previa in the presence of a uterine scar Ultrasound is the primary tool for diagnosis but MRI is helpful in cases of inconclusive or if placenta percreta is suspected.Methods: Review of case records (Retrospective case study) of women with adherent placenta during the years 2009 – 2015 at Amrita Institute Of Medical Sciences &Research Centre, Kochi. To evaluate the high risk factors, management of morbidly adherent placenta and the maternal as well as fetal outcome in our institution.Results: Out of 17 cases the incidence of placenta accreta increased from 0.15% in 2009 to 0 .26% in 2015. Placenta previa and LSCS were the major risk factors. Ultrasound and MRI was done in the vast majority. The mean age of termination of pregnancy was 36.51 weeks. Elective surgery were done in 14 with Ceasarean hysterectomy in almost 50%. Haemostatic surgical measures were taken in all cases.The complications included bladder injury, DIC and wound dehiscence. Blood and blood products were replaced .The average time of surgery was 2.21hours and blood loss was 2.34L.. There was no maternal or perinatal mortality.Conclusion: In suspected cases, screening for placenta accrete should be done by 18- 24 weeks. Early admission, prophylactic corticosteroids, elective surgery around 36 -37 weeks in a tertiary care with multidisciplinary appproach helps to reduce the maternal and neonatal morbidity and mortality.

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2016

Journal Article

R. Reddy, Iyer, S., Sharma, M., Vijayaraghavan, S., Kishore, P., Mathew, J., Unni, A. K. K., Reshmi, P., Sharma, R., and Prasad, C., “Effect of external volume expansion on the survival of fat grafts”, Indian J Plast Surg , vol. 41, pp. 151-8, 2016.

2016

Journal Article

D. M. Vasudevan, “Text book of Biochemistry for Medical Students, 8th edition”, 2016.

2016

Journal Article

R. Prabhu, Bhaskaran, R., Shenoy, V., .G, R., and Sidharthan, N., “Clinical Characteristic outcomes of Primary HLA”, 2016.

2016

Journal Article

P. K, “Carcinoma esophagus. Practical Gastroenterology”, 2016.

2016

Journal Article

S. Vijayrajratnam, Pushkaran, A. Choorakott, Balakrishnan, A., Vasudevan, A., Biswas, R., and Mohan, C. Gopi, “Bacterial Peptidoglycan with Amidated meso -diaminopimelic acid Evades NOD1 Recognition: An insight on NOD1 Structure-Recognition Study”, Biochemical Journal, 2016.[Abstract]


Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is an intracellular pattern recognition receptor that recognizes bacterial peptidoglycan (PG) containing meso -diaminopimelic acid ( meso DAP) and activates the innate immune system. Interestingly, few pathogenic and commensal bacteria modify their PG stem peptide by amidation of meso DAP ( meso DAPNH2). In this study, NOD1 stimulation assays were performed using bacterial PG containing meso DAP (PGDAP) and meso DAPNH2 (PGDAPNH2) to understand the differences in their biomolecular recognition mechanism. PGDAP was effectively recognized, while PGDAPNH2 showed reduced recognition by NOD1 receptor. Re-stimulation of the NOD1 receptor which was initially stimulated with PGDAP, using PGDAPNH2, did not show any further NOD1 activation levels than PGDAP alone. But NOD1 receptor, initially stimulated with PGDAPNH2 responded effectively to re-stimulation with PGDAP. The biomolecular structure-recognition relationship of the ligand sensing LRR domain of human NOD1 (NOD1-LRR) with PGDAP and PGDAPNH2 was studied by different computational techniques to further understand the molecular basis of our experimental observations. The D-Glu- meso DAP motif of GMTPDAP, which is the minimum essential motif for NOD1 activation, was found involved in specific interactions at the recognition site, but the interactions of the corresponding D-Glu- meso DAP motif of PGDAPNH2 occurs away from the recognition site of NOD1 receptor. Hot-spot residues identified for effective PG recognition by NOD1-LRR include W820, G821, D826 and N850, which are evolutionarily conserved across different host species. These integrated results thus successfully provided the atomic level and biochemical insight on how PGs containing meso DAPNH2 evade NOD1-LRR receptor recognition.

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2016

Journal Article

Anil kumar, Prakash, A., Singh, A., Kumar, H., Hagen, F., Meis, J., and Chowdhary, A., “Candida Haemulonii Species Complex: an Emerging Species in India and its Genetic Diversity by Multilocus Sequence Typing and Amplified Fragment Length Polymorphism”, Emerging microbes and infections, 2016.

2016

Journal Article

R. Biswas, Chatterjee, M., D'Morris, S., Baranwal, G., Warrier, S., Vasudevan, A., Vanuopadath, M., Nai, S., and Mohan, C., “Lactobacillus Fermentum Secreted Phenyl Lactic Acid Mediates Quorum Quenching in Pseudomonas Aeruginosa”, 2016.

2016

Journal Article

R. Babu, Anil kumar, Karim, S., Warrier, S., Nair, S. G., K.Singh, S., and Biswas, R., “Fecal Carriage Rate of Extended Spectrum Beta Lactamase (ESBL) Producing Enterobacteriaceae in Hospitalized Patients and Healthy Asymptomatic Individuals Coming for Health Check-up”, Journal of global antimicrobial resistance, 2016.

2016

Journal Article

P. S, S, S. P., and A, T., “PET/CT in Paediatric Malignancies - An Update”, International journal of medical and paediatric oncology, vol. 37, 2016.

2016

Journal Article

M. Z. U, F, M., C, singh, and A, S., “Experiences in End-of-life Care in the Intensive Care Unit: A Survey of Resident Physicians”, Indian journal of critical care and medicine, vol. 20, no. 8, pp. 459-464, 2016.

2016

Journal Article

D. R. Krishnakumar and Raj, D. Manu, “Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants”, The Lancet, vol. 387, pp. 1377 - 1396, 2016.[Abstract]


Summary Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (&lt;18·5 kg/m2 [underweight], 18·5 kg/m2 to &lt;20 kg/m2, 20 kg/m2 to &lt;25 kg/m2, 25 kg/m2 to &lt;30 kg/m2, 30 kg/m2 to &lt;35 kg/m2, 35 kg/m2 to &lt;40 kg/m2, ≥40 kg/m2 [morbid obesity]), by sex in 200 countries and territories, organised in 21 regions. We calculated the posterior probability of meeting the target of halting by 2025 the rise in obesity at its 2010 levels, if post-2000 trends continue. Findings We used 1698 population-based data sources, with more than 19·2 million adult participants (9·9 million men and 9·3 million women) in 186 of 200 countries for which estimates were made. Global age-standardised mean BMI increased from 21·7 kg/m2 (95% credible interval 21·3–22·1) in 1975 to 24·2 kg/m2 (24·0–24·4) in 2014 in men, and from 22·1 kg/m2 (21·7–22·5) in 1975 to 24·4 kg/m2 (24·2–24·6) in 2014 in women. Regional mean BMIs in 2014 for men ranged from 21·4 kg/m2 in central Africa and south Asia to 29·2 kg/m2 (28·6–29·8) in Polynesia and Micronesia; for women the range was from 21·8 kg/m2 (21·4–22·3) in south Asia to 32·2 kg/m2 (31·5–32·8) in Polynesia and Micronesia. Over these four decades, age-standardised global prevalence of underweight decreased from 13·8% (10·5–17·4) to 8·8% (7·4–10·3) in men and from 14·6% (11·6–17·9) to 9·7% (8·3–11·1) in women. South Asia had the highest prevalence of underweight in 2014, 23·4% (17·8–29·2) in men and 24·0% (18·9–29·3) in women. Age-standardised prevalence of obesity increased from 3·2% (2·4–4·1) in 1975 to 10·8% (9·7–12·0) in 2014 in men, and from 6·4% (5·1–7·8) to 14·9% (13·6–16·1) in women. 2·3% (2·0–2·7) of the world's men and 5·0% (4·4–5·6) of women were severely obese (ie, have BMI ≥35 kg/m2). Globally, prevalence of morbid obesity was 0·64% (0·46–0·86) in men and 1·6% (1·3–1·9) in women. Interpretation If post-2000 trends continue, the probability of meeting the global obesity target is virtually zero. Rather, if these trends continue, by 2025, global obesity prevalence will reach 18% in men and surpass 21% in women; severe obesity will surpass 6% in men and 9% in women. Nonetheless, underweight remains prevalent in the world's poorest regions, especially in south Asia. Funding Wellcome Trust, Grand Challenges Canada.

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2016

Journal Article

K. R.K, “Congenital Heart Disease Profile: Four Perspective”, Annals of paediatrics cardiology, vol. 9, no. 3, 2016.

2016

Journal Article

D. R. Krishnakumar and Raj, D. Manu, “A Century of Trends in Adult Human Height”, 2016.

2016

Journal Article

L. Guo, Cui, Y., Bobhate, P., Kumar, S., Jain, S., Elgendi, M., Pharis, S., Ryerson, L., and Adatia, L., “Measurement of Oxygen Consumption In Critically Ill Children: Breath-By-Breath Method Vs Mass Spectrometry”, American journal of critical care, 2016.

2016

Journal Article

J. E. MacLean, DeHaan, K., Fuhr, D., Hariharan, S., Kamstra, B., Hendson, L., Adatia, I., Majaesic, C., Lovering, A. T., Thompson, R. B., Nicholas, D., Thebaud, B., and Stickland, M. K., “Altered Breathing Mechanics and Ventilatory Response During Exercise in Children born Extremely Preterm”, Thorax, 2016.

2016

Journal Article

M. raj and R, Kkumar, “World Wide Trends in Adult Human Height”, Elife, 2016.

2016

Journal Article

S. EM, A, H., Y, I., and S, N., “Characterization of Greater Middle Eastern Genetic Variation for Enhanced Disease Gene Discovery”, Nat Genet. , vol. 48, no. 9, pp. 1071-6, 2016.[Abstract]


The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1,2,3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized 'genetic purging'. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics.

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2016

Journal Article

D. Mathew Vad L, Gopalakrishnan, D. Rajesh, and Eapen, D. Malini, “Correlation of Insulin Resistance with Liver Histology in Obese Patients with NASH and in Lean NASH”, Journal of clinical and experimental hepatology, 2016.

2016

Journal Article

S. N. Khan, Joseph, S., and Sasidharan, P., “A Study of Clinical Pharmacist Initiated Intervention for the Optimal use of Medications in a Neonatal Intensive Care Unit (NICU) of a Tertiary Care Hospital, South India”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 1, pp. 23-26, 2016.

2016

Journal Article

A. A Babu, Rani, S., Revikumar, K. G., Mattumal, S., and Unnikrishnan, U. G., “Assessment of Correlation in Gender and Age with Lipoprotein Levels in Hyperlipidemia Patients”, Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, pp. 197-199, 2016.

2016

Journal Article

P. R. Roshni, Thampi, A., Ashok, B. A., Joy, J., Thomas, T., and Kumar, K. P. G., “A Study on Adverse Drug Reactions of Anti-retroviral Therapy in HIV Patients”, International Journal of Pharmaceutical Sciences Review and Research, , vol. 36, no. 2, 2016.

2016

Journal Article

R. Mary Jacob V, L, S., K, R., Krishnan, S., and R, S. K., “Endometriosis is Associated with Hypothyroidism in Married Women”, J.Evolution Med Dent Sci, vol. 5, no. 29, pp. 1497-1499, 2016.

2016

Journal Article

R. G, BN, G., and V., S. Balakrishn, “Risk Factors for Pancreatic Cancer in Patients with Chronic Pancreatitis”, Tropical Gastroenterology, 2016.

2016

Journal Article

D. .Akhilesh.k, “Yield of Sputum Induction with 3% Hypertonic Saline in Smear Negative Pulmonary Tuberculosis”, International journal of pharma and bioscience, vol. 7, no. 2, 2016.

2016

Journal Article

V. R, K.S, A., and P A, M., “Persistent Left Upper Lobe Opacity in a Middle Aged Gentleman”, Lung India, vol. 33, no. 4, 2016.

2016

Journal Article

C. G. Prameela, P Ravind, R., ,, Sheejamol, V. S., and Dinesh, M., “Radiation Dose to Dysphagia Aspiration Related Structures and its Effect on Wallowing: Comparison of Three Dimensional Conformal Radiotherapy and Intensity modulated Radiation Therapy Plans”, Journal of cancer research and therapeutics, vol. 12, no. 2, 2016.

2016

Journal Article

B. Kunheri, Kottarathil, V. Dehannathp, Makuny, D., Keechilat, P., and Padmanabhan, T. K., “Neoadjuvant Chemotherapy Followed by Neoadjuvant Concurrent Chemoradiation for Locally Advanced Breast Cancer: a Feasibility Study and 10-year Follow-up Results”, Indian Journal of Gynecologic Oncology, vol. 14, p. 60, 2016.[Abstract]


Locally advanced breast cancer (LABC) is best managed by neoadjuvant chemotherapy followed by surgery and radiotherapy. Recent reports suggest that complete pathological response is associated with improved survival. Major concern of using concurrent chemoradiation in LABC is toxicity and cosmesis, and only very few studies addressed this issue. This study is carried out to study the feasibility, toxicity profile, pathological response of neoadjuvant anthracycline-based chemotherapy followed by concurrent chemoradiation with biweekly paclitaxel in locally advanced breast cancer patients.

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2015

Journal Article

S. Balaji and Kumar, R. K., “Partnership in healthcare: What can the west learn from the delivery of pediatric cardiac care in low- and middle-income countries”, Annals of Pediatric Cardiology, vol. 8, pp. 1-3, 2015.

2015

Journal Article

M. Sarma, Sonik, B., Subramanyam, P., and P. Sundaram, S., “Isolated skeletal muscle metastatic deposit in a patient with micropapillary carcinoma thyroid identified by 18F FDG PET CT”, Journal of the Egyptian National Cancer Institute, 2015.[Abstract]


Micropapillary carcinoma of thyroid is said to be low risk differentiated thyroid malignancy with excellent prognosis. We report the identification of an isolated FDG avid muscle deposit in a treated case of micropapillary carcinoma of the right lobe and widely invasive follicular carcinoma of the left lobe thyroid gland. Patient was found to have an elevated thyroglobulin level with negative iodine scan (TENIS syndrome) on follow up at 6. months. An 18F FDG PET CT (18 fluorine-fluorodeoxyglucose positron emission computed tomography) whole body study revealed a solitary FDG avid deltoid muscle deposit which was histopathologically confirmed to be metastatic papillary carcinoma. While follicular carcinoma is known to have distant metastases, this may be the first reported case of solitary skeletal metastases from micropapillary carcinoma of thyroid and probably the second reported skeletal muscle deposit from DTC detected on 18F FDG PET CT done following elevated thyroglobulin level and negative 131 iodine WB scan (TENIS). This case also assumes importance because it demonstrates possibility of metastases even from a micropapillary carcinoma in contrast to American Thyroid Association guidelines (2009) which suggests that micropapillary carcinoma of thyroid does not merit further treatment after a Total Thyroidectomy. More »»

2015

Journal Article

Rajan S., J., P., and L., K., “Converting a nasoendotracheal tube to orotracheal, following fibreoptic intubation under general anaesthesia in a paediatric patient with complete cleft palate”, Indian Journal of Anaesthesia, vol. 59, pp. 131-132, 2015.

2015

Journal Article

Udayakumaran S and Onyia C.U., “Beckwith–Wiedemann syndrome and Chiari I malformation—a case-based review of central nervous system involvement in hemihypertrophy syndromes”, Child's Nervous System, 2015.[Abstract]


<p>Background: Beckwith–Wiedemann syndrome (BWS) is an unusual complex of abnormalities that includes mainly omphalocele, macroglossia, gigantism, visceromegaly, and neonatal hypoglycemia. Type I Chiari malformation, on the other hand, is defined as ectopia of the cerebellar tonsils below the plane of the foramen magnum. Only one case of association of BWS with Chiari I malformation has been previously reported in the literature. Discussion: Several conditions involving congenital hemihypertrophy have been previously reported in association with Type I Chiari malformation. The pathophysiological mechanism for most of these associations is thought to be quite complex and still remains unclear. However, the presence of tonsillar herniation in BWS has been explained by Tubbs and Oakes in the only one existing case report of BWS with Type I Chiari malformation in the literature, to be due to associated hemihypertrophy of the skull base. We additionally suggest that cerebellar hypertrophy may also contribute to the tonsillar herniation and fourth ventricular outlet obstruction. Illustrative case: We now report our recent experience on this association following a review of the literature on association of other hemihypertrophy syndromes with the central nervous system anomalies. Conclusion: We believe that a common pathogenesis of Type I Chiari malformation occurs in conditions of hemihypertrophy including BWS, probably secondary to dysmorphology involving the posterior cranial fossa, and is not just an associated finding.</p>

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2015

Journal Article

T. C. Thomas, K. Kumar, A., Mohamed, S., Krishnan, V., Mathew, A., and Manju, V., “The effect on the flexural strength, flexural modulus and compressive strength of fibre reinforced acrylic with that of plain unfilled acrylic resin – an in vitro study”, Journal of Clinical and Diagnostic Research, vol. 9, pp. ZC12-ZC14, 2015.[Abstract]


Aim: The aim of this in vitro study was to compare the flexural strength, the flexural modulus and compressive strength of the acrylic polymer reinforced with glass, carbon, polyethylene and Kevlar fibres with that of plain unfilled resin. Materials and Methods: A total of 50 specimens were prepared and divided into 10 specimens each under 5 groups namely group 1- control group without any fibres, group 2 – carbon fibres, group 3- glass fibres, group 4 – polyethylene, group 5- Kevlar. Universal testing machine (Tinius olsen, USA) was used for the testing of these specimens. Out of each group, 5 specimens were randomly selected and testing was done for flexural strength using a three point deflection test and three point bending test for compressive strength and the modulus was plotted using a graphical method. Statistical analysis was done using statistical software. Results: The respective mean values for samples in regard to their flexural strength for PMMA plain, PMMA+ glass fibre, PMMA+ carbon, PMMA+ polyethylene and PMMA+ Kevlar were 90.64, 100.79, 102.58, 94.13 and 96.43 respectively. Scheffes post hoc test clearly indicated that only mean flexural strength values of PMMA + Carbon, has the highest mean value. One-way ANOVA revealed a non-significant difference among the groups in regard to their compressive strength. Conclusion: The study concludes that carbon fibre reinforced samples has the greatest flexural strength and greatest flexural modulus, however the compressive strength remains unchanged. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

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2015

Journal Article

S. Udayakumaran, Ayiramuthu, P., and Panikar, D., “Extradural temporopolar approach for parahypothalamic hypothalamic hamartoma and use of posterior communicating artery as resection margin pointer”, Child's Nervous System, vol. 31, pp. 603-608, 2015.[Abstract]


Background: Hypothalamic hamartomas (HH) are malformations originating from the hypothalamus and are associated with seizures, hormonal and behavioral abnormalities.Method: Most patients, especially those with a typical syndrome characterized by gelastic seizures, precocious puberty, cognitive decline, and behavior problems, are diagnosed in childhood. Pedunculated and parahypothalamic types of hamartomas are attached to the floor by a narrow or wide peduncle in the absence of distortion of the overlying hypothalamus. This location is most commonly associated with a clinical presentation of precocious puberty, and surgical removal has proved curative in small case series. Enthusiastic resection of hypothalamic lesions are known to produce severe hypothalamic disturbance while under resection might mean inadequate response to surgery.Conclusions: In this article, the authors describe the use of extradural temporopolar approach to hypothalamic hamartoma as an improvisation to improve access with reduced morbidity and describe a surgical nuance of using posterior communicating artery to determine a safe but maximal resection margin. © 2015, Springer-Verlag Berlin Heidelberg.

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2015

Journal Article

S. Khan, Kumar, A., Vinod, V., Prabhakar, V., Eapen, M., Thomas, J., Dinesh, K., and Karim, S., “Chromoblastomycosis Due to Fonsecaea Pedrosoi: An Old Wine in a Rare Bottle”, Journal of Infection in Developing Countries, vol. 9, pp. 325-329, 2015.[Abstract]


Chromoblastomycosis is a chronic subcutaneous mycosis commonly caused by Fonsecaea, Phialophora, and Cladophialophora spp. Out of these, Fonsecaea pedrosoi is the most common etiological agent, implicated in 70%–90% of the cases reported worldwide. The histopathological diagnosis of chromoblastomycosis is based on visualization of medlar or sclerotic bodies in the tissue. These sclerotic bodies divide by planar division. Rarely, budding is seen in these sclerotic bodies. As this entity can be confused with phaeohyphomycosis, it is important to be aware of such a presentation also. We report two cases of chromoblastomycosis that showed budding sclerotic bodies. © 2015, Khan et al.

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2015

Journal Article

N. Nair, Vinod, V., Suresh, M. K., Vijayrajratnam, S., Dr. Lalitha Biswas, Peethambaran, R., Vasudevan, A. K., and Dr. Raja Biswas, “Amidase, a cell wall hydrolase, elicits protective immunity against Staphylococcus aureus and S. epidermidis”, International Journal of Biological Macromolecules, vol. 77, pp. 314-321, 2015.[Abstract]


The morbidity and the mortality associated with Staphylococcus aureus and S. epidermidis infections have greatly increased due to the rapid emergence of highly virulent and antibiotic resistant strains. Development of a vaccine-based therapy is greatly desired. However, no staphylococcal vaccine is available till date. In this study, we have identified Major amidase (Atl-AM) as a prime candidate for future vaccine design against these pathogens. Atl-AM is a multi-functional non-covalently cell wall associated protein which is involved in staphylococcal cell separation after cell division, host extracellular matrix adhesion and biofilm formation. Atl-AM is present on the surface of diverse S. aureus and S. epidermidis strains. When used in combination with Freund's adjuvant, Atl-AM generated a mixed Th1 and Th2 mediated immune response which is skewed more toward Th1; and showed increased production of opsonophagocytic IgG2a and IgG2b antibodies. Significant protective immune response was observed when vaccinated mice were challenged with S. aureus or S. epidermidis. Vaccination prevented the systemic dissemination of both organisms. Our results demonstrate the remarkable efficacy of Atl-AM as a vaccine candidate against both of these pathogens. © 2015 Elsevier B.V.

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2015

Journal Article

A. Mehta, Gupta, A., Aziz, K. S., and Venkitakrishnan, R., “Endobronchial foreign body (FB): A rare cause of empyema”, Journal of Clinical and Diagnostic Research, vol. 9, pp. 2-3, 2015.

2015

Journal Article

L. Kumar, Kanneganti, Y. S., and Rajan, S., “Outcomes of Implementation of Enhanced Goal Directed Therapy in High-Risk Patients Undergoing Abdominal Surgery”, Indian Journal of Anaesthesia, vol. 59, pp. 228-233, 2015.[Abstract]


Background and Aims: Advanced monitoring targeting haemodynamic and oxygenation variables can improve outcomes of surgery in high-risk patients. We aimed to assess the impact of goal directed therapy (GDT) targeting cardiac index (CI) and oxygen extraction ratio (O<inf>2</inf> ER) on outcomes of high-risk patients undergoing abdominal surgery. Methods: In a prospective randomised trial, forty patients (American Society of Anaesthesiologists II and III) undergoing major abdominal surgeries were randomised into two groups. In-Group A mean arterial pressure ≥ 65 mmHg, central venous pressure ≥ 8–10 mmHg, urine output ≥ 0.5 mL/kg/h and central venous oxygen saturation ≥ 70% were targeted intra-operatively and 12 h postoperatively. In-Group-B (enhanced GDT), in addition to the monitoring in-Group-A, CI ≥ 2.5 L/min/m2 and O<inf>2</inf> ER ≤ 27% were targeted. The end-points were lactate levels and base deficit during and after surgery. The secondary end points were length of Intensive Care Unit (ICU) and hospital stay and postoperative complications. Wilcoxon Mann Whitney and Chi-square tests were used for statistical assessment. Results: Lactate levels postoperatively at 4 and 8 h were lower in-Group-B (P < 0.05). The mean base deficit at 3, 4, 5 and 6 h intra-operatively and postoperatively after 4, 8 and 12 h were lower in-Group-B (P < 0.05). There were no significant differences in ICU stay (2.10 ± 1.52 vs. 2.90 ± 2.51 days) or hospital stay (10.85 + 4.39 vs. 13.35 + 6.77 days) between Group A and B. Conclusions: Implementation of enhanced GDT targeting CI and OER was associated with improved tissue oxygenation. © 2015, Indian Journal of Anaesthesia. All right reserved.

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2015

Journal Article

S. P. Sundaram and Padma, S., “Hughes syndrome with cerebral, skeletal infarction & retinal vein thrombosis”, Indian Journal of Medical Research, vol. 141, pp. 249-250, 2015.

2015

Journal Article

S. Khan, Kumar, V. A., Sidharthan, N., Mehta, A., Backer, B., and Dinesh, K. R., “Salmonella Typhimurium pneumonia in a patient with multiple myeloma”, Tropical Doctor, vol. 45, pp. 135-136, 2015.[Abstract]


Pneumonia due to non-typhoidal Salmonella is a rarely reported entity. A fatal case of Salmonella pneumonia is reported here where Salmonella Typhimurium was isolated from the endotracheal aspirate and blood culture. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav

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2015

Journal Article

Dr. Praveen Varma, “Risk Assessment Scores in Cardiac Surgery”, Annals of Cardiac Anaesthesia, vol. 18, pp. 170-171, 2015.

2015

Journal Article

Dr. Praveen Varma, Raman, S. P., Neema, P. K., and Shekar, P. S., “Hypertrophic cardiomyopathy”, Indian Journal of Thoracic and Cardiovascular Surgery, vol. 31, pp. 153-161, 2015.[Abstract]


Hypertrophic cardiomyopathy is a common genetic cardiovascular disease affecting the general population with an estimated prevalence of 1 in 500 with autosomal dominant pattern of inheritance and is an important cause of intractable heart failure. Up to 70 % of patients present with left ventricular outflow tract obstruction due to asymmetric hypertrophy of the interventricular septum and systolic anterior motion of anterior mitral leaflet. These patients are initially managed with medical treatment. Persistent symptoms (dyspnea and chest pain NYHA class 3 or 4 and syncope) in spite of optimal medical therapy and presence of gradients above 50 mm of Hg at rest or by provocation are usually referred for invasive strategy. Extended surgical myectomy and alcohol septal ablation are current strategies employed for relief of left ventricular outflow tract gradients. There is a higher incidence of residual gradients, more incidences of conduction blocks requiring pacemaker implantation and more risk of life-threatening arrhythmias with alcohol ablation compared to surgery and hence is currently recommended as a treatment option only in elderly patients with poor risk profile for surgery. Early and long-term results after surgery are excellent, making it as the gold standard for management of hypertrophic cardiomyopathy. © 2015, Indian Association of Cardiovascular-Thoracic Surgeons.

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2015

Journal Article

Anilkumar B. Pillai, Nair, J. Va, Gupta, N. Kb, and Swati P. Gupta, “Microemulsion-loaded hydrogel formulation of butenafine hydrochloride for improved topical delivery”, Archives of Dermatological Research, 2015.[Abstract]


Topical microemulsion systems for the antifungal drug, butenafine hydrochloride (BTF) were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of BTF in oils, surfactants and co-surfactants was evaluated to screen the components of the microemulsion. Isopropyl palmitate was used as the oil phase, aerosol OT as the surfactant and sorbitan monooleate as co-surfactant. The pseudoternary diagrams were constructed to identify the area of microemulsion existence and optimum systems were designed. The systems were assessed for drug-loading efficiency and characterized for pH, robustness to dilution, globule size, drug content and stability. Viscosity analysis, spreadability, drug content assay, ex vivo skin permeation study and antifungal activity assay were performed for the optimized microemulsion-loaded hydrogel. The optimized BTF microemulsion had a small and uniform globule size. The incorporation of microemulsion system into Carbopol 940 gel was found to be better as compared to sodium alginate or hydroxyl propyl methyl cellulose (HPMC K4 M) gel. The developed gel has shown better ex vivo skin permeation and antifungal activity when compared to marketed BTF cream. Thus, the results provide a basis for the successful delivery of BTF from microemulsion-loaded hydrogel formulation, which resulted in improved penetration of drug and antifungal activity in comparison with commercial formulation of BTF. © 2015 Springer-Verlag Berlin Heidelberg

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2015

Journal Article

T. Ra Yamini, Nichter, Mbc, Nichter, Mb, Sairu, Pd, Aswathy, Se, Leelamoni, Ke, Unnikrishnan, Bf, P., P. Mf, Thapar, Rf, Basha, S. Rg, Jayasree, A. Kh, Mayamol, T. Rh, Muramoto, Mc, Mini, G. Ka, and Thankappan, K. Ra, “Developing a fully integrated tobacco curriculum in medical colleges in India”, BMC Medical Education, 2015.[Abstract]


Background: This paper describes a pioneering effort to introduce tobacco cessation into India's undergraduate medical college curriculum. This is the first ever attempt to fully integrate tobacco control across all years of medical college in any low and middle income country. The development, pretesting, and piloting of an innovative modular tobacco curriculum are discussed as well as challenges that face implementation and steps taken to address them and to advocate for adoption by the Medical Council of India. Methods: In-depth interviews were conducted with administrators and faculty in five medical colleges to determine interest in and willingness to fully integrate smoking cessation into the college curriculum. Current curriculum was reviewed for present exposure to information about tobacco and cessation skill training. A modular tobacco curriculum was developed, pretested, modified, piloted, and evaluated by faculty and students. Qualitative research was conducted to identify challenges to future curriculum implementation. Results: Fifteen modules were successfully developed focusing on the public health importance of tobacco control, the relationship between tobacco and specific organ systems, diseases related to smoking and chewing tobacco, and the impact of tobacco on medication effectiveness. Culturally sensitive illness specific cessation training videos were developed. Faculty and students positively evaluated the curriculum as increasing their competency to support cessation during illness as a teachable moment. Students conducted illness centered cessation interviews with patients as a mandated part of their coursework. Systemic challenges to implementing the curriculum were identified and addressed. Conclusions: A fully integrated tobacco curriculum for medical colleges was piloted in 5 colleges and is now freely available online. The curriculum has been adopted by the state of Kerala as a first step to gaining Medical Council of India review and possible recognition. © 2015 Yamini et al.

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2015

Journal Article

A. Sreedevi, Javed, R., and Dinesh, A., “Epidemiology of cervical cancer with special focus on India”, International Journal of Women's Health, vol. 7, pp. 405-414, 2015.[Abstract]


Cervical cancer is on the declining trend in India according to the population-based registries; yet it continues to be a major public health problem for women in India. Multifactorial causation, potential for prevention, and the sheer threat it poses make cervical cancer an important disease for in-depth studies, as has been attempted by this paper. This paper attempts to review the available knowledge regarding the epidemiology and pattern of cervical cancer; types of HPV (human papilloma virus) prevalent among cervical cancer patients and among women in general, high-risk groups such as commercial sex workers, and HIV (human immunodeficiency virus)-positive women; and the role of the national program on cancer in control efforts. The peak age of incidence of cervical cancer is 55–59 years, and a considerable proportion of women report in the late stages of disease. Specific types of oncogenic HPV-16, 18 have been identified in patients with cervical cancer. Other epidemiological risk factors are early age at marriage, multiple sexual partners, multiple pregnancies, poor genital hygiene, malnutrition, use of oral contraceptives, and lack of awareness. A multipronged approach is necessary which can target areas of high prevalence identified by registries with a combination of behavior change communication exercises and routine early screening with VIA. Sensitizing the people of the area, including menfolk, is necessary to increase uptake levels. Vaccination against types 16 and 18 can also be undertaken after taking into confidence all stakeholders, including the parents of adolescent girls. Preventing and treating cervical cancer and reducing the burden are possible by targeting resources to the areas with high prevalence. © 2015 Sreedevi et al.

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2015

Journal Article

H. R. Gandhi, Thomas, A., Nair, B., and Pooleri, G., “Laparoscopic pyelolithotomy: An emerging tool for complex staghorn nephrolithiasis in high-risk patients”, Arab Journal of Urology, vol. 13, pp. 139-145, 2015.[Abstract]


Abstract Objectives: To evaluate the effectiveness of laparoscopic pyelolithotomy (LP) for staghorn stones (>3-4 cm) in patients with chronic liver disease or coronary artery disease. Patients and methods: In all, 49 patients underwent LP; they were divided into four groups, with stones in group 1 in the renal pelvis only, in group 2 in the renal pelvis and one calyx, in group 3 in the renal pelvis and two calyces, and in group 4, in the renal pelvis and more than two calyces. Patient demography, stone characteristics, surgical outcomes and complications were evaluated. Results: The mean stone-free rate in one session was 90% among all groups. The mean (SD) stone size was 4.27 (1.72) cm. The stone-free rate decreased with greater stone burden, but the operative time, estimated blood loss and need for ancillary procedures increased with stone burden. No blood transfusion was required and one patient each in groups 2 and 4 had a urine leak. Conclusion LP provides acceptable results in complex cases for managing renal stone disease with a larger stone burden in high-risk situations. © 2014 Arab Association of Urology.

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2015

Journal Article

Sa Krishna, Dr. Sanjeev K. Singh, Dinesh, K. Ra, KP, Rc, Siyad, Id, and Karim, Sa, “Percutaneous endoscopic gastrostomy (PEG) site infections: a clinical and microbiological study from university teaching hospital, India”, Journal of Infection Prevention, vol. 16, pp. 113-116, 2015.[Abstract]


Background:
Percutaneous endoscopic gastrostomy (PEG) is used to provide enteral access in patients who are unable to swallow. Infection of the stoma is an important complication and there is little data from India on this problem, which can be used to inform infection prevention and prophylactic strategies.

Aim:
The objective was to assess the prevalence and the role of contributory factors in PEG site infections.

Methods:
A total of 173 patients underwent PEG insertion from January 2011 to May 2012. Clinical and microbiological data were collected for culture-positive cases. Insertion was performed using a standard sterile pull-through technique. Infections were defined as two of: peristomal erythema, induration, and purulent discharge.

Results:
A total of 54 PEG infections occurred in 43 patients (28.85%). Seventy-seven organisms were isolated. Pseudomonas aeruginosa was the most common (n=29) followed by coliforms (n=21) and meticillin resistant Staphylococcus aureus (MRSA) (n=6). Thirty-one (72%) received amoxicillin-clavulanic acid as prophylaxis and 12 (28%) were receiving concomitant antibiotics for their underlying conditions. The occurrence of PEG site infections was statistically independent of the administered prophylactic antibiotics (p=0.3).

Conclusions:
This study has demonstrated the importance of PEG sites as a cause of healthcare associated infections. Educating patients on wound care practices would play a significant role in prevention of PEG site infections.

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2015

Journal Article

S. Rajan, Paul, J., and Kumar, L., “Ultrasound guided transversus abdominis plane block through surgical wound”, Indian Journal of Anaesthesia, vol. 59, pp. 394-395, 2015.

2015

Journal Article

M. S. Mahajan, S. Moorthy, Karumathil, S. P., Rajeshkannan, R., and Pothera, R., “Hilar cholangiocarcinoma: Cross sectional evaluation of disease spectrum”, Indian Journal of Radiology and Imaging, vol. 25, pp. 184-192, 2015.[Abstract]


Although hilar cholangiocarcinoma is relatively rare, it can be diagnosed on imaging by identifying its typical pattern. In most cases, the tumor appears to be centered on the right or left hepatic duct with involvement of the ipsilateral portal vein, atrophy of hepatic lobe on that side, and invasion of adjacent liver parenchyma. Multi-detector computed tomography (MDCT) and magnetic resonance cholangiopancreatography (MRCP) are commonly used imaging modalities to assess the longitudinal and horizontal spread of tumor.

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2015

Journal Article

Sab Abraham and Raghavan, Pa, “Myths and Facts About Vitiligo: An Epidemiological Study”, Indian Journal of Pharmaceutical Sciences, vol. 77, pp. 8-13, 2015.[Abstract]


Vitiligo is a pigmentary disorder associated with many disease conditions that necessitates multiple drug regimens, which make the treatment complicated. This stigmatic disease forces the patient to approach all system of medicines as well as alternative medicines of non proven value, which further worsens the situation. At the same time the nonadherence to the treatment reflects poor prognosis, which is misunderstood for lack of response resulting in poor faith to the medications. The aim of this work was to assess the patient compliance and the factors affecting, and to monitor the adverse effects as well as drug interactions. The study was carried out in the Institute of Applied Dermatology for a period of one year. Patient compliance was assessed using Morisky Medication Adherence Scale and found that 71% of the patients were low adherent to medications. Family support, faith in doctor, higher educational status and effectiveness of the treatment were some of the reasons for medication adherence whereas forgetfulness, feasibility, occupational problem, polypharmacy, longer duration of treatment and the feeling that the disease under is control were some of the reasons listed for nonadherence. Three adverse reactions were reported with narrow band ultraviolet B and topical tacrolimus therapy and they were categorized into possible and probable according to causality assessment by Naranjo scale. Five drug interactions were reported and the causality assessment was done using drug interaction probability scale. None of the reactions were serious or life threatening. The present study revealed the hurdles in providing safe and effective treatment to the patients and also it suggest the need of doing more research on this disease since there is a general belief that vitiligo is an incurable disease.

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2015

Journal Article

R. K. Kumar, “Training Pediatric Heart Surgeons for the Future: A Global Challenge”, Annals of Pediatric Cardiology, vol. 8, pp. 99-102, 2015.

2015

Journal Article

O. M. Bhat, Kumar, P. U., Giridharan, N. V., Kaul, D., Kumar, M. J. M., and Dhawan, V., “Interleukin-18-induced atherosclerosis involves CD36 and NF-κB crosstalk in Apo E-/- mice”, Journal of Cardiology, vol. 66, pp. 28-35, 2015.[Abstract]


Objective: Interleukin (IL)-18 is a pleotropic cytokine involved in various inflammatory disorders. The transcription factor, nuclear factor kappa-B (NF-κB), is thought to play an important role in IL-18 signaling. The present study proposes a novel role for IL-18 in cholesterol efflux and plaque stability and demonstrates that pyrrolidine dithiocarbamate (PDTC), a NF-κB inhibitor blocks IL-18 signaling in apolipoprotein (Apo) E-/- mice. Methods: Three groups of normal chow-diet-fed, male Apo E-/- mice, aged 12 weeks (n = 6/group) were employed: Gp I, PBS (2 mo); Gp II, recombinant (r)IL-18 (1 mo) followed by PBS (1 mo); Gp III, rIL-18 (1 mo) followed by PDTC (1 mo). Results: Significantly augmented expression of IL-18 receptor (R)α by fluorescence-activated cell sorting analysis and plasma IL-18 was observed in Gp II. There was a significant increase in total cholesterol and low-density lipoprotein cholesterol whereas high-density lipoprotein cholesterol was significantly decreased in Gp II. However, this pattern was reversed in Gp III. Significantly augmented mRNA expression of IL-18, CD36, matrix metalloproteinase (MMP)-9, and NF-κB was observed in Gp II but liver X receptor alpha (LXR-α) gene was significantly reduced. A significant increase in frequency of atherosclerotic lesions was observed in Gp II animals, whereas there was a significant decrease in the Gp III. Conclusion: IL-18 administration initiates inflammatory cascade by binding with IL-18 Rα via NF-κB which is involved in progression and destabilization of atherosclerotic plaques in Apo E-/- mice. This study also reveals that NF-κB blockade with PDTC, blocks IL-18 signaling through down-regulation of IL-18, IL-18 Rα, CD36, and MMP-9, thus reducing inflammation and restoring plaque instability via upregulation of LXR-α © 2014 Japanese College of Cardiology.

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2015

Journal Article

M. R. Krishna, Kottayil, B. P., Sunil, G. S., and Kumar, R. K., “A life-threatening infective pseudoaneurysm of the left ventricle in a toddler”, Annals of Pediatric Cardiology, vol. 8, pp. 137-139, 2015.[Abstract]


Pseudoaneurysms of the ventricle are an uncommon occurrence in children. They may be secondary to previous cardiac surgery or infection of the pericardial space. Infective pseudoaneurysms require urgent surgery because rupture of the pseudoaneurysm may have catastrophic consequences. The outcome with surgery is excellent. We report a toddler with ruptured pseudoaneurysm secondary to purulent pericarditis who recovered with an emergency surgical closure of the opening of the pseudo-aneurysm.

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2015

Journal Article

H. Kundu, Patthi, B., Singla, A., Dr. Chandrashekar Janakiram, Jain, S., and Singh, K., “Dental caries scenario among 5, 12 and 15-year-old children in India- A retrospective analysis”, Journal of Clinical and Diagnostic Research, vol. 9, 2015.[Abstract]


Objectives: Dental caries is the most prevalent dental disease and children are one of the most affected groups. Thus, the present study was conducted to assess the average dental caries prevalence across different WHO index age groups (5, 12 &amp; 15 years) for the past fifteen years. Materials and Methods: Literature search was performed electronically in various search engines like google scholar, PubMed, Copernicus, etc. using Dental caries and India as MeSH terms. Articles from the past 15 years reporting on dental caries prevalence and experience in India were searched and this online searching strategy collected and listed 781 articles. After evaluating their titles and abstracts, only 30 articles fulfilled the inclusion and exclusion criteria &amp; were finally selected for complete review and data collection. Five articles which were hand searched were also included. Pooled estimates were calculated for different index age groups and different regions (Northern and Southern) separately with a confidence interval of 95% both for prevalence and experience of dental caries. Results: The pooled prevalence of dental caries was found to be highest in 15 year olds followed by 5 and 12 years (62.02%, 48.11% &amp; 43.34% respectively). Weighted mean was also found to be highest for 15 years, followed by 5 and 12 years (2.56±6.508, 2.49±7.78, 1.48±3.292 respectively). Pooled prevalence and weighted mean for the Northernern India region was found to be more in all the index age groups as compared to the Southernern India region. C onclusion: More than 40% of the children in India have shown dental caries in both primary and permanent teeth in the past 15 years. Also, Northernern region was found to be more affected by dental caries than Southern region. Since children are seen as the future of the nation, this data could be helpful in the planning of oral health care services by the concerned authorities in the community. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

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2015

Journal Article

Ra Balachandran, Dr. Mahesh K., Sen, A. Cb, Sudhakar, Ab, Nair, Sa, Dr. Sunil G. S., Raj, Rc, and Kumar, Rb, “Impact of the International Quality Improvement Collaborative on outcomes after congenital heart surgery: A single center experience in a developing economy”, Annals of Cardiac Anaesthesia, vol. 18, pp. 52-57, 2015.[Abstract]


Background: The International Quality Improvement Collaborative (IQIC) for Congenital Heart Surgery in Developing Countries was initiated to decrease mortality and major complications after congenital heart surgery in the developing world. Objective: We sought to assess the impact of IQIC on postoperative outcomes after congenital heart surgery at our institution. Methods: The key components of the IQIC program included creation of a robust worldwide database on key outcome measures and nurse education on quality driven best practices using telemedicine platforms. We evaluated 1702 consecutive patients ≤18 years undergoing congenital heart surgery in our institute from January 2010-December 2012 using the IQIC database. Preoperative variables included age, gender, weight at surgery and surgical complexity as per the RACHS-1 model. The outcome variables included, in- hospital mortality, duration of ventilation, intensive care unit (ICU) stay, bacterial sepsis and surgical site infection. Results: The 1702 patients included 771(45.3%) females. The median age was 8 months (0.03-216) and the median weight was 6.1Kg (1-100). The overall in-hospital mortality was 3.1%, Over the three years there was a significant decline in bacterial sepsis (from 15.1%, to 9.6%, P < 0.001), surgical site infection (11.1% to 2.4%, P < 0.001) and duration of ICU stay from 114(8-999) hours to 72 (18-999) hours (P < 0.001) The decline in mortality from (4.3% to 2.2%) did not reach statistical significance. Conclusions: The inclusion of our institution in the IQIC program was associated with improvement in key outcome measures following congenital heart surgery over a three year period.

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2015

Journal Article

S. Rajan, Srikumar, S., Paul, J., and Kumar, L., “Effectiveness of single dose conivaptan for correction of hyponatraemia in post-operative patients following major head and neck surgeries”, Indian Journal of Anaesthesia, vol. 59, pp. 416-420, 2015.[Abstract]


Background and Aims: Conivaptan, a vasopressin receptor antagonist, is commonly used for the treatment of euvolaemic, hypervolaemic hyponatraemia. Usually, an intravenous (IV) bolus followed by infusion is administered for many days. We decided to assess the effectiveness of single dose conivaptan for correction of hyponatraemia in post-operative patients. Methods: This was a prospective, randomised trial conducted in 40 symptomatic post-operative Intensive Care Unit (ICU) patients with a serum sodium level of ≤130 mEq/L. Group A patients received IV conivaptan 20 mg over 30 min, whereas in group B infusion of 3% hypertonic saline was started as an infusion at the rate of 20–30 ml/h. Serum sodium levels were measured at 12, 24, 48 and 72 h and the daily fluid balance was measured for 3 days. The Chi-square test, Wilcoxon signed rank test and Mann–Whitney tests were used as applicable. Results: The serum sodium levels before initiating treatment were comparable between groups. However, subsequent sodium levels at 12, 24 and 48 h showed significantly high values in group A. Though at 72 h the mean sodium value was high in group A, it was not statistically significant. Group A showed a significantly high fluid loss on day 1, 2 and 3. The mean volume of hypertonic saline required in group B showed a steady decline from day 1 to 3 and only 13 patients required hypertonic saline on the 3rd day. Conclusion: Single dose conivaptan is effective in increasing serum sodium levels in post-operative ICU patients up to 72 h associated with a significant negative fluid balance. © 2015, Indian Society of Anaesthetists. All rights reserved.

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2015

Journal Article

P. Subramanyam and Palaniswamy, S. Sundaram, “Dual Time Point 18 F-FDG PET/CT Imaging Identifies Bilateral Renal Tuberculosis in an Immunocompromised Patient with an Unknown Primary Malignancy”, Infection & Chemotherapy , vol. 47, 2015.

2015

Journal Article

S. Jagadeesan, Balasubramanian, P., Panicker, V., Anjaneyan, G., and Thomas, J., “A Rare Association of Childhood Alopecia Areata and Blepharophimosis-ptosis-epicanthus Inversus Syndrome: Successfully Treated with Diphenylcyclopropenone”, International Journal of Trichology, vol. 7, pp. 77-79, 2015.[Abstract]


The genetic background of alopecia areata has only recently begun to get unraveled. We report the association of a case of pediatric alopecia areata with a rare genetic syndrome-blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), which responded well to topical immunotherapy with diphenylcyclopropenone. In the background of increasing evidence surfacing on the genetic basis of alopecia areata, this association may be of significance.

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2015

Journal Article

P. Balasubramanian, Jagadeesan, S., Thomas, J., Panicker, V., and Anjanayen, G., “Diaper Dermatitis with Psoriasiform id Eruptions”, Indian Journal of Dermatology, Venereology and Leprology, vol. 81, p. 435, 2015.

2015

Journal Article

L. Kumar, Varghese, R., Menon, R. N., and Dr. Neeraj Siddarthan, “Perioperative Management of a Patient with Severe Haemophilia B for Abdominal Pseudotumour Surgery”, Indian Journal of Anaesthesia, vol. 59, pp. 461-462, 2015.

2015

Journal Article

A. John, Gopalakrishnan, R., and Javed, R., “Reflections on use of participatory methods in the capacity building program for tribal community health volunteers”, Indian Journal of Community Health, vol. 27, pp. 290-294, 2015.[Abstract]


Background: Participatory Rural Appraisal (PRA) constitutes a process of involvement with rural people, for indigenous knowledge building exercises. The effectiveness of such capacity building programs, depends largely on fulfilling objectives which reflect the real needs of the people, while ensuring their participation. As part of a project for self-reliant villages, where community volunteers were trained in various aspects of health, participatory methods were chosen over conventional models of capacity building. Objectives: 1. To develop a model participatory capacity building program for grass root level health functionaries based on participatory need assessment using PRA techniques. 2. To develop an appropriate teaching methodology using participatory learning approaches. 3. To assess the impact of the training program based on pre and post evaluation. Results: The training program based on participatory approach resulted in a statistically significant difference in the knowledge of the volunteers. © 2015, Indian Association of Preventive and Social Medicine. All rights reserved.

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2015

Journal Article

J. M. Wilmshurst, Gaillard, W. D., P, D. Vinayan K., Tsuchida, T. N., Plouin, P., Van Bogaert, P., Carrizosa, J., Elia, M., Craiu, Di, Jovic, N. J., Nordli, D., Hirtz, D., Wong, Vn, Glauser, T., Mizrahi, E. M., and Cross, J. H., “Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics”, Epilepsia, 2015.[Abstract]


<p>Evidence-based guidelines, or recommendations, for the management of infants with seizures are lacking. A Task Force of the Commission of Pediatrics developed a consensus document addressing diagnostic markers, management interventions, and outcome measures for infants with seizures. Levels of evidence to support recommendations and statements were assessed using the American Academy of Neurology Guidelines and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The report contains recommendations for different levels of care, noting which would be regarded as standard care, compared to optimal care, or "state of the art" interventions. The incidence of epilepsy in the infantile period is the highest of all age groups (strong evidence), with epileptic spasms the largest single subgroup and, in the first 2 years of life, febrile seizures are the most commonly occurring seizures. Acute intervention at the time of a febrile seizure does not alter the risk for subsequent epilepsy (class 1 evidence). The use of antipyretic agents does not alter the recurrence rate (class 1 evidence), and there is no evidence to support initiation of regular antiepileptic drugs for simple febrile seizures (class 1 evidence). Infants with abnormal movements whose routine electroencephalography (EEG) study is not diagnostic, would benefit from video-EEG analysis, or home video to capture events (expert opinion, level U recommendation). Neuroimaging is recommended at all levels of care for infants presenting with epilepsy, with magnetic resonance imaging (MRI) recommended as the standard investigation at tertiary level (level A recommendation). Genetic screening should not be undertaken at primary or secondary level care (expert opinion). Standard care should permit genetic counseling by trained personal at all levels of care (expert opinion). Genetic evaluation for Dravet syndrome, and other infantile-onset epileptic encephalopathies, should be available in tertiary care (weak evidence, level C recommendation). Patients should be referred from primary or secondary to tertiary level care after failure of one antiepileptic drug (standard care) and optimal care equates to referral of all infants after presentation with a seizure (expert opinion, level U evidence). Infants with recurrent seizures warrant urgent assessment for initiation of antiepileptic drugs (expert opinion, level U recommendation). Infantile encephalopathies should have rapid introduction and increment of antiepileptic drug dosage (expert opinion, level U recommendation). There is no high level evidence to support any particular current agents for use in infants with seizures. For focal seizures, levetiracetam is effective (strong evidence); for generalized seizures, weak evidence supports levetiracetam, valproate, lamotrigine, topiramate, and clobazam; for Dravet syndrome, strong evidence supports that stiripentol is effective (in combination with valproate and clobazam), whereas weak evidence supports that topiramate, zonisamide, valproate, bromide, and the ketogenic diet are possibly effective; and for Ohtahara syndrome, there is weak evidence that most antiepileptic drugs are poorly effective. For epileptic spasms, clinical suspicion remains central to the diagnosis and is supported by EEG, which ideally is prolonged (level C recommendation). Adrenocorticotropic hormone (ACTH) is preferred for short-term control of epileptic spasms (level B recommendation), oral steroids are probably effective in short-term control of spasms (level C recommendation), and a shorter interval from the onset of spasms to treatment initiation may improve long-term neurodevelopmental outcome (level C recommendation). The ketogenic diet is the treatment of choice for epilepsy related to glucose transporter 1 deficiency syndrome and pyruvate dehydrogenase deficiency (expert opinion, level U recommendation). The identification of patients as potential candidates for epilepsy surgery should be part of standard practice at primary and secondary level care. Tertiary care facilities with experience in epilepsy surgery should undertake the screening for epilepsy surgical candidates (level U recommendation). There is insufficient evidence to conclude if there is benefit from vagus nerve stimulation (level U recommendation). The key recommendations are summarized into an executive summary. The full report is available as Supporting Information. This report provides a comprehensive foundation of an approach to infants with seizures, while identifying where there are inadequate data to support recommended practice, and where further data collection is needed to address these deficits. © 2015 International League Against Epilepsy.</p>

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2015

Journal Article

Dr. Anil Kumar V. and S. Khan, “Defining Multidrug Resistance in Gram-negative Bacilli”, Indian Journal of Medical Research, vol. 141, pp. 491-493, 2015.

2015

Journal Article

J.b Thilak, Panakkal, J. Jab, Kim, T. - Ya, Goodman, S. Mc, Lee, S. - Sa, and Salvati, E. Ac, “Risk Factors of Heterotopic Ossification Following Total Hip Arthroplasty in Patients With Ankylosing Spondylitis”, Journal of Arthroplasty, 2015.[Abstract]


This study was to identify the risk factors of heterotopic ossification (HO) after total hip arthroplasty (THA) in ankylosing spondylitis. We analyzed 47 hips (24 patients) with ankylosing spondylitis that underwent primary THA. The incidence of HO was 14.9%. The risk factors were divided into modifiable and nonmodifiable factors. Female gender (P = 0.008), preoperative ankylosed hip (P . <. 0.001), occurrence of HO in previous surgery (P = 0.036) were nonmodifiable risk factors which increased the prevalence of HO. Of the various modifiable risk factors, elevated preoperative ESR (P = 0.007), elevated preoperative CRP (P = 0.004) and prolonged duration of surgery (P = 0.014) were associated with increased occurrence of HO. Perioperative medical intervention to reduce inflammation (ESR and CRP) may help to decrease HO. © 2015.

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2015

Journal Article

A. V. Rajive and Dr. Minnie Pillay, “A study of variations in the origin of obturator artery and its clinical significance”, Journal of Clinical and Diagnostic Research, vol. 9, pp. AC12-AC15, 2015.[Abstract]


Introduction: The large number of organs and anatomical structures within the cramped pelvic cavity makes the study of vascular pattern and their variations of much importance in this particular anatomical region. Clear awareness of the vascular anatomy of pelvis is critical in surgeries performed here, which require ligation of the arteries concerned and also because such anomalous origins may cause profuse bleeding during surgical procedures. This is particularly true with regard to the variations in the origin of the obturator artery, while performing pelvic and groin surgeries. Aim: The aim of the present study was to find out the prevalence of normal and aberrant origins of obturator artery and to describe its surgical implications. Materials and Methods: The study was carried out on fifty hemipelvises of embalmed cadavers and the origin and course of the arteries were traced and noted. Results: Of the 50 pelvic halves, in 27 specimens, the obturator took origin from the anterior division of internal iliac artery. Remaining 23 specimens showed variations. The origin of the obturator artery was from the inferior epigastric artery in 11 cases, from the common stem of the internal iliac artery and the external iliac artery in 2 cases each, from the posterior trunk of the internal iliac artery in 5 and one each from superior gluteal, inferior gluteal, and internal pudendal artery. Conclusion: The present study indicates that the origin of the obturator artery is highly variable. It can take origin from the stem of the internal iliac artery or from its anterior or posterior division, or from one of the branches of the divisions. It can also take origin from external iliac artery or its inferior epigastric branch. Advancements in diagnostic and surgical techniques in obstetric procedures and urogenital interventions make it essential to have a clear-cut understanding of the vasculature in the abdomen and pelvis. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved.

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2015

Journal Article

A. Rajanbabu, Venkatesan, R., Chandramouli, S., and Nitu, P. V., “Sentinel node detection in endometrial cancer using indocyanine green and fluorescence imaging - A case report”, ecancermedicalscience, vol. 9, 2015.[Abstract]


Sentinel lymph node mapping in endometrial cancer can help to provide the prognostic information needed while avoiding the morbidity associated with a complete lymphadenectomy. Studies with blue dye and technetium colloid have only given about 80% detection rates whereas with indocyanine green injection and fluorescence imaging, it gives about 88-100% detection rates. Herein, we report a case where indocyanine green was injected intracervically and sentinel nodes were detected at the paraaortic nodal area. © The authors; licensee ecancermedicalscience.

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2015

Journal Article

Dr. Biju Urumese Palatty, Veeramani, Rb, and Manjunath, K. Yc, “Junctura tendinae in the first intermetacarpal space: A case report”, Journal of Clinical and Diagnostic Research, vol. 9, 2015.[Abstract]


The anatomy of extensor tendons and juncturae tendinum (JT) is of interest to both anatomists and surgeons. Understanding the structure of the JTs and the interactions between the tendons of the fingers is of utmost importance in hand assessment, especially during the reconstructive procedures such as tendon transfers. During routine dissection of extensor tendons of dorsum of hand there was a filamentous band between the tendon of extensor pollicis longus and extensor indices in the first intermetacarpal space. This band was identified as Juncturae tendinae of Type 1. It was attached to the extensor tendons on either side of the first intermetacarpal space in a transverse direction. The presence of Juncturae tendinae in the first intermetacarpal space is a rare variation. This variation is important as it interferes with independent motion of thumb and index finger and also in tendon repairs. © 2015,Journal of Clinical and Diagnostic Research. All rights reserved.

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2015

Journal Article

R. Sankaran, Shah, R., Dr. Sajesh K. Menon, and Pillai, A., “Congenital subaxial cervical subluxation presenting as a bilateral Erb’s palsy: surgical management, rehabilitation, and outcome”, Child's Nervous System, 2015.[Abstract]


Introduction: Subaxial spine injuries during infancy are uncommon. Case report: We present the case of an infant referred to our brachial plexus clinic with proximal weakness of both arms noted immediately following a complicated breech delivery. Nerve conduction studies were consistent with bilateral proximal upper plexus injury; however, radiological evaluation revealed a C4–C5 subluxation and MRI features of bilateral C5 root avulsions. He was immobilized in a cervical-body orthosis and underwent open reduction and posterior C4-C5-C6 fixation at 10 weeks age using luque rods, sublaminar wires, and rib graft. The spine was immobilized in a custom molded cervicothoracic brace for a total of 3 months, and a home exercise program prescribed. Follow-up radiographic evaluation showed good posterior bony fusion by 2 months but persistent bilateral proximal upper limb weakness with reduced compound motor action potential (CMAP) amplitudes of the axillary and musculocutaneous nerves. Bilateral supraclavicular exploration and C5 root neurotization using the ipsilateral C7 nerve roots were performed at 7 months of age. Voluntary biceps activity followed by voluntary external rotation with gravity eliminated was noted within the next 2–3 months. He progressed to develop near normal motor control of bilateral upper limbs within 1 year. Conclusions: We wish to report this rare entity and our favorable outcome using a strategy of early spinal stabilization and neurotization repair to restore function following proximal nerve root injury. © 2015 Springer-Verlag Berlin Heidelberg

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2015

Journal Article

T. T. Sukumaran, Dr. Minnie Pillay, and Gopalakrishnan, A., “An anomalous right subclavian artery with a retrotracheal course: A case report”, Journal of Clinical and Diagnostic Research, vol. 9, pp. AD01-AD02, 2015.[Abstract]


An aberrant right subclavian artery arising as the last vessel of the arch of aorta is an uncommon anatomic anomaly with prevalence reported between 0.2% and 2.0%. In 80% of the cases the aberrant right subclavian artery takes a retro-oesophageal course to the right upper limb. During routine dissection of cadavers for teaching undergraduate medical students an anomalous Retrotracheal right subclavian artery which is a very rare vascular anomaly was encountered in a 35-year-old male cadaver. The artery arose as the last branch of the arch of aorta and coursed to the right between the trachea and oesophagus. The presence of this vascular anomaly could be an unusual cause of dysphagia and breathing difficulty. The clinical significance and embryological aspects of this vascular variant is discussed in this paper. © 2015 Journal of Clinical and Diagnostic Research All rights reserved.

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2015

Journal Article

S. Padma, Sundaram, P., and Arun, B. R., “Unusual presentation of Warthin variant of Papillary thyroid carcinoma with lymph nodal metastases in a patient of Graves' disease”, Journal of Cancer Research and Therapeutics, vol. 11, p. 652, 2015.[Abstract]


Warthin-like Papillary thyroid carcinoma (WPTC) is a rare variant of papillary carcinoma of thyroid, PTC which derives its name by closely resembling Warthin's tumor of salivary gland. Hallmark histological feature of this variant is papillary folding lined by oncocytic neoplastic cells with clear nuclei and nuclear pseudoinclusions, accompanied by prominent lymphocytic infiltrate in the papillary stalks. It is thought to be one of those differentiated thyroid cancers with favorable prognosis. We report a case of Graves' disease with a cold nodule harboring WPTC with initial presentation of lymph nodal metastases. It is important to identify this peculiar variant of PTC as 5 to 10% of them undergo dedifferentiation and 30% have the lymph nodal metastases and extra thyroidal extension.

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2015

Journal Article

Da Raghunadharao, Kannan, Rb, Hingnekar, Cc, Vijaykumar, D. Kd, Mani, C. Se, Ghosh-Laskar, Sg, Gujral, Sh, Chaudhari, Si, Nayak, Sf, Dikshit, Rj, Badwe, R. Ak, and Pramesh, C. Sk, “Institutional external peer review: A unique National Cancer Grid initiative”, Indian Journal of Medical and Paediatric Oncology, vol. 36, pp. 186-188, 2015.

2015

Journal Article

Dr. Santhosh Kumar C., K.I., R., and A.A., K., “Vital sign normalisation for improving performance of multi-parameter patient monitors”, Electronics Letters, vol. 51, pp. 2089-2090, 2015.[Abstract]


Using covariance normalisation (CVN) of vital signs is explored to improve the performance of multi-parameter patient monitors with heart rate, arterial blood pressure, respiration rate, and oxygen saturation (SpO2) as its input. The baseline system for the experiments is a support vector machine classifier with a radial basis function kernel. Although an improvement in the overall classification accuracy with the use of CVN is obtained, there was a deterioration in sensitivity. Furthermore, it is noted that the estimate of the covariance is often noisy, and therefore the covariance estimates is smoothed to obtain a performance improvement of 0.23% absolute for sensitivity, 1.34% absolute for specificity, and 1.08% absolute for the overall classification accuracy. Multi-parameter intelligent monitoring in intensive care II database for all the experiments is used.

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2015

Journal Article

Rajan S., R.K., S., J., P., and L., K., “Anaesthetic management of bilateral hand transplantation”, Indian Journal of Anaesthesia, vol. 59, pp. 819-820, 2015.

2015

Journal Article

Kuriachan D., Suresh R., M., J., and Savithri V., “Oral Lesions: The Clue to Diagnosis of Pemphigus Vulgaris”, Case Reports in Dentistry, vol. 2015, 2015.[Abstract]


Pemphigus is a group of potentially fatal dermatoses with both cutaneous and oral manifestations. Characterized by the appearance of vesicle or bullae, their manifestations in the oral cavity often precede those on the skin by many months or may remain as the only symptoms of the disease. It is therefore important that the oral manifestations of the disease are recognized on time, to make a proper diagnosis and initiate timely treatment. Here we present a case of Pemphigus Vulgaris (PV) that presented with oral lesions at multiple sites including tongue, to highlight the importance of timely recognition of the oral lesions during routine dental practice for the diagnosis and management of this disease. © 2015 Diana Kuriachan et al.

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2015

Journal Article

R. Krishnakumar and Lenke, L. G., “Sternum-Into-Abdomen Deformity With Abdominal Compression Following Osteoporotic Vertebral Compression Fractures Managed By 2-Level Vertebral Column Resection and Reconstruction.”, Spine Journal, vol. 40, no. 18, 2015.[Abstract]


STUDY DESIGN:
A unique case report.
OBJECTIVE:
To report a case of severe thoracolumbar kyphosis with abdominal compression causing gastric disturbance after treatment of an osteoporotic vertebral compression fracture and its ultimate management by vertebral column resection (VCR). We propose a new terminology "sternum-into-abdomen deformity" to describe this condition.
SUMMARY OF BACKGROUND DATA:
Management of osteoporotic vertebral compression fractures mainly aims at pain control and deformity reduction. VCR for decreasing abdominal compression due to the development of severe kyphosis after treatment of osteoporotic compression fractures has never been reported in the literature to our knowledge.
METHODS:
This is a case report on a single patient. The hospital and office charts were reviewed. Reports of prior treatment of his compression fracture were analyzed.
RESULTS:
This 73-year-old cachectic patient underwent vertebroplasty for a midthoracic compression fracture with progressive, severe kyphosis. His condition worsened and spinal reconstruction with a 2-level VCR restored more normal sagittal alignment and decreased his gastric compression. His back pain decreased and his ability to tolerate oral intake returned.
CONCLUSION:
We propose the term "sternum-into-abdomen deformity" to describe this type of severe kyphosis with abdominal compression. Treatment with a VCR and fusion for realignment of focal kyphosis can improve the quality of life for patients with this condition.
LEVEL OF EVIDENCE: 5.

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2015

Journal Article

S. Palazhy, Dr. Damodaran Vasudevan, and Kamath, Pb, “Elevated oxidative stress among coronary artery disease patients on statin therapy: A cross sectional study”, Indian Heart Journal, vol. 67, pp. 227-232, 2015.[Abstract]


{Background Statins are a major group of drugs that reduces LDL-C levels, which are proven to have other beneficial effects such as preventing coronary events. The objective of this study was to evaluate oxidative stress and select novel coronary artery disease risk factors among coronary artery disease patients on statins. Methods In this observational, cross-sectional study, we compared total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, apolipoprotein B, lipoprotein (a), homocysteine, reduced glutathione, glutathione peroxidase, superoxide dismutase, ascorbic acid, malondialdehyde and oxidized LDL among male coronary artery disease patients on statin therapy (group 2) More »»

2015

Journal Article

S. Mukherjee, Vasudevan, D. M., and Das, S. K., “Protective role of extracts of grape skin and grape flesh on ethanol-induced oxidative stress, inflammation and histological alterations in rat brain”, Archives of Physiology and Biochemistry, vol. 121, pp. 144-151, 2015.[Abstract]


Ethanol consumption has deleterious effects on all organs and especially on brain. In our study, the radical scavenging properties of grape skin and grape flesh (contains natural antioxidants like polyphenols) was determined in vitro and for in vivo studies, male Wistar rats (16-18 week-old) and 100-120 gm weight were divided in five groups of six animals each. One group were fed with ethanol (1.6 gm/kg body weight), while second group were fed with ethanol (1.6 g/kg body weight) and grape skin extract (2.5 g/kg body weight), the third group were fed with ethanol (1.6 g/kg body weight) and grape flesh extract, daily once for 12 weeks, while the fourth group were fed with ethanol (1.6 g/kg body weight) and tocopheryl acetate (80 mg/kg/day) daily once for 12 weeks. Results of in vitro studies indicate that grape skin extracts showed significant radical scavenging properties (ROS). There was also significantly alteration of serum cytokines in our study. © 2015 Taylor and Francis. More »»

2015

Journal Article

A. Sreedevi, “An overview of the development and status of national nutritional programs in India”, Journal of Medical Nutrition and Nutraceuticals, vol. 4, pp. 5-13, 2015.[Abstract]


Under nutrition is still a major problem in India and at the same time overweight and obesity are also beginning to affect a substantial proportion of the population. Macro and micronutrient deficiencies affect a significant proportion of the population. Children, pregnant, and lactating women are the most affected with the retardation of cognitive and physical growth, increased susceptibility to infections which ultimately affects productivity of the country. Hence, the Government has devised several national programs like Integrated Child development services (ICDS), National Iron + initiative, National Iodine deficiency disorder control program (NIDDCP) etc., The activities under each program have been listed and its impact as assessed by various evaluation programs has also been mentioned. The determinants of under nutrition are a result of a complex interaction between various factors articulated by UNICEF as immediate, underlying, and fundamental determinants. The fact remains that inspite of all the programs, household food security is determined by a more complex array of factors. Concerted effort and a convergence by all the programs are required with particular emphasis on gender equity. More attention is required in rural areas, scheduled caste and tribe people, very young children between 0-2 years, and the girl child.

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2015

Journal Article

V. Kiruthika, Maya, S., Suresh, M. K., V. Kumar, A., Dr. Jayakumar Rangasamy, and Dr. Raja Biswas, “Comparative Efficacy of cChloramphenicol Loaded Chondroitin Sulfate and Dextran Sulfate Nanoparticles to Treat Intracellular Salmonella Infections”, Colloids and Surfaces B: Biointerfaces, vol. 127, pp. 33-40, 2015.[Abstract]


Salmonella Paratyphi A is a food-borne Gram-negative pathogen and a major public health challenge in the developing world. Upon reaching the intestine, S. Paratyphi A penetrates the intestinal epithelial barrier; and infects phagocytes such as macrophages and dendritic cells. S. Paratyphi A surviving within macrophages is protected from the lethal action of antibiotics due to their poor penetration into the intracellular compartments. Hence we have developed chloramphenicol loaded chondroitin sulfate (CS-Cm Nps) and dextran sulfate (DS-Cm Nps) nanoparticles through ionotropic-gelation method for the intracellular delivery of chloramphenicol. The size of these nanoparticles ranged between 100 and 200. nm in diameter. The encapsulation efficiency of both the nanoparticles was found to be around 65%. Both the nanoparticles are found to be non-hemolytic and non-toxic to fibroblast and epithelial cells. The prepared nanoparticles exhibited sustained release of the drug of up to 40% at pH 5 and 20-25% at pH 7.0 after 168 h. The anti-microbial activities of both nanoparticles were tested under in vitro and ex vivo conditions. The delivery of DS-Cm Nps into the intracellular compartments of the macrophages was 4 fold more compared to the CS-Cm Nps which lead to the enhanced intracellular antimicrobial activity of Ds-Cm Nps. Enhanced anti-microbial activity of Ds-Cm Nps was further confirmed in an ex vivo chicken intestine infection model. Our results showed that Cm loaded DS Nps can be used to treat intracellular Salmonella infections. © 2015 Elsevier B.V.

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2015

Journal Article

A. Gopinathan, Shemin, Z., Kumar, A., Augustine, D., Siyad, I., Jojo, A., Philip, R., Dinesh, K., and Karim, S., “Pancreatic botryomycosis caused by viridans streptococci: A case report”, Infectious Diseases in Clinical Practice, vol. 23, pp. e23-e25, 2015.[Abstract]


Botryomycosis is a chronic suppurative granulomatous disease of the skin viscera. It is known to mimic diseases such as actinomycosis and invasive carcinoma. Visceral botryomycosis is a rare entity compared with its cutaneous counterpart. It can be identified using staining techniques such as Gomori methenamine silver, periodic acid-Schiff Gram stain, histopathological examination, and aerobic culture of the lesion. Splendore-Hoeppli phenomenon is a characteristic feature of this disease. It responds to prolonged treatment with beta-lactams and surgery.There have been very few case reports on visceral botryomycosis across the world. We report a case of pancreatic botryomycosis caused by viridans streptococci in a patient with chronic calcific pancreatitis who was presumptively diagnosed as having carcinoma of the head of the pancreas. © 2015 Wolters Kluwer Health, Inc. All rights reserved.

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2015

Journal Article

S. Jampala, Meera, P., Vivek, V., and Kavitha, D. R., “Skin and soft tissue infections due to Shewanella algae – An emerging pathogen”, Journal of Clinical and Diagnostic Research, vol. 9, pp. DC16-DC20, 2015.[Abstract]


Introduction: Shewanella spp. are emerging human pathogens, the predominant species being Shewanella algae. Shewanella skin and soft tissue infections are more commonly seen in immunocompromised patients with a pre-existing cutaneous ulcer and most often associated with exposure to marine environments.
Aim: The study was conducted to investigate the epidemiological and clinical characteristics of Shewanella skin and soft tissue infections (SSTIs) for a period of five years.
Materials and Methods: All Gram-negative non-fermenting motile isolates which produced pigmented colonies and positive for oxidase and H2S were further identified with Vitek 2 system.
Conclusion: Shewanella algae should be considered as an emerging pathogen of SSTIs mainly in patients with chronic ulcers and at times be multidrug resistant. These infections have a good clinical outcome if prompt medical, surgical and supportive treatment is offered.
Results: A total of 16 patients with SSTIs due to Shewanella species were identified during the period from 2010 to 2014. Majority of patients were urban, elderly and fisher men. Shewanella algae (n=12, 75%) was the predominant isolate. Skin or mucosal portal of entry was found in all patients and seawater contact was recorded in 56.25% of the patients. 81% of infections were polymicrobial, common concomitant pathogens being gut and marine flora. Peripheral vascular diseases were the predominant risk factors with comorbidities like diabetes, hypertension and hepatobiliary diseases. Third generation cephalosporins, meropenem and gentamicin were the most effective antibiotics while two of the isolates were multidrug resistant. 75% of the infected patients recovered completely and three patients died of complications. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

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2015

Journal Article

A. J. Mathew, Sukumaran, T. T., and Joseph, S., “Versatile but temperamental: A morphological study of palmaris longus in the Cadaver”, Journal of Clinical and Diagnostic Research, vol. 9, pp. AC01-AC03, 2015.[Abstract]


Introduction: Palmaris longus (PL) is one of the most variable muscles in our body and is vestigial functionally. Its long tendon and its superficial location make it an ideal source for tendon harvesting. Variations such as absence, duplication and reversal have far reaching clinical impact. The aim of this study is to estimate the presence, variants and nerve supply of the PL.
Materials and Methods: Upper extremity of 24 cadavers was dissected and PL was examined. The results were compared to other studies on the PL and literature survey was carried out.
Results: Thirty nine specimens showed normal morphology and four showed complete agenesis. Other morphological variations seen included - reversed, hybrid, fusiform, fleshy and bifurcated tendon of insertion.
Conclusion: Every surgeon must be aware of the variations of the versatile but temperamental PL. Prior knowledge of the layout of the muscle helps in planning intricate surgeries to which this tendon is put use to. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

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2015

Journal Article

M. Sathiyasekaran, Bavanandam, S., Sankaranarayanan, S., Mohan, N., M., G., Wadhwa, N., Kehar, M., and Biradar, V., “A questionnaire survey of pediatric inflammatory bowel disease in India”, Indian Journal of Gastroenterology, vol. 33, pp. 543-549, 2015.[Abstract]


Background: Inflammatory bowel disease (IBD) is not uncommon in children and is an important cause of morbidity. Since information on IBD in Indian children is sparse, the study aimed at highlighting the salient features in them. Materials and Methods: A questionnaire survey was done among 221 children and adolescents with IBD [ulcerative colitis (UC) 93 (42.1 %); Crohn’s disease (CD) 122 (55.2 %); unclassified (IBD-U) 6 (2.7 %)] across seven centers in India. The cut-off age was 18 years and below. Results: The mean age of presentation for UC and CD was 10.2 ± 4.4 and 11.0 ± 4.5 years, respectively, with no gender difference. Diarrhea (69.9 %, p = 0.001) and blood in the stools (90.3 %, p = 0.0001) were common in UC, whereas abdominal pain (73.8 %, p = 0.01), fever (39.3 %, p = 0.0001), anemia (64.7 %, p = 0.001), and growth failure (76.2 %, p = 0.0001) were common in CD. Extraintestinal manifestations (EIM) were a feature in 23.6 % and 36.1 % of UC and CD, respectively. Pancolitis (E3) was predominant in UC (70.9 %) and 88 % required steroids. Ileocolonic CD (L3) was common in 72.9 %; 76.2 % required azathioprine for maintenance. Of the children with UC, 11.8 % had complications like massive hemorrhage and toxic megacolon, while 27 % of CD had fistulae, perianal abscess, stricture, and perforation. Biologicals were used in 0.8 % of severe UC and in 12.2 % of CD. In UC, 4.3 % required surgical intervention. Conclusion: Pediatric inflammatory bowel disease (P-IBD) in India shares similarities with adult-onset IBD. Distinctive features were growth failure and more severe forms of the disease necessitating immunomodulators. © 2015, Indian Society of Gastroenterology.

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2015

Journal Article

G. C. Nair, ,, Jacob, P., Menon, R. R., and , “Inflammatory diseases of the non-lactating female breasts”, International Journal of Surgery, vol. 13, pp. 8-11, 2015.[Abstract]


Chronic inflammatory diseases of the non-lactating breasts cause considerable difficulty in diagnosis and treatment. There is a spectrum of aetiological factors ranging from infection to autoimmune disorders. The disease causes considerable morbidity and psychological distress in relatively young females. The study aimed to analyse the spectrum of chronic disease and to formulate a treatment protocol. Method: Female patients with histological confirmation of inflammatory disease of the breast in the non-lactational phase were included in the study. The patients were categorized based on histological findings supplemented with immunohistochemical staining with CD3 and CD20 antibodies. Result: Out of 50 patients included in the study, 38 patients (76%) were diagnosed as idiopathic granulomatous mastitis (IGM) and 12 (24%) patients as periductal mastitis (PD). The possible aetiology of IGM was localized autoimmunity as evidenced by the infiltration of CD3 positive T lymphocyte. Systemic prednisolone was given for 6 months and 95.6% patients were disease-free after 24months. Out of 15 patients who did not receive prednisolone, only 2 patients were disease-free after 24 months (p = .003). Conclusion: Idiopathic granulomatous mastitis is an uncommon inflammatory disease of the non-lactating breast. The combination of limited surgical treatment and systemic prednisolone given for 6 months effectively controls the disease as well as prevents recurrence. © 2014.

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2015

Journal Article

D. Mathai, Dr. Anil Kumar V., Paul, B., Sugumar, M., John, K. R., Manoharan, A., and Kesavan, L. M., “Fecal carriage rates of extended-spectrum β-lactamase-producing escherichia coli among antibiotic naive healthy human volunteers”, Microbial Drug Resistance, vol. 21, pp. 59-64, 2015.[Abstract]


Introduction: Higher prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli fecal carriage has been reported in the nosocomial setting than in the community. We tried to determine the fecal carriage of ESBL-producing E. coli among healthy volunteers in a relatively isolated community. Materials and Methods: This study was conducted on 115 healthy adult volunteers from whom one fecal sample was collected and was plated on selective media. Each morphotypes were identified, characterized, and ESBL phenotype was confirmed by double-disk potentiation method. Molecular characterization of ESBL gene was done using multiplex polymerase chain reaction and pulse-field gel electrophoresis (PFGE) was done to identify their clonal relation. Results: ESBL-producing E. coli had a prevalence of 19% (22/115) among the healthy volunteers in the community. CTX-M was the predominant type, showed a presence 95.5% (21/22), TEM 63%, SHV 9%, and both TEM and CTX-M were present in 63.6% (14/22), all three present in 4.5% (1/22). The lineage using PFGE showed a single clone in 17 isolates. Seven isolates were type A (all TEM & CTX-M), six were type A1 (all TEM & CTX-M except 2), four were type A2 (all CTX-M), and three belonged to types B, C, and D respectively Conclusion: High prevalence rate of 19% in the community indicated by this study implies the possibility of sustained ESBL carriage even among isolated population, which could serve as a reservoir for enriching the ESBL pool in the hospital. Clonal relations also indicate a possible epidemiological source that needs to be evaluated. © Copyright 2015, Mary Ann Liebert, Inc. 2015.

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2015

Journal Article

M. R. Krishna, Singhi, A. K., and Kumar, R. K., “Selected summaries”, Annals of Pediatric Cardiology, vol. 8, pp. 82-87, 2015.

2015

Journal Article

A. Kumar, Udayakumaran, S., Babu, R., Rajamma, B. M., Prakash, A., Panikar, D., Karim, S., and Chowdhary, A., “Trichosporon Asahii Infection Presenting as Chronic Meningo-ventriculitis and Intra Ventricular Fungal Ball: A Case Report and Literature Review”, Mycoses, vol. 58, pp. 99-103, 2015.[Abstract]


Summary: Central nervous system trichosporonosis is a rare clinical entity and so far only six cases including three each of brain abscess and meningitis has been on record. We report a rare case of chronic meningo-ventriculitis and intraventricular fungal ball due to Trichosporon asahii in an 18-year-old immunocompetent male from Burundi, east Africa. Neuroendoscopy showed multiple nodules and a fungal ball within the ventricle, which on culture grew T. asahii. He was initially empirically treated with liposomal amphotericin B. However, the antifungal susceptibility testing of T. asahii isolate revealed high minimum inhibitory concentration for amphotericin B (2 μg ml-1), flucytosine (16 μg ml-1) and caspofungin (2 μg ml-1) but exhibited potent activity for voriconazole, posaconazole, itraconazole and fluconazole. The patient rapidly succumbed to cardiac arrest before antifungal therapy could be changed. Although disseminated trichosporonosis has been increasingly reported the diagnosis represents a challenge especially in rare clinical settings such as intraventricular fungal ball in the present case, which has not been described previously.

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2015

Journal Article

D. Dayana, “Superior semicircular canal dehiscence syndrome”, Research in Otolaryngeology , vol. 4, pp. 45-48 , 2015.

2015

Journal Article

S. Sebastian, Nair, P. G., Thomas, P., and Tyagi, A. Kumar, “Oropharyngeal Dysphagia: neurogenic etiology and manifestation”, Indian Journal of Otolaryngology and Head & Neck Surgery, vol. 67, pp. 119–123, 2015.[Abstract]


To determine the type, severity and manifestation of dysphagia in patients with neurogenic etiology. Clinical documentation was done on the different etiologies, its manifestation, assessment findings and management strategies taken for patients with neurogenic oropharyngeal dysphagia who were referred for assessment and management of dysphagia over a period of three months in a tertiary care teaching hospital. Flexible endoscopic examination was done in all the patients. The severity of dysphagia in these patients were graded based on Gugging Swallowing Screen (GUSS). A total of 53 patients with neurogenic oropharyngeal dysphagia were evaluated by an otolaryngologist and a speech language pathologist over a period of three months. The grading of severity based on GUSS for these patients were done. There were 30 patients with recurrent laryngeal nerve injury due to various etiologies, one patient with Neurofibroma-vestibular schwanoma who underwent surgical excision, 16 patients with stroke, two patients with traumatic brain injury, two patients with Parkinsonism and two patients with myasthenia gravis. The manifestation of dysphagia was mainly in the form of prolonged masticatory time, oral transit time, and increased number of swallows required for each bolus, cricopharyngeal spasms and aspiration. Among the dysphagia patients with neurogenic etiology, dysphagia is manifested with a gradual onset and is found to have a progressive course in degenerative disorders. Morbidity and mortality may be reduced with early identification and management of neurogenic dysphagia. More »»

2015

Journal Article

K. Renugadevi, Mary, J. Asnet, Perumalsamy, V., Seshadri, S., Jagadeesh, S., Suresh, B., Dr. Sheela Nampoothiri, Shenbagarathai, R., Krishnaswamy, S., and Sundaresan, P., “Molecular Genetic Testing for Carrier-Prenatal Diagnosis and Computational Analysis of Oculocutaneous Albinism Type 1”, Genetic Disorders & Genetic Reports, vol. 2014, 2015.[Abstract]


In India epidemiological-communicable diseases are on the decline due to better living conditions and healthcare delivery in the society. On the other hand, the relative increase in the prevalence of genetic diseases threatens to be a public health problem. One such group of metabolic disorder is Albinism. General population based oculocutaneous albinism (OCA) carrier screening is controversial in all the races. Because of the occurrence of this disease in prior generations, it is necessary to create the knowledge, so that even uneducated affected family members will be willing to diagnose the disease status. As a result, the carrier detection in general population has become necessary in Indian population. More »»

2015

Journal Article

S. Menon, Rajesh, G., and Balakrishnan, V., “Pancreas and Diabetes Mellitus: The Relationship between the Organ and the Disease”, Journal of The Association of Physicians of India, vol. 63, p. 51, 2015.[Abstract]


Diabetes mellitus has been a fascinating disease from the dawn of medical history. The first breakthrough in its treatment came in 1922, with the discovery of insulin which was extracted from the pancreas of a dog. Even earlier, a relationship between pancreas and diabetes mellitus had been suspected by medical scientists. However, the study of diabetes mellitus is much more than its relationship with the pancreas. On the other hand the pancreas has been known to be a very reclusive organ that is hidden away from physicians and surgeons for centuries. In recent times, it has become more accessible and has yielded some of its secrets. The relationship between the pancreas and diabetes mellitus is a story full of complexities and surprises. This article attempts to reveal some of the important events and persons in the story and the controversies surrounding them. More »»

2015

Journal Article

S. Padma and Sundaram, P. Shanmuga, “Rare association of schizophrenia and unilateral Graves’ disease with contralateral thyroid hemiagenesis in two cases of McCune-Albright syndrome”, Iranian Journal of Nuclear Medicine, vol. 23, no. 2, pp. 124–127, 2015.[Abstract]


The classical triad of McCune-Albright syndrome (MAS) consists of polyostotic fibrous dysplasia (FD), skin hyperpigmentation (café-au-lait spots), and endocrine dysfunction, frequently seen in females as precocious puberty. Etiology is genetically based and is explained by mosaicism of activating somatic mutations of the alpha-subunit of Gs protein. Clinical presentation is varied and is dependent on the particular distribution of affected cells, causing a broad spectrum of endocrine and non-endocrine manifestations. Typical endocrinopathies are precocious puberty, hyperthyroidism, growth hormone excess, hyperprolactemia, and hypercortisolism. Manifestations usually occur during infancy and childhood. We present 2 classical cases of MAS with rare association of cerebral and endocrine dysfunction (unilateral Graves’ disease with contralateral thyroid hemi agenesis). The first case is an adult onset MAS with hyperparathyroidism and schizophrenia; this association is hitherto unreported in literature. Literature search showed that mutations in the Gsα gene may be associated with the pathogenesis of schizophrenia which is similar to the underlying factor in MAS. The second is a child exhibiting classical MAS with hyperthyroidism (unilateral Graves' disease) which is common but is associated contralateral thyroid hemiagenesis. More »»

2015

Journal Article

G. Rajesh, Girish, B. Narasimham, Panicker, S., and Balakrishnan, V., “Time trends in the etiology of chronic pancreatitis in South India”, Tropical Gastroenterology, vol. 35, pp. 164–167, 2015.[Abstract]


Background: Recent reports indicate a decline in prevalence of classical tropical chronic pancreatitis (TCP). We studied the etiologies and risk factors over a 14-year period at a tertiary care university hospital. Methods: We compared the etiology in chronic pancreatitis (CP) patients presenting and followed-up in our Pancreas Clinic over two time periods (2000-06 and 2007-13). Results: Idiopathic chronic pancreatitis (ICP) was the predominant etiology seen over the two time periods. However an increase in prevalence of alcoholic chronic pancreatitis (ACP) during the latter time period suggests that it may be emerging as a dominant etiology over recent years. Hypertriglyceridemia and hyperparathyroidism were uncommon causes of nonalcoholic CP. Autoimmune pancreatitis was noted only during 2007-13, but remains a rare cause of CP. There are multiple risk factors for CP in our population. Conclusions: The high prevalence of ICP indicates need closer examination of risk factors and ICP pathogenesis. ACP appears to be emerging as a dominant cause of CP which suggests a need to reorient preventive strategies. More »»

2015

Journal Article

S. Khan, V Kumar, A., Venkitachalam, A., Vishwam, V., Dinesh, K., and Karim, S., “Detached Ciliary Tufts Masquerading as Free-living Amoebae”, International Journal of Infectious Diseases, vol. 30, pp. 142–143, 2015.

2015

Journal Article

S. Udayakumaran, Nair, P., Anil kumar, and Panikar, D., “Role of endoscopy in recalcitrant intraventricular tuberculoma—innovative novel treatment adjunct”, British Journal of Neurosurgery, vol. 29, pp. 59-63, 2015.[Abstract]


AbstractIntroduction. Intraventricular tuberculomas are rare entities. To the best of our knowledge, only 14 cases have been reported in English literature. Medical management of cerebral tuberculomas is well accepted. Intraventricular tuberculomas may be recalcitrant for unclear reasons. An effective management protocol for this entity is unclear. To the best of our knowledge, the definitive indication, timing, and possible role of surgery in these lesions have not been discussed in literature. Materials and methods. A 27-year-old nursing professional who was undergoing treatment for miliary tuberculosis at another center presented to us in 2008 with right hemiparesis, deteriorating vision, and progressive decline in consciousness. In addition to antituberculous therapy (ATT), she underwent multiple CSF diversion procedures for the obstructive hydrocephalus secondary to a recalcitrant third ventricular tuberculoma. Finally, she underwent endoscopic decompression of the lesion with a very good clinical response at 1-year follow-up. Discussion. We discuss a patient with recalcitrant intraventricular tuberculoma managed using neuroendoscopy along with the standard antituberculous therapy. We also discuss in detail the technique we utilized for endoscopic management of this lesion. Conclusion. Being a rare entity, a consensus for management of these lesions is not possible, but we have demonstrated that neuroendoscopic management of these rare entities is an option giving the advantage of definitive diagnosis when required, hastening the resolution, and clearing the CSF pathway.

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2015

Journal Article

N. Bhavani, Asirvatham, A. Reena, Kallur, K., Menon, A. S., Pavithran, P. V., Nair, V., Vasukutty, J. R., Menon, U., and Kumar, H., “Utility of Gallium-68 DOTANOC PET/CT in the localization of Tumour-induced osteomalacia.”, Clin Endocrinol (Oxf), vol. 84, no. 1, pp. 134-40, 2015.[Abstract]


BACKGROUND:Tumour-induced osteomalacia (TIO) is a rare disorder characterized by hypophosphataemic osteomalacia caused by small mesenchymal tumours secreting fibroblast growth factor 23 (FGF 23). The most difficult part in the management of these patients is the localization of tumours causing TIO.</p><p><b>OBJECTIVE: </b>We describe the utility of Gallium (Ga)-68 DOTANOC PET/CT in the localization of tumours causing TIO.</p><p><b>PATIENTS AND METHODS: </b>The study was conducted in a single tertiary referral university teaching hospital in India. Ten patients with TIO who underwent Ga-68 DOTANOC PET/CT from the time period 2009 to 2014 were included in this study. Their detailed clinical history, biochemical parameters, imaging modalities, surgical interventions, histopathology and outcomes were reviewed.</p><p><b>RESULTS: </b>Ga-68 DOTANOC PET/CT could correctly localize the tumours in TIO in 9 of the 10 cases in which it was performed. Complete resection of the tumour led to full clinical recovery in six of the ten patients; two patients who had partial resection and one patient who underwent radiofrequency ablation showed partial remission. One patient in whom Ga-68 DOTANOC PET/CT was positive in vertebral body with a low standardized uptake value (SUV) did not show up the tumour on surgery.</p><p><b>CONCLUSIONS: </b>We conclude that Ga-68 DOTANOC PET/CT can be used as the first imaging modality in patients diagnosed with TIO. The extremely good outcome following the resection of these small otherwise undiagnosed tumours far outweighs its cost even in resource limited settings.

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2015

Journal Article

A. Mohan, Joseph, S., Sidharthan, N., and Murali, D., “Carbimazole-induced agranulocytosis.”, J Pharmacol Pharmacother, vol. 6, no. 4, pp. 228-30, 2015.[Abstract]


<p><b>UNLABELLED: </b>A 47 year old lady with hyperthyroidism for past 1½ years was initially on Carbimazole 20 mg orally then changed to 30 mg (during Hysterectomy) but was taking 10 mg for last 1 year. She had intermittent fever with severe B/L bifrontal headache since 3 weeks. Routine investigations showed anaemia, neutropenia, leucopenia and CRP elevation. Peripheral smear showed normocytic normochromic anaemia with Rouleaux formation, leucopenia with 2% atypical cells and mild thrombocytosis. Widal test, RA factor (Rheumatoid factor) test, Ig M (Immunoglobulin M) dengue, Ig M Lepto, TORCH infections (Toxoplasmosis, Other (Syphilis, varicella-zoster, parvovirus B19), Cytomegalovirus and Herpes infections), ANA (Antinuclear antibody) screen cANCA (Cytoplasmic antineutrophil cytoplasmic antibodies) and pANCA (Perinuclear Anti-Neutrophil Cytoplasmic Antibodies) tests were negative. Bone marrow aspiration showed normo to hypercellular marrow with 15% atypical cells and plasma cells. Multiple myeloma workup was done. Carbimazole was withheld.</p><p><b>CONCLUSION: </b>Drug induced agranulocytosis occurs with in 1-2 months of taking the antithyroid medication but onset delayed by 1½ year. De-challenge resulted normalization of blood parameters.</p>

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2015

Journal Article

A. V. Nair, Sandya, C. J., Moorthy, S., and Ramachandran, P. V., “Role of PET-CT versus MRI in carcinoma breast: Which one is indicated for detecting the primary?”, Indian J Cancer, vol. 52, no. 4, pp. 652-3, 2015.

2015

Journal Article

S. Zahoor Ahmad, Rajanbabu, A., Vijaykumar, D. K., Haji, A. Gauhar, and Pavithran, K., “A prospective comparison of perioperative morbidity in advanced epithelial ovarian cancer: Primary versus interval cytoreduction - experience from India.”, South Asian J Cancer, vol. 4, no. 3, pp. 107-10, 2015.[Abstract]


<p><b>OBJECTIVES: </b>The objective was to compare perioperative morbidity and mortality of patients with advanced epithelial ovarian cancer (EOC) treated with either of the two treatment approaches; neoadjuvant chemotherapy (NACT) followed by interval debulking versus upfront surgery.</p><p><b>DESIGN: </b>Prospective comparative observational study.</p><p><b>PARTICIPANTS: </b>In total, 51 patients were included in the study. All patients with diagnosed advanced EOC (International Federation of Gynecology and Obstetrics IIIC and IV) presenting for the 1(st) time were included in the study.</p><p><b>INTERVENTIONS: </b>Patients were either operated upfront (n = 19) if deemed operable or were subjected to NACT followed by interval debulking (n = 32).</p><p><b>PRIMARY AND SECONDARY OUTCOMES: </b>Intra- and postoperative morbidity and mortality were the primary outcome measures.</p><p><b>RESULTS: </b>Patients with interval cytoreduction were noted to have significantly lesser operative time, blood loss, and extent of surgery. Their discharge time was also significantly earlier. However, they did not differ from the other group vis. a vis. postoperative complications or mortality.</p><p><b>CONCLUSIONS: </b>Neoadjuvant chemotherapy although has a positive impact on various intraoperative adverse events, fails to show any impact on immediate postoperative negative outcomes.</p>

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2015

Journal Article

J. Ramu, Wakure, A., and Sharma, M., “A simple method to facilitate oral surgery in patients with orthodontic appliances.”, Indian J Plast Surg, vol. 48, no. 3, pp. 328-9, 2015.

2015

Journal Article

V. Prabhakar and Kaliyadan, F., “A case of verrucous hemangioma and its dermoscopic features.”, Indian Dermatol Online J, vol. 6, no. Suppl 1, pp. S56-8, 2015.

2015

Journal Article

S. M. Alex, Banerjee, S., Dipu, Ts, Sabarish, B., Pillai, A., Dr. Umadevi P., and Menon, V., “Meropenem Induced Reduction in Serum Valproate Level- A case Report”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, pp. 403-404, 2015.[Abstract]


Objective: To report a case of meropenem induced reduction in serum valproate level. Methods: The clinical data of an epileptic patient who experienced a decrease in seizure control due to a drug interaction between valproate and meropenem is described. Results: The patient was a 26 years old male who was a known case of refractory focal epilepsy and underwent surgery for the same. This patient was on five antiepileptic drugs including valproate. On treatment with meropenem for the management of post surgical site infection due to multidrug resistant Klebsiella pneumoniae, the patient experienced seizures due to decline in valproate level. Increasing the dose of valproate could not control the seizures. However, changing the antibiotics to a non carbapenem controlled the seizures. Conclusion: The present report highlights the potential drug interaction between valproate and meropenem. Physicians should thus avoid co-administration of both these agents. If concomitant administration is essential, close monitoring of valproate concentration and clinical monitoring for breakthrough seizures are necessitated.

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2015

Journal Article

S. M. Alex, Sreelekshmi, B., Smitha, S., Jiji, K., Menon, A. S., and Dr. Umadevi P., “Drug Utilization Pattern of Anti-diabetic Drugs Among Diabetic Outpatients in a Tertiary Care Hospital”, Asian Journal of Pharmaceutical and Clinical Research, vol. 8, pp. 144-146, 2015.[Abstract]


Objective: The aim was to evaluate the drug utilization pattern of anti-diabetic drugs in diabetic outpatients and monitor the adverse drug reactions (ADRs) associated with anti-diabetic therapy. Methods: A prospective observational study was carried out in adult diabetic patients visiting the outpatient Departments of General Medicine and Endocrinology of a tertiary care hospital. Demographic data, drug utilization pattern and ADRs due to anti-diabetic drugs were summarized. Results: In the present study, 99 (50.3%) of the 197 diabetic patients were males. Majority of patients were in the age group of 51-60 years (39.6%) and most of the patients (36.5%) had a diabetic history of <5 years. Metformin was the most commonly prescribed drug (68%), followed by sulfonylurea class of drugs (49.7%). Nearly, 42% patients were using insulin preparations with 30.4% using biphasic isophane human insulin. Majority of the patients (58.4%) were on multidrug therapy with two drug therapies being received by nearly 40%. Metformin was the most commonly prescribed drug in monotherapy (18.8%) and glimepiride + metformin was the most common two drug therapy (13.2%). Co-morbid condition was found in 172 patients (87.3%) with hypertension (68.5%) being the most common co-morbid condition. 17 ADRs were observed with hypoglycemia being the most common ADR reported. Conclusions: Metformin was the most commonly used drug. The prescribing trend also appears to be moving towards combination therapy particularly two drug therapies. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.

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2015

Journal Article

A. V. Nair, Sandya, C. J., Shagos, G., Anirudh, S., Rajamma, B. M., ,, and Moorthy., S., “Role of Dual Time Fluorodeoxyglucose (FDG) Positron Emission Tomography-Computed Tomography in Identifying Co-Existing Inflammatory and Malignant Disease: Who Holds It (FDG) Longer?”, Indian Journal of Nuclear Medicine , vol. 30, 2015.

2015

Journal Article

A. Mary Thomas, John, A., Leelamoni, K., Radhakrishnan, N., Patki, S., and Harsha, M., “Prevalence and Predictors of Ocular Morbidity Among Primary School Children of Urban Kerala”, National Journal of Research in Community Medicine, vol. 4, no. 3, pp. (268-277, 2015.

2015

Journal Article

U. Biju Palatty, Joseph, K. V., Amrutha, and Abraham, “Surface Variations of Caudate Lobe and Its Clinical Implications”, International Journal of Health Sciences and Research (IJHSR) , vol. 5, pp. 236-240, 2015.

2015

Journal Article

R. Anupama, Venkatesan, R., Thomas, S. B., Dinesh, M., Pavithran, K., and Vijaykumar, D. K., “Early-Stage Endometrial Cancer: Recurrence Pattern and Survival Analysis from a Tertiary Cancer Centre in South India”, Indian Journal of Gynecologic Oncology, vol. 13, p. 3, 2015.[Abstract]


The incidence of endometrial cancer is rising in India possibly due to the change in lifestyle and urbanization. Recent years have also shown a change in the adjuvant therapy for endometrial cancer. We evaluated the pattern of recurrence and survival of stage I and II carcinoma endometrium treated at our institution during a 5-year period.

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2015

Journal Article

T. G. Abhilash, Satheesan, P., and Kumar, R. K., “Clinical Management of Congenital Heart Disease from Infancy to Adulthood”, Annals of Pediatric Cardiology , vol. 8, 2015.

2015

Journal Article

Baby, ,, Joseph, S., and Kumar, G., “Nebulised Adrenaline in Chronic Obstructive Pulmonary Disease and Asthma – A Review”, 2015.

2015

Journal Article

Bansal and Somendra, “CKP MENON BEST PAPER PRIZE SESSION PAPERS”, Indian Journal of Urology , vol. 31, no. 1, 2015.

2015

Journal Article

P. Bhasi, ,, and , “Glycemic Control Is Difficult to Attain in Type 2 Diabetes Mellitus despite Insulin Therapy”, International Journal of Diabetes in Developing Countries, pp. 1 - 2, 2015.

2015

Journal Article

Balasubramanian, Pradeep, Jagadeesan, S., Anjaneya, G., and Jacob, “An Interesting Case Report of Azathioprine-Induced Anagen Effluvium”, Indian Journal of Dermatology , vol. 60, 2015.

2015

Journal Article

A. M. Bidchol, Dalal, A., Trivedi, R., Shukla, A., Nampoothiri, S., Sankar, V. H., and Danda, S., “Recurrent and Novel GLB1 Mutations in India”, Gene, 2015.

2015

Journal Article

Bhattacharya, Shreya, Vijayan, S. N., and Iyer, S., “Bronchogenic Cyst Presenting as Neck Swelling in an Adult: A Case Report”, Egyptian Journal of Bronchology , vol. 9, 2015.

2015

Journal Article

B. Urumese Palatty, “Anatomical Study of Extensor Tendons of Medial Four Fingers in Adults and Foetus-A Cadaveric Study”, People's Journal of scientific research, vol. 8, no. 1, 2015.

2015

Journal Article

C. Borde, S, P., and P, S. Sundaram, “FDG PET CT in Evaluation of Cancer Cervix: All that you Need, Nothing that You Don’t!”, JCRT, 2015.

2015

Journal Article

Lazaro A., Han W. W., Manrique‐Saide P., George L., Velayudhan R., Toledo J., Runge Ranzinger S., and O., H., “Community Effectiveness of Copepods for Dengue Vector Control: Systematic Review”, Tropical Medicine & International Health, vol. 20, pp. 685-706, 2015.[Abstract]


Abstract Objective Vector control remains the only available method for primary prevention of dengue. Several interventions exist for dengue vector control, with limited evidence of their efficacy and community effectiveness. This systematic review compiles and analyses the existing global evidence for community effectiveness of copepods for dengue vector control. Methods The systematic review follows the PRISMA statement, searching six relevant databases. Applying all inclusion and exclusion criteria, 11 articles were included. Results There is evidence that cyclopoid copepods (Mesocyclops spp.) could potentially be an effective vector control option, as shown in five community effectiveness studies in Vietnam. This includes long‐term effectiveness for larval and adult control of Ae.&nbsp;aegypti, as well as dengue incidence. However, this success has so far not been replicated elsewhere (six studies, three community effectiveness studies – Costa Rica, Mexico and USA, and three studies analysing both efficacy and community effectiveness – Honduras, Laos and USA), probably due to community participation, environmental and/or biological factors. Judging by the quality of existing studies, there is a lack of good study design, data quality and appropriate statistics. Conclusion There is limited evidence for the use of cyclopoid copepods as a single intervention. There are very few studies, and more are needed in other communities and environments. Clear best practice guidelines for the methodology of entomological studies should be developed.

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2015

Journal Article

A. Duseja, Singh, S. P., Saraswat, V. A., Acharya, S. K., Chawla, Y. K., ,, and Dhiman, R. K., “Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome-Position Paper of the Indian National Association for the Study of the Liver, Endocrine Society of India, Indian College of Cardiology and Indian Society of Gastroenterology”, Journal of Clinical and Experimental Hepatology , vol. 5, 2015.

2015

Journal Article

P. T. Francis, H Mahajan S, Garg, V. K., and Sarkar, B. K., “A Qualitative Study of Newborn Care Practices among Mothers in a Rural Setting”, Indian Journal of Public Health Research & Development , vol. 6, 2015.[Abstract]


The first 48 hours after birth is the most crucial period in the life of an infant as the risk of death is highest during this period. The problem is more profound in rural areas of India as most deliveries are conducted at home with poor environmental conditions and unhealthy newborn practices. Methodology: The present research work is a community based field study done in Bisrakh block of district Gautam Budh Nagar. The study conducted in all the villages of two randomly selected sub- center areas each from two randomly selected PHC field areas of Bisrakh Block, Gautam Budha Nagar, U.P. Observations: 14% newborns did not cry immediately after birth, requiring resuscitation; 22% newborns were clothed within 6 hours of birth; breastfeeding started within one hour of birth among 11% newborns; 86% of newborns delivered at home were given pre-lacteal feeds; colostrum given to 34% of newborns and 26% of newborns were exclusively breastfed. Conclusions: Newborn care practices in deliveries conducted at home are far from ideal, it is of paramount importance that practical strategies involving behavioral change communication should be adopted in order to realistically reduce neonatal mortality in Rural India.

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2015

Journal Article

P. Dhar, ,, and Saraf, V., “Pancreatic Cancer in Chronic Pancreatitis”, Indian Journal of Surgical Oncology , vol. 6, pp. 57-62, 2015.

2015

Journal Article

Gadi, Daksh, Pai, M., and Rao, R., “Clinicoradiological Outcome of Short Segment Fusion in Thoracolumbar Vertebral Fractures…. A Study of 20 Cases”, 2015.

2015

Journal Article

B. Gandham SriLakshmi, Hitesh, S., B., D. Ashwin, Anju, S., Sumita, D., Shagun, A., R., P. Shubha, Neerja, G., Madhulika, K., Kalpana, G., Anju, G., Meenakshi, B., D., P. Ratna, Sunita, B. ‐M., Sheela, N., M., M. Kavitha, S., R., M., K. Akhil, L., K. Muralidhar, Prajnya, R., Radha, R. A., V., H. Sankar, and Mohan, G. Katta, “Novel and Recurrent Mutations in WISP3 and an Atypical Phenotype”, American Journal of Medical Genetics Part A, vol. 167, pp. 2481-2484, 2015.

2015

Journal Article

MELVIN J. GEORGE and Thilak, J., “SIMULTANEOUS BUCKET HANDLE TEAR OF BOTH MENISCI WITH ACL INJURY.”, Kerala Journal of Orthopaedics, vol. 27, pp. 127 - 130, 2015.[Abstract]


Meniscal tears can be degenerative or traumatic. It may cause pain and functional impairment. Bucket handle tear of two menisci of either knee is rare and that of both menisci of the same knee is still rarer. This case report presents a 33 year old man with bucket handle tear of both menisci of the right knee which occurred simultaneously due to a trauma. The lesions were treated with arthroscopic repair of medial meniscus and partial menisectomy of lateral meniscus. To our knowledge, this case report of traumatic bucket handle tear of both menisci with ACL injury of the same knee is the first such case reported in India

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2015

Journal Article

Hegde and Aparna, “Scientific Program of USICON 2015”, Indian Journal of Urology , vol. 31, no. 1, 2015.

2015

Journal Article

B. James and Sasidharan, A., “Cut Throat Injuries – Three Case Scenarios”, Journal of South India Medicolegal Association , vol. 7, pp. 36-39, 2015.

2015

Journal Article

S. T. Joseph, Sharankumar, S., Sandya, C. J., Sivakumar, V., Sherry, P., Krishnakumar, T., and Subramania., I., “Easy and Safe Method for Facial Nerve Identification in Parotid Surgery”, Journal of Neurological Surgery Part B: Skull Base, 2015.

2015

Journal Article

Jacob and Pradeep, “Recurrent Varicose Veins”, In Chronic Venous Disorders of the Lower Limbs, 95–103. Springer, 2015.

2015

Journal Article

N. Kanan, “Comparison Between Retrograde Intrarenal Surgery (rirs) and Percutaneous Nephrolithotomy (pcnl) in the Treatment of Single Renal Stone 2-3cm”, Accessed, 2015.

2015

Journal Article

Krishna, Anirudh Nair, and Varma, P. Kerala, “Risk Stratification in Cardiac Surgery”, Indian Journal of Thoracic and Cardiovascular Surgery, 2015.

2015

Journal Article

S. Kathuria, Singh, P. K., Sharma, C., Prakash, A., Masih, A., Kumar, A., Meis, J. F., and Chowdhary, A., “Multidrug-Resistant Candida Auris Misidentified as Candida Haemulonii: Characterization by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and DNA Sequencing and Its 58. Antifungal Susceptibility Profile Variability by Vitek ”, Journal of Clinical Microbiology , vol. 53, pp. 1823–30, 2015.

2015

Journal Article

A. Kumar, Nambiar, T. P. Vivek, Sreekrishnan, V., and Ajith, N. Mohan, “Stroke Progression”, Universal Journal of Medical Science , vol. 3, no. 3, pp. 60-64, 2015.

2015

Journal Article

L. George, Lenhart, A., Toledo, J., Lazaro, A., Han, W. Wai, Velayudhan, R., Ranzinger, S. Runge, and Horstick, O., “Community-Effectiveness of Temephos for Dengue Vector Control: A Systematic Literature Review”, PLOS Neglected Tropical Diseases , 2015.

2015

Journal Article

B. Menon, Nayar, R., Suresh Kumar, Cherkil, S., Venkatachalam, A., Surendran, K., and Deepak, K., “Parkinson's Disease, Depression, and Quality-of-Life”, Indian Journal of Psychological Medicine , vol. 37, no. 144, 2015.

2015

Journal Article

J. Menon, Vijayakumar, N., Joseph, J. K., David, P. C., Menon, M. N., Mukundan, S., Dorphy, P. D., and Banerjee, A., “Below the Poverty Line and Non-Communicable Diseases in Kerala: The Epidemiology of Non-Communicable Diseases in Rural Areas (ENDIRA) Study”, International Journal of Cardiology , vol. 187, pp. 519-24, 2015.

2015

Journal Article

R. Ramachandr Menon, “Endovenous Thermal Ablation”, In Chronic Venous Disorders of the Lower Limbs, pp. 69 - 80, 2015.

2015

Journal Article

N. Mohan and Karunanithi, K., “Can Venous Blood Gases Replace Arterial Blood Gases in Diabetic Ketoacidosis/Renal Failure Induced Metabolic Acidosis”, Universal Journal of Medical Science , vol. 3, pp. 65 - 69, 2015.

2015

Journal Article

A. Mehta, Gupta, A., and Aziz, K. S., “Images in Medicine”, 2015.

2015

Journal Article

R. Ramachandr Menon, “Lower Limb Venous Anatomy”, Chronic Venous Disorders of the Lower Limbs: A Surgical Approach, pp. 9–16, 2015.[Abstract]


The venous system of the lower limbs is a well-organized functioning unit promoting unidirectional cephalad flow toward the heart. Altered anatomy and physiology are responsible for the symptoms and signs of chronic venous disorders (CVD) of the lower limbs.

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2015

Journal Article

R. Ramachandr Menon, “Nonthrombotic Iliac Vein Lesion (May-Thurner Syndrome)”, In Chronic Venous Disorders of the Lower Limbs, pp. 223-28, 2015.

2015

Journal Article

R. Ramachandr Menon, “Venous Physiology and Hemodynamics of Lower Limbs”, Chronic Venous Disorders of the Lower Limbs: A Surgical Approach, pp. 17–23, 2015.[Abstract]


The venous system of the lower limbs is an organized and functional unit. Returning blood to the heart is its primary function. Several factors are involved in the control of this system. These include gravity, the reservoir capacity, venous tone, sympathetic control of smooth muscles, and many other mechanisms. Most of our misunderstanding of venous diseases stems from the inability to appreciate the delicate anatomy and physiology. Details of anatomy were considered in Chap. 2.

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2015

Journal Article

A. V. Nair, ,, ,, Shemin, Z., Jojo, A., and Moorthy., S., “Endolymphatic Sac Tumor: A Temporal Rarity Revisited”, Indian Journal of Otology , vol. 21, 2015.

2015

Journal Article

R. S. Nair, Snima, K. S., Kamath, R. C., Nair, S. V., and Lakshmanan, V. K., “Synthesis and Characterization of Careya Arborea Nanoparticles for Assessing Its in Vitro Efficacy in Pancreatic Cancer Cells”, Journal of Natural Products , vol. 8, 2015.

2015

Journal Article

Narayanmoorthy, ,, Ganesan, P., and Ramanan, R., “A Rare Case of Postpartum Ovarian Vein Thrombosis”, International Journal of Reproduction, Contraception, Obstetrics and Gynecology , vol. 4, pp. 878-80, 2015.

2015

Journal Article

S. Padma, Sundaram, P. Shanmuga, Shagos, G. S., and Kumar, S., “Unsuspected early necrotizing fasciitis identified by 18F-FDG PET imaging in a patient with acute myeloid leukemia”, Iranian Journal of Nuclear Medicine, vol. 23, pp. 53-55, 2015.[Abstract]


Necrotizing fasciitis is a part of a spectrum of necrotizing soft tissue infections that usually follow a surgical intervention or a chronic / acute medical illness. Diagnosis is often based on symptoms which classically start within hours after an injury. There are no reports on the use of PET/CT in this condition. Sparing reports of its association in patients with malignancy (Ca of colon and rectum) are available. Here we present a young lady in remission from acute myeloid leukemia (AML) with sudden onset right knee pain and fever after a trivial foot injury. Clinically an osteomyelitis or acute septic arthritis was suspected, although the location is not appropriate for osteomyelitis. 99mTc-MDP bone scan was performed followed by 18F-FDG PET. 18F-FDG PET scan was incremental in diagnosing subcutaneous infection around right knee even before appearance of an ulcer or skin erosion. Tissue culture confirmed necrotizing fasciitis. This is the first case report highlighting necrotizing fasciitis in a patient with AML

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2015

Journal Article

S. Padma and P. Sundaram, S., “Radioiodine as an Adjuvant Therapy and Its Role in Follow-up of Differentiated Thyroid Cancer”, 2015.

2015

Journal Article

B. Parameswar Pillai, ,, Kumar, H., Jayakumar, R. Vilasam, Alur, V. Chandra, and Sheejamol, V. S., “The prevalence of metabolic syndrome in polycystic ovary syndrome in a South Indian population and the use of neck circumference in defining metabolic syndrome”, International Journal of Diabetes in Developing Countries, vol. 35, pp. 469–475, 2015.[Abstract]


Polycystic ovary syndrome (PCOS) is a common endocrine disorder in young women with a high prevalence of insulin resistance (IR) and metabolic syndrome (MetS). The prevalence of MetS differs based on the defining criteria used. Neck circumference (NC) has been proposed as a surrogate marker of MetS which is simple and easy to perform in the outpatient setting. The aim of the study was to estimate the prevalence of metabolic syndrome in women with PCOS and to study the use of NC in defining metabolic syndrome. This was a prospective observational cross-sectional study involving 121 PCOS patients over a period of 2 years. The prevalence of metabolic syndrome was estimated using the modified Adult Treatment Panel (ATP) III criteria as well as the International Diabetes Federation (IDF) criteria. The Pearson correlation coefficient was used to find the degree of correlation between NC and waist circumference (WC). The Receiver operating characteristic (ROC) curves of NC were used to predict the metabolic syndrome. The independent sample t test and the Mann-Whitney U test were used for comparing the average NC and WC between the groups of patients with and without MetS. The prevalence of MetS was found to be 30.6 {%} using the modified ATP III criteria and 52 {%} using the IDF criteria. There is a statistically significant positive correlation between NC and WC (rþinspace}=þinspace}0.758, pþinspace}<þinspace}0.001). The mean NC is higher in patients who have MetS by both criteria (pþinspace}<þinspace}0.001). Based on ROC curve analysis, the NC cutoff of 33.5 cm detected MetS (by IDF criteria) with a sensitivity of 60.3 {%} and a specificity of 70.7 {%} (area under ROC curveþinspace}=þinspace}0.70, pþinspace}<þinspace}0.001) and the NC cutoff of 33.87 cm detected MetS (by ATP III criteria) with a sensitivity of 73 {%} and a specificity of 69 {%} (area under ROC curveþinspace}=þinspace}0.722 pþinspace}<þinspace}0.001). The IDF criteria identified a higher number of PCOS subjects with MetS compared to the ATP III criteria. NC correlated very well with MetS as well as WC, and this could replace the waist circumference to define MetS in the future.

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2015

Journal Article

Prameela, Chelakkot G, Ravind, R., and Dinesh, M., “Significance of Patterns of Failure after Curative Intent Treatment in Adenocarcinoma of Stomach: Lessons Learnt”, 2015.

2015

Journal Article

V. Prathapan and Umadethan, B., “Fall from Heights–Pattern of Injuries”, International Journal of Biomedical Research , vol. 6, no. 1, pp. 8 - 13, 2015.

2015

Journal Article

G. Praveen, “Role of Hgf Loaded Fibrin Nano Constructs in Alginate Agarose Scaffolds for Liver Assist Devices”, 2015.

2015

Journal Article

S. Patil, Nagarajan, K., Vadukot, M., and Nair, H., “Hepatic Osteodystrophy: Prevalence and Correlation with Aetiology and Functional Class”, Journal of Clinical and Experimental Hepatology , 2015.

2015

Journal Article

C. Prameela, Ravind, R., and Dinesh, M., “P0033 Significance of Patterns of Failure after Treatment with Curative Intent in Adenocarcinoma of Stomach”, European Journal of Cancer , vol. 51, 2015.

2015

Journal Article

N. Puthenveettil, ,, ,, and , “Accidental Subdural Placement of Labor Epidural Catheter Leading to Sudden Maternal Collapse”, Journal of Obstetric Anaesthesia and Critical Care, 2015.

2015

Journal Article

R. R. Ravind, Prameela, C. G., and Dinesh, M., “P0111 Sub-Ventricular Zone Irradiation in Glioblastoma: Can It Increase Survival?””, European Journal of Cancer , vol. 51, 2015.

2015

Journal Article

S. Rajan, Krishnankutty, S. Valsala, and Nair, H. Muraleedha, “Efficacy of Alpha 2 Agonists in Obtunding Rise in Intraocular Pressure after Succinylcholine and That Following Laryngoscopy and Intubation”, Anesthesia: Essays and Researches , vol. 9, 2015.

2015

Journal Article

A. Rajanbabu, Nair, I. R., Goel, G., Jojo, A., and K., V. D., “Evaluating the Impact of Frozen Section Analysis in Surgery for Ovarian Neoplasms”, Indian Journal of Gynecologic Oncology, vol. 13, p. 7, 2015.[Abstract]


Frozen section is a valuable diagnostic tool that can identify the nature of the ovarian lesions intra-operatively thus helping to select appropriate surgery for the patient. In the present study, we are analyzing the accuracy of frozen section in diagnosing benign, borderline, and malignant ovarian tumors and the impact of change which frozen section diagnosis made on planned surgery.

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2015

Journal Article

S. Rajan, Mohan, P., Paul, J., and Cherian, A., “Comparison of Margin of Safety Following Two Different Techniques of Preoxygenation”, Journal of Anaesthesiology Clinical Pharmacology , vol. 31, pp. 165-168, 2015.

2015

Journal Article

S. Sreedharanunni, Paulose, R., Jojo, A., Dhar, P., and Gangadharan, P., “Colonic polyposis syndromes–-An experience from a tertiary centre in South India”, Indian Journal of Gastroenterology, vol. 34, pp. 233–239, 2015.[Abstract]


Several polyposis syndromes of the gastrointestinal tract have been recognized which carry increased risk for cancer and have a genetic predisposition. There is a paucity of literature regarding the occurrence and the burden of colonic polyposis syndromes in the Indian subcontinent. This study attempts to highlight this hitherto unaddressed burden and the associated increased risk for inherited colonic cancer in this geographical location.

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2015

Journal Article

B. Sonik, ,, and P. Sundaram, S., “Impact of 18F-FDG PET/CT Derived Nodal Staging in Overall Staging and Management of Newly Diagnosed Cases of Squamous Cell Carcinoma of Head and Neck (SCCHN)-A Prospective Study”, Journal of Nuclear Medicine , vol. 56, 2015.

2015

Journal Article

Z. Shemin, Sreehari, S., and Jojo, A., “Renal Cell Carcinoma with Xp11. 2 translocation/TFE3 Gene Fusions-Experience from a Tertiary Care Hospital in Kerala, India”, 2015.

2015

Journal Article

M. Sharma, Dudipala, R. Reddy, Mathew, J., Wakure, A., Thankappan, K., Balasubramaniam, D., and Iyer, S., “Objective Analysis of Microtia Reconstruction in Indian Patients and Modifications in Management Protocol”, Indian Journal of Plastic Surgery , vol. 48, 2015.

2015

Journal Article

G. Sali, Thomas, A., Kumar, G., Nair, B., Sanjeevan, K., Mathew, G., and Nair, K., “Extensive prostatic calculi in alkaptonuria: An unusual manifestation of rare disease”, Asian Journal of Urology, vol. 2, pp. 179 - 181, 2015.[Abstract]


Extensive prostatic calculi in a young man should always elicit the suspicion of alkaptonuria. Although prostatic calculi are seen in chronic prostatitis, chronic pelvic pain syndrome and benign prostate hyperplasia, none of these have prostatic calculi or calcification as extensive as in alkaptonuria. A 36 years young man who had severed obstructive lower urinary tract symptoms with extensive prostatic calculi was found to be alkaptonuric on further evaluation.

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2015

Journal Article

S. H, .Beena, K., and .K.Padmanabhan, T., “The predictors of survival and outcome in localized carcinoma prostate treated with radical conformal radiation -Experience from a tertiary center”, JIPMER Journal of Cancer, no. 1, 2015.

2015

Journal Article

M. Sharma, Thankappan, K., Wakure, A., Dudipala, R. R., Iyer, S., Jairaj, D., and Mathew, J., “Anatomic Basis for an Algorithmic Approach for Free Fibula Flap Donor Side Selection in Composite Oro-Mandibular Defects”, Indian Journal of Plastic Surgery , vol. 48, 2015.

2015

Journal Article

G. S. Shagos, Shanmugasundaram, P., Varma, A. K., Padma, S., and Sarma., M., “18-F Flourodeoxy Glucose Positron Emission Tomography-Computed Tomography Imaging: A Viable Alternative to Three Phase Bone Scan in Evaluating Diabetic Foot Complications?”, Indian Journal of Nuclear Medicine , vol. 30, 2015.

2015

Journal Article

K. N. Subhakumari and Reshmy, G. S., “Evaluation of Antioxidant Status in Myocardial Infarction in Diabetic and Non-Diabetic Subjects: A Comparative Study”, Advances in Diabetes and Metabolism , vol. 3, 2015.

2015

Journal Article

P. Subramanyam and Palaniswamy, S. Sundaram, “Pictorial Essay of Developmental Thyroid Anomalies Identified by Thyroid Scintigraphy”, 2015.

2015

Journal Article

P. J. Tessy, Jojo, A., Sreejesh, S., and Krishnan, S. A., “Role of FNAC in the Diagnosis of Carotid Body Paraganglioma”, 2015.

2015

Journal Article

P. Kerala Varma and Krishna, N., “Class Room”, 2015.

2015

Journal Article

N. Vikkath, Valiyaveedan, S., Nampoothiri, S., Radhakrishnan, N., Pillai, G. S., Nair, V., Pooleri, G. Kumar, Mathew, G., Menon, K. N., Ariyannur, P. S., and Pillai, A. B., “Genotype–phenotype analysis of von Hippel–Lindau syndrome in fifteen Indian families”, Familial Cancer, vol. 14, pp. 585–594, 2015.[Abstract]


The general prevalence of the familial multi-organ tumor disorder, von Hippel–Lindau syndrome (VHL), was estimated to be 1 in 25–40,000 in western studies two decades back. Few studies were done in Indian sub-continent, amidst a surge in clinical reports on VHL specific manifestations. The syndrome is correlated with mutations of the gene VHL (located in Chr 3p25.3). We aimed to conduct a prospective case series describing phenotypic and genotypic characteristics in Indian population. The VHL-specific clinical and radiological features were collected from patients and family members. Genotypic changes such as deletion/duplication or point mutation in the VHL locus were identified using sequencing and MLPA. Thirty-one subjects, from fifteen families with diagnosed VHL, were included in the study. Multicystic pancreas was found in 71 {%} (22/31), CNS hemangioblastoma in 68 {%} (21/31), renal cell carcinoma and retinal angiomas in 23 {%} (7/31) each, pheochromocytoma in 9.7 {%} (3/31) of the population and endolymphatic sac tumor in one subject. Four families (9 subjects) had full length deletion of VHL, three families (4 subjects) had a deletion of exon 3, eight families (18 subjects) had different exonic, splice-site and intronic point mutations and one subject had a de novo in-frame indel in exon 1. Multicystic pancreas and CNS hemangioblastomas were the most common manifestations in our population. The phenotypic expression patterns in terms of tumorigenesis, tissue tropism and penetrance in comparison to the genotypic features were found to be different from previous correlative studies.

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2015

Journal Article

N. Vadera, Anusha Ashokan, Gowd, G. S., Sajesh, K. M., Chauhan, R. P., Dr. Jayakumar Rangasamy, Shantikumar V Nair, and Dr. Manzoor K., “Manganese doped Nano-bioactive Glass for Magnetic Resonance Imaging”, Materials Letters, vol. 160, pp. 335 - 338, 2015.[Abstract]


Magnetic resonance imaging (MRI) is an attractive method to image biomaterial implants owing to its high spatial resolution and absence of ionizing radiation. However, most of the biomaterials lack magnetic contrast sufficient enough to be imaged in MRI. Here, we report synthesis of manganese doped nano-bioactive glass (Mn-nBG) giving bright contrast for MRI. We have optimized a room temperature method of doping nBG for efficient T1 weighted magnetic contrast. In vitro study using primary mesenchymal stem cells showed no toxicity for Mn-nBG up to a tested concentration of 100µg/ml, suggesting potential applications in cell labeling and tissue engineering.

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2015

Journal Article

Vijayan, Vinaya, and Sebastian, N. C., “Correlation between Anthropometric Measurements and Peak Expiratory Flow Rate in Healthy Young Adults”, 2015.

2015

Journal Article

S. Vaidyanathan, “Pelvic Venous Syndromes.” In Chronic Venous Disorders of the Lower Limbs”, Springer, 2015.

2015

Journal Article

S. Vaidyanathan, “Deep Vein Obstruction: Management Strategies”, In Chronic Venous Disorders of the Lower Limbs, pp. 195-203, 2015.

2015

Journal Article

J. Xue, Sakthivel, S., Pavithran, P. V., Vasukutty, J. R., and Kannan, K., “Urinary Levels of Endocrine-Disrupting Chemicals, Including Bisphenols, Bisphenol A Diglycidyl Ethers, Benzophenones, Parabens, and Triclosan in Obese and Non-Obese Indian Children”, Environmental Research , 2015.

2015

Journal Article

Moorthy S, “Percutaneous Transhepatic Balloon Dilatation of Benign Bilioenteric Strictutes : A Analysis of Technique and Long Term Outcome”, Journal of Gastrointestinal Intervention (Gastrointest Interv 4), 2015.

2015

Journal Article

L. Susan George, Lalu, J. S., Paul, N., and K, L., “Awareness and Social Stigma Associated with HIV/AIDS and Tuberculosis Among Students : A Comparative Study”, Journal of Evidence Based Med & Healthcare, vol. 2, no. 51, p. 8617, 2015.

2015

Journal Article

P. G. Nair, Devassy, D., Faizal, B., and K, G., “Superior Semicircular Canal Dehiscence Syndrome-A case report”, Research in Otolaryngology , vol. 4, no. 4, pp. 45-48, 2015.

Year of Publication Title
2014 Screening for breast cancer in a low middle income country: predictors in a rural area of Kerala,India.AswathySreedevi,Mariya Amin Quereshi,Beteena Kurian, Leelamoni Kamalamma(15(5),1919-24 Asian Pac J of Cancer prevention 2014.  Read More»»
2014 Quaternary prevention and diabetes.Sanjay Kalra, Aswathy Sreedevi, AG Unnikrishnan.J Of pak Med Asso. Vol. 64, No. 11, November 2014. Read More»»
2013 Anupama Rajanbabu, Sheik Zahoor Ahmad, D. K. Vijaykumar, K. Pavithran and Santhosh Kuriakose, The significance of the site of origin in primary peritoneal carcinosarcoma: case report and literature review, ecancer, 7:7: 295, 2013.
2013 Ajit Kumar Varma, Charcot neuroarthropathy of the foot and ankle : A review, The Journal of Foot and Ankle Surgery xxx, 1-10 (2013)
2013 Ajit Kumar Varma, Praveen Jeyapathy, Mangalanandan TS, Arun Bal, Harish Kumar, Reconstructive foot and ankle surgeries in destroyed diabetic charcot’s neuroarthropathy, stabilized with Amrita-Sling Technique : A one year follow up, The Journal of Diabetic Foot Complications, Vol.5, Issue 3, No.2, pages 62-72, 2013.
2013 Bidisha Saha, Davor Lessel, Sheela Nampoothiri, Anuradha S. Rao, Fuki M. Hisama, Dincy Peter, Chris Bennett, Gudrun N€urnberg, Peter N€urnberg, George M. Martin, Christian Kubisch & Junko Oshima. Ethnic-specific WRN mutations in South Asian Werner syndrome patients: potential founder effect in patients with Indian or Pakistani ancestry, Molecular Genetics & Genomic Medicine, 2013; 1(1): 7–14, 2013.
2013 Fransiska Malfait, Sofie Symoens, Nathalie Goemans, Yolanda Gyftodimou, Eva Holmberg, Vanesa López-González, Geert Mortier, Sheela Nampoothiri, Michael Bjorn Petersen and Anne De Paepe, Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome, Orphanet Journal of Rare Diseases, 8:78, 2013.
2013 Gijs W. E. Santen, Emmelien Aten, Anneke T. Vulto-van Silfhout, Caroline Pottinger, Bregje W. M. van Bon, Ivonne J. H. M. van Minderhout, Ronelle Snowdowne, Christian A. C. van der Lans, Merel Boogaard, Margot M.L. Linssen, Linda Vijfhuizen, Michiel J.R. van der Wielen, M.J. (Ellen) Vollebregt, Sheela Nampoothiri 1 the Coffin-Siris consortium, Martijn H. Breuning, Marjolein Kriek, Arie van Haeringen, Johan T. den Dunnen, Alexander Hoischen, Jill Clayton-Smith, Bert B. A. de Vries, Raoul C. M. Hennekam, and Martine J. van Belzen, Coffin–Siris Syndrome and the BAF Complex: Genotype–Phenotype Study in 63 Patients, HUMAN MUTATION, Vol. 00, No. 00, 1–10, 2013.
2013 Lakshmi R. Lakshman, P. T., Sudheesh Kumar, Sreeja V. Nair, Shantikumar V. Nair, and R. Jayakumar*, Chitosan Sponge Containing the Herb Coleus Plectranthus as a Wound Dressing, Journal of Chitin and Chitosan Science Vol. 1, 1– 8, 2013.
2013 Lakshmi R. Lakshman, K. T. Shalumon, Sreeja V. Nair,R. Jayakumar & S. V. Nair Preparation of Silver Nanoparticles Incorporated Electrospun Polyurethane Nano-fibrous Mat for Wound Dressing Journal of Macromolecular Science, Part A: Pure and Applied Chemistry Volume 47, Issue 10, 2010
2013 Lakshmi R. Lakshman, Binu Parameswaran Pillai, Rahul Lakshman, Harish Kumar, S. Sudha1, RV Jayakumar, Comparison of vitamin D levels in obese and non obese patients with polycystic ovarian syndrome in a South Indian population, International Journal of Reproduction, Contraception, Obstetrics and Gynecology , Sep;2(3):336-343, 2013
2013 Mohan K Abraham, Bindu Sudarsanan, Naveen Viswanath, Ramakrishnan P, Anup B Pallival, Aisha Naaz, Narasimha K Nandakumar, Ashwin Prabhakaran, Divya Prakash, A safer way of suturing in Foker’s Technique, Journal of Paediatric Surgery 48; 1819-1821, 2013. (nternational)
2013 Michael Gonzalez, Sheela Nampoothiri, Cornelia Kornblum, Andre´s Caballero Oteyza, Jochen Walter, Ioanna Koindari, William Hulme, Fiorella Speziani, Ludger Scho¨ls, Stephan Zu¨chner and Rebecca Schu¨le*, Mutations in phospholipase DDHD2 cause autosomal recessive Hereditary spastic paraplegia (SPG54). European Journal of Human Genetics 00, 1–5, 2013
2013 Rajesh R Nair, Unni VN, Indu NK, Sheela Nampoothiri, Anil Mathew, George Kurian, Vimala A. “Exceptional Case - Nail patella syndrome – a novel mutation in the LMX1B gene” Clin Kidney J. 0: 1-3, 2013.
2013 Sajini Sivasundar, Akash Thomas Oommen, Ohm Prakash, Sujatha Baskaran, Raja Biswas, Shantikumar Nair, C. Gopi Mohan, Lalitha Biswas, Molecular defect of ‘Prothrombin Amrita,: Substitution of arginine by glutamine (Arg553 to Gln) near the Na+ binding loop of prothrombin. Blood Cells, Molecules and Diseases, 50 182–183, 2013..
2013 Sheila Unger, Maria W. Go´ rna,, Antony Le Be´chec, Sonia Do Vale-Pereira, Maria Francesca Bedeschi, Stefan Geiberger, Giedre Grigelioniene, Eva Horemuzova, Faustina Lalatta, Ekkehart Lausch, Cinzia Magnani, Sheela Nampoothiri, Gen Nishimura, Duccio Petrella,Francisca Rojas-Ringeling, Akari Utsunomiya, Bernhard Zabel, Sylvain Pradervand, Keith Harshman, Belinda Campos-Xavier, Luisa Bonafe, Giulio Superti-Furga, Brian Stevenson, and Andrea Superti-Furga. FAM111A Mutations Result in Hypoparathyroidism and Impaired Skeletal Development, The American Journal of Human Genetics 92, 1–6, June 6, 2013
2013 Vijaykumar D. K., Michelle Aline Antony. Adult Granulosa Cell Tumor(GCT) – A Practical Approach: Research & Reviews: A Journal of Oncology and Hematology; Vol 2; No.1, 2013.
2013 Zaheeruddin P. M., Prameela C. G., Antony M. A., Pavithran K., Dinesh M., Metastatic endometrial carcinoma in the lung : Unusual timing and site, South African Journal of Gynaecology, 5(2) : 64-67, 2013.
2013

Asmita Mehta, Venkitakrishnan Rajesh, K. S. Indira, A Young Woman with Recurrent Lower Respiratory Tract Infection, Journal of Bronchoscopy and Interventional Pulmonology, 20, 1: 35-37, 2013

2013

Dhiraj Khadakaban, Tejal Gorasia K Khadakaban, D. K . Vijayakumar, K. Pavithran, R. Anupam, Factors Associated with Better Survival After Surgery in Metastatic Breast Cancer Patients, Springer, Vol: 4 , No: 1, March 2013.

2013

Dinesh T. A., Sanjeev Singh, Prem Nair, Remya T. R., Reducing Waiting Time in Outpatient Services of Large University Teaching Hospital – A Six Sigma Approach, Management in Health, pp 31-37, 2013.

2013

Prem G., N. Shivashankar, N. Girish, B. Indira, S. G. Srikanth and V. Shanmugham, Temporal Resolution in Patients with Cerebellopontine Angle Tumors, Research in Otolaryngology, Vol. 2, No. 1, pp. 1-5, 2013.

2013

Rajesh R. Nair, Unni V. N., Indu N. K., Sheela Nampoothiri, Anil Mathew, George Kurian, Vimala A., Exceptional Case - Nail patella syndrome – a novel mutation in the LMX1B gene, Clinical Kidney Journal, 2013.

2013

Shivashankar N., Taly A. B., Rose Dawn Bharath, Prem G., Telephonic conversational difficulty as the sole symptom in a patient with cerebellopontine angle epidermoid, A case report, Research in Otolaryngology, 2013.

2013

Thankappan K . R., Yamini T. R., Mini G. K., Arthur C., Sairu P., Leelamoni K., Sani M., Unnirkshnan B., Basha S . R., and Nichter M., Assessing the readiness to integrate tobacco control in medical curriculum : Experience from five medical colleges in southern India, The National Medical Journal of India, Vol. 26, No.1, 2013.

2012 Lakshman L.R. Rahul Lakshmanan, DM Vasudevan, A comparative study of verbal IQ, performance IQ and verbal IQ-performance IQ disparity among Turner syndrome patients and patients with primary amenorrhoea due to other aetiologies, International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 1(1):1-4, December, 2012
2012

Krishnakumar R., Renjitkumar J., Teaching NeuroImages: Rib Penciling and Intra Spinal Dislocation of Rib Heads in Type 1 Neurofibromatosis. Neurology Journal, Vol. No. 78(13), e85, March 2012. 

2012 Rakhi K. Retnamma, Suresh G. Nair, G. S. Sunil, R. Benedict, ST segment depression during PA banding. Brief communication, Ann Card Anaesth(Annals of Cardiac Anaesthesia Journal)Vol. No. 15, Pp. 64, 2012. 
2012 Vinitha Varghese Panicker, Anil Mathew, Dharmarathnam, Cosmetically disfiguring side effects of Cyclosporin, International Journal of Trichology, Vol. 4 (1), January - March 2012.
2012 Srija, B. K. Brahmbhat, G. Lakshminarayana, A. Mathew, R. Rajesh, G. Kurien, V. N. Unni, Unni. Extensive vascular calcification in end stage renal disease, Amrita Journal of Medicine, Vol. 8 (1), pp. 42-44, January – June 2012.
2012

Sushma Krishna, Aswathy.S, Panicker K.N, Sanjeev Singh, KavithaDinesh, Shamsul Karim. Morbidity trends in Lymphatic Filariasis:Trends from a tertiary care centre.Global J of Medicine and Public Health Vol 1, No 2 (2012) Read More»»

2011 Anita Rajah, K. R. Sundaram, Anand Kumar, A Change in intellectual and academic performance of children following computer-based training : Preliminary results, Indian Journal of Psychiatry, Vol. 53 (3), pp. 249-252, 2011.
2011 Mohandas Nair K., Sakamoto O., Jagadeesh S., Sheela Nampoothiri, Fanconi-Bickel Syndrome, Indian Journal of Pediatrics, 2011.
2011 Rajesh G., V. Balakrishnan, Chronic Pancreatis, Amrita Journal of Medicine, Vol. 7 (1), pp. 4-10, January - June 2011.
2011 P. Shanmughasundaram, P. George, Role of PET CT in Carcinoma Lung, Amrita Journal of Medicine, Vol. 7 (1), pp. 11-16, January-June 2011.
2011 S. K. Pillai, Clinical Spectrum and Management of Dengue Fever, Amrita Journal of Medicine, Vol. 7 (1), pp. 24-27, January - June 2011.
2011 Rajeeve B., Scope of Medical Astrology and its Research in Ayurveda, Amrita Journal of Medicine, Vol. 7 (1), pp. 28-31, January - June 2011.
2011 Viswam D., Nair S. G., Patel V., Nagaraj, Ultra-Short Course of Low-Dose Amiodarone-Induced Post-Operative Fatal Pulmonary Toxicity, Journal of Association of Physicians of India, Vol. 59 (7), pp. 443-447, 2011.
2011 Palaniappan, Jose W., Bindhu, Sudheer
2011 Pavithran, Carcinosarcoma of the Pancreas: Report of a Case with a Concise Review of the Literature, Journal of Clinical and Diagnostic Research, Vol. 5 (3), pp. 621-624, 2011.
2011 Mehta A. A., Jose W., Pavithran K., Hyperesoinophilic Syndrome with FIP1L1 PDGFR? Mutation: A Case Study, Journal of Clinical and Diagnostic Research, Vol. 5 (3), pp. 625-627, 2011.
2011 Jose W., Unnikrishnan A., Muthu P., Kumar K., Pavithran K., Aplastic Anaemia Complicating Systemic Lupus Erythematosus (SLE) at Presentation: A Clinical Vignette and Review of Literature,Journal of Clinical and Diagnostic Research, Vol. 5 (3), pp. 637-639, 2011.
2011 Qureshi U. A., Gupta A. K., Mahajan B., Qurieshi M. A., Altaf U., Parihar R., Bhau K. S., Microbiological Diagnosis of Pulmonary Tuberculosis in Children: Comparative Study of Induced Sputum and Gastric Lavage, Indian Journal of Pediatrics, 2011.
2011 Mehta A. A., Anil Kumar V., Vithalani K. G., Patel K. R., Clinico-Epidemiological Profile of HIV Patients with Respiratory Infections and Tubeculosis in Western India, Journal of Clinical and Diagnostic Research, Vol. 5 (2), pp. 206-209, 2011.
2011 Kumar A. V., Pillai V. S., Dinesh K., Karim S., The Phenotypic Detection of Carbapenemase in Meropenem Resistant Acinetobacter Calcoaceticus-Baumannii Complex in a Tertiary Care Hospital in South India, Journal of Clinical and Diagnostic Research, Vol. 5 (2), pp. 223-226, 2011.
2011 A. Kumar, A. Mehta, G. Kavathia, M. Madan, Pulmonary and Extra Pulmonary Tuberculosis Along with Pulmonary Nocardiosis in a Patient with Human Immuno Deficiency Virus Infection, Journal of Clinical and Diagnostic Research, Vol. 5 (1), pp. 109-111, 2011.
2011 Feroze Kaliyadan, Dharmaratnam A., Rapid Response to Acitretin, Combined with Cryotherapy, for Extensive and Recalcitrant Verruca Vulgaris on the Scalp, Indian Journal of Dermatology, Venereology and Leprology, Vol. 77 (3), pp. 338-340, 2011.
2011 Feroze Kaliyadan, Venkitakrishnan S., Late Onset Calcification Following Juvenile Dermatomyositis: Response with Weekly Alendronate, Indian Journal of Dermatology, Vol. 56 (3), pp. 357-359, 2011.
2011 Manoj J., Kaliyadan F., Unni M., Dharmaratnam
2011 A. D., Cytophagic Histiocytic Panniculitis: Report of Two Cases, Indian Journal of Dermatology, Vol. 56 (3), pp. 306-308, 2011.
2011 Nair S. G., Pediatric Cardiac Program in India: Changing Perspectives, Annals of Cardiac Anaesthesia, Vol. 14 (2), pp. 79-81, 2011.
2011 Das S. K., Balakrishnan V., Role of Cytokines in the Pathogenesis of Non-Alcoholic Fatty Liver Disease, Indian Journal of Clinical Biochemistry, 2011.
2011 Sukumar S., Jadhav S., Nair B., Bhat S., Kumar G., Mathew G., Laparoscopic Adrenal Surgery in Children: Lessons from a Single Centre Experience, Journal of Minimal Access Surgery, Vol. 7 (2), pp. 141-144, 2011.
2011 Shanmuga Sundaram P., Padma S., Sudha S., Sasikala K., Transient Cytotoxicity of 131I Beta Radiation in Hyperthyroid Patients Treated with Radioactive Iodine, Indian Journal of Medical Research, Vol. 133 (4), pp. 401-406, 2011.
2011 Tripathi S., Chandalia H. B., Rao P. V., Badgandi M., Patni R., Subbanna P. K., Shetty R., Kumar H.,Improved Glycaemic Control with No Weight Gain: A 26-Week, Open Label, Non-Randomised, Noninterventional Observational Study on Type 2 Diabetes Subjects using Insulin Detemir,Journal of the Indian Medical Association, Vol. 109 (4), pp. 275-278, 2011.
2011 Girish B. N., Rajesh G., Vaidyanathan K., Balakrishnan V., Assessment of Oxidative Status in Chronic Pancreatitis and its Relation with Zinc status, Indian Journal of Gastroenterology, Vol. 30 (2), pp. 84-88, 2011.
2011 Udayakumaran S., Bilateral Transtentorial Herniation and Isolated Fourth Ventricle: A Scientific Note, Neurology India, Vol. 59 (2), 2011.
2011 Murali B., Vijayaraghavan S., Kishore P., Iyer S., Jimmy M., Sharma M., Paul G., Chavare S., Cross-Chest Liposuction in Gynaecomastia, Indian Journal of Plastic Surgery, Vol. 44 (1), pp. 81-86, 2011.
2011 Krishna S., Desai S., Anjana V. K., Paranthaaman R. G, Typhidot (IgM) as a Reliable and Rapid Diagnostic Test for Typhoid Fever, Annals of Tropical Medicine and Public Health, Vol. 4 (1), pp. 42-44, 2011.
2011 Palaniswamy S. S., Padma S., Harish V., Rai J. K., Hypercalcemia with Extraosseous MDP Uptake in a Bone Scan as Initial Presentation in a Case of Cutaneous T-Cell Lymphoma, Journal of Cancer Research and Therapeutics, Vol. 7 (1), pp. 72-74, 2011.
2011 Satish G., Rajam L., Regi S., Nazar P. K., Multiple Amoebic Abscesses with Erythema Nodosum,Indian Journal of Pediatrics, 2011.
2011 Feroze Kaliyadan, Using a Simple Jewelers Loupe as a Dermoscopic Instrument, Indian Journal of Dermatology, Venereology and Leprology, Vol. 77 (5), pp. 617-620, 2011.
2011 U. K. Menon, The use of FEES in Dysphagia Evaluation and management – A preliminary study,Amrita Journal of Medicine, Vol. 7(1), pp. 40-42, January-June 2011.
2011 G. Rajesh, N. V. Seethalakshmy, B. Shivaprasad, V. R. Mujeeb, L. Siyad, Skin Metastasis from Esophageal Squamous Cell Carninoma, Amrita Journal of Medicine, Vol. 7(1), pp. 43-44, January-June 2011.
2011 J. B. Honnamurthy, P. C. Jagathlal, K. N. Subhakumari, A. G. Unnikrishnan, Nisha Bhavani, B. P. Pillai,Prevalence of Anti thyroid peroxidase (Anti TPO) in type 1 diabetes mellitus, Thyroid Research and Practice, Vol. 8(2), pp. 13-15, May- August 2011.
2011 Mehta A. A., Jose W., Pavithran K., Hyperesoinophilic syndrome with FIP1L1 PDGFR? mutation: A case study, Journal of Clinical and Diagnostic Research, Vol. 5(3), pp. 625-627, 2011.
2011 Qureshi U. A., Gupta A. K., Mahajan B., Qurieshi M. A., Altaf U., Parihar R., Bhau K. S., Microbiological Diagnosis of Pulmonary Tuberculosis in Children: 487 Comparative Study of Induced Sputum and Gastric Lavage, Indian Journal of Pediatrics, Vol. 78(11), pp. 1429-1430, 2011.
2011 Kumar A. V., Pillai V. S, Dinesh K., Karim S., The phenotypic detection of carbapenemase in meropenem resistant acinetobacter calcoaceticusbaumannii complex in a tertiary care hospital in South India, Journal of Clinical and Diagnostic Research, Vol. 5(2), pp. 223-226, 2011.
2011 Sheela Nampoothiri, Natasha Radhakrishnan, Andrea Schwentek, Michael Marcus Hoffmann, Lipoprotein Lipase Deficiency in an Infant, Indian Pediatrics, Vol. 48, pp. 805-806, 2011.
2011 Anand K. M, Biradar V. M, Panicker J. N, Sheela Nampoothiri, Congenital Myotonic Dystrophy with Asymptomatic Mother, Indian Pediatrics, Vol. 48, pp. 565-567, 2011.
2011 Mohandas Nair K., Sakamoto O., Jagadeesh S., Nampoothiri S., Fanconi - Bickel Syndrome, The Indian Journal of Pediatrics, February 2011.
2011 S. Nampoothiri, Natasha Radhakrishnan, Andrew Schwantck, Michael Marcus Hoffman, Lipoprotein lipase deficiency in an infant, Indian Journal of Pediatrics, October 2011.
2011 Dr. Anuradha Rao, Excimer laser phototherapeutic keratectomy followed by antiinflammatory therapy for recurrent corneal erosion, Kerala Journal of Ophthalmology, Vol. 24, 2011.
2011 A. Parasuraman, K. Rajeev, D. Panikar, Fenestrated proximal middle cerebral artery with an associated aneurysm - a case report, Amrita Journal of Medicine, Vol. 7 (2), pp. 1-44, July- December 2011.
2011 G. Lakshminarayana, A. Mathew, R. Rajesh, G. Kurien, V. N. Unni Hennekam, Lymphangiectasia Syndrome, Indian Journal of Nephrology, Vol. 21, 2011.
2011 B. K. Brahmbhatt, A. Mathew, R. Rajesh, G. Kurian, V. N. Unni, Brachiocephalic artery thrombosis in adult nephrotic syndrome, Indian Journal of Nephrology, Vol. 21 (3), pp. 204-207, 2011.
2011 Srija, G. Lakshminarayana, A. Mathew, R. Rajesh, G. Kurien, V. N. Unni, Pattern of renal diseases in a tertiary care hospital in Kerala, Amrita Journal of Medicine, Vol. 7, pp. 32-39, 2011.
2011 Nampoothiri S., Kuthiroly S., Fauth C., Krabichler B., Attie - Bitach T., Hennekam R. C. Macrostomia, thin upper vermilion border, long philtrum, broad halluces, and intellectual disability in two sibs. Am J Med Genet(American Journal of Medical Genetics), Part - A 155, Pp. 2465 - 2468, 2011. 
2011 Lisenka E. L. M. Vissers, Ekkehart Lausch, Sheila Unger, Ana Belinda Campos-Xavier, Christian Gilissen, Antonio Rossi, Marisol Del Rosario, Hanka Venselaar, Ute Knoll, Sheela Nampoothiri, Mohandas Nair, Ju¨rgen Spranger, Han G. Brunner, Luisa Bonafe´, Joris A. Veltman, Bernhard Zabel and Andrea Superti-Furga. Chondrodysplasia and Abnormal Joint Development Associated with Mutations in IMPAD1, Encoding the Golgi-Resident Nucleotide Phosphatase, gPAPP. The American Journal of Human Genetics, Vol. 88, Pp. 1 – 8, 2011.
2011 Vandana Balakrishnan, Kannan Vaidyanathan, Lakshmiy Ammal Saraswathy, Karimassery Ramaiyer Sundaram, Harish Kumar, Impact of Integrated Amrita Meditation Technique on Adrenaline and Cortisol Levels in Healthy Volunteers, Evidence - Based Complementary and Alternative Medicine, 2011.
2011 Girish B. N., Rajesh G., Vaidyanathan K., Balakrishnan V., Alterations in Plasma Amino Acid Levels in Chronic Pancreatitis, Journal of Pancreas, Vol. 12 (1), pp. 11-18, 2011.
2011 Thankappan K., Kuriakose M. A., Chatni S. S., Sharan R., Trivedi N. P., Vijayaraghavan S., Sharma M., Iyer S., Lateral Arm Free Flap for Oral Tongue Reconstruction: An Analysis of Surgical Details, Morbidity, and Functional and Aesthetic Outcome, Annals of Plastic Surgery, Vol. 66 (3), pp. 261-266, 2011.
2011 V. Balakrishnan, Kamisawa T., Kim M. H., Liao W. C., Liu Q., Okazaki K., Shimosegawa T., Choudhuri G., Clinical Characteristics of 327 Asian Patients with Autoimmune Pancreatitis Based on Asian Diagnostic Criteria, Pancreas, Vol. 40 (2), pp. 200-205, 2011.
2011 Scaria S., James E., Dharmaratnam A. D., Epidemiology and Treatment Pattern of Atopic Dermatitis in Patients Attending a Tertiary Care Teaching Hospital, International Journal of Research in Pharmaceutical Sciences, Vol. 2 (1), pp. 38-44, 2011.
2011 Jayalekshmi P. A., Gangadharan P., Akiba S., Koriyama C., Nair R. R. K, Oral Cavity Cancer Risk in Relation to Tobacco Chewing and Bidi Smoking Among Men in Karunagappally, Kerala, India: Karunagappally Cohort Study, Cancer Science, Vol. 102 (2), pp. 460-467, 2011.
2011 Laksmivenkateshiah S., Singhi A. K., Vaidyanathan B., Francis E., Karimassery S. R., Kumar R. K., Decline in Arterial Partial Pressure of Oxygen After Exercise: a Surrogate Marker of Pulmonary Vascular Obstructive Disease in Patients with Atrial Septal Defect and Severe Pulmonary Hypertension, Cardiology in the Young, 2011.
2011 Kalra S., Kalra B., Agrawal N., Unnikrishnan A., Understanding Diabetes in Patients with HIV/AIDS, Diabetology and Metabolic Syndrome, Vol. 3 (1), 2011.
2011 Singhi A. K., Nicholson I., Francis E., Kumar R. K., Hawker R., Anomalous Systemic Arterial Supply to Normal Basal Segment of the Left Lung, Heart, Lung and Circulation, 2011.
2011 Verma S. K., Ganesan T. S., Kishore U., Parker P. J., The Tumor Suppressor RASSF1A is a Novel Effector of Small G Protein Rap1A, Protein and Cell, Vol. 2 (3), pp. 237-249, 2011.
2011 John M., Kalra S., Unnikrishnan A. G., Ganapathy B., Baruah M. P., Sahay R. K., Recommendations for Insulin Initiation Based on Ethnicity, Medical Hypotheses, 2011.
2011 Elango K. J., Anandkrishnan N., Suresh A., Iyer S. K., Ramaiyer S. K., Kuriakose M. A., Mouth Self-Examination to Improve Oral Cancer Awareness and Early Detection in a High-Risk Population, Oral Oncology, Vol. 47 (7), pp. 620-624, 2011.
2011 Kumar A., Sanjeevan K. V., Dinesh K. R., Vinod V., Karim S., Primary Perinephric Abscess Due to Hydrogen Sulfide Producing Variant of Salmonella Paratyphi A, Infectious Diseases in Clinical Practice, Vol. 19 (4), pp. 288-290, 2011.
2011 Anil Kumar V., Krishna S., Thilak J., Dinesh K. R., Karim S., Salmonella Typhimurium in the Hip: Look Before a SLE Patient Leaps, Tropical Doctor, Vol. 41 (3), pp. 166-167, 2011.
2011 Kekatpure V. D., Rajan G. P., Patel D., Trivedi N. P., Arun P., Iyer S., Kuriakose M. A., Morbidity Profile and Functional Outcome of Modified Facial Translocation Approaches for Skull Base Tumors,Skull Base, 2011.
2011 Lone G. N., Sheikh A. A., Sheikh Z. A, Baba K. M., Qurieshi M. A., Mufti G. N., Naikoo Z. A., Syed A. A., Ahangar A. G, Lone R. A., Sharma M. L, Role of Preoperative Chemotherapy in Squamous Cell Carcinoma of Esophagus in Kashmir, a Cancer Belt - A Pilot Study, Asian Pacific Journal of Cancer Prevention, Vol. 12 (2), pp. 465-470, 2011.
2011 Qurieshi M. A., Masoodi M. A, Kadla S. A., Ahmad S. Z, Gangadharan P., Gastric Cancer in Kashmir,Asian Pacific Journal of Cancer Prevention, Vol. 12 (1), pp. 303-307, 2011.
2011 Nambiar A. Pv, Susheelan V., Kuriakose M. A, The Concepts in Poorly Differentiated Carcinoma of the Thyroid: A Review Article, Journal of Surgical Oncology, Vol. 103 (8), pp. 818-821, 2011.
2011 Vissers L. E. L. M., Lausch E., Unger S., Campos Xavier A. B., Gilissen C., Rossi A., Del Rosario M., Venselaar H., Knoll U., Sheela Nampoothiri, Nair M., Chondrodysplasia and Abnormal Joint Development Associated with Mutations in IMPAD1, Encoding the Golgi-Resident Nucleotide Phosphatase, GPAPP, American Journal of Human Genetics, Vol. 88 (5), pp. 608-615, 2011.
2011 Sreehari S., Naik D. R., Eapen M., Osteopetrosis: A Rare Cause of Anemia, Hematology Reviews, Vol. 3 (1), pp. 1-2, 2011.
2011 Anupama R., Ahmad S. Z., Kuriakose S., Vijaykumar D. K., Pavithran K., Seethalekshmy N. V.,Disseminated Peritoneal Leiomyosarcomas After Laparoscopic "Myomectomy" and Morcellation, Journal of Minimally Invasive Gynecology, Vol. 18 (3), pp. 386-389, 2011.
2011 Sharan R., Thankappan K., Iyer S., Panicker D., Kuriakose M. A., Intraoperative Transillumination to Determine the Extent of Frontal Sinus in Subcranial Approach to Anterior Skull Base, Skull Base, Vol. 21 (2), pp. 71-74, 2011.
2011 Edery P., Marcaillou C., Sahbatou M., Labalme A., Chastang J., Touraine R., Tubacher E., Senni F, Bober M. B., Sheela Nampoothiri, Jouk P. S., Association of TALS Developmental Disorder with Defect in Minor Splicing Component U4atac SnRNA, Science, Vol. 332 (6026), pp. 240-243, 2011.
2011 Shenoy P. D., Agarwal V., Tadalafil: A New Role in Raynaud's Phenomenon?, International Journal of Clinical Rheumatology, Vol. 6 (2), pp. 115-117, 2011.
2011 Krishnadas R., Cavanagh J., Sustained Remission of Rheumatoid Arthritis with a Specific Serotonin Reuptake Inhibitor Antidepressant: A Case Report and Review of the Literature,Journal of Medical Case Reports, Vol. 5 (112), 2011.
2011 Das S. K., Mukherjee S., Vasudevan D. M., Balakrishnan V., Comparison of Haematological Parameters in Patients with Non-Alcoholic Fatty Liver Disease and Alcoholic Liver Disease,Singapore Medical Journal, Vol. 52 (3), pp. 175-181, 2011.
2011 Pavithran K., Sudhindran S., Hanging Liver Tumor, Journal of Gastrointestinal and Liver Diseases, Vol. 20 (1), 2011.
2011 Ahmad S. Z., Anupama R., Vijaykumar D. K., Benign Metastasizing Leiomyoma - Case Report and Review of Literature, European Journal of Obstetrics Gynecology and Reproductive Biology, 2011.
2011 Asuthosh Kumar Sharma, Heavy Metal Contamination of River Ganges: Detection of Ten Heavy Metals by Inductively Coupled Plasma Atomic Emission Spectroscopy, International Medical Journal of Students’ Research, 2011.
2011 Asuthosh Kumar Sharma, Relationship of Diabetic Foot Ulcer with Diabetic Retinopathy,International Medical Journal of Students’ Research, 2011.
2011 V. Balakrishnan, Tropical Chronic Pancreatitis: A Historical Perspective, Gut, Vol. 60 (10), 2011.
2011 Pillai S. K., Subramaniam T., Rao G. G., Spinal Stroke in Older People Secondary to Dural Arteriovenous Fistula, BMJ Case Reports, 2011.
2011 V. U. Menon, Gupta R., Pandey R. M., Misra A., Agrawal A., Misra P., Dey S., Rao S., Guptha S., High Prevalence and Low Awareness, Treatment and Control of Hypertension in Asian Indian Women, Journal of Human Hypertension, 2011.
2011 Kalra S., Unnikrishnan A. G., Agrawal N., Singh A. K., Linagliptin and Newer DPP-4 Inhibitors: Newer Uses and Newer Indications, Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, Vol. 5 (3), pp. 197-202, 2011.
2011 V. U. Menon, Pandey R. M., Gupta R., Misra A., Misra P., Singh V., Agrawal A., Dey S., Determinants of Urban-Rural Differences in Cardiovascular Risk Factors in Middle-Aged Women in India: A Cross - Sectional Study, International Journal of Cardiology, 2011.
2011 Panicker K. N., Dori G. U., Belay T., Belete H., Hailu A., Parasitological and Clinico - Epidemiological Features of Onchocerciasis in West Wellega, Ethiopia, Journal of Parasitic Diseases, 2011.
2011 Abraham M. K., Viswanath N., Bindu S., kedari P., Ramakrishnan P., Naaz A., Mohan S., A Simple and Safe Technique for Trocar Positioning in Vesicoscopic Ureteric Reimplantation, Pediatric Surgery International, 2011.
2011 Anilkumar A., M. Kappanayil, M. V. Thampi, S. Nampoothiri, K. R. Sundaram, D. M. Vasudevan, Variation in prevalence of chromosome 22q11 deletion in subtypes of conotruncal defect in 254 children, Acta Paediatrica Journal 100, Pp. e97 – e100, 2011.
2011 Kaplan F. S., Shore E. M., Pignolo R. J. (eds), Sheela Nampoothiri, The International ClinicalConsortium on FOP, The medical management of fibrodysplasia ossificans progressiva: current treatment considerations, Clin Proc Intl Clin Consort FOP 4:1-100, 2011.
2011 Sheth F., Andrieux J., Ewers E., Kosyakova N., Weise A., Sheth H., Romana S. P., Lelorc'h M., Delobel B., Theisen O., Liehr T., Nampoothiri S., Sheth J., Characterization of sSMC by FISH and molecular techniques, European Journal of Medical Genetics Vol. 54, Pp. 247 – 255, 2011.
2011 P. Devkota, S. K. Shrestha, R. Krishnakumar and J. Renjith Kumar, Posterior lumbar interbody fusion for the management of spondylolisthesis Nepal Medical College Journal, Vol: 13(1), Pp. 46 - 49, March 2011. 
2011 Asai E., Wada T., Sakakibara Y., Toga A., Toma T., Nampoothiri S., Imai K., Nonoyama S., Yachie A ., et al. Analysis of mutations and recombination activity in RAG - deficient patients, The Journal of Clinical Immunology, Vol. No. 138(2), Pp. 172-177, 2011.
2011 Palaniswamy S. S., Padma S., Cardiac Fatty Acid Metabolism and Ischemic Memory Imaging with Nuclear Medicine Techniques, Nuclear Medicine Communications, Vol. 32 (8), pp. 672-677, 2011.
2011 Balachandran R., Nair S. G., Sivadasan P. C., Sunil G.S., Vaidyanathan B., Sreedharan K. H., Mathew C. S., Prone ventilation in the management of infants with acute respiratory distress syndrome after complex cardiac surgery, Journal of Cardiothoracic and Vascular Anesthesia, 2011.
2011 Suresh G. Nair, Pediatric cardiac program in India: Changing perspectives, Ann Card Anaesth(Annals of Cardiac Anaesthesia Journal), Vol. No. 14, Pp. 79 - 81, 2011. 
2010 Aswathy.S, Kurian Beteena etal . Effect of music on comprehension and recall among medical students in Kerala.NMJI 2010 Nov -Dec
2010 Varma P., Dinesh K. R., Menon K. K., Biswas R., Lactobacillus Fermentum Isolated from Human Colonic Mucosal Biopsy Inhibits the Growth and Adhesion of Enteric and Foodborne Pathogens,Journal of Food Science, Vol. 75 (9), pp. 546-551, 2010.
2010 Palaniappan M., Jose W. M., Mehta A., Kumar K., Pavithran K., Umbilical Metastasis: A Case Series of Four Sister Joseph Nodules from Four Different Visceral Malignancies, Current Oncology, Vol. 17 (6), pp. 78-81, 2010.
2010 Suresh R., Janardhanan M., Joseph A. P., Vinodkumar R. B., Peter S., A Rare Case of Dentigerous Cyst in a One Year Old Child: The Earliest Known Reported Occurrence, Head and Neck Pathology, 2010.
2010 Sheila Unger, Ekkehart Lausch, Antonio Rossi, Sheela Nampoothiri et al, Phenotypic Features of Carbohydrate Sulfotransferase 3 (CHST3) Deficiency in 24 Patients: Congenital Dislocations and Vertebral Changes as Principal Diagnostic Features, American Journal of Medical Genetics Part, pp. 2543-2549, 2010.
2010 Subir Kumar Das, D. M. Vasudevan, Long-Term Ethanol Consumption Leads to Lung Tissue Oxidative Stress and Injury, Oxidative Medicine and Cellular Longevity, Vol. 3 (6), November 2010.
2010 Sundaram P., Palaniswamy S. S., George S., Harish V., Rai J. K., Tibial Hemangiopericytoma Diagnosed by Nuclear Medicine Techniques, Fooyin Journal of Health Sciences, Vol. 2 (3 - 4), pp. 109-112, 2010.
2010 Trivedi N. P., Ravindran H. K., Sundram S., Iyer S., Kekatpure V., Durah S., Kuriakose M. A., Pathologic Evaluation of Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma, Head and Neck, Vol. 32 (11), pp. 1437-1443, November 2010.
2010 W. Jose, M. Palaniappan, K. Pavithran, A. A. Mehta, R. Venkatakrishnan, Multiple Myeloma Presenting as Eosinophilic Pleural Effusion, Asia Pacific Journal of Clinical Oncology, Vol. 6 (4), pp. 256-259, December 2010.
2010 Kumar S., Vaidyanathan B., Gayathri S., Rajam L., Systemic Onset Juvenile Idiopathic Arthritis with Macrophage Activation Syndrome Misdiagnosed as Kawasaki Disease Case Report and Literature Review, Rheumatology International, 2010.
2010 Anita Rajah, Gitanjali Natarajan, Sundaram K. R., Profile of Couples Seeking Help in the Family Court a Clinic Based Study, Psychological Studies, Vol. 55 (2), pp. 172-176, 2010.
2010 Thankappan K., Microvascular Free Tissue Transfer After Prior Radiotherapy in Head and Neck Reconstruction - A Review, Surgical Oncology, Vol. 19 (4), pp. 227-234, 2010.
2010 Pastrana T., Vallath N., Mastrojohn J., Namukwaya E., Kumar S., Radbruch L., Clark D., Disparities in the Contribution of Low- and Middle-Income Countries to Palliative Care Research, Journal of Pain and Symptom Management, Vol. 39 (1), pp. 54-68, 2010.
2010 S. Kumar, Wolfram Syndrome: Important Implications for Pediatricians and Pediatric Endocrinologists, Pediatric Diabetes, Vol. 11 (1), pp. 28-37, February 2010.
2010 Panicker J. N., Menon L., Anandkumar A., Sundaram K. R., Fowler C. J., Lower Urinary Tract Symptoms Following Neurological Illness may be Influenced by Multiple Factors: Observations from a Neurorehabilitation Service in a Developing Country, Neurology and Urodynamics, Vol. 29 (3), pp. 378-381, 2010.
2010 Sabitha P., Vasudevan D. M., Kamath P., Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits,Journal of Atherosclerosis and Thrombosis, Vol. 17 (2), pp. 213-218, 2010.
2010 S. Kumar, Need for Determining the Incidence and Prevalence of JIA in Developing Countries: The Indian Predicament, Rheumatology, Vol. 49 (8), pp. 1598-1599, 2010.
2010 Maurya K., Sivanandam S. E., Sukumar S., Bhat S., Kumar G., Nair B., Concomitant Laparoscopic Urological Procedures -Does it Contribute to Morbidity, Journal of Minimal Access Surgery, Vol. 6 (2), pp. 56-57, 2010.
2010 Mehta A. K., Baskaran S., Alam M. P., Datta S., Majumdar S., Gulati N., Brahmachari V., Comparative Analysis of DNA Methylation in Transgenic Mice with Unstable CGG Repeats from FMR1 Gene,Epigenetics, Vol. 5 (3), pp. 241-248, 2010.
2010 Francis E., Singhi A., Srinivas L., Kumar R. K., Transcatheter Occlusion of Patent Ductus Arteriosus in Preterm Infants, Journal of the American College of Cardiovascular Interventions, Vol. 3 (5), pp. 550-555, 2010.
2010 Gaurav K., Vilas J., A New Approach to the Management of Fixed Flexion Deformity of the Knee using Ilizarovg's Principle of Distraction Histogenesis: A Preliminary Communication,International Journal of Lower Extremity Wounds, Vol. 9 (2), pp. 70-73, 2010.
2010 Feroze Kaliyadan, Manoj J., Dharmaratnam A. D., Sreekanth G., Self-learning Digital Modules in Dermatology: A Pilot Study, Journal of the European Academy of Dermatology and Venereology, Vol. 24 (6), pp. 655-660, 2010.
2010 Mahajan C. V., Acharya N. K., Kumar R. J., Varma H. K., Menon V. K., Can Iliac Crest Reconstruction Reduce Donor Site Morbidity?: A Study Using Degradable Hydroxyapatite-Bioactive Glass Ceramic Composite, Journal of Spinal Disorders and Techniques, Vol. 23 (4), pp. 266-271, 2010.
2010 Ahmad S. Z., Parray F.Q., Sherwani A.Y., Chowdri N. A., Wani K. A., Primary Paraspinal Hydatid Cyst: A Rare Presentation of Echinococcosis, International Journal of Surgery, Vol. 8 (5), pp. 404-406, 2010.
2010 Singhi A. K., Srinivas L., Vaidyanathan B., Krishna Kumar R., Mechanism of Tricuspid Regurgitation in Corrected Transposition of Great Arteries, Journal of Echocardiography, 2010.
2010 A. G. Unnikrishnan, Herbal Medicines for Type 2 Diabetes, International Journal of Diabetes in Developing Countries, Vol. 30 (3), pp. 111-112, 2010.
2010 Sheela Nampoothiri, Malan V., Rajan D., Thomas S., Shaw A. C., Louis Dit Picard H., Layet V., Till M., Cormier-Daire V., Distinct Effects of Allelic NFIX Mutations on Nonsense-Mediated mRNA Decay Engender Either a Sotos-Like or a Marshall-Smith Syndrome, American Journal of Human Genetics, Vol. 87 (2), pp. 189-198, 2010.
2010 Qurieshi M. A., Yasmeen J., Manzoor N. A., Asiya W., Ahmad S. Z., Community-Based Screening of Cervical Cancer in a Low Prevalence Area of India: A Cross Sectional Study, Asian Pacific Journal of Cancer Prevention, Vol. 11 (1), pp. 231-234, 2010.
2010 Dalwai R., Menon K. V., Kumar R. J., Pyogenic Diskitis of the L5-S1 Disk Space Following Inadvertent Placement of a Sacrocolpopexy Screw, International Journal of Gynecology and Obstetrics, Vol. 111 (3), pp. 268-269, 2010.
2010 Kumar S., Nair S., Rajam L., Case Series of Pediatric Systemic Lupus Erythematosus from Kerala: Comparison with Other Indian Series, International Journal of Rheumatic Diseases, Vol. 13 (4), pp. 391-395, 2010.
2010 Lingegowda D., Moorthy S., Sreekumar K., Kannan R., Imaging in Diabetic Ischemic Foot,International Journal of Diabetes in Developing Countries, Vol. 30 (4), pp. 179-184, 2010.
2010 Qurieshi M. A., Qureshi U. A., Wani N. A., Charoo B. A., Kosar T., Altaf U., Klebsiella Brain Abscess in a Neonate, Archives of Disease in Childhood: Fetal and Neonatal Edition, 2010.
2010 Sheela Nampoothiri, Malfait F., Syx D., Vlummens P., Symoens S., Hermanns-Lê T., Van Laer L., De Paepe A., Musculocontractural Ehlers-Danlos Syndrome (Former EDS Type VIB) and Adducted Thumb Clubfoot Syndrome (ATCS) Represent a Single Clinical Entity Caused by Mutations in the Dermatan-4-Sulfotransferase 1 Encoding CHST14 Gene, Human Mutation, Vol. 31 (11), pp. 1233-1239, 2010.
2010 R. K . Kumar, Panda B. R., Sumangala S. G., Katewa A., Naik S. K., Mishra J., Intrapericardial Diaphragmatic Hernia After Arterial Switch Operation, Annals of Thoracic Surgery, Vol. 90 (5), pp. 73-74, 2010.
2010 Sheela Nampoothiri, Adam Shaw, Inge DC Van Balkom, Mislen Bauer et al, Phenotype and Natural History in Marshall Smith Syndrome, American Journal of Medical Genetics, 2010.
2010 Sheela Nampoothiri, J. Dai, O. H. Kim, T. J Cho et al, Novel and Recurrent TRPV4 Mutations and their Association with Distinct Phenotypes Within the TRPV4 Dysplasia Family, Journal of Molecular Genetics, 2010.
2010 V. V. Pillay, Rigor Mortis or Something Else, American Journal of Forensic Medicine and Pathology, 2010.
2010 Anil V. Kumar, Karthikeyan K. Kumarasamy, Mark A Toleman, Timothy R Walsh, Jay Bagaria, Fafhana Butt, Ravikumar Balakrishnan, Uma Chaudhary, Michel Doumith, Christian G Giske, Seema Irfan, Padma Krishnan, Emergence of a New Antibiotic Resistance Mechanism in India, Pakistan, and the UK: A Molecular, Biological, and Epidemiological Study, The Lancet Infectious Diseases, 2010.
2010 Gopalakrishna Rajesh, Banavara Narasimhamurthy Girish, Kannan Vaidyanathan, Menon Saumya, Vallath Balakrishnan, Folate Deficiency in Chronic Pancreatitis, Journal of Pancreas, Vol. 11 (4), pp. 409-410, June 2010.
2010 Gopi Chellan, Shashikala Shivaprakash, Sundaram Karimassery Ramaiyar, Ajit Kumar Varma, Narendra Varma, Mangalanandan Thekkeparambil Sukumaran, Jayakumar Rohinivilasam Vasukutty, Arun Bal, Harish Kumar, Footwear Practice can Predict Bacterial Infection and Wound Depth in Diabetic Foot Wounds, Diabetes, June 2010.
2010 S. Chatterjee, A. Kumar, K. N. Prasad, D. Mathai, A. Manoharan, Clinico-Epidemiologic and Molecular Characterization of Metallo Beta-Lactamases (MBLs) Producing Nosocomial Pseudomonas Aerugionsa (PSA), International Journal of Infectious Diseases, Vol. 14, pp. e31-e32, March 2010.
2010 Gopi Chellan, Shashikala Shivaprakash, Sundaram Karimassery Ramaiyar, Ajit Kumar Varma, Narendra Varma, Mangalanandan Thekkeparambil Sukumaran, Jayakumar Rohinivilasam Vasukutty, Arun Bal, Harish Kumar, Spectrum and Prevalence of Fungi Infecting Deep Tissues of Lower-Limb Wounds in Patients with Type 2 Diabetes, Journal of Clinical Microbiology, Vol. 48 (6), pp. 2097-2102, June 2010.
2010 Feroze Kaliyadan, Sheela Nampoothiri, V. Sunitha, Vikas Elias Kuruvillai, Nevus Comedidonicus Associated with Ipsilateral Polysyndactyly and Bilateral Oligodontia, Pediatric Dermatology, Vol. 27 (4), pp. 377-379, 2010.
2010 Sheela Nampoothiri, Asai E., Wada T., Sakakibara Y., Toga A., Toma T., Shimizu T. S., Yachie A., Analysis of Mutations and Recombination Activity in RAG Deficient Patients 2010.
2010 Gopi Chellan, Shashikala S., Narendra Varma, Ajit Kumar Varma, Arun Bal, Jayakumar R. V., K. R. Sundaram, Harish Kumar, Mangalanandan T. S., Footwear Practice Can Predict Bacterial Infection and Wound Depth in Diabetic Foot Wounds, Diabetes, June 2010.
2010 Raj M., Sundaram K. R., Kumar R. K., Sudhakar A., Paul M., Body Mass Index Trend and Its Association with Blood Pressure Distribution in Children, Journal of Human Hypertension, 2010.
2010 Rajeshkannan R., Moorthy S., Remadevi K. S., Kumar R. K., Ramachandran P. V., Sreekumar K. P., Role of 64-MDCT in Evaluation of Pulmonary Atresia with Ventricular Septal Defect, American Journal of Roentgenology, Vol. 194, pp. 110-118, 2010.
2010 Hariharan G., Ramachandran S., Parapurath R., Congenital Afibrinogenemia Presenting as Antenatal Intracranial Bleed: A Case Report, Italian Journal of Pediatrics, Vol. 36 (1), 2010.
2010 Sukumar S., Khanna V., Bhat H. S., Nair B., Adult Presentation of Congenital Ectopic Vas Deferens Insertion Into Ureter with Unilateral Renal Agenesis, Surgical and Radiologic Anatomy, Vol. 32 (1), pp. 9-10, 2010.
2010 Vishwanath P., Adhikari D., Menezes R., Pillay V. V., Poudel K., Poudel A. R., Myocarditis and Mobitz Type I Heart Block Following Wasp Sting, Internet Journal of Cardiology, Vol. 8 (1), 2010.
2010 S. Chatterjee, A. Kumar, A. Manoharan, D. Mathai, K. N. Prasad, Clinico-epidemiologic and Molecular Characterization of Metallo Beta-Lactamases (MBLs) Producing Nosocomial Pseudomonas Aeruginosa (PSA), International Journal of Infectious Diseases, Vol. 14 (1), pp. e31-e32, March 2010.
2010 Ganesan T. S., Rustin GJ & Shreeves G., Zweifel M., Balkissoon J., Stratford M. R., Chaplin D. J., Poupard L., Boxall J., Wang D., Gaya A., Nathan P. D., A Phase Ib Trial of CA4P (Combretastatin A-4 Phosphate); Carboplatin; and Paclitaxel in Patients with Advanced Cancer, British Journal of Cancer, April 2010.
2010 Ganesan T. S., Paige AJ & Zucknick M., Gabra H &Paul J., Brown R& Janczar S., Smyth J. F., Perren T., Richardson S., Gourley C., Stewart M., Taylor K. J., Sanket Sharad Pendsey, WWOX Tumour Suppressor Gene Polymorphisms and Ovarian Cancer Pathology and Prognosis, European Journal of Cancer, Vol. 46 (4), pp. 818-825, March 2010.
2010 Anil Kumar Singhi, Prashant Bobhate, Mahesh Kappanayil, Acute Rheumatic Fever – Subcutaneous Nodules and Carditis, Circulation, Vol. 121, pp. 946-947, 2010.
2010 Feroze Kaliyadan, Sheela Nampoothiri, V. Sunitha, Vikas Elias Kuruvillai, Nevus Comedidonicus Associated with Ipsilateral Polysyndactyly and Bilateral Oligodontia, Pediatric Dermatology, Vol. 27 (4), pp. 377-379, 2010.
2010 Sheela Nampoothiri, Sunitha Vaidyanathan, Murali. D. Bashyam et al, Phenylanine Hydroxylase Gene Mutations in Phenylketonuria Patients from India: Identification of Novel Mutations that Affect PAH RNA, Molecular Genetics and Metabolism, Vol. 100, pp. 96-99, 2010.
2010 Gopalakrishna Rajesh, Banavara Narasimhamurthy Girish, Kannan Vaidyanathan, Menon Saumya, Vallath Balakrishnan, Folate Deficiency in Chronic Pancreatitis, Journal of Pancreas, Vol. 11 (4), pp. 409-410, Jul 5 2010.
2010 Gopi Chellan, Shashikala Shivaprakash, Sundaram Karimassery Ramaiyar, Ajit Kumar Varma, Narendra Varma, Mangalanandan Thekkeparambil Sukumaran, Jayakumar Rohinivilasam Vasukutty, Arun Bal, Harish Kumar, Spectrum and Prevalence of Fungi Infecting Deep Tissues of Lower-Limb Wounds in Patients with Type 2 Diabetes, Journal of Clinical Microbiology, Vol. 48 (6), pp. 2097-2102, June 2010.
2010 S. Chatterjee, A. Kumar, K. N. Prasad, D. Mathai, A. Manoharan, Clinico-Epidemiologic and Molecular Characterization of Metallo Beta-Lactamases (MBLs) Producing Nosocomial Pseudomonas Aerugionsa (PSA), International Journal of Infectious Diseases, Vol. 14, pp. e31-e32, March 2010.
2009 S. Mohana, N. V. Seethalekshmy, K. Pavithran, Splenic Cystic Lymphangiomatosis Presenting with Massive Splenomegaly, The Internet Journal of Pathology, Volume 8, Number 1, 2009. 
2009 Remadevi K. S., Francis E., Kumar R. K. Catheter Closure of Atrial Septic Defects with Inferior Vena Cava Rum Under Transesophaegal Echo Guidance. Catheterization and Cardiovascular Interventions, 73: 90 - 9, 2009.
2009 Shekhar Sharma, Vijaykumar D. K., Altaf Gauhar Haji, Poulome Mukherjee, Fouzia Ziad, Primary Mammary Small Cell Carcinoma – A Case Report And Review of Literature, Journal of Medical Case Reports, 2009. 
2009 Manu Raj, K.R. Sundaram, Mary Paul, Abish Sudhakar, R. Krishna Kumar, Dynamics of Growth and Weight Transitions in a Pediatric Cohort from India, Nutrition Journal, 2009.
2009 Kalavathy E., Iyer S., Kuriakose M. A., Oral Self Examination to Increase Awareness of Oral Cancer in a High Risk Population, Oral Oncology (Suppl) Vol.3 (1) 228, July 2009.
2009 Battoo A. J., Thankappan K., Chatni S., Kuriakose M. A., Iyer S. Lateral Arm Flap for Oral Tongue Defect Reconstruction, Oral Oncology (Suppl) Vol.3 (1) 182, July 2009.
2009

Peixoto P. M., Ryu S. Y., Pruzansky D. P., Kuriakose M., Gilmore A., Kinnally K. W., Mitochondrial Apoptosis is Amplified Through Gap Junctions, Biochemical and Biophysical Research Communications, 390 (1), 38-43, 2009. 

2009 Abraham M. K., Nasir A. R. A., Sudarsanan B., Puzhankara R., Kedari P. M., Unnithan, G. R., Damisetti K. R. P., Narayanan T., Role of Alpha Adrenergic Blocker in the Management of Posterior Urethral Valves, Pediatric Surgery, 25 (12): 1113 - 15, PMID 19727771, December 2009. 
2009 Jones M. R., Mudaliar S., Hernandez - Triana E., Unnikrishnan A. G., Lai Y. L., Abby S. L., Misir S., Nagendran S., Rationale and Design of a Clinical Trial to Evaluate Metformin and Colesevelam HCl as Firstline Therapy in Type 2 Diabetes and Colesevelam HCl in Prediabetes, Current Medical Research and Opinion, 25 (9), 2239 - 2249, 2009.
2009 Kande G. B., Subbaiah P. V., Savithri T. S. Unsupervised Fuzzy Based Vessel Segmentation in Pathological Digital Fundus Images Journal of Medical Systems, 1 - 10, 2009.
2009

Sharma S., Hiran K. R., Pavithran K., Vijaykumar D. K., A Pilot Study to Assess the Feasibility of Evaluation of Markers of Response to Chemotherapy at One Day & 21 Days After First Cycle of Chemotherapy in Carcinoma of Breast: A prospective Nonrandomized Observational Study, World Journal of Surgical Oncology, 7, art. no. 35, 2009. 

2009 Shah S., Das A. K., Kumar A., Unnikrishnan A. G., Kalra S., Baruah M. P., Ganapathi B., Sahay R. K., Baseline Characteristics of the Indian Cohort from the IMPROVE Study: A Multinational, Observational Study of Biphasic Insulin Aspart 30 Treatment for Type 2 Diabetes, Advances in Therapy, 1-11, 2009. 
2009 Sudarsanan B., Nasir A. A., Puzhankara R., Kedari P. M., Unnithan G. R., Damisetti K. R. P., Posterior Urethral Valves: A Single Center Experience Over 7 years, Pediatric Surgery International, 25 (3), 283 - 287, 2009.
2009 Thankappan K., Comment on ‘Management of Clinically Negative Neck for the Patients with Head and Neck Squamous Cell Carcinomas in the Modern Era, Oral Oncology, 45 (2), 192, 2009.
2009 Sridhar G. R., Rao A. A., Muraleedharan M. V., Kumar R. V. J., Yarabati V., Electronic Medical Records and Hospital Management Systems for Management of Diabetes, Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 3 (1), 55 - 59, 2009. 
2009 Minnie Pillay, Suja Mary Jacob, Bilateral Presence of Axillary Arch Muscle Passing Through the Posterior Cord of the Brachial Plexus, International Journal of Morphology, 27 (4) 1047-1050, 2009.
2009 Amit Kumar C. Jain, Ajit Kumar Varma, Rejitha Mol K. S., Mangalanandan, Harish Kumar, Surgical Outcome of Necrotizing Fascitis in a Diabetic Lower Limb, The Journal of Diabetic Foot Complications, 2009. 
2009 Kuriakose M. A., Trivedi N., Current Status of Sentinal Node Biopsy in Head and Neck Cancer, Current Opinion in Otolaryngology and Head and Neck Surgery, March 2009.
2009 Suresh A., Vannan M,. Dhanya K., Elango E. K., Thangaraj K., Kuriakose M. A., Identification and Validation of Diagnostic/Prognostic Markers for Tongue Cancer, Oral Oncology, Suppl. Vol 3 (1), 107, July 2009.
2009 Battoo S. Durah , Patel D., Iyer S., Kuriakose M. A., Effectiveness of Per Oral Access in the Surgical Management of T2 - T3 Oral Cavity Squamous Cell Carcinoma, Oral Oncology (Suppl) Vol.3 (1) 174, July 2009. 
2009 Palaniswamy S. S., Sundaram P., Kumar S. A., Rare Case of Menkes Kinky Hair Syndrome With Osseous Involvement, Fooyin Journal of Health Sciences, 1 (2), 92-95, 2009. 
2009 Trivedi N. P., Kekatpure V., Kuriakose M. A., Iyer S., Safe and Simple Method for Secondary Tracheoesophageal Puncture Using Curved Forceps, Journal of Laryngology and Otology, 123 (10), pp E19, 2009.
2009 R. Krishna Kumar and J. Sandoval, Advanced Pulmonary Vascular Disease: The Eisenmenger Syndrome.Cardiology in the Young, Volume 19, Issue E-SUPP. 1, 2009, Pages 39-44, 2009.
2009 Borade A., Prabhu A. S., Kumar S., Prasad V., Rajam L., Magnetic Resonance Imaging Findings in Ophthalmoplegic Migraine, Journal of Postgraduate Medicine, 55 (2), 137-138, 2009.
2009 Reshma K., Bharathi B., Rao A. V., Dinesh M., Vasudevan D. M. Phagocytosis: A Marker of Decreased Immune Response in Radiation Treated Oral Cancers., Biomedical Research, 20 (1), 75-77, 2009.
2009 M. G. Pillai, V. Kumaravel, B. Nisha, C. Hareesh, A. G. Unnikrishnan, V. Nair, R. V . Jayakumar and Harish Kumar, Prevalence of Musculoskeletal Manifestations in Thyroid Disease, Thyroid Research and Practice, 6(1): January - April 2009.
2009 S. Jain and Balu Vaidyanathan, Digoxin in Management of Heart Failure in Children: Should It Be Continued or Relegated to the History Books, Annals of Pediatric Cardiology, Volume 2, Issue 2, Pages 149-152, 1 July 2009.
2009 Sukhesh Mukherjee, Subir Kumar Das and D. M. Vasudevan, Role of Polyphenols in Diet and Nutrition; An Updated Review, Current Nutrition and Food Science. 5 (2), 149-159, May 2009. 
2009 Vaidyanathan B., Radhakrishnan R., Aravindakshan D. S., Sundaram K. R., Kumar R. K., What Determines Nutritional Recovery in Malnourished Children Undergoing Correction of Congenital Heart Defects? A Prospective Study,Pediatrics, 2009; 124:e294-e299. 
2009 Srinivas L., Kumar R. K., Case Studies of Congenital Heart Disease with Pulmonary Hypertension: Atrial Septal Defect, PVRI Review, 2009,1:183-187. 
2009 Manu Raj, K. R. Sundaram, Mary Paul, Abish Sudhakar, R. Krishna Kumar, Dynamics of Growth and Weight Transitions in a Pediatric Cohort from India, Nutrition Journal, November 2009.
2009 Joye Varghese, Vallath Balakrishnan, Shine Sadasivan, Prem Nair, Venkadeswaran Anantha Narayanan, Muscle cell membrane damage by very low serum sodium, Pan African Medical Journal 2009; 3:14. 
2009 Thekkumpurath P., Venkateswaran C., Bennett M. I., Newsham A., Kumar M., Screening for Psychological Distress in Palliative Care: Performance of Touch Screen Questionnaires Compared with Semistructured Psychiatric Interview, Journal of Pain and Symptom Management, Vol. 38 (4), pp. 597-605, 2009.
2009 Unnikrishnan A. G., Study of Early Onset of Diabetes, Annals of the New York Academy of Sciences, 2009.
2009 Sharath Kumar, Kawasaki Disease in a tertiary Hospital: Changing Epidemiology, Internal Medicine Journal, Vol. 39, 2009.
2009 Francis E., Singhi A., Kumar R. K., Srinivas L., Transcatheter Occlusion of Patent Ductus Arteriosus in Preterm Infants, Journal of the American College of Cardiovascular Interventions, 2009.
2009 Shekhar Sharma, Charu Singh, Altaf Gauhar Haji, A Phase II Pilot Study to Evaluate Use of Intravenous lidocaine for Opioid Refractory Pain in Cancer Patients, Journal of Pain and Symptom Management, 2009.
2009 Kalavathy E., Iyer S., Kuriakose M. A., Oral Self Examination to Increase Awareness of Oral Cancer in a High Risk Population, Oral Oncology, Vol. 3 (1), July 2009.
2009 Pawar U., Rao K. N., Varghese J., Thilak J., Sundaram P. S., Scintigraphic Assessment of Patellar Viability in Total Knee Arthroplasty After Lateral Release, Journal of Arthroplasty, Vol. 24 (4), pp. 636-Â 640, 2009.
2009 Durah S., Patel D., Kuriakose M. A., Iyer S., Kekatpure V., Morbidity Profile of Facial Translocation Approaches to Skull Base Tumours, Oral Oncology, Vol. 3 (1), July 2009.
2009 Sharma M., Iyer S., Sharan R., Sudhir V. R., Arun P., Vijayaraghavan S., Kuriakose M. A., Functional Reconstruction of Near Total Glossectomy Defects Using Composite Gastro Omental-dynamic Gracilis Flaps, Journal of Plastic Reconstructive and Aesthetic Surgery, Vol. 62 (10), pp. 1277-1280, 2009.
2009 Vaidyanathan B., Simpson J. M., Kumar R. K., Transesophageal Echocardiography for Device Closure of Atrial Septal Defects. Case Selection; Planning and Procedural Guidance, JACC - Cardiovascular Imaging, Vol. 2 (10), pp. 1238-1242, 2009.
2009 Chatni S. S., Sharan R., Kuriakose M. A., Tiwari R. M., Iyer S., Patel D., Transmandibular Approach for Excision of Maxillary Sinus Tumors Extending to Pterygopalatine and Infratemporal Fossae,Oral Oncology, Vol. 45 (8), pp. 720-726, 2009.
2009 Vaidyanathan B., Radhakrishnan R., Kumar R. K., Sundaram K. R., Sarala D. A., What Determines Nutritional Recovery in Malnourished Children After Correction of Congenital Heart Defects?,Pediatrics, Vol. 124 (2), pp. e294-e299, 2009.
2009 Abraham M. K., Nasir A. R. A., Damisetti K. R. P., Unnithan G. R., Kedari P. M., Ramakrishnan P., Bindu S.,Experience with Laparoscopy - Assisted Retroperitoneal Pyeloplasty in Children, Pediatric Surgery International, Vol. 25 (7), pp. 601-605, 2009.
2009 Thankappan K., Microvascular Free Tissue Transfer After Prior Radiotherapy in Head and Neck Reconstruction – A Review, Surgical Oncology, 2009.
2009 Dinesh Kumar V. P., Thomas T., Menon K. V., Content-based Image Retrieval of Spine Radiographs with Scoliosis, Journal of Spinal Disorders and Techniques, Vol. 22 (4), pp. 284-289, 2009.
2009 Feroze Kaliyadan, Bhaskaran M., Sreekanth G., Manoj J., Dharmaratnam A. D., Anti-phospholipid Syndrome Preceding a Diagnosis of Lepromatous Leprosy, Dermatology Online Journal, Vol. 15 (6), 2009.
2009 Iyer S. K., Reply Regarding the Article Response to 'Comparison of Quality of Life in Advanced Laryngeal Cancers After Concurrent Chemoradiotherapy Vs Total laryngectomy', Otolaryngology –Head and Neck Surgery, Vol. 140 (6), pp. 952-953, 2009.
2009 Feroze Kaliyadan, Dharmaratnam A. D., Sreekanth, Jayasree M. G., Linear Verrucous Hemangioma,Dermatology Online Journal, Vol. 15 (5), 2009.
2009 Kuriakose M. A., Trivedi N. P., Sentinel Node Biopsy in Head and Neck Squamous Cell Carcinoma,Opinion in Otolaryngology and Head and Neck Surgery, Vol. 17 (2), pp. 100-110, 2009.
2009 Jayalekshmi P., Gangadharan P., Rajan B., Tsuji M., Nair R. R. K., Akiba S., Tobacco Chewing and Female Oral Cavity Cancer Risk in Karunagappally Cohort (India), British Journal of Cancer, Vol. 100 (5), pp. 848-852, 2009.
2009 Pillai P., Menon S. K., Panikar D., Pillai A. B., Kariyattil R., Manjooran R. P., Temporal Fossa Arachnoid Cyst Presenting with Bilateral Subdural Hematoma Following Trauma: Two Case Reports, Journal of Medical Case Reports, Vol. 3, 2009.
2009 Thankappan K., Management of Clinically Negative Neck for the Patients with Head and Neck Squamous Cell Carcinomas in the Modern Era, Oral Oncology, Vol. 45 (2), 2009.
2009 Nair R. R. K., Rajan B., Sugahara T., Koga T., Gangadharan P., Nair M. K., Jayalekshmi P., Akiba S.,Background Radiation and Cancer Incidence in Kerala (India) - Karunagappally Cohort Study,Health Physics, Vol. 96 (1), pp. 55-66, 2009.
2009 Thankappan K., Sharan R., Kuriakose M. A., Iyer S., Esthetic and Anatomic Basis of Modified Lateral Approach, Journal of Oral and Maxillofacial Surgery, Vol. 67 (1), pp. 231-234, 2009.
2009 Balakrishnan V., The Making of a Physician, Mens Sana Monographs, Vol. 7 (1), pp. 184-188, 2009.
2009 Sharan R., Sharma M., Iyer S., Kuriakose M. A., Sasidharan P. R., Vijayaraghavan S., A Simplified Technique of Free Flap Pedicle Transfer for Reconstruction of Defects Following Head and Neck Cancer Ablation, Journal of Surgical Oncology, Vol. 99 (1), pp. 80-81, 2009.
2009 Girish B. N., Rajesh G., Balakrishnan V., Vaidyanathan K., Zinc Status in Chronic Pancreatitis and Its Relationship with Exocrine and Endocrine Insufficiency, Journal of Pancreas, Vol. 10 (6), pp. 651-656, November 2009.
2009 Feroze Kaliyadan, Erythema Elevatum Diutinum Presenting with Vesicular Lesions in the Setting of Rheumatoid Arthritis and P-ANCA Positivity, Egyptian Dermatology Online Journal, Vol. 5 (1), 2009.
2009 Unnikrishnan A. G., Tibaldi J., Raz I., Mu Y., Ger? L., Gumprecht J., Damci T., Ligthelm R., Krentz A. J., Hadley-Brown M., Practical Guidance on Intensification of Insulin Therapy with BIAsp 30: A Consensus Statement, International Journal of Clinical Practice, Vol. 63 (11), pp. 1571-1577, 2009.
2009 Anish Ahamed, Ambika Gopalakrishnan Unnikrishnan, Emma L. Edghill, Sian Ellard, Vasantha Nair, Rohinivilasam Vasukutty Jayakumar, Harish Kumar, Valliyaparambil Pavithran Praveen, Nisha Bhavani, Sheela Nampoothiri, Sanket Sharad Pendsey, Permanent Neonatal Diabetes Mellitus Due to a C96Y Heterozygous Mutation in the Insulin Gene : A Case Report, Clinical Genetics, Vol. 76 (5), pp. 441-448, 2009.
2009 G. Zaidi, RP Sahu & L Zhang, E. Bhatia, G. S. Eisenbarth, R. V. Jayakumar, G. Jevalikar, A. Bhansali, V. Bhatia, N. Shah, N. Bhavani, G. George, Two Novel AIRE Mutations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) Among Indians, Clinical Genetics, October 2009.
2009 Amit Kumar C. Jain, Ajit Kumar Varma, Harish Kumar, Mangalanadan, Triple Site Necrotizing Fascitis in a Diabetic Patient: 4 Case Reports, The Journal of Diabetic Foot Complications, 2009.
2009 Pillay V. V., The Present Scenario of Poison Control Centres in India and the Need for Many More, Toxicology Newsletter - American College of Emergency Physicians, Vol. 16, 2009.
2009 Kuriakose M. A., Effectiveness of Sentinel Node Biopsy in Oral Cancer, International Journal of Oral and Maxillofacial Surgery, Vol. 38 (5), pp. 397-399, 2009.
2009 Robin George C., Shekhar Sharma, Altaf Gauhar Haji, Vijaykumar D. K., Recurrent Endometrial Carcinoma: Unusual Type and Timing of Presentation, Nepal Journal of Medicine, 2009.
2009 Suresh Am Durah S., Hiran K.R., Kuriakose M. A., Kekatpure V., Sundaram S., Evaluation of Molecular Markers for the Assessment of Occult Metastasis in Lymph Nodes in Head and Neck Squamous Cell Carcinoma, Oral Oncology, Vol. 3 (1), July 2009.
2009 Battoo S., Durah S., Kuriakose M. A., Iyer S., Patel D., Effectiveness of Per Oral Access in the Surgical Management of T2-T3 Oral Cavity Squamous Cell Carcinoma, Oral Oncology, Vol. 3 (1), July 2009.
2009 Vaidyanathan S., Kurup R. P., Nampoothiri S., Kumar I. V. A., Extensive Mongolian Spots as a Clue in GM1 Gangliosidosis: Report of Two Cases, Journal Of Pediatric Neurology, Vol. 7 (4), pp. 411-414, 2009.
2009 Feroze Kaliyadan, Jayasree M. G., Neeraj S., Unni M., Localized Cutaneous T Cell Lymphoma Presenting as Disfiguring Facial Lesions, Dermatology Online Journal, Vol. 15 (11), 2009.
2009 Samuel C., Naveen T., Supe S. S., Ganesh K. M., External Beam Radiotherapy for Palliation of Painful Bone Metastases: Pooled Data Bioeffect Dose Response Analysis of Dose Fractionation,Polish Journal of Medical Physics and Engineering, Vol. 15 (1), pp. 33-35, 2009.
2009 Jayalekshmi P., Varughese S. C., Kalavathi Krishnan Nair, M. Jayaprakash, V. Gangadharan, P. Nair, Akiba S., A Nested Case-Control Study of Female Breast Cancer in Karunagappally Cohort in Kerala, India, Asian Pacific Journal of Cancer Prevention, Vol. 10 (2), pp. 241-246, 2009.
2009 Aswathy. S, Beteena K and Leelamoni.K. Mass Drug Administration against filariasis in India: Perceptions and practices in a rural community in Kerala. Annals of Tropical Medicine and Parasitology – 2009, 103(7). Read More»»
2008 Feroze K., Dharmaratnam A. D., Erythema Nodosum - An Association with Rabies Vaccination. Dermatology Online Journal, 2008;14(6). 
2008 Joye Varghese, Vallath Balakrishnan, Venkadeswaran Narayanan, Tracheoesophageal Fistula, International Journal of Emergency Medicine, 2008.
2008 Denny E. D., Ashok L., Varghese J., Jayanthi V., Predictive Role of Endoscopy in Dysphagia with Associated Symptoms, Digestive Endoscopy 2008; 20(1):51.
2008 H. Nagahama, N. Nwe, R. Jayakumar, T. Furuike, H. Tamura, Preparation of Chitinous Compound/ Gelatin Composites & Thier Biomedical Applications, Macromolecular Symposia, Vol.264(1), (IF: 0.758). 
2008

H. Nagahama, T. Kashiki, N. Nwe, R. Jayakumar, T. Furuike & H. Tamura, Preparation of Biodegradable Chitin/ Gelatin Membranes with GlcNAc for Tissue Engineering Applications, Carbohydrate Polymers, (IF:1.203). (Accepted)

2008

H. Nagahama, N. Nwe, R. Jayakumar, S. Koiwa, T. Furuike & H. Tamura, Novel Biodegradable Chitin Membranes for Tissue Engineering Applications, Carbohydrate Polymers, (IF: 1.203). (Accepted)

2008 Elango E. M., P. R. Ram Mohan, R. Lakshmi, V. Balakrishnan, Nove Utations in Calcium Sensing Receptor Gene in Tropical Chronic Pancreatitis in India, Scandinavian Journal of Gasteroenterology, pp.43117-121, (IF:1.758).
2008 Sudhir S., Balagopal N., Ginil Kumar P., Bhat H. S., Laparoscopic Adrenalectomy: A Single Centre Experience Over 5 Years, Indian Journal of Urology, Vol. 24, pp.S12.
2008

Shanti Nair, U.S. Sajeev, K. Anoop Anand, Deepthy Menon, Control of Nanostructures in PVA, PVA / Chitosan Blends & PCL Polymers Through Electrospinning, Bulletin of Materials Science, (IF: 0.49). (Accepted) 

2008

Litty Irimpan, A. Deepthy, Bindu Krishnan, L.M. Kukreja, V. P. N. Nampoori, P. Radhakrishnan. Effect of Self Assembly on the Nonlinear Optical Characteristics of ZnO Thin Films.Optics Communications, (IF: 1.48). (Accepted)

2008 Sukumar S., Nair B., Sanjeevan K.V., Mathew G., Bhat H.S, Laparoscopic Assisted Dismembered Pyeloplasty in Children - Intermediate Results, Paediatric Surgery International, 39856, 2008.
2008 R. Jayakumar, H. Tamura. Synthesis, Characterization & Thermal properties of Chitin-g-Poly(e-caprolactone) Copolymers by Using Chitin Hydrogel. International Journal of Biological Macromolecules. 
2008 Francis P.T., Maternal Vaccination to Prevent Pertussis, LANCET Infect Dis., Vol.8, pp.214, (IF:12.058). 
2008 Feroze K . Digital Photography in Patient Counseling - A Study, Journal of European Academy of Dermatology & Venereology, April 2008. 
2008

A. Deepthy, S. Vanishri, D. Ambika, Sajan D. George, V. P. N. Nampoori, H. L. Bhat, E de Matos Gomes, M. Belsley, Photoacoustic Investigations on Thermal Anisotropy in ULMA Single Crystals, Materials Research Bulletin. (Accepted)

2008 R. Jayakumar, N. Nwe, H. Nagahama, H. Tamura. Synthesis, Characterization & Biospecific Degradation Behavior of Sulfated Chitin, Macromolecular Symposia, Vol.264(1), (IF:0.798).
2008

Litty Irimpan, Bindu Krishnan, A.Deepthy, V. P. N.Nampoori, P. Radhakrishnan, Nonlinear Optical Characterization of Self Assembled Thin Films of ZnO, Journal of Applied Physics, (IF: 2.316). (Accepted)

2008 Verma S. K., Ganesan T. S., Parker P. J., The Tumour Suppressor RASSF1A is a Novel Substrate of PKC, FEBS Lett, Vol.582, pp.2270-2276, (IF:3.2163). 
2008 Uday Pawar, K. Narasimha Rao, P. S. Sundaram, Jai Thilak, Jacob Varghese, Scintigraphic Assessment of Patellar Viability in Total Knee Arthroplasty After Lateral Release Corrected Proof 21 May 2008. Journal of Arthroplasty, Vol.10, pp.1016, (IF:1.609)
2008 Kariyattil R., Panikar D., Choroid Plexus Cyst of the Third Ventricle Presenting as Acute Triventriculomegaly, Childs Nervous System, Vol.24(7), July 2008, pp.875-877, (IF:0.993).
2008

H. Nagagama, T. Higuchi, R. Jayakumar, T. Furuike, H. Tamura, XRD Studies of ß-chitin from Squid Pen with Calcium Solvent, International Journal of Biological Macromolecules, (IF: 1.177). (Accepted)

2008 S. Kumar Das, V. Balakrishnan, S. Mukherjee, & D. M. Vasudevan, Evaluation of blood oxidative stress related parameters in alcoholic liver disease & non-alcoholic fatty liver disease,Scandinavian Journal of clinical Lab.Investigations, Vol. 68, pp.68, 323 - 334, (IF:1.2)
2008

Rashmi Kumar, Kumari Indira, A. Rizvi, T. Rizvi, L. Jeyaseelan, Antibiotic Prescribing Practices in Primary & Secondary Health Care Facilities in Uttar Pradesh, India, Journal of Clinical Pharmacy & Therapeutics, (IF: 1.364). (Accepted)

2008

Das S. K., Dhanya L., Vasudevan D. M., Biomarkers of Alcoholism; An Updated Review, Scandinavian Journal of clinical Lab Investigations, pp.68, 81-92, (IF:1.2).

2008

Sonal Sekhar M. Herbalism - A Phenomenon For New Age in Medicine, Internet Journal of Alternate Medicine.

2008

Deepa T. Vasudevan, Occurrence of Toxic Microbial Load in Herbal Drugs, Advances in Pharmacology & Toxicology.

2008 Dr. Chandrashekar J., Dental Health Care Waste Disposal Among Private Dental Practices in Bangalore,India,  International Dental Journal., 
2008 V. V. Pillai, Use of Rescue Burns as Another Term of Expression in Certain Situations of Burns, Burns, Vol.34, pp.427.
2008 Rajeev K., Kiran M., Panikar D, Ventriculosubgaleal Shunts in the Management of Infective Hydrocephalus, Childs Nervous System, Vol.24, pp.1033-1035, (IF:0.993). 
2008 Kumar R. K., Shrivastava S., Pediatric Heart Care in India. Heart, Vol.94, pp.984-990.
2008 Dr. Chandrashekar J., Dental Helath Care Waste disposal Among Private Dental Practices in Bangalore City, International Dental Journal, Vol.58, pp.51-54.
2008 V. V. Pillai, Jet Lagged Individual Vis-à-Vis Local Resident & Susceptibility to Malaria, Med Hypotheses, Vol.70, pp.458 - 460.
2008 Deepa T. Vasudevan, Pharmacological Screening of Some Selected Medicinal Plants From India for Anti-Microbial Activity, International Journal of Pharmacology & Biological Sciences.
2008 G. Rajesh, B. N. Girish, V. Balakrishnan, K. Vaidyanathan, Pancreatic Exocrine Insufficiency and Zinc Status in Alcoholic and Tropical Chronic Pancreatitis, Journal of Gastroenterology and Hepatology, Vol. 23, pp. 131-132, 2008.
2008 S. Kumar Das, D. M. Vasudevan, Genesis of Hepatic Fibrosis and Its Biochemical Markers, Scandinavian Journal of Clinical Laboratory Investigations, Vol. 68, pp. 260-269, 2008.
2008 Satish G., Nampoothiri S., Kappanayil M., Arterial Tortuosity Syndrome Phenotypic Features and Cardiovascular Manifestations, Circulation, Vol. 117 (23), pp. e477-e478, 2008.
2008 Pillay V. V., Why is Medical Administration Run by Former C-Students?, Medical Hypotheses, Vol. 70, pp. 191-192, 2008.
2008 Pillay V. V., Jet Lagged Individual vis-Ã -vis Local Resident and Susceptibility to Malaria, Medical Hypotheses, Vol. 70, pp. 458-460, 2008.
2008 Chatni S. S., Thankappan K., Lymph Node Status Cannot Be Ignored in Surwiwal Analysis of Laryngeal Cancer, Archives of Otolaryngology - Head and Neck Surgery, Vol. 134 (7), 2008.
2008 Rajesh G., Nair A. S., Balakrishnan V., Narayanan V. A., Tropical Pancreatitis and Fibrocalculous Pancreatic Diabetes--Two Sides of the Same Coin?, Tropical gastroenterology : official journal of the Digestive Diseases Foundation, Vol. 29 (3), pp. 175-176, 2008.
2008 Sharan Rajeev, Subramania Iyer, Increased Plate and Osteosynthesis Related Complications Associated with Post Operative Concurrent Chemoradiotherapy in Oral Cancer, Head and Neck, Vol. 30 (11), pp. 1422-1430, 2008.
2008 J. Kalavathy Elango, Sundaram K. R., Kuriakose M. Abraham, Subhash Pramod, Oral Cancer Awareness in a Semi-Urban Population in South India, Pacific Journal of Cancer Prevention, 2008.
2008 Xavier D., Pais P., Yusuf S., Gupta R., Reddy K. S., Prabhakaran D., Xie C., Devereaux P., Treatment and Outcomes of Acute Coronary Syndromes in India (CREATE): A Prospective Analysis of Registry Data, The Lancet, Vol. 371 (9622), pp. 1435-1442, 2008.
2008 Chandra A., Dhar P., Schou M., Kapoor V. K., Hardikar V., Gupta R., Goel A., Dharap S., Cefoperazone-Sulbactam for Treatment of Intraabdominal Infections: Results from a Randomized Parallel Group Study in India, Surgical Infections, Vol. 9 (3), pp. 367-376, 2008.
2008 Duarah S., Thankappan K., Kekatpure V., Sharan R., In Reference to Classification and Management of Tracheoesophageal and Tracheopharyngeal Fistulas After Laryngectomy, Laryngoscope, Vol. 118 (5), 2008.
2008 Chatni S., Sainani R., Mohandas K., Mehta S., Infusion Chemotherapy with Cisplatinum and Fluorouracil in the Treatment of Locallyadvanced and Metastatic Gallbladder Cancer, Journal of Cancer Research and Therapeutics, Vol. 4 (4), pp. 151-155, 2008.
2008 Viswanathan S., Kumar R. K., Assessment of Operability of Congenital Cardiac Shunts with Increased Pulmonary Vascular Resistance, Catheterization and Cardiovascular Interventions, Vol. 71 (5), pp. 665-670, 2008.
2008 Tang W. R., Varkey P., Chen H. C., Rose V., Tan N. C., Girotto R., The Venous Flap - A Safe Alternative to the Simple Vein Graft in a Special Situation, Journal of Plastic Reconstructive and Aesthetic Surgery, Vol. 61 (4), pp. 434-437, 2008.
2008 Naveen T., Lokesh V., Samuel J., Ganesh K. M., Supe S. S., Radiotherapy in Metastatic Spinal Cord Compression: A Review of Fractionation, Reports of Practical Oncology and Radiotherapy, Vol. 13 (3), pp. 144-149, 2008.
2008 Chungath M., Shorvon S., The Mortality and Morbidity of Febrile Seizures, Nature Clinical Practice Neurology, Vol. 4 (11), pp. 610-621, 2008.
2008 Balakrishnan V., Abdominal Wall Metastasis After Percutaneous Endoscopic Gastrostomy, Journal of Gastroenterology and Hepatology, Vol. 23, 2008.
2008 Balakrishnan V., Small Cell Carcinoma of the Esophagus, Saudi Journal of Gastroenterology, Vol. 14 (3), 2008.
2008 Elango E. M., P. R. Ram Mohan, V. Balakrishnan, R. Lakshmi, Novel Mutations in Calcium Sensing Receptor Gene in Tropical Chronic Pancreatitis in India, Scandinavian Journal of Gasteroenterology, Vol. 43, pp. 117-121, 2008.
2008 Kumar R. K., Nair A. C., Coil Occlusion of the Large Patent Ductus Arteriosus, Images in Paediatric Cardiology, Vol. 34, pp. 8-26, 2008.
2008 K. N. Acharya, J. Renjit Kumar, K. Venugopal Menon, H. K. Varma, Hydroxyapatite-Bio-Active Glass Ceramic Composite as Stand - Alone Graft Substitute for Posterolateral Fusion of Lumbar Spine: A Prospective Matched and Controlled Study, Journal of Spinal Disorders and Techniques, Vol. 21 (2), pp. 106-111, 2008.
2008 K. N. Acharya, J. Renjit Kumar, K. Venugopal Menon, Binod, Ilio-Lumbar Fixation - The Amrita Technique, Journal of Spinal disorders and techniques, Vol. 21 (7), pp. 493-499, 2008.
2008 Kuriakose M. A., Sorin A., DeLacure M. D., Babu R, Fishman A. J., Sharan R., Quantitative Evaluation of Transtemporal and Facial Translocation Approaches to Infratemporal Fossa, Skull Base, Vol. 18 (1), pp. 17-27, 2008.
2008 Varkey P., Tan N. C., Chen H. C., Liu Y. T., Tang W. R., Girotto R., A Picture Speaks a Thousand Words: The Use of Digital Photography and the Internet as a Costeffective Tool in Monitoring Free Flaps, Annals of Plastic Surgery, Vol. 60 (1), pp. 45-48, 2008.
2008 Chaturved S. K., Venkateswaran C., New Research in Psychooncology, Current Opinion in Psychiatry, Vol. 21 (2), pp. 206-210, 2008.
2008 Menon V. U., Kumar K. V., Kumar H., Nair V., Jayakumar R. V., Vishwanath P., Gilchrist A., Acanthosis Nigricans and Insulin Levels in a South Indian Population - (ADEPS paper 2), Obesity Research and Clinical Practice, Vol. 2 (1), pp. 43-50, 2008.
2008 Saha A., Kumar S., Vasudevan D. M., Factors of Occupational Injury: A Survey in a Chemical Company, Industrial Health, Vol. 46 (2), pp. 152-157, 2008.
2008 Parmar C., Jojo A., Vijayan S. N., Vachhani K. C., Primary Chondrosarcoma of the Heart, European Journal of Cardio-thoracic Surgery, Vol. 33 (3), pp. 513-515, 2008.
2008 Skandhan K. P., Shilpa V. S., Vesuna P. R., Amith S., Dodia A., Semen of Impotent patients, Sexologies, Vol. 17 (2), pp. 96-101, 2008.
2008 P. Varma, K. R. Dinesh, D. M. Vasudevan, V. Balakrishnan, In Vitro Studies on the Anticancerous Properties of Probiotic Lactic Acid Bacteria (LAB) from Human Colonic Mucosa, Journal of Gastroenterology and Hepatology, Vol. 23, 2008.
2008 S. Nair, S. T., Cai L., Kong A. N., Chan J. Y., Regulatory Potential for concerted Modulation of Nrf2 - and Nfkb1 - Mediated Gene Expression in Inflammation and Carcinogenesis, British Journal of Cancer, Vol. 99 (12), pp. 2070-2082, 2008.
2008 Ahamed A., Unnikrishnan A. G., Edghill E. L., Kumar H., Praveen V. P., Bhavani N., Nampoothiri S., Pendsey S. S., Permanent Neonatal Diabetes Mellitus Due to a C96Y Heterozygous Mutation in the Insulin Gene : A Case Report, Journal of the Pancreas, Vol. 9 (6), pp. 715-718, 2008.
2008 Mahesh K., Francis E., Kumar R. K., Aorta to Right Atrial Tunnel. Prenatal Diagnosis and Transcatheter Management in a Neonate, JACC: Cardiovascular Interventions, Vol. 1 (6), pp. 716-717, 2008.
2008 Unnikrishnan A. G., Bhatia E., Kumaravel V., Kannan A., Sahay R. K., Bhadada S. K., Bhatia V., Type 1 Diabetes Versus Type 2 Diabetes with Onset in Persons Younger than 20 Years of Age: Results from an Indian Multicenter Study, Annals of the New York Academy of Sciences, Vol. 1150, pp. 239-244, 2008.
2008 Narayanan D., Varghese S. T., Dinesh D., New-onset Psychosis After Temporal Lobectomy, Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 20 (4), pp. 50-501, 2008.
2008 Krishnan P., Othiyil Vayoth S., Ponnambathayil S., Surendran S., Dhar P., Laparoscopy in Suspected Abdominal Tuberculosis is Useful as an Early Diagnostic Method, ANZ Journal of Surgery, Vol. 78 (11), pp. 987-989, 2008.
2008 Mukherjee S., Das S. K., Vasudevan D. M., Vaidyanathan K., Consequences of Alcohol Consumption on Neurotransmitters – An Overview, Current Neurovascular Research, Vol. 5 (4), pp. 266-272, 2008.
2008 Varghese S. T., Narayanan D., Dinesh D., Mania in a Patient with Wilson's Disease Awaiting Liver Transplant, Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 20 (4), pp. 501-502, 2008.
2008 Haji A. G., Sharma S., Paul J., Vijaykumar D. K., Transfusion Related Acute lung injury presenting with Acute Dyspnoea: A Case Report, Journal of Medical Case Reports, Vol. 2, 2008.
2008 Sukumar S., Nair B., Sanjay B. H., Sanjeevan K. V., Ginil K. P., Supracostal Access for Percutaneous Nephrolithotomy: Less Morbid; More Effective, International Journal of Urology and Nephrology, Vol. 40 (2), pp. 263-267, 2008.
2008 Veeraraghavan, Ravi, Moni Abraham Kuriakose, Subramania Iyer, CT Based Contouring of Free Fibula for Mandibular Reconstruction, International Journal of Oral and Maxillofacial Surgery, Vol. 66 (10), pp. 2185-2192, 2008.
2008 Jayalekshmy P. A., Akiba S., Bidi, Sugahara T., Nair R. K., Rajan B., Gangadharan P., Nair M. K., Bidi Smoking and Lung Cancer Incidence Among Males in Karunagappally Cohort in Kerala (India), International Journal of Cancer, Vol. 123 (6), pp. 1390-1397, 2008.
2008 Singh H. K., Gupta A., Kulkarni V., Shah I., Kinikar A., Sastry J., Gupte N., Siberry G. K., The Indian Pediatric HIV Epidemic: A Systematic Review, Current HIV Research, Vol. 6 (5), pp. 419-432, 2008.
2008 Feroze Kaliyadan, Dharmaratnam, Manoj J., Palmar and Flagellate Hyperpigmentation Following Low Dose Intralesional Injection of Bleomycin for Cystic Hygroma, Dermatology Online Journal, Vol. 14 (8), 2008.
2008 Francis P. T., Non-responders and Self Selection Bias, Public Library of Science Medicine, January 2008.
2008 Nair B. T., Bhat S. H., Sudhindran S., Kurien G., Saheed M., Sukumar S., Narayan U. V., A Phase 3; Open-label; Non-comparative Study of Tigecycline in the Treatment of Patients with Selected Serious Infections Due to Resistant Gram-negative Organisms Including Enterobacter Species; Acinetobacter Baumannii and Klebsiella Pneumonia, Journal of Antimicrobial Chemotherapy, Vol. 62, pp. i29-40, September 2008.
2008 Pillay V. V., A Most Memorable Experience, Journal of Forensic Medicine and Toxicology, Vol. 9 (2), 2008.
2008 Feroze Kaliyadan, Ray S., Pai R., Sasikala L., Pai S., Mathew M. K., A Rapidly Progressing Fatal Case of Primary Systemic Anaplastic Large Cell Lymphoma Presenting as Erythroderma Association with Carbamazepine, Dermatology Online Journal, Vol. 14 (12), 2008.
2007 Vaishali Bafna, Nambiar A. R. & Indudharan R., Lymphangioma of the Larynx, The Journal of Laryngology & Otology (England), Vol.25, January 2007, pp.1-3, (IF:0.501). 
2007 Panicker J. N., Vinayan K. P., Ahsan Moosa N. V., Elango E. M. & Kumar A. A., Juvenile Behcet's Disease: Highlighting Neuropsychiatric Manifestations & Putative Genetic Mechanisms.Clin Neurol Neurosurg, Vol.109(5), June 2007, pp.436 - 8, (IF:1.l553).
2007 Litty Irimpan, Bindu Krishnan, A. Deepthy, V. P. N. Nampoori & P. Radhakrishnan, Excitation Wavelength Dependent Fluorescent Behaviour of Nanocolloids of ZnO, Journal of Physics D: Applied Physics, Vol.40, pp.5670 - 5674.
2007 Kariyattil R., Steinbok P., Singhal A., Cochrane D. D., Ascites & Abdominal Pseudocysts Following Ventriculoperitoneal Shunt Surgery: Variations of the Same Theme.Journal of Neurosurgery Pediatrics, Vol.106, May 2007, pp.350-353, (IF:3.007). 
2007 Wyrwich K. W., Metz S. M., Kroenke K., Tierney W. M., Babu A. N. & Wolinsky F. D., Triangulating patient & clinician perspectives on clinically important differences in health-related quality of life among patients with heart disease, Health Services Research, Vol. 42, December 2007, pp.2257 - 74, (IF:2.554)
2007 Krishnakumar R., Soft Tissue Recurrence Of Giant Cell Tumour, Journal of Orthopaedics, Vol. 4(4), e3, 2007. 
2007 Metz S. M., Wyrwich K. W., Babu A. N., Kroneke K. A., Tierney W. W., Wolinsky F. D., Validity of Patient - Reported Health-Related Uality of Life Global Ratings of Change Using Structural Equation Modeling, Quality Life Res, 39970 2007, (IF: 2.466). 
2007 Bakshi K. D., Vaidyanathan B., Sundaram K. R., Roth S. J., Shivaprakasha K., Rao S. G., Nair S. G., Chengode S., Kumar R. K., Determinants of Early Outcome After Neonatal Cardiac Surgery in a Developing Country, Journal of Thoracic & Cardiovascular Surgery, Vol.134, pp.765 - 771, (IF:3.354). 
2007 Viswanathan S., Rao S. G., Krishna Kumar R., Rupture of the Non Coronary Sinus of Valsalva Into the Right Ventricle, Cardiology in the Young, Vol. - 17, 40126 2007, pp.691-2, (IF:0.912). 
2007 Viswanathan S., Kumar R. K., Vaidyanathan B., Thrombus in Juxtaposed Right Atrial Appendage in a Patient with Tricuspid Atresia & Transposed Great Arteries, Cardiology in the Young, Vol.17, 39999 2007, pp.574, (IF:0.912). 
2007 Viswanathan S., Kumar R. K., Vaidyanathan B., Transcatheter Closure of Aorto-Pulmonary Window in a Symptomatic Infant Using the Amplatzer Ductal Occluder, Heart, Vol.93, pp.1519. 
2007 Shashikala S., Kavitha R., Panikar D., Natarajan K. U., Shamsul Karim P. M., Cerebral Artery Mycotic Aneurysm with Erysipelothrix Rhusiopathiae Endocarditi, Infectious Diseases in Clinical Practice, Vol.15, pp.400 - 402. 
2007 Pillai A., Menon S. K., Kumar S., Rajeev K., Kumar A., Panikar D., Decompressive Hemicraniectomy in Malignant Middle Cerebral Artery Infarction: An Analysis of Long-term Outcome & Factors in Patient Selection, Journal of Neurosurgery, Vol.106(1), January 2007, pp. 59 - 65, (IF:1.99).
2007 Wyrwich K. W.,Metz S. M., Kroenke K., Tierney W. M., Babu A. N. & Wolinsky F. D., Measuring Patient & Clinician Perspectives to Evaluate Change in Health-related Quality of Life Among Patients with Chronic Obstructive Pulmonary Disease, Journal of General and Internal Medicine, Vol.22(2), February 2007, pp.161-70, (IF:2.886). 
2007 R. Jayakumar, R. L. Reis, J. F. Mano, Synthesis & Characterization of N-Methylenephenyl Phosphonic Chitosan, Journal of Macromolecular Science, Pure & Applied Chemistry, Vol. A44(3), pp.271-275, (IF:0.548). 
2007 Subir Kumar Das, D. M. Vasudevan, Alcohol Induced Oxidative Stress: Mini Review, Life Sciences, pp.81, 177-187.
2007 Sukhesh Mukherjee, Subir Kumar Das, D. M. Vasudevan, Effects of Ethanol Consumption on Different Organs: A Brief Overview, Asian Journal of Biochemistry, Vol.2(6), pp.386-394.
2007 Das S. K., Vasudevan D. M., Essential Factors Associated with Hepatic Angiogenesis; A Mini Review, Life Sciences, Vol.81(23), pp.1555-1564, (IF:2). 
2007 Vaishali Bafna, Nambiar A. R., Indudharan R., Lymphangioma of the Larynx, Journal of Laryngol Otol., Vol.121(4), April 2007, (IF: 0.4). (Published)
2007 Padmanabhan K., Cr. Vaishali Bafna, R. Indudharan, Internal Jugular Vein Ectacia - A Rare Cause for Paroxymal Cough, Journal of Laryngol Otol., Vol.742(4), August 2007, (IF: 0.4). (Published)
2007 R. Indudharan, M. Reddy, Allergic Fungal Rhinosinusitis: A Prospective study, Otolaryngology - Head & Neck surgery, Vol.137(2), February 2007, pp.202-202, (IF:1.04). (Published)
2007 Shashikala Shivaprakasha, Kavitha Radhakrishnan, Prakash Kamath, P. M. Shamsul Karim, Routine Screening for ESBL Production, A Necessity of Today, Internet Journal of Microbiology, Vol.3(1).
2007 P. Shanmuga Sundaram, S. Padma, S. Kumar, V. Nair, H. Kumar, Role of 99m TC MDP Bone and 67 Gallium Imaging in Evaluation of Diabetic Osteopathy, The Foot, Vol. 20 (17), pp. 94-101, 2007.
2007 K. Manzoor, V. Aditya, S. R. Vadera, N. Kumar, T. R. N. Kutty, A Single-Source Solid-Precursor Method for Making Eco-Friendly Doped Semiconductor Nanoparticles Emitting Multi-Color Luminescence, Journal of Nanosciences & Nanotechnology, Vol.7, pp.463, (IF:3.1). 
2007 R. Jayakumar, R. L. Reis, J. F. Mano, Synthesis & Characterization of pH-Sensitive Thiol - Containing Chitosan Beads for Controlled Drug Delivery Applications, Drug Delivery, Vol.14(1), pp.9 - 17, (IF:0.792). 
2007 S. S. Sujdar & T. S. Ganesan, Role of Lymphangiogenesis in Cancer, Journal of Clinical Oncology, Vol.25, pp.4298 - 4307, (IF:15.584). 
2007 R. Jayakumar, N. T. Nwe, S. Tokura, H. Tamura, Sulfated Chitin & Chitosan as Novel Biomaterials, International Journal of Biological Macromolecules, Vol.40(3), pp.175-181, (IF:1.177). (Published)
2007 Litty Irimpan, Bindu Krishnan, A. Deepthy, V. P. N. Nampoori, P. Radhakrishnan, Size Dependent Fluorescence Spectroscopy of Nanocolloids of ZnO, Journal of Applied Physics, Vol.102, pp.063524 - 063530, (IF:2.316). 
2007 Steinbok P., Kariyattil R., MacNeily A., Comparison of Section of Filum Terminale & Non- Neurosurgical Management for Urinary Incontinence in Patients with Normal Conus Position, Neurosurgery, Vol.61(3), September 2007, pp.550 - 556, (IF:3.007). 
2007 Litty Irimpan, Bindu Krishnan, A. Deepthy, V. P. N.Nampoori, P. Radhakrishnan, Excitation Wavelength Dependent Fluorescent Behaviour of Nanocolloids of ZnO, Journal of Physics D - Applied Physics, Vol.40, pp.5670-5674, (IF:1.366). 
2007 Pillai A., Kumar S., Kumar A., Panikar D., An Unusual Parasagittal Tumour with Acute Blindness & Response to Cerebrospinal Fluid Shunting, Journal of Clinical Neuroscience, Vol.14(11), November 2007, pp.1112-6., (IF:0.801). 
2007 Manjunatha Pattabi, B. Saraswathi Amma, K. Manzoor, Effect of 8 MeV Electron Irradiation on the Optical Properties of PVP Capped CdS Nanoparticles, Solar Energy Materials & Solar Cells, Vol.91, pp.1403, (IF:2.32). 
2007 Manjunatha Pattabi, B. Saraswathi Amma, K. Manzoor, Photoluminescence Study of PVP capped CdS Nanoparticles Embedded in PVA Matrix, Bulletin of Materials Science, Vol.42, pp.828, (IF:1.8). 
2007 Morris L. G., Sikora A. G., DeLacure M. D., Kuriakose M. A., Tamoxifen Therapy for Aggressive Fibromatosis of the Posterior Triangle of the Neck, Otolaryngology - Head and Neck Surgery, Vol. 136 (4), pp. 674-676, 2007.
2007 Madhusudan S., Ganesan T. S., Intraperitoneal Gene Therapy, Cancer Treat Res, Vol.134, pp.515-524. 
2007 Madhusudan S., Ganesan T. S., Tyrosine Kinase Inhibitors & Cancer Therapy, Recent Results, Cancer Res, Vol.172, pp.25-44.
2007 Bignone P. A., Lee K. Y., Liu Y., Emilion G., Finch J., Soosay A. E., Charnock F. M., Beck S., Dunham I., Mungall, A. J., and Ganesan T. S., RPS6KA2: A Putative Tumour Suppressor Gene at 6q27 in Sporadic Epithelial Ovarian Cancer, Oncogene, Vol.26, pp.683-700, (IF:6.44). 
2007 R. Jayakumar, R. L. Reis, J. F. Mano, Phosphorous Containing Chitosan Beads for Controlled Oral Drug Delivery, Journal of Bioactive & CompatiblePolymers, Vol.21(4), pp.327-340, (IF:0.52). 
2007 Dr. Ravi V., 3D CT Based Contouring of Free Fibula for Mandibular Reconstruction, International Journal of OMFS, November 2007.
2007 Pillai A., Menon S. K., Kumar S., Rajeev K., Kumar A., Panikar D., Decompressive Hemicraniectomy in Malignant Middle Cerebral Artery Infarction: An Analysis of Long-Term Outcome & Factors in Patient Selection, Journal of Neurosurgery, Vol.106, January 2007, pp.59-65, (IF:1.686). 
2007 Francis P.T., Surveillance of Acute Flaccid Paralysis in India: Author's Reply, LANCET, Vol.370, pp.131, (IF:28.638). 
2007 Francis P.T., Protective Efficacy of a Monovalent Oral Type 1 Poliovirus Vaccine, LANCET, Vol. 370, pp.129, (IF:28.638).
2007 Nair B. T., Bhat S. H., Narayan U. V., Sukumar S., Saheed M., Kurien G. & Sudhindran S., Donate Organs not Malignancies: Postoperative Small Cell Lung Carcinoma in a Marginal Living Kidney Donor, Transplant Proc Journal, Vol.39, pp.3477-80, (IF:1.027). 
2007 Dr. Latha P. Rao, Patterns of Mandibular Invasion in Oral SCC of Mandibular Region, World Journal of Surgical Oncology, January 2007. 
2007 Dr.Latha P. Rao, Methods Indications & Morbidity Profile of Various Facial Translocation & Approaches, International Journal of OMFS, November 2007.
2007 Pillay V. V., Menezes R. G., D. M. Vasudevan, Kanchan T., Bhat N. B., Vishwanath P., Adhikari D., Lobo S. W., Pillay M., Krishnaprasad R., Biotechnology in Forensic Science: The Revolution Continues, Nepal Medical College Journal, Vol. 9 (1), pp. 57-62, March 2007.
2007

Kedar P. S., Nampoothiri S., Kanno H., Shimizu K., Ghosh K., Sreedhar S., First-trimester Prenatal Diagnosis of Pyruvate Kinase Deficiency in an Indian Family with the Pyruvate Kinase-Amish Mutation, Genetics and Molecular Research, Vol. 6 (2), pp. 470-475, 2007.

2007 Unnikrishnan A. G., Gowri P., Arun K., Varma A. K., Kumar H., Tropical Chronic Pancreatitis & Peripheral Vascular Disease, Journal of Pancreas, Vol.8(2), pp.198-200. 
2007 Balakrishnan V., Chatni S., Radhakrishnan L., Narayanan V.A., Nair P., Groove Pancreatitis: A Case Report & review of Literature, Journal of the Pancreas, Vol.8(5), 40063 2007, pp.592 - 7, (IF:5.423). 
2007 Vinayan K. P. and Terada K., A Case of Congenital Bilateral Perisylvian Syndrome due to Bilateral Schizencephaly, Epileptic Disord, Vol.9(2), June 2007, pp.190-3, (IF:0.919).
2007 Indira K. S., V. P. Gopinathan, Darasana Viswam, Shalini Vinod, Natasha Sasankan, Medical Ablation of Endobronchial Mucormyioscs with Amptiotecs B., Journal of Association of Physicians of India. 
2007 Thankappan K., Rugmini S. V., Kuriakose M. A., Iyer S., Sundaram K. R., Pavithran K., Padmanabhan T. K., Samuel J., Sunil B., Cohen R. F., Prognostic Factors of Concurrent Chemo-radiotherapy in Head and Neck Cancers, Journal of Clinical Oncology, Vol. 25 (18S), June 2007.
2007 Sudha S. Sundar, Huijuan Zhang, Philip Brown, Sanjiv Manek, Cheng Han, Kulwinder Kaur, Mark F. L.Charnock, David Jackson and S. Ganesan, T. Prognostic Significance of Lymphangiogenesis and Angiogenesis in Epithelial Ovarian Cancer,  Vol.94, pp.1650-1657, (IF:4.635). 
2007 Geetha Samak, Muddanna S. Rao, D. M. Vasudevan, Rajendra Kedlaya, Hypolipidemic Efficacy of Ocimum Sanctum in the Prevention of Atherogenesis in Male Albino Rabbits, Pharmacology Online, Vol. 2, pp. 115-127, 2007.
2007 Peter S., Subash P., Airway Management During Second-stage Tongue Flap Procedure, Anesthesia and Analgesia, Vol. 104 (1), 2007.
2007 Panicker J. N., Jyothi B., Sreekumar K. P., Mid-brain Molar Tooth Sign- Expanding the Clinical Spectrum, Journal of Neurology-Neurosurgery and Psychiatry, Vol. 78 (1), 2007.
2007 Supe S. S., Rana B. S., Solomon J. G. R., Samuel J., Naveen T., Jyothi S., Validity of Bioeffect Dose Response Models for Normal Tissue Early and Late Complications of the Skin, Reports of Practical Oncology and Radiotherapy, Vol. 12 (1), pp. 19-29, 2007.
2007 Menezes R. G., Kanchan T., Subba S. H., Lobo S. W., V. V. Pillay, Self Inflicted Burn Injuries, Burns, Vol. 34 (4), 2007.
2007 Shaikh Nisar A. N., Avni K. P. S., A New Capillary Method for Erythrocyte Sedimentation Rate, Gazzetta Medica Italiana Archivio per le Scienze Mediche, Vol. 166 (5), pp. 187-189, 2007.
2007 Madhumita K., Nambiar A., Prathapan P., Solitary Neurofibroma of the Palatine Tonsil: A Case Report, Ear Nose and Throat Journal, Vol. 86 (12), pp. 756-759, 2007.
2007 K. P. Jiyo, C. S., Amith S., Different Electrolytes and Metals in Human Seminal Plasma Skandhan,Gazzetta Medica Italiana Archivio per le Scienze Mediche, Vol. 166 (5), pp. 181-186, 2007.
2007 Shekhar Sharma, Vijaykumar D. K., Manoj Babu, Altaf Gauhar Haji, Androgen Secreting Steroid Cell Tumor of the Ovary in a Young Lactating Women with Acute Onset Severe Hyperandrogenism, Journal of Medical Case Reports, Vol. 1, 2007.
2007 Kurup S., Bharihoke V., Sangari S. K., Musculotopic Organization of the Orbicularis Oculi within the Facial Motor Nucleus of the Albino Rat, Neuroanatomy, Vol. 6, pp. 46-48, 2007.
2007 Elango E. M., Ram Mohan P. R., Balakrishnan V., Prem Nair, Homo Sapiens Cystic Fibrosis Transmembrane Conductance Regulator ATP Binding Cassette Sub Family C Member 7 Mutant (CFTR) Gene ; Partial CDS, GenBank Accession, 2007.
2007 Rao S. G., Pediatric Cardiac Surgery in Developing Countries, Pediatric Cardiology, Vol. 28 (2), pp. 144-148, 2007.
2006 Balu Vaidyanathan, Stephen J. Roth, Krishnanaik Shivaprahasha, Suresh G. Rao and R. Krishnakumar., Somatic Growth After Ventricular Septal Defect Closure in Malnourished Infants, Journal of Pediatrics, Vol.149, pp.205 - 9, (IF:4.017). 
2006 Sumithra S., Aswathy S., et al. Maternal & Child Health Services Utilization in Married Women of Age 15-45 years, Journal of Communicable Diseases, Vol.38(1), pp.102-105.
2006 R. Prasanth, L. K. Van Vugt D., A. M. Vanmaekelbergh, H. C. Gerritson, Resonance Enhancement of Optical Second Harmonic Generation in a ZnO Nanowire, Applied Physics Letters, Vol.88(181501), (IF: 3.849). 
2006 Wyrwich K. W.,Metz S. M., Kroenke K., Tierney W. M., Babu A. N., Wolinsky F. D., Interpreting Quality-of-Life Data: Methods for Community Consensus in Asthma, Annals of Asthma, Allergy & Immunology, Vol.96(6), pp.826-33, (IF:2.221). 
2006 Kroenke K., Wyrwich K. W., Tierney W. M., Babu A. N., Wolinsky F. D., Physician-Estimated Disease Severity in Patients with Chronic Heart or Lung Disease: A Cross-Sectional Analysis., Health Quality Life Outcomes, Vol.4, pp.60.
2006 Metz S. M., Wyrwich K. W., Babu A. N., Kroneke K. A., Tierney W. W., Wolinsky F. D., A Comparison of Traditional & Rasch Cut Points for Assessing Clinically Important Change in Health-Related Quality of Life Among Patients with Asthma, Quality Life Research, Vol.15(10), December 2006, pp.1639-49, (IF:2.466). 
2006 L. K. van Vugt, R. Prasanth, Sven Rühle, H. C. Gettitson, K. L. Kuipers, D. A. M. Vanmaekelbergh, Exciton Polaritons Confined in a ZnO Nanowire Cavity, Rev. Lett., Vol.97(147401).
2006 Saheed M. C. S., Ginilkumar P., Bhat S. H., Sanjeevan K. V., Combined Surgical Intervention and Medical Management in a Case of a Typical Idiopathic Retroperitoneal Fibrosis, International Journal of Urology, Vol. 13 (3), pp. 291-293, 2006
2006 Pradeep P. V., Mishra S. K., Basnet R., Ramalingam K., Nair C. G., Vaidyanathan S., Telementoring in Endocrine Surgery: Preliminary Indian Experience, Telemedicine Journal and e-Health, Vol. 12 (1), pp. 73-77, 2006
2006 Rajiv Mehta, Shine Sadasivan, Balakrishnan V., Prem Nair, Puneet Dhar, Narayanan V. A., Anil John, Nandakumar R., Factors Predicting Successful Outcome Following First Dose of Neostigmine in Acute Colonic Pseudo Obstruction: a Prospective Study, Journal of Gastroenterology and Hepatology, Vol. 21 (2), pp. 459-461, 2006
2006 Abraham M. K., Joy M. G., Ramakrishnan P., Bindu S., Menon S. S., A Simple and Safe Technique for Pneumatic Reduction of Intussuception, Journal of Surgery, Vol. 29 (3), pp. 170-172, 2006
2006 I. R. Samal, M. Maneesh, A. Chakrabarty, Evidence for Systemic Oxidative Stress in Tobacco Chewers, Scandinavian Journal of Clinical Laboratory Investigations, Vol. 66, pp. 517-522, 2006.
2006 Sumithra S., Aswathy S., Self Reported Morbidity and Awareness Regarding Common Cancers in Elderly Women, Journal of Communicable diseases, Vol. 38, 2006
2006 J. Kalavathy Elango, P. Gangadharan, M. A. Kuriakose, S. Sumithra, Trends of Head and Neck Cancers in Urban and Rural India, Asian Pacific Journal of Cancer Prevention, Vol. 7, pp. 108-112, 2006.
2006 Rakesh K. V., N. S., Pillai B. K., Satheesh P. P., Joby M., Erratum: Design and Characterization of Total Skin Electron Beam Irradiation Facility with High Energy Linear Accelerator, Journal of Medical Physics, Vol. 31 (4), 2006.
2006 Saheed M. C. S., Sudhindran S., Vishnuprìya N., Laparoscopic Live-donor Nephrectomy, BJU International, Vol. 98 (5), pp. 1121-1122, 2006.
2006 Betigeri V. M., Kareem R. A., Nair S. K., Kamath P., Nair S. G., Nair R. S., Left Ventricular Posterior Wall Pseudoaneurysm: A Rare Sequel of Mitral Valve Infective Endocarditis in a Chronic Patient of HL B27 Positive Spondyloarthritis, Annals of Thoracic Surgery, Vol. 82 (6), pp. 2294-2296, 2006.
2006 Supe S. S., K. M., Sankar B. N., Jacob S., Naveen T., Spinal Cord Response to Altered Fractionation and Re-irradiation: Radiobiological Considerations and Role of Bioeffect Models, Journal of Cancer Research and Therapeutics, Vol. 2 (3), pp. 105-118, 2006.
2006 Sasidharan B., Moideen I., Shivaprakasha K., Rao S. G., Nair S. G., Koshy S., Prabhu A., Warrier G.,Cardiac Herniation Following Closure of Atrial Septal Defect Through Limited Posterior Thoracotomy, Interactive Cardiovascular and Thoracic Surgery, Vol. 5 (3), pp. 272-274, 2006.
2006 Ajith Nambiar, Schwannoma of the Penis: A Common Tumour at Rare Site, Scandinavian Journal of Urology and Nephrology, Vol. 4, pp. 166-167, 2006.
2006 Mohan Abraham, A Safe and Simple Technique for Reduction of Intussusception, Asian Journal of Surgery (3), pp. 170-172, 2006.
2006 P. Jayalekshmi, Paleth Gangadharan and K. S. Mani, Cancer in Women in Kerala – A Transition from Less-developed State, Asian Pacific Journal of Cancer Prevention, Vol. 7, pp. 186-190, 2006.
2006 Seema Nair, Sam Peter, A. K.K. Unni, Sujatha Sistla, Abilash S., Incidence of Mycotic Infections in Diabetic Foot, International Journal of Culture Collection, Vol. 5, pp. 11-13, 2006.
2006 Dhar P., Sudhindran S., Moorthy S., Jayaraman M., Inferior Pancreaticoduodenal Artery Pseudoaneurysm A rare Presentation and Novel Therapy, Hepatogastroenterology, Vol. 53, 2006.
2006 Ramesh M. K., Sastry R. A., Ellis-Grosse E. J., Dhar P., Ashok A. C., Rekha A., Tigecycline as Effective as Imipenem/Cilastatin in the Treatment of Complicated Intra-abdominal Infections: Experience in India, Clinical Microbiology and Infection, Vol. 2 (12), 2006.
2006 B. R. J. Kannan, Haridas K. K., Anil S. R., Kumar R. K., Bioptome-assisted Closure of the Pulmonary Arterial Fistula, Journal of Vascular and Interventional Radiology, 2006.
2006 Kuriakose M. A., Rajeev Sharan, Oral Cancer Prevention, Journal of Oral and Maxillofacial Surgery Clinics of North America, Vol. 18 (4), November 2006.
2006 J. Kalavathy Elango, Gangadharan P., Kuriakose M. A., Sumithra S., Trends of Head and Neck Cancers in Urban and Rural India, Asia Pacific Journal of Cancer Prevention, Vol. 7 (1), pp. 108-112, Jan-Mar 2006.
2006 Debnath U. K., Guha A. R., Evans G. A., Varghese J., Karlakki S., Combined Femoral and Chiari Osteotomies for Reconstruction of the Painful Subluxation or Dislocation of the Hip in Cerebral Palsy: A Long-term Outcome Study, Journal of Bone and Joint Surgery - Series B, Vol. 88 (10), pp. 1373-1378, 2006. /td>
2006 John J., Manoj P., Satyaprasad V., Chandrasekharan A. P., Nair S. G., Paraplegia After Thoracotomy: An Unusual Cause, Journal of Cardiothoracic and Vascular Anesthesia, Vol. 20 (5), pp. 696-699, 2006.
2006 Geeta S. N., Padmanabhan T. K., Kuriakose M. A., Iyer S., Pavithran K., Samuel J., Comparison of Acute Toxicities of Two Chemotherapy Schedules, Journal of Cancer Research and Therapeutics, Vol. 2 (3), pp. 100-104, 2006.
2006 V. Usha Menon, K. Vinod Kumar, Harish Kumar, Vasantha Nair, R. K. Sundaram, T. N. Sugathan, Allison Gilchrist, Prevalence of Known and Diabetes and Associated Risk Factors in Central Kerala- ADEPS, Diabetes Research and Clinical Practice, 2006.
2006 Ajit Kumar Varma, A. Bal, Sandhya M. N., Rajesh K., H. Kumar, Efficacy of Polyurethane Foam Dressings in Debrided Diabetic Lower Limb Wounds - Results of a Prospective Study of 48 Type-2 diabetic Patients with operated Lower Limb Wounds, Wounds, Vol. 18 (10), October 2006.
2006 Varghese J., Ajit Nambiar J., Mahajan C. V., Arthroscopic Treatment of Acute Traumatic Posterior Glenohumeral Dislocation and Anatomic Neck Fracture, Arthroscopy, Vol. 22, 2006.
2005 Unnikrishnan G., Sudhindran S., Chemoradiotherapy for Rectal Cancer, New England Journal of Medicine, Vol. 352, pp. 509-511, 2005
2005 K. K. Haridas, Effects of Reviparin : a Low-Molecular- Weight Heparin on Mortality; Reinfarction and Strokes in Patients with Acute Myocardial Infarction Presenting With ST- Segment Elevation, Journal of American Medical Association (JAMA), Vol. 293 (4), pp. 427-436, January 2005
2005 K. K. Haridas, Effect of Glucose- Insulin-Potassium Infusion on Mortality in Patients with Acute ST- Segment Elevation Myocardial Infarction. The CREATE-ECLA Randomized Controlled Trial, Journal of American Medical Association (JAMA), Vol. 296 (4), pp. 437-446, January 2005
2005 Georgie T., Vijayakumar M., Haridas K. K., Mahesh K. K., Encasement of the Heart by Calcific Constructive Pericardium - Images in Cardiovascular Medicine, Circulation, Vol. 112, pp. e148-e150, September 2005
2005 Rao A. N., Trace Element Estimation - Methods & Clinical Context, Online Journal of Health and Allied Sciences, Vol. 4 (1), 2005
2005 Renjit Kumar, Treatment of Degenerative Lumbar Stenosis, Physicians Digest, Vol. 13 (4), pp. 84-92, 2005
2005 V. Usha Menon, V. Nair, U. Rajanikanth, H. Kumar, Oncogenic Osteomalacia, The Endocrinologist, Vol. 15 (2), April 2005
2005 Pillai M. G., Unnikrishnan A. G., Kumar H., Jayakumar R. V., Nair V., Diencephalic Cachexia: A Rare Cause for Failure to Thrive, Journal of Pediatrics, Vol. 147 (5), 2005
2005 Indudharan R., Valuyeetham K. A., Raju S., Role of glucocorticoids in Ototopical Antibiotic-Steroid Preparations in the Treatment of Chronic Suppurative Otitis Media, Archives of Medical Research, Vol. 36 (2), pp. 154-158, Mar-Apr 2005
2005 Gandhi V., Unnikrishnan G., Sudhindran S., Balakrishnan D., Ruptured Mycotic Aneurysm of Peroneal Artery, European Journal of Vascular and Endovascular Surgery, Vol. 10 (1), pp. 21-23, 2005
2005 S. Sukumar, H. S. Bhat, K. V. Sanjeevan, C. S. M. Saheed, B. Nair, Haemangiopericytoma of the Prostate- A Rare Case Report and Novel Treatment Strategy, African Journal of Urology, Vol. 11 (3), pp. 236-237, 2005
2005 S. Namboothiri, Renjit Kumar, K. V. Menon, Early Changes in Pulmonary Function Test Following Thoracotomy for Scoliosis Correction, European Spine Journal, Vol. 14 (2), pp. 144-148, 2005
2005 Satheesh J. Philip, Renjit Kumar, K. V. Menon, Morphological Study of Rib Regeneration Following Costectomy in Adolescent Idiopathic Scoliosis, European Spine Journal, Vol. 14 (8), pp. 772-776, 2005
2005 Hardikar J. V., Reddy Y. C., Suresh K. R., Santa Rao G., Prasad E. D., Shilotri P. P., Varma N., Bung D. D., Efficacy of Recombinant Human Platelet-Derived Growth Factor (rhPDGF) Based Gel in Diabetic Foot Ulcers: A Randomized; Multicenter; Double-blind Placebo-Controlled Study in India, Wounds, Vol. 17 (6), pp. 141-152, 2005
2005 Pillai M. G., Unnikrishnan A. G., Kumar H., Jayakumar R. V., Nair V., Diencephalic Cachexia: A Rare Cause for Failure to Thrive, Journal of Pediatrics, Vol. 147 (5), 2005
2005 Bhaskaran S., Unnikrishnan A. G., Jayakumar R. V., Nair V., Kumar H., A Tale of Three Tumours, Postgraduate Medical Journal, Vol. 81, 2005
2005 Muthipeedika J. M. A., Moosa A., Kostic V. S., Suchowersky O., Kumar A., Bilateral Chorea-Ballism Associated with Hyperthyroidism, Movement Disorders, Vol. 20 (4), 2005
2005 Pillay V. V., Kumar K. U., Vishnuprìya N., Rajesh R. R., Krishnaprasad R., A Most Memorable Experience: A Unique Case of Attempted Murder with B Complex Vitamins, Anil Aggrawal's Internet Journal of Forensic Medicine and Toxicology, Vol. 6 (1), 2005
2005 Pillay V. V., Toxicology: Need of the Hour, Anil Aggrawal's Internet Journal of Forensic Medicine and Toxicology, Vol. 6 (1), 2005
2004 Geetha, R. Kedlaya and D. M. Vasudevan, Inhibition of Lipid Peroxidation by Botanical Extracts of Ocimum Sanctum: In Vivo and in Vitro Studies, Life Sciences, Vol. 76, pp. 21-28, 2004
2004 Madumita K., Sreekumar K. P., Indudharan R., Malini H., Tracheal Haemangioma: Case Report, The Journal of Laryngology and Otology, August 2004
2004 Balakrishnan V., Sikka S., Bhatia S., Tegaserod is Effective and Well-tolerated in the Indian Population with IBS-C, Journal of Gastroenterology and Hepatology, Vol. 19, 2004
2004 A. G. Unnikrishnan, H. Kumar, Obesity: A Chronic Disease Needing Therapy, Obesity Matters, pp. 3-5, 2004
2004 Vijayakumar, T. Rajesh, K. K. Haridas, Prasanna kumar, Intra Arterial Thrombolysis for Left Middle Cerebral Artery Embolic Stroke During Percutaneous Mitral Commissurotomy, Catheterization and Cardiovascular Interventions, Vol. 62 (2), pp. 249-251, June 2004
2004 Elango E. M., Asita H., Nidhi G., Seema P., Banerji A., Kuriakose M. A., Inhibition of Cyclooxygenase-2 by Diallyl Sulfides (DAS) in HEK 293T cells, Journal of Applied Genetics, Vol. 45 (4), pp. 469-471, 2004
2004 Moosa A., Joy M. A., Kumar A., Extensive Radiculopathy: Another False Localizing Sign in Intracranial Hypertension, Journal of Neurology Neurosurgery and Psychiatry, Vol. 75 (7), pp. 1080-1081, 2004
2004 Vaidyanathan B., Kannan B. R., Kumar R. K., Images in Cardiovascular Medicine. Catheter Closure of Pseudoaneurysm of the Main Pulmonary Artery, Circulation, Vol. 110 (13), pp. e322-e323, 2004
2004 Moideen I., Nair S .G., Cherian A., Anomalous Origin of the Left Coronary Artery from the Right Pulmonary Artery Complicating a Case of Coarctation of the Aorta, Journal of Cardiothoracic and Vascular Anesthesia, Vol. 18 (3), pp. 327-331, 2004
2004 Kuriakose M. A., Chen WT& He ZM, Chen F. A., Delacure M. D., Elango EM & Sikora A. G., Brown S. M., McMunn-Coffran C., Hsu D. F., Qiu W. L., Zhang Z. Y., Zhang P., Selection and Validation of Differentially Expressed Genes in Head and Neck Cancer, Cellular and Molecular Life Sciences, Vol. 61 (11), pp. 1372-1383, 2004
2004 Elango E. M., Asita H., Kuriakose M. A., Banerji A., Seema P., Nidhi G., Inhibition of Cyclooxygenase - 2 by Diallyl Sulfides (DAS) in HEK 293T Cells, Journal of Applied Genetics, Vol. 45 (4), pp. 469-471, 2004
2004 K. V. Kumar, A. P. Radhakrishnan, H. Kumar, V. Nair, Erectile Dysfunction in Diabetic Men, International Journal of Diabetes in developing countries, Vol. 24 (1), pp. 23-26, 2004
2004 Pillai A., Rajeev K., Unnikrishnan M., Chandi S., Intrinsic Brainstem Choroid Plexus Papilloma - Case Report, Journal of Neurosurgery, Vol. 100, pp. 1076-1078, 2004
2004 Bhatt M., Roth S. J., Rao S. G., Shivaprakasha K., Chengode S., Nair S. G., Gauvreau K., Kumar R. K., Management of Infants with Large Unrepaired Ventricular Septal Defects and Respiratory Infection Requiring Mechanical Ventilation, Journal of Thoracic and Cardiovascular Surgery, Vol. 127 (5), pp. 1466-1473, 2004
2004 Balakrishnan V., Changing Time Trends in the Natural History of Tropical Pancreatitis, Journal of Gastroenterology and Hepatology, Vol. 19, 2004
2004 Unnikrishnan A. G., Singh S. K. and Sanjeevi C. B., Prevalence of GAD65 Antibodies in Lean Subjects with Type 2 Diabetes, Annals of the New York Academy of Sciences, Vol. 1037, pp. 118-121, 2004
2004 Unnikrishnan A. G., Tissue Specific Insulin Resistance (Editorial), Postgraduate Medical Journal, Vol. 80, August 2004
2004 Rajan R., Dhar P., Moorthy, Sudhindran S., Praseedom R. K., Role of Contrast CT in Acute Lower Gastrointestinal Bleeding, Digestive Surgery, Vol. 21 (4), pp. 293-296, 2004
2004 Shivaprakasha K., Isaac Rameshkumar, Suresh G. Rao, New Technique Of Right Heart Bypass In Congenital Heart Surgeries With Autologus Lung As Oxygenator, Annals of Thoracic Surgery, Vol. 77, pp. 988-993, 2004
2003 Minnie Pillay, P53 Expression in Oral Cancer: Observations of a South Indian Study, Journal of Experimental and Clinical Cancer Research, Vol. 22 (3), pp. 447-451, 2003
2003 S. Geetha, R. Kedlaya and D. M. Vasudevan, Super Oxide and Hydrogen Peroxide Scavenging Action of Ocimum Sanctum Extracts and their Fraction, Natural Product Sciences, Vol. 9, pp. 223-225, 2003
2003 Rajagopal M. R., From India - Palliative Medicine, Palliative Medicine, Vol. 17 (2), 2003
2003 Rajagopal M. R., Lipman A. G., Mazza D., Commentary: Is Freedom from Pain Truly Possible, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 11-12, 2003
2003 Rajagopal M. R., Lipman A. G., Mazza D., Commentary: On the International Association for Hospice and Palliative Care Traveling Fellowships, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 199-200, 2003
2003 Anil S. R., Sivakumar K., Kumar R. K., Francis E., Philip A., Management Strategies for Hemolysis After Transcatheter Closure of the Patent Arterial Duct, Catheterization and Cardiovascular Interventions, Vol. 59, pp. 538-543, 2003
2003 K. K. Haridas, Vijayakumar, N. Mahesh, T. Rajesh, Viveka kumar, Fracture of Cutting Balloon Microsurgical Blade Inside Coronary Artery During Angioplasty of Tough Restenosis Lesions: A Case Report, Catheterisation & Cardiovascular Interventions, Vol. 58 (2), pp. 199-201, 2003
2003 R. Jaya Kumar, K. V. Menon, T. C. Ranjith, Use of Epidural Analgesia in Pain Management After Major Spinal Surgery, Journal of Orthopaedic Surgery, Vol. 11 (1), pp. 67-72, 2003
2003 Kannan B. R. J., Anil S. R., Kumar R. K., Anomalous Left Coronary Artery From the Anterior Sinus of Pulmonary Artery, Cardiology in the Young, Vol. 13, pp. 95-97, 2003
2003 Sivakumar K., Anil S. R., Kumar R. K., Shivaprakash K., Rao S. G., Closure of Muscular Ventricular Septal Defects Guided by En-face Reconstruction of the Right Ventricular Septal Surface Using Two Dimensional Echocardiography, Annals of Thoracic Surgery, Vol. 76, pp. 158-166, 2003
2003 Kannan B. R. J., Anil S. R., Kumar R. K., Sivakumar K., Transcatheter Closure of the Very Large Atrial Septal Defects Using the Amplatzer Septal Occluder, Catheterization and Cardiovascular Interventions, Vol. 59, pp. 522-527, 2003
2003 Rajagopal M. R., Lipman A. G., Commentary: Acceptance of Palliative Care in Hong Kong, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 75-76, 2003
2003 Rajagopal M. R., Lipman A. G., Mazza D., Palliative Care: Where Do We Go From Here?, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 239-241, 2003
2003 Rajagopal M. R., Lipman A. G., Commentary: Spirituality and Religion in Palliative Care Potential Benefits and Risks, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 167-169, 2003
2003 Rajagopal M. R., Lipman A. G., Commentary: Documenting Thai Palliative Care, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 63-64, 2003
2003 Rajagopal M. R., Lipman A. G., Commentary: Research is Needed to Improve Practice, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 183-184, 2003
2003 Anil S. R., Rao S. G. and Kumar R. K., Duplication of the Tricuspid Valve Apparatus, Cardiology in the Young, Vol. 13, pp. 100-102, 2003
2003 Geetha S., Kedlaya R., D. M. Vasudevan, Superoxide and Hydrogen Peroxide Scavenging Action of Ocimum Sanctum Extracts and their Fractions, Natural Product Sciences, Vol. 9 (4), pp. 223-225, 2003
2003 Rajagopal M. R., Commentary: Lessons From Saudi Arabia, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 51-52, 2003
2003 Rajagopal M. R., Lipman A. G., Commentary On the Experience of Hospice in Uganda (Africa), Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 119-120, 2003
2003 Rajagopal M. R., Venkiteswaran, Palliative Care in India: Successes and Limitations, Journal of Pain and Palliative Care Pharmacotherapy, Vol. 17 (3-4), pp. 121-128, 2003
2002 Haridas K. K., Tapan Ghose & Rakesh R. Sapra, Ram D Yadave & Pramod kumar, Rajiv Agarwal & Madhukar Shah, Balbir Sign & Ajith Bhagwant, Kamal K. Sethi, Saligrama S. Ramesh, Ripen K. Gupta, Upendra Kaul, Pratik Koni & Rajiv Bajaj, Omen P. Mthews, Platelet Glycoprotein Lib/Lia Inhibition Using Eptifibatide with Primary Coronary Artery for Acute Myocardial Infarction- A 30 days Follow-up Study. Integrelin in Acute Myocardial Infarction (INAMI) Stenting Study Investigators, Catheterization and Cardiovascular Interventions, Vol. 51, pp. 497-503, 2002
2002 Balu Vaidyanathan, Roth S. J., Kumar R. K., Shivaprakasha K ., Gauvreau K., Rao S. G., Outcome of Ventricular Septal Defect Repair in a Developing Country, Journal of Pediatrics, Vol. 140, pp. 736-741, 2002
2002 Gopalraj S. Sunil, Sajan Koshy, Suresh G. Rao, Shivaprakasha K., Seetharaman Dhinakar, Limited Right Posterior Thoracotomy Approach to Atrial Septal Defects, Asian Cardiovascular and Thoracic Annals, Vol. 10, pp. 240-243, 2002
2002 Sajan Koshy, Gopalraj Sumangala Sunil, Suresh Gururaja Rao, Krishnanaik Shivaprakasha, Seetharaman Dhinakar, Sivadas Radha Anil, Tricuspid Valve Detachment for Transatrial Closure of Ventricular Septal Defects, Asian Cardiovascular and Thoracic Annals, Vol. 10, pp. 314-317, 2002
2002 Balakrishnan V., Fibrocalculous Pancreatopathy, International Journal of Diabetes in Developing Countries, Vol. 22, 2002
2002 Abraham I., Dhar P., Praseedom R. K., Adjuvant Chemoradiotherapy for Gastric Cancer, New England Journal of Medicine, Vol. 346, pp. 210-211, 2002
2002 Anil S. R., Sivakumar K., Kumar R. K., Coil Occlusion of the Small Patent Ductus Arteriosus Without Arterial Access, Cardiology in the Young, Vol. 12, pp. 51-56, 2002
2002 Srikanth Moorthy, Nirmal Prabhu, Spectrum of MR Imaging Findings in Spinal Tuberculosis, American Journal of Roentgenology, Vol. 179, pp. 979-983, October 2002
2002 Minnie Pillay, Pillay V. V., Forensic Significance of Micro-haemorrhages in Thyroid and Neck tissues, International Journal of Medical Toxicology and Legal Medicine, Vol. 5, pp. 67-68, 2002
2002 Srinivas, B. K., Satyaprasad V., Mahadevan R., Gopalakrishnan M., Lipoma of the Left Ventricle, Asian Cardiovascular and Thoracic Annals, Vol. 10 (1), pp. 64-65, 2002
Year of Publication Title
2015 S. Aswathy and,“An overview of the development and status of national nutritional programs in India”, Journal of Medical Nutrition and Nutraceuticals, vol. 4, p. 5, 2015 Read More»»
2013 Bajaj S, Jawad F, Islam N, Mahtab H, Bhattarai J, Shrestha D, Wijeyaratne C, Muthukuda DT, Widanage NW, Aye TT, Aung MW, Kalra B, Anjana R M, Sreedevi A, Verma K. South Asian women with diabetes: Psychosocial challenges and management: Consensus statement. Indian J Endocr Metab 2013;17:548-62 Read More»»
2013 Aswathy.S,AG Unnikrishnan,Sanjay kalra Effective management of type 2 diabetes in India:looking at low cost adjunctive therapy. Jan-Feb2013,Vol17,Issue 1,149-152. Indian J of Endocrinology &metabolism Indian J of Endocrinology Read More»»
2013 Sanjay Kalra,G.R.Sridhar,yatan pal singh Balhara,Rakesh Kumar Sahay,Ganapathy Bantwal,Manash P.Baruah,Mathew John,Ambika Gopalakrishnan Unnikrishnan,K.Madhu,Komal Verma,Aswathy Sreedevi,Rishi Shukla,K.M Prasanna kumar.National recommendations:Psychosocial management of diabetes in India.IJEMMay-June 2013,Vol17,issue3 Read More»»
2013 Aswathy.S, AG Unnikrishnan,Sanjay kalra,Leelamoni K.Peer Support as a strategy for effective management of diabetes in India. Jan-Feb2013,Vol17,Issue 1,5-7. Indian J of Endocrinology &metabolism. Read More»»
2013 Anu Sasidharan,. Post Infarction Rupture of Heart – A Case Report, Journal of South Indian Medico-legal Association in March 2013 Issue , Volume No. 5, 2013.
2013 Ajay Balachandran, Krishnan B, Liza John, Accidental deaths due to electrocution during amateur electro-fishing, Journal of Evolution of Medical and Dental Sciences, Vol2, Issue 48, December 02; Page: 9376-9379, 2013.
2013 Biju James, Ajay Balachandran, Anu Sasidharan, Ramakrishanan U K, Prem T N, Thomas Jerry, Unusual Incised Stab wound Produced by a Single Edged Weapon: A Case, Indian Journal of Forensic Medicine & Toxicology, Vol. 7, No. 2, July-December, 2013.
2013 Dhanya Lakshmi Narayanan, Dhanya Yesodharan, Mahesh Kappanayil, Shwetha Kuthiroly, M. V. Thampi, Zareena Hamza, Alka Anilkumar, K. Mohandas Nair, K. R. Sundaram, R. Krishna Kumar, Sheela Nampoothiri, Cardiac Spectrum, Cytogenetic Analysis and Thyroid Profile of 418 Children with Down Syndrome from South India: A Cross-sectional Study, Indian J Pediatr, DOI: 10.1007/s12098-013-1088-6, 2013.
2013 Hariharan Gopakumar, Andrea Superti-Furga , Sheila Unger , Gerd Scherer, P. K. Rajiv, Sheela Nampoothiri, Acampomelic Form of Campomelic Dysplasia with SOX9 Missense Mutation, Indian J Pediatr, DOI 0.1007/s12098-013-1007-x, 2013.
2013 Mariyal Vijayakumar, Prakash Kamath, Praveen G Pai, Permanent pacing in a patient with tricuspid prosthesis – widening therapeutic use of coronary sinus. Indian Heart Journal XXX , 1-3 , 2013.
2013 Prasad V. G., Article on organ donation in the August (15-31) issue of Malayalam magazine VANITHA. Title – "Brain Death and Organ Donation". This article tries to clear the frequently asked questions about brain death and organ donation among general public (2013).
2013 Narayanan D. L., Yesodharan D., Kappanayil M., Kuthiroly S., Thampi M. V., Hamza Z. , anilkumar A, Nair K. M., Sundaram K. R., Kumar R. K., Nampoothiri S., Cardiac Spectrum, Cytogenetic Analysis and Thyroid Profile of 418 Children with Down Syndrome from South India:A Cross- sectional Study. Indian J Pediatr. Aug 10, 2013.
2013 Sundaram K. R., Concept and Analysis of Correlation & Regression, Kerala Journal of Ophthalmology,Vol. XXV ,March., 45-50, 2013.
2013 Sundaram K. R., Inference Statistical Methods, Kerala Journal of Ophthalmology, Vol. XXV, June, 2013.
2013 Umadethan B., An Unusual case of thoracic gossypioma, Ann-card An aesthesia, 2013.
2013 Vijaykumar Dehannathparambil Kottarathil, Michelle Aline Antony,Indu R. Nair, Keechilat Pavithran; Recent advances in Granulosa Cell Tumor Ovary: A Review. Indian Journal of Surgical Oncology, Volume 4, Issue 1, Page 37-47, 2013.
2013 Anil Kumar, Phenotypic Screening of Resistance Mechanism in S.aureus, Indian Journal of Medical Research, 137, pp 31-32, March 2013.
2013 Jithin K . S., Sursh G Nair, Rakhi B., Rakhi K . R, Joel Devasia Vazhakatt, Jomson John, Post extubation stridor in Paediatrics cardiac surgery patients, Indian Journal Respiratory care (IJRC), vol. 4, January 2013.
2013 Jithin K . S., Vazkatt Joel Devasia, Suresh G Nair, Basic Principals of respiratory care for managing patients with tracheotomy, Indian Journal of Respiratory Care, January 2013.
2013 Rajan Babu Anupama, Santhosh Kuriakose, D . K . Vijayakumar, K. Pavithran, Annie Jojo, R. Indu Nair, V . S. Sheejamol, Carcinosarcoma of the Uterus-A single Institution Retrospective Analysis of the Management and a Brief Review of Literature, Sringer, Indian Journal Of Surgical Oncology, January 2013.
2013 Praveen P . V., Usha V Menon, Vivek Lakshmanan, Sanjeev Vasudevan, Ajitha Kumari, Harish Kumar, Iodine and thyroid status in a tribal village in Wayanad, Kerala in the post ioxination era – observations and implications, National Journal of Community Medicine, Vol. 4, Issue 1, Jan-March 2013.
2013 Shanmuga Sundram, R. Bharath, Arun Bal, Unnikrishnan A . G, Praveen V . P, Nisha B, Vasantha Nair, Harish Kumar R . V, Jayakumr A., Comparative Study of Zoledronic Acid and Once Weekly Alendonate in the Management of Acute Charcot Arthropathy of Foot Patients with Diabetes Mellitus, Indian Journal of Endocrinology and Metabolism, Vol. 17, issue. 1, January - February 2013.
2013 Vaidyanathan B., Kumar S., Sudhakar A., Kumar R . K., Conotruncal anomalies in the fetus: Referral patterns and pregnancy outcomes in a dedicated fetal cardiology unit in South India, Annals of Pediatric Card, 2013.
2013 Vijayakumar D . K., Michelle Alline Antony, Adult Cell Tumor of Ovary -A Practical Approach, STM Journals, Vol-2 , Issue-2, January 2013.
2013 K R Thankappan, T.R. Yamini, G.K. Mini, C Arthur, P. Sairu, K Leelamoni, etal- Assessing the readiness to integrate tobacco control in medical curriculum: Experiences from five medical colleges in South India. - NMJI – 2013 Jan – Feb.
2012 Aswathy.S, Mariya AQ, Beteena K, Leelamoni K. Cervical Cancer Screening:Current knowledge and practice among women in a rural population of Kerala,India. Aug 2012,pp205-210. Indian J of Medical Research.Read More»»
2012 Bindu Menon, Sandhya Cherkil, Aswathy.S, UnnikrishnanAG, Rajani G . The Process and challenges in the translation of World Health Organization Quality of Life (WHOQOL- BREF) to a Regional Language; Malayalam-.Indian J of Psychological medicine. 2012 Apr;34(2):149-52.Read More»»
2012 Krishnakumar R., Renjitkumar J., Methicillin resistant Staphylococcus aureus vertebral osteomyelitis following epidural catheterization - A case report and literature review. Global Spine Journal, Vol. 2(4), Pp. 231 - 234, May 2012. 
2012 Krishnakumar R., The Efficacy of Transforaminal Epidural Steroid Injections in Lumbosacral Radiculopathy: A Commentary. Neurol India, Vol. 59(6), Pp. 948, January 2012. 
2012 Krishnakumar R., Arun K., Spontaneous Rupture of Quadriceps Tendon and Total Joint Arthroplasty in Alkaptonuria, Kerala Journal of Orthopaedics, Vol. No. 25, Pp. 30-33, 2012.
2012 Feroze K., Ambika Kumar, Camouflage for Patients with Vitiligo, Indian Journal of Dermatology, Venereology and Leprology, Vol 78(1), Pp. 8 - 15, January - February 2012. 
2012 Sheela Nampoothiri, Surjit Singh, K. N. Parameswaran Nampoothiri, Stephanie Boisson-Dupuis, Laurent Abel, Jean-Laurent Casanova, Multifocal Tuberculous Osteomyelitis: Possible Inherited Interferon Gamma Axis Defect, The Indian Journal of Pediatrics, DOI 10.1007/s 12098-012-0720-1, 2012.
2011 Aswathy S,Dinesh S,.Kurian Beteena,Johnson AJ,Leelamoni K.A post epidemic study on awareness of vector habits of Chikungunya and vector indices in a rural area of Kerala J Of Comm dis.43(3)2011:209-15 (published in 2012) Read More»»
2011 Indira Nair L., Open Access Literature : A boon to the researcher, Open Source Software and Libraries, Baby Valsala (Ed) CUSAT 2011.
2011 Krishnakumar R., Renjitkumar J., Postpartum Tuberculous Sacroiliitis - A case report, Amrita Medical Journal, Vol. 7, Pp. 43 - 44, 2011. 
2011 Krishnakumar R., Renjitkumar J., Acute cauda equina syndrome due to primary Ewing's sarcoma of the spine, Neurol India, VOl. 59, Pp. 931-933, 2011. 
2011 Krishnakumar R., Comment on: Use of O-arm for spinal surgery in academic institution in India: Experience from JPN apex trauma centre, Neurol India, Vol. 59, Pp. 795-796, 2011. 
2011 Balu Vaidyanathan, Sathish G., Mohanan S. T., Sundaram K. R., Kumar R. K., Clinical Screening for Congenital Heart Disease at Birth : A ProspectiveStudy in a Community Hospital in Kerala, Indian Pediatrics, 48(1),pp. 25-30, January 2011. 
2011 Anita Rajah, K. R. Sundaram and Anand Kumar, A Change in intellectual and academic performance of children following computer-based training: Preliminary results, Indian Journal of Psychiatry, 53(3), pp. 249-252, 2011. 
2011 Sukumar S., Sivanandam E., Bhat H. S., Mathew G., Sudheer O. V., Dhar P., Revisiting the double-barreled wet colostomy for simultaneous urinary and fecal diversion-an Indian experience, Indian Journal of Gastroenterology, 2011. 
2011 S. Kumar and L. Rajam, Posterior Reversible Encephalopathy Syndrom (PRES/RPLS) During Pulse Steroid Therapy in Macrophage Activation Syndrome, Indian Journal of Pediatrics, 78 (8), pp. 1002-1004, 2011. 
2011 Narayanan M. P., Kannan V., Vinayan K. P. and Vasudevan D. M., Diagnosis of Major Organic Acidurias in Children: Two Years Experience at a Tertiary Care Centre, Indian Journal of Clinical Biochemistry, 26 (4), pp. 347-353, 2011. 
2011 Vaidyanathan K., Narayanan M. P., Vasudevan D. M., Organic Acidurias: An Updated Review, Indian Journal of Clinical Biochemistry, 26 (4), pp. 319- 325, 2011. 
2011 D. M. Vasudevan, S. Mukherji and Subir Kumar Das, Effects of Long Term Ethanol Consumption on Cell Death in Liver, Indian Journal of Clinical Biochemistry, 26 (1), pp. 84-87, 2011. 
2011 A. G. Unnikrishnan, Harish Kumar, R. V. Jayakumar, P. Jeyapathy and B. P. Pillai, The promise of Eprotirome, Thyroid Research and Practice, 8(1), pp 3-4, January-April 2011. 
2011 Mehta A. A., Jose W., Pavithran K., Hyperesoinophilic syndrome with FIP1L1 PDGFRa mutation: A case study, Journal of Clinical and Diagnostic Research, 5 (3), pp. 625-627, 2011. 
2010 Bharath R., Unnikrishnan A. G., Thampy M. V., Anilkumar A., Nisha B., Praveen V. P., Nair V., Jayakumar R. V., Kumar H, Turner Syndrome and its Variants, Indian Journal of Pediatrics, Vol. 77 (2), pp. 193-5, 2010.
2010 P. Bhooshan, S. Shivaprakasha, M. Kiran, P. M. S. Karim, K. R. Dinesh, Chronic Subdural Empyema and Cranial Vault Osteomyelitis Due to Salmonella Paratyphi, Indian Journal of Medical Microbiology, Vol. 28 (1), 2010.
2010 Vaidyanathan K., Kumar P., Reddy C. O., Deshmane V., Somasundaram K., Mukherjee G., ErbB-2 Expression and its Association with Other Biological Parameters of Breast Cancer Among Indian Women, Indian Journal of Cancer, Vol. 47 (1), pp. 14-21, 2010.
2010 Kumar S., Janardhanam S., Bagga A., Sinha A., Differential for Neutrophilic Leucocytosis, Indian Journal of Pediatrics, Vol. 77 (2), pp. 219-220, 2010.
2010 Sukumar S., Kumar P. G., Thomas A., Thoracic Curlicue: A Case of Ureteral Herniation, Indian Journal of Urology, Vol. 26 (1), pp. 131-132, 2010.
2010 Unnikrishnan R., Renjitkumar J., Menon V., Adolescent Idiopathic Scoliosis: Retrospective Analysis of 235 Surgically Treated Cases, Indian Journal of Orthopaedics, Vol. 44 (1), pp. 35-41, 2010.
2010 Prasad V., Rajam L., Yatheesha B. L., Reactive Hemophagocytic Syndrome, Indian Journal of Pediatrics, Vol. 75 (12), pp. 1261-1263, 2010.
2010 A. P. Bhooshan, S. Shivaprakasha, K. R. Dinesh, M. Kiran, P. M. S. Karim, Chronic Subdural Empyema and Cranial Vault Osteomyelitis due to Salmonella Paratyphi, Indian Journal of Medical Microbiology, Vol. 28 (1), January-March 2010.
2010 A. Varma, Reconstructive Foot and Ankle Surgeries in Diabetic Patients, Amrita Journal of Medicine, Vol. 6 (1), pp. 6-9, January - June 2010.
2010 P. Gangadharan, Cancer and Its Distribution in India, Amrita Journal of Medicine, Vol. 6 (1), pp. 14-22, January - June 2010.
2010 Kumar Menon, M. Bielefeld, Dinesh Nair, Prem Nair, Role of Mobile Telehospitals in Disaster Response, Amrita Journal of Medicine, Vol. 6 (1), pp. 23-24, January - June 2010.
2010 B.P. Rao, Old is Gold, Amrita Journal of Medicine, Vol. 6 (1), pp. 25-28, January - June 2010.
2010 A.S. Prabhu, A. Borade, GS. Prabhu, SR. Prabhu, S. Chandramohan, Antenatal Diagnosis of Bilateral Multicystic Dysplastic Kidney, Amrita Journal of Medicine, Vol. 6 (1), pp. 36-37, January - June 2010.
2010 L. Gopakumar, L. Kailas, Hema, Inflammatory Pseudotumour, Amrita Journal of Medicine, Vol. 6 (1), pp. 38-39, January - June 2010.
2010 A. Pawar, Sheela Nampoothiri, S. Balakrishnan, L. Kumar, Abnormal Haemoglobins in Infants Presenting for Surgery, Amrita Journal of Medicine, Vol. 6 (1), pp. 40-41, January - June 2010.
2010 A.S. Prabhu, A. Borade, K.P. Vinayan, Walker-Warburg Syndrome: A Case Report, Amrita Journal of Medicine, Vol. 6 (1), pp. 42-444, January - June 2010.
2010 Anita Rajah, K. R. Sundaram, Anand Kumar, A Change in Intellectual and Academic Performance of Children Following Computer-Based Training: Preliminary Results, Indian Journal of Psychiatry, 2010.
2010 Prabhu R., Novel Strategies to Improve Recombinant Factor VIII Production and its in vivo Recovery, Indian Journal of Hematology and Blood Transfusion, 2010.
2010 Katewa A., Katanna H. B. R., Rao S. G., A Simple Technique to Circumvent the Aorto-Pulmonary Size Mismatch in Arterial Switch Operation with Arch Repair: a Report of Five Cases, Indian Journal of Thoracic and Cardiovascular Surgery, 2010.
2010 A. S. Prabhu, S. Balan, Approach to a Child With Monoarthritis, Indian Journal of Pediatrics, 2010.
2010 Feroze Kaliyadan, Undergraduate Dermatology Teaching in India: Need for Change, Indian Journal of Dermatology, Vol. 76 (5), pp. 455-457, 2010.
2010 Bhansali A., Maji D., Rao P. V., Banerjee S., Kumar H., Historical Overview of Incretin Based Therapies, Journal of Association of Physicians of India (58), pp. 10-14, 2010.
2010 Bhattacharyya A., Unnikrishnan A. G., Sahay R. K., Wangnoo S. K., Chadha M., Beneficial Effects of Liraglutide Beyond Glycaemic Control, Journal of Association of Physicians of India (58), pp. 23-28, 2010.
2010 Sivasubramanian S., Moorthy S., Sreekumar K. P., Kannan R. R., Diffusion-Weighted Magnetic Resonance Imaging in Acute Reversible Toxic Leukoencephalopathy: A Report of Two Cases, Indian Journal of Radiology and Imaging, Vol. 20 (3), pp. 192-194, 2010.
2010 Satish S., Rajesh R., Shashikala S., Kurian G., Unni V. N., Cryptococcal Sepsis in Small Vessel Vasculitis, Indian Journal of Nephrology, Vol. 20 (3), pp. 159-161, 2010.
2010 Feroze Kaliyadan, Venkitakrishnan S., Manoj J., Use of a Wood's Lamp as a Ultra-Violet Light Source to Improve the Speed and Quality of Suction Blister Harvesting, Indian Journal of Dermatology, Venereology and Leprology, Vol. 76 (4), pp. 429-431, 2010.
2010 Sundaram P. S., Maramattom B. V., Philip C., Idiopathic Anti-NMDA-Receptor Encephalitis in a Young Indian Girl, Neurology India, Vol. 58 (4), pp. 671-672, 2010.
2010 Raj M., Sundaram K. R., Paul M., Kumar R. K., Blood Pressure Distribution in Indian Children, Indian Pediatrics, Vol. 47 (6), pp. 477-485, 2010.
2010 D. M. Vasudevan, S. Mukherji, Subir Kumar Das, Effects of Long-Term Ethanol Consumption on Adhesion Molecules in Liver, Indian Journal of Experimental Biology, Vol. 48 (4), pp. 394-401, 2010.
2010 Nambiar A., Vivek N., Bindu M., Sudheer O., Bai L., Completeness of Low Anterior Resection Pathology Report: A Hospital-Based Audit With Recommendations on Improving Reporting, Indian Journal of Cancer, Vol. 47 (2), pp. 156-159, 2010.
2010 V. V. Pillay, The Utility of Poison Control Centres in Diagnosing and Managing Cases of Poisoning and Overdose, Journal of the Indian Medical Association, Vol. 108 (3), pp. 162-166, 2010.
2010 D. M. Vasudevan, Das S. K., Mukherjee S., Gupta G., Rao D. N., Protective Effect of Resveratrol and Vitamin E Against Ethanol-Induced Oxidative Damage in Mice: Biochemical and Immunological Basis, Indian Journal of Biochemistry and Biophysics, Vol. 47 (1), pp. 32-37, 2010.
2010 D. M. Vasudevan, Das S. K., Mukherjee S., K. Vaidyanathan, Role of Plasma Amino Acids and GABA in Alcoholic and Non-Alcoholic Fatty Liver Disease - A Pilot Study, Indian Journal of Clinical Biochemistry, Vol. 25 (1), pp. 37-42, 2010.
2010 Iyer S., Kuriakose M., Tensor Facia Lata-Iliac Crest Osteocutaneous Flap for Orbitomaxillary Reconstruction: A Preliminary Report, Indian Journal of Plastic Surgery, Vol. 43 (1), pp. 8-13, 2010.
2010 A. G. Unnikrishnan, Prusty V., Peri-Operative Management of Glucose, Journal of the Indian Medical Association, Vol. 108 (1), pp. 52-55, 2010.
2010 Nair S. G., Kumar R. K., Balachandran R., Establishing a Pediatric Cardiac Intensive Care Unit - Special Considerations in a Limited Resources Environment, Annals of Pediatric Cardiology, Vol. 3 (1), pp. 40-49, 2010.
2010 S. Jain, Balu Vaidyanathan, Oral Anticoagulants in Pediatric Cardiac Practice: A Systematic Review of the Literature, Annals of Pediatric Cardiology, Vol. 3 (1), pp. 31-34, 2010.
2010 Singhi A. K., Mahesh K., Kumar R. K, Pulmonary Edema Following Transcatheter Closure of Atrial Septal Defect, Annals of Pediatric Cardiology, Vol. 3 (1), pp. 90-91, 2010.
2010 A. G. Unnikrishnan, P. Jeyapathy, H. Kumar, R. V. Jayakumar, Subclinical Hypothroidism and Common Bile Duct Stones, Thyroid Research and Practice, Vol. 7 (1), Jan - April 2010.
2010 A. G. Unnikrishnan, B. Nisha, Congenital Hypothyroidism A Primer for the Primary Care Physician, Thyroid Research and Practice, Vol. 7 (1), Jan - April 2010.
2010 A. Ahamed, A. G. Unnikrishnan, B. Nisha, V. P. Praveen, R. V. Jayakumar, Insulin Autoimmune Syndrome (Hirata Disease) Associated with Carbimazole Therapy, Thyroid Research and Practice, Vol. 7 (1), Jan - April 2010.
2010 S. Bhat, A. G. Unnikrishnan, P. Jeyapathy, H. Kumar, R. V. Jayakumar, Glaucoma and Thyroid Disease An Interesting Association, Thyroid Research and Practice, Vol. 7 (2), May - August 2010.
2010 A. G. Unnikrishnan, B. Nisha, Thyroid Status in Metabolic Syndrome, Thyroid Research and Practice, Vol. 7 (2), May - August 2010.
2010 A. G. Unnikrishnan, P. Jeyapathy, B. Pillai, S. Kalra, H. Kumar, R. V. Jayakumar, Needle Tracking Seeding of Tumors After Thyroid Fine Needle Biopsy, Thyroid Research and Practice, Vol. 7 (3), September - December 2010.
2010 V. U . Menon, Gopi Chellan, H. Kumar, S. Moorthy, K. R. Sundaram, R. V. Jayakumar, Normal Thyroid Volume and its Determinants in Healthy Middle Age and Above Female Population in Central Kerala (Amrita Thyroid Survey), Thyroid Research and Practice, Vol. 7 (3), September - December 2010.
2010 A. S. Shinto, L. Pachen, T. K. Sreekanth, Fixed Dose Radioactive Iodine Therapy in Hyperthyroidism Outcome and Factors Affecting it in a Region in South India, Thyroid Research and Practice, Vol. 7 (3), September - December 2010.
2010 Balu Vaidyanathan, Sathish G., Mohanan S. T., Sundaram K. R., Kumar R .K., Clinical Screening for Congenital Heart Disease at Birth : A Prospective Study in a Community Hospital in Kerala, Indian Pediatrics, August 2010.
2010 N. Abraham, A. G. Unnikrishnan, Obesity and the Metabolic Syndrome, Amrita Journal of Medicine, Vol. 6 (2), pp. 5-9, July - December 2010.
2010 H. Gopakumar, M. Geetha, Upper Gastrointestinal Bleeding in Neonates, Amrita Journal of Medicine, Vol. 6 (2), pp. 13-16, July - December 2010.
2010 S. Kurup, F. H. Hirata, Radiography – An Important Diagnostic Tool in Rheumatoid Arthritis of the Temporomandibular Joint, Amrita Journal of Medicine, Vol. 6 (2), pp. 17-22, July - December 2010.
2010 S. Vasudevan, The Health and Life of Tribes: A Health Worker’s Perspective, Amrita Journal of Medicine, Vol. 6 (2), pp. 27-29, July - December 2010.
2010 C. V. Lalithambika, L. Saraswathy, Manu Raj, K. R. Sundaram, Correlation Between Anthropometric Measurements and percentage Body Fat, Amrita Journal of Medicine, Vol. 6 (2), pp. 30-33, July - December 2010.
2010 R. Krishnakumar, J. Renjit Kumar, Diaphyseal Osteomyelitis Masquerading as Osteoid Osteoma, Amrita Journal of Medicine, Vol. 6 (2), pp. 37-38, July-December 2010.
2010 S. Jayakumar, U. K. Menon, M. X. Arun, B. Faizal, Odontogenic Pansinusitis with Orbital Cellulitis in a Child, Amrita Journal of Medicine, Vol. 6 (2), pp. 39-40, July - December 2010.
2010 K. R. Sundaram, J. Amrutha, Teaching - Estimation of Minimum Sample Size and The Impact of Effect Size and Altering The Type - I & II Errors on it in Clinical Research, Amrita Journal of Medicine, Vol. 6 (2), pp. 41-44, July - December 2010.
2010 D. M. Vasudevan, S. Mukherji, Subir Kumar Das, Effects of Long Term Ethanol Consumption on Cell Death in Liver, Indian Journal of Clinical Biochemistry, pp. 1-4, 2010.
2010 Lakshminarayana G., Mathew A., Rajesh R., Kurien G., Unni V. N., A Rare Congenital Anomaly of Urinary Bladder-"Bladder Ears, Indian Journal of Nephrology, Vol. 20 (4), pp. 220-221, 2010.
2010 Satish S., Rajesh R., Kurian G., Seethalekshmi N. V., Unni M., Unni V. N., Recurrent Acute Renal Failure, Indian Journal of Nephrology, Vol. 20 (4), pp. 217-219, 2010.
2010 Aswathy S., Beteena Kurian, Sreeja K. L., S. Valsala, Adarsh Kalapurakal, Amrita Anil Kumar, Anjana A. S., Anju Sarah Thomas, Aparna Prathap, Archana Rajendran Nair, Effect of Music on Comprehension and Recall among Medical Students in Kerala, National Medical Journal of India, Vol. 23 (6), 2010. Read More»»
2010 Chakravarthy M., Sanjeev Singh, Arora A., Sengupta S., Munshi N., The Epinet Data of Four Indian Hospitals on Incidence of Exposure of Healthcare Workers to Blood and Body Fluid: A Multicentric Prospective Analysis, Indian Journal of Medical Sciences, Vol. 64 (12), pp. 540-551, 2010.
2010 M. Raj, R. K. Kumar, Obesity in Children and Adolescents, Indian Journal of Medical Research, Vol. 132 (11), pp. 598-607, 2010.
2010 Sundaram P. S., Padma S., Rai J. K., Harish V., Staring Secondaries, Where is the Primary?, Indian Journal of Medical and Paediatric Oncology, Vol. 31 (4), pp. 148-150, 2010.
2010 S. G. Nair, Atrial Fibrillation After Cardiac Surgery, Annals of Cardiac Anaesthesia, Vol. 13 (3), pp. 196-205, 2010.
2010 Sheikh Z. A., Nair I., Vijaykumar D. K., Jojo A., Nandeesh M., Neuroendocrine Tumor of Vulva: A Case Report and Review of Literature, Journal of Cancer Research and Therapeutics, Vol. 6 (3), pp. 365-366, 2010.
2010 Retnamma R. K., Nair S. G., Umadethan B., Manoj P., An Unusual Case of Thoracic Gossypiboma, Annals of Cardiac Anaesthesia, Vol. 13 (3), pp. 261-263, 2010.
2010 Singhi A. K., Mahesh K., Kumar R. K., Isolated Absence of Right Pulmonary Artery, Annals of Pediatric Cardiology, Vol. 3 (2), pp. 119-122, 2010.
2009 V. Sunitha, M. G. Usha, S. Nampoothiri, Mucopolysaccharidosis Type 1 (Hurler syndrome): Prenatal Dagnosis and Recent Advances, Amrita Journal of Medicine, Vol. 5 (2), pp. 23-25, July-December 2009.
2009 Subir Kumar Das, Sukhes Mukherjee, Gaurav Pandey, V. Balakrishnan, D. M. Vasudevan, Clinicopathological Spectrum of Non-alcoholic Fatty Liver Disease Among Patients in Kerala, Indian Journal of Biochemistry, Vol. 24 (25), pp. 155-158, 2009.
2009 P. Ganesan, M. Prabhu, S. Sivaprakash, P. Jacob, S. Vaidyanathan, Canine Heart to Human Skin: Increased Prevalence of Dirofilaria in Kerala, Amrita Journal of Medicine, Vol. 5 (2), pp. 38-41, 2009.
2009 Mailankot M., Jayalekshmi H., Chakrabarti A., D. M. Vasudevan, Effect of Exogenous Lornithine L-aspartate on Ethanol Induced Testicular Injury in Wistar Rats, Indian Journal of Clinical Biochemistry, Vol. 24 (1), pp. 94-97, 2009.
2009 Feroze Kaliyadan, Manoj J., Dharmaratnam A. D., Multiple Cutaneous Leiomyomas: Pain Relief with Pulsed Hysocine Butyl Bromide, Indian Journal of Dermatology, Vol. 54 (1), pp. 72-74, 2009.
2009 Sabitha P., Vaidyanathan K., D. M. Vasudevan, Kamath P., Comparison of Lipid Profile and Antioxidant Enzymes Among South Indian Men Consuming Coconut Oil and Sunflower Oil, Indian Journal of Clinical Biochemistry, Vol. 24 (1), pp. 76-81, 2009.
2009 Sukhes Mukherjee, Subir Kumar Das, D. M. Vasudevan, Role of Polyphenols in Diet and Nutrition; An Updated Review, Current Nutrition and Food Science, Vol. 5 (2), pp. 149-159, 2009.
2009 Subhakumari K. N., Jagathlal P. C., Anuja P. S., Importance of Tacrolimus Measurement and Assessment of its Toxicity in Monitoring Post Liver Transplantation Patients, Indian Journal of Clinical Biochemistry, Vol. 24, pp. 7-23, 2009.
2009 Nandini, Leela Menon N., Evaluation of Procalcitionin on a Diagnostics Marker of Sepsis, Indian Jounal of Clinical Biochemistry, Vol. 24, pp. 7-21, 2009.
2009 Jayakumar N., Sujaya P., Kannan V., Elisa Based Evaluation of 17a Hydroxy Progesterone as a Diagnostic Marker for Congenital Adrenal Hyperplasia and Assessment of Hyperhomocysteinemia in CAD and Cerebrovascular Accidants, Indian Journal of Clinical Biochemistry, Vol. 24, pp. 1-22, 2009.
2009 Sajitha Krishnan, Mrudula E. V., Comparison of Various Parameters with the Serum Free Light Chain Assay in the Diagnostic Multiple Myeloma, Indian Journal of Clinical Biochemistry, Vol. 24, pp. 219-220, 2009.
2009 Sweetha Mary Mammen, Subhakumari K. N., Thampi M. V., Hyperprolinemia in 22q.11 Deletion Syndromes and its Association with Neurological Deficits, Indian Journal of Clinical Biochemistry, Vol. 24, pp. 1-14, 2009.
2009 B. Vandana, V. Kannan, T. K. Sindu, L. Saraswathy, H. Kumar, Integrated Amrita Meditation Technique Lowers Adrenaline Levels, Amrita Journal of Medicine, Vol. 5 (1), pp. 28-30, 2009.
2009 Aswathi K. I., Narayanan M. P., Kannan Vaidyanathan, A Study on Organic Aciduria: Detection and Quantification Using HPLC, Indian Journal of Clinical Biochemistry, Vol. 24, 2009.
2009 Amalmol Peter, Kannan Vaidyanathan, Standardisation of Chromatographic Techniques: HPLC & GC – A Diagnostic Tool for Inborn Errors of Metabolism, Indian Journal of Clinical Biochemistry, Vol. 24, pp. 110-111, 2009.
2009 M. P. Narayanan, Kannan Vaidyanathan, O. Gajendra, S. Shine, Balakrishnan V., Faecal Calprotectin in Inflammatory Bowel Diseases, Indian Journal of Clinical Biochemistry, Vol. 24, pp. 111-112, 2009.
2009 Kannan Vaidyanathan, Aminoacidurias – Diagnosis by HPLC – Interesting Cases, Indian Journal of Clinical Biochemistry, Vol. 24, 2009.
2009 Borade A., Prabhu A. S., Kumar S., Prasad V., Rajam L., Magnetic Resonance Imaging Findings in Ophthalmoplegic Migraine, Journal of Postgraduate Medicine, Vol. 55 (2), pp. 137-138, 2009.
2009 S. K. Das, Varadhan S., Dhanya L., Mukherjee S., Mohana S., Balakrishnan V., D. M. Vasudevan, Diagnostic Efficiency of Amylase and Type IV Collagen in Predicting Chronic Pancreatitis, Indian Journal of Clinical Biochemistry, Vol. 24 (1), pp. 60-64, 2009.
2009 Girish P. Pandey, Sukhes Mukherjee, Kannan Vaidyanathan, D. M. Vasudevan, Role of Plasma Homocysteine Level in Coronary Artery Disease and Stroke- A Clinical Perspective, Indian Journal of Clinical Biochemistry, Vol. 24, 2009.
2009 M. P. Narayanan, Kannan Vaidyanathan, D. M. Vasudevan, Diagnosis of Organic Acidurias in Children – 2 Years Experience in a Tertiary Care Center, Indian Journal of Clinical Biochemistry, Vol. 24, 2009.
2009 Raj M., Sundaram K. R., Kumar R. K., Paul M., Blood Pressure Distribution in Children, Indian Pediatrics, 2009.
2009 K. Ramakrishnan, Anaemia as a Risk Factor for Childhood Asthma, Lung India, 2009.
2009 Kumar R. K., Paul M., Francis P. T., Rheumatic Heart Disease in India: Are We Ready to Shift from Secondary Prophylaxis to Vaccinating High risk Children, Current Science, Vol. 97 (3), pp. 397-404, 2009.
2009 Rajesh G., Elango E. M., Balakrishnan V., Vidya V., Genotype-phenotype Correlation in 9 Patients with Tropical Pancreatitis and Identified Gene Mutations, Indian Journal of Gasteroenterology, Vol. 28 (2), pp. 68-71, 2009.
2009 G. Lakshminarayana, R. Rajesh, G. Kurian, V. N. Unni, Zygomycosis in a Renal Allograft Recipient, Indian Journal of Nephrology, Vol. 19 (1), pp. 30-33, 2009.
2009 A. Mathew, B. Brahmbhatt, R. Rajesh, G. Kurian, V. N. Unni, Page Kidney, Indian Journal of Nephrology, Vol. 19, pp. 170-71, 2009.
2009 Thankaan K., Trivedi N. P., Sharma M., Kuriakose M. A., Iyer S., Free Radial Forearm Adiposo-fascial Flap for Inferior Maxillectomy Defect Reconstruction, Indian Journal of Plastic Surgery, Vol. 42 (1), pp. 100-103, 2009.
2009 S. K. Das, Varadhan S., Gupta G., Mukherjee S., Dhanya L., Rao D. N., D. M. Vasudevan, Time-dependent Effects of Ethanol on Blood Oxidative Stress Parameters and Cytokines, Indian Journal of Biochemistry and Biophysics, Vol. 46 (1), pp. 116-121, 2009.
2009 Nampoothiri S., Anikster Y., Carbonic Anhydrase II Deficiency: A Novel Mutation, Indian Pediatrics, Vol. 46 (6), pp. 532-534, 2009.
2009 Kaliyadan F., Dharmaratnam A. D., Manoj J., Venkitakrishnan, Electronic Medical Records in Dermatology, Indian Journal of Dermatology; Venereology and Leprology, Vol. 75 (2), pp. 157-161, 2009.
2009 Nayar P. G., Development in Drug Delivery with Special Reference to Nanotechnology, Indian Journal of Toxicology, 2009.
2009 Usha Menon V., Sundaram K. R., Unnikrishnan A. G., Jayakumar R. V., Nair V., Kumar H., High Prevalence of Undetected Thyroid Disorders in an Iodine Sufficient Adult South Indian Population, Journal of the Indian Medical Association, Vol. 107 (2), pp. 72-77, 2009.
2009 Ramakrishnan K., Sajitha S. Nair, Sathyajith Nair, Hyper Calcemia and Metastatic Calcification in a Neonate with Subcutaneous Fat Necrosis, Indian Jounal of Pediatrics, Vol. 76, pp. 1155-1157, 2009.
2009 V. V. Pillay, Camphor Ingestion: An Unusual Cause of Seizure, Journal of the Association of Physicians of India, Vol. 57 (3), 2009.
2009 Srinivas L., Kumar R. K., Case Studies of Congenital Heart Disease with Pulmonary Hypertension: Atrial Septal Defect, PVRI review, Vol. 1, pp. 183-187, 2009.
2009 Kumar R. K., The Nuts and Bolts of Pediatric Heart Care for the Economically Challenged, Annals of Pediatric Cardiology, Vol. 2, pp. 99-102, 2009.
2009 Jain S., Kiran K., Kumar R. K., Advances in Pediatric Cardiac Emergencies, Indian Journal of Practical Pediatrics, 2009.
2009 Kumar R. K., Guidelines for Management of Pulmonary Hypertension in Congenital Heart Disease: Unique Opportunity to Address an Urgent Need, PVRI review, Vol. 1, pp. 109-110, 2009.
2009 Vaidyanathan Balu, Is There a Role for Carvedilol in the Management of Pediatric Heart Failure: A Meta-Analysis and E-mail Survey, Annals of Pediatric Cardiology, Vol. 2, pp. 74-78, 2009.
2009 Feroze Kaliyadan, Jayasree Manoj, Venkitakrishnan S., Acrokeratosis Verruciformis of Hopf Associated with Dilated Cardiomyopathy, Indian Journal of Dermatology, Vol. 54 (3), pp. 296-297, 2009.
2009 Feroze Kaliyadan, Venkitakrishnan S., Teledermatology – Clinical Case Profiles and Practical Issues – A Study, Indian Journal of Dermatology; Venereology and Leprology, Vol. 75 (1), pp. 32-35, 2009.
2009 Feroze Kaliyadan, Jayasree Manoj, Dharmaratnam A. D., Type 2 Segmental Leiomyoma –Response to Treatment with Pulsed Hyoscine Butyl Bromide, Indian Journal of Dermatology, Vol. 54 (1), pp. 72-74, 2009.
2009 Feroze Kaliyadan, Gopinath S., Jayasree M. G., Parmar C., Isomorphic and Isotopic Phenomenon Occurring Simultaneously in a Case of Granuloma Annulare, Journal of Dermatology; Venereology and Leprology, Vol. 75, pp. 307-9, 2009.
2009 Balu Vaidyanathan, R. Krishna Kumar, Fetal Echocardiography, Manorama Aragyam Health Magazine, 2009.
2009 Prasad V., Rajam L., Borade A., Cardiogenic Shock with Hypereosinophilic Syndrome, Indian Pediatrics, Vol. 46 (9), pp. 801-803, 2009.
2009 Feroze Kaliyadan, Ganesan T. S., Lichen Planus Associated with Imatinib Mesylate, Indian Journal of Dermatology; Venereology and Leprology, Vol. 75 (5), pp. 527-528, 2009.
2009 Feroze Kaliyadan, Vinayan K., Fernandes B., Jayasree M., Acral Dyschromatosis with Developmental Regression and Dystonia in a Seven Year- Old Child: Dyschromatosis Symmetrica Hereditaria Variant or a New Syndrome, Indian Journal of Dermatology; Venereology and Leprology, Vol. 75 (4), pp. 412-414, 2009.
2009 S. K. Das, Dhanya L., Varadhan S., Mukherjee S., D. M. Vasudevan, Effects of Chronic Ethanol Consumption in Blood: A Time Dependent Study on Rat, Indian Journal of Clinical Biochemistry, Vol. 24 (3), pp. 301-306, 2009.
2009 Mailankot M., Jayalekshmi H., Chakrabarti A., Alang N., D. M. Vasudevan, Effect of Alpha-tocopherol Sulementation on Renal Oxidative Stress and Na+/K+-Adenosine Triphosphatase in Ethanol Treated Wistar Rats, Indian Journal of Experimental Biology, Vol. 47 (7), pp. 608-610, 2009.
2009 Sivanantham S. E., Mathew G., Bhat S. H., Emerging Role of Multi-detector Computed Tomography in the Diagnosis of Hematuria Following Percutaneous Nephrolithotomy: A Case Scenario, Indian Journal of Urology, Vol. 25 (3), pp. 392-394, 2009.
2009 Feroze Kaliyadan, Dharmaratnam A., Jayasree M. G., Parmar C., Asymptomatic Yellowish Papules and Plaques Over Flexures, Indian Journal of Dermatology; Venereology and Leprology, Vol. 75 (4), pp. 453-454, 2009.
2009 Manu Raj, Obesity in Children- Time Trends and Implications, Indian Journal of Pediatrics, 2009.
2009 Kumar R. K., Teamwork in Pediatric Heart Care, Annals of Pediatric Cardiology, 2009.
2009 Jayaram M., Dhar P., Sudhindran S., Sudheer O. V., Annie Jojo, GIST – a Paradigm Shift from Surgeon to Physician, Amrita Journal of Medicine, 2009.
2009 Feroze Kaliyadan, Enhancing Digital Images Using Unsharp-mask, Indian Journal of Dermatology; Venereology and Leprology, Vol. 75 (6), 2009.
2009 Maurya K., Sivanandam S. E., Sukumar S., Bhat S., Kumar G., Nair B., Concomitant Laparoscopic Urological Procedures: Does it Contribute to Morbidity, Journal of Minimal Access Surgery, Vol. 5 (3), pp. 67-71, 2009.
2009 Reshma K., Bharathi B., Rao A. V., Dinesh M., D. M. Vasudevan, Phagocytosis: A Marker of Decreased Immune Response in Radiation Treated oral Cancers, Biomedical Research, Vol. 20 (1), pp. 75-77, 2009.
2009 Sharath Kumar, Retrospective Analysis of Pediatric SLE in India: A Case Series and An Overview, Annals of Rheumatic Diseases, Vol. 68, 2009.
2009 Altaf Gauhar Haji, Shekhar Sharma, K. Abdul Majeed, Vijaykumar D. K., K. Pavithran, M. Dinesh, Primary Pancreatic Lymphoma: Report of Three Cases with Review of Literature, Indian Journal of Medical and Pediatric Oncology, Vol. 30 (1), pp. 20-23, 2009.
2009 Vijaykumar D. K., Chitrathara K., Shekhar Sharma, Kishore Kumar, K. Pavithran, Epithelial Ovarian Carcinoma at Amrita Institute (Cochin Kerala); A 4 Year Experience, Indian Journal of Medical and Pediatric Oncology, Vol. 30 (1), pp. 24-25, 2009.
2009 Shekhar Sharma, Tumor Markers in Clinical Practice - General Principles and Guidelines, Indian Journal of Medical and Pediatric Oncology, Vol. 30 (1), pp. 1-8, 2009.
2009 Manoj Babu R., Altaf Gauhar Haji, Chitrathara K., Vijaykumar D. K., Jayeta Samanta, Hiran K. R., Primary Transitional Cell Carcinoma of the Fallopian Tube in a Premenopausal Woman: A Case Report and Review of Literature, Indian Journal of Medical and Pediatric Oncology, Vol. 30 (1), pp. 35-38, 2009.
2009 Altaf Gauhar Haji, Shekhar Sharma, Vijaykumar D. K., Poulome Mukherjee, R. Manoj Babu, K. Chitrathara, Primary Mammary Small Cell Carcinoma: A Case Report and Review of the Literature, Indian Journal of Medical and Pediatric Oncology, Vol. 30 (1), pp. 31-34, 2009.
2009 Pramod R. Pillai, Shekhar Sharma, Sheikh Zahoor Ahmed, Vijaykumar D. K., Study of Incidence of Lymphedema in Indian Patients Undergoing Axillary Dissection for Breast Cancer, Indian Journal of Surgical Oncology, Vol. 54, pp. 171-183, 2009.
2009 Harish Kumar, Editorial: Doctors need to be Good Managers, Amrita Journal of Medicine, Vol. 5 (2), July-December 2009.
2009 Harish Kumar, Editorial: The Health Industry is Resilient, Amrita Journal of Medicine, Vol. 5 (1), January-June 2009.
2009 A. Thampi, A. Pankajakshan, Ajit Babu, Cases- Evidence and Verdicts: Peptic Ulcer Diseases and H.Pylori, Amrita Journal of Medicine, Vol. 5 (1), pp. 41-43, January-June 2009.
2009 S. Chatni, S. Sadasivan, V. A. Narayanan, V. Balakrishnan, Chilaiditis Sign, Amrita Journal of Medicine, Vol. 5 (1), January-June 2009.
2009 V. Balakrishnan, Casabianca, Amrita Journal of Medicine, Vol. 5 (1), pp. 34-35, January-June 2009.
2009 B. P. Rao, Jasmine has Enchanting Fragrance, Amrita Journal of Medicine, Vol. 5 (1), pp. 25-27, January-June 2009.
2009 Umadethan B., Ethical and Legal Aspects of Biomedical Research, Amrita Journal of Medicine, Vol. 5 (1), pp. 21-24, January-June 2009.
2009 G. Paul, Depression in Geriatric Population, Amrita Journal of Medicine, Vol. 5 (1), pp. 18-20, January-June 2009.
2009 S. Sharma, Tumor Markers in Clinical Practice – General Principles and Guidelines, Amrita Journal of Medicine, Vol. 5 (1), pp. 10-17, January-June 2009.
2009 C. G. Nair, P. Jacob, R. Riju, Principles of Thyroid Surgery, Thyroid Research and Practice, Vol. 6 (3), pp. 75-78, 2009.
2009 K. Baiju, Diabetes – Cooking oils need Quality, Amrita Journal of Medicine, Vol. 5 (1), pp. 5-9, January-June 2009.
2009 A. G. Unnikrishnan, P. Jeyapathy, R. Bharath, R. V. Jayakumar, H. Kumar, Is Procalcitonin Returning to the Thyroidologist, Thyroid Research and Practice, Vol. 6 (3), pp. 67-69, 2009.
2009 S. Nair, A. Borade, M. Unni, K. Ramakrishnan, Paroxysmal Nocturnal Hemoglobinuria: A Rare Cause of Anemia in Childhood, Amrita Journal of Medicine, Vol. 5 (2), pp. 26-28, July-December 2009.
2009 K. K. Chandrababu, S. Gangavarapu, S. Nampoothiri, Bilateral Carpal Tunnel Syndrome in Children with Mucolipidosis Type III: Two Case Reports, Amrita Journal of Medicine, Vol. 5 (2), pp. 33-37, July-December 2009.
2009 V. Sunitha, M. G. Usha, S. Nampoothiri, Mucopolysaccharidosis Type 1 (Hurler syndrome): Prenatal Dagnosis and Recent Advances, Amrita Journal of Medicine, Vol. 5 (2), pp. 23-25, July-December 2009.
2009 L. Krishnan, R. K. Kumar, S. Vasudevan, A. Sanjeev, Knowledge and Attitude of School Teachers in Wayanad-Kerala towards Rheumatic Fever and Rheumatic Heart Disease, Amrita Journal of Medicine, Vol. 5 (2), pp. 15-19, July-December 2009.
2009 S. K. Ramachandran Nair, Emerging Trends in Hospital Organizations and Services, Amrita Journal of Medicine, Vol. 5 (2), pp. 10-12, July-December 2009.
2009 H. Gopakumar, B. Sunil, P. K. Rajiv, Permissive Hypercapnia in Neonatal Ventilation, Amrita Journal of Medicine, Vol. 5 (2), pp. 5-9, July-December 2009.
2009 Feroze Kaliyadan, Sheela Nampoothiri, Type 4 Ehlers Danlos Syndrome Associated With Factor 7 Deficiency, Indian Journal of Dermatology, Venereology and Leprology, Vol. 74 (6), pp. 664-665, 2009.
2009 John A., Chatni S., Narayanan V. A., Balakrishnan V., Nair P., Seroprevalence of Hepatitis A Virus in Patients With Chronic Liver Disease from Kerala: Impact on Vaccination Policy, Journal of the Indian Medical Association, Vol. 107 (12), pp. 859-861, 2009.
2009 Girish B. N., Gopalakrishna Rajesh, Kannan Vaidyanathan, Vallath Balakrishnan, Fecal Elastase 1 and Acid Steatocrit Estimation in Chronic Pancreatitis, Indian Journal of Gastroenterology, Vol. 28 (6), pp. 201-205, 2009.
2009 Peedikayil M. C., Nair P., Seena S. M., Radhakrishnan L., Sadasivan S., Narayanan V. A., Balakrishnan V., Colorectal Cancer Distribution in 220 Indian Patients Undergoing Colonoscopy, Indian Journal of Gastroenterology, Vol. 28 (6), pp. 212-215, 2009.
2009 A. K. Singhi, R. K .Kumar, Pulmonary Arteriovenous Malformations After Cavopulmonary Anastomosis, Annals of Pediatric Cardiology, Vol. 2 (2), pp. 177-178, July 2009.
2009 S. Jain, Balu Vaidyanathan, Digoxin in Management of Heart Failure in Children: Should it be Continued or Relegated to the History Books, Annals of Pediatric Cardiology, Vol. 2 (2), pp. 149-152, July 2009.
2009 Francis E., Gayathri S., Vaidyanathan B., Kannan B. R. J, Kumar R. K., Balu Vaidyanathan, Emergency Balloon Dilation or Stenting of Critical Coarctation of Aorta in Newborns and Infants: An Effective Interim Palliation, Annals of Pediatric Cardiology, Vol. 2 (2), pp. 111-115, July 2009.
2009 Thankappan K., Duarah S., Trivedi N. P., Panikar D., Kuriakose M. A., Iyer S., Vascularised Fibula Osteocutaneous Flap for Cervical Spinal and Posterior Pharyngeal Wall Reconstruction, Indian Journal of Plastic Surgery, Vol. 42 (2), pp. 252-254, July 2009.
2009 Laxminarayana S, Ponticelli Regimen and Nephrotic Syndrome, Indian Journal of Nephrology, Vol. 19 (3), pp. 126-127, July 2009.
2009 Riju R., Jadhav S., Kanthaswamy R., Jacob P., Nair C. G., Is Total Thyroidectomy Justified in Multinodular Goitre, Journal of the Indian Medical Association, Vol. 107 (4), pp. 223-225, April 2009.
2009 Rajah A., Kumar R. S., Somasundaram C. P., Kumar A. A., Dissociative Fugue in the Elderly, Indian Journal of Psychiatry, Vol. 51 (4), pp. 305-307, 2009.
2008 G. Lakshminarayana, R. Rajesh, N. V. Seethalekshmy, G. Kurian, Unni V. N., Thrombotic Microangipathy with Severe renal Failure in Adenocarcinoma, Indian Journal of Nephrology, Vol. 18 (2), 2008.
2008 Rajesh G., Gajendra O., Siyad I., Geetha M., Bohari H., Narayanan V. A., Cronkhite Canada Syndrome, Journal of Association of Physicians of India, Vol. 56, 2008.
2008 Menezes R. G., Kanchan T., Bodhe A. V., Jagadish Rao, P. P. Lobo, Shetty M., V. V. Pillay, S.W., Academic Promotions: The Dust Has Not Yet Settled, Current Science, Vol. 94 (6), 2008.
2008 Usha Menon V., Guruprasad U., Sundaram K. R., Jayakumar R. V., Nair V., Kumar H., Glycaemic Status and Prevalence of Comorbid Conditions Among People with Diabetes in Kerala, National Medical Journal of India, Vol. 21 (3), pp. 112-115, 2008.
2008 Acharya K. N., Senthil Nathan T. S., Kumar J. R., Menon K. V., Primary and Revision Lumbar Discectomy: A Three-Year Review from One Centre, Indian Journal of Orthopaedics, Vol. 42 (2), pp. 178-181, 2008.
2008 Meenakshi Dhar, Glaucoma Masqueraders, Kerala Journal of Ophthalmology, Vol. 19 (2), pp. 147-157, 2008.
2008 Meenakshi Dhar, Is UBM Useful for Zonular Integrity, Kerala Journal of Ophthalmology, Vol. 19 (2), pp. 147-157, 2008.
2008 Rajesh G., Nair A. S., Narayanan V. A., Balakrishnan V., Acute Pancreatitis in Viral Infections with Possible Progression to Chronic Pancreatitis, Indian Journal of Gastroenterology, Vol. 27 (4), pp. 162-164, 2008.
2008 Srinivas L., Changela V., Francis E., Kumar R. K., Vein of Galen Arteriovenous Malformation: Diagnostic Clues from Echocardiography, Indian Heart Journal, Vol. 60 (4), pp. 349-351, 2008.
2008 G. Lakshminarayana, R . Rajesh, Annie Jojo, G. Kurain, Unni V. N., Reucurrent Hemolytic Virennic Syndrome, Indian Journal of Nephrology, Vol. 18 (3), pp. 127-129, 2008.
2008 S. K. Das, Varadhan S., Dhanya L., Mukherjee S., D. M. Vasudevan, Effects of Chronic Ethanol Exposure on Renal Function Tests and Oxidative Stress in Kidney, Indian Journal of Clinical Biochemistry, Vol. 23 (4), pp. 341-344, 2008.
2008 Vaidyanathan B., Nair S. B., Sundaram K. R., Babu U. K., Shivaprakasha K., Rao S. G., Kumar R. K., Malnutrition in Children with Congenital Heart Disease (CHD): Determinants and Short-Term Impact of Corrective Intervention, Indian Pediatrics, Vol. 45 (7), pp. 541-546, 2008.
2008 Viswanathan S., Bakshi K. D., B. R. J. Kannan, Nair A. C., Kumar R. K., Management of Complications that Arise During Transcatheter Closure of Atrial Septal Defects and Patent Ductus Arteriosus, Indian Heart Journal, 2008.
2008 Kannan Vaidyanathan, D. M. Vasudevan, The Challenge of Metabolic Disorders in India, Amala Research Bulletin, Vol. 27, pp. 278-84, 2008.
2008 Unnikrishnan A. G., Approach to a Patient with a Diabetic Foot, National Medical Journal of India, Vol. 21 (3), pp. 134-137, 2008.
2008 Sundaram K. R., Statistics in Evidence Based Medicine, Amrita Journal of Medicine, Vol. 4 (1), pp. 18-20, 2008.
2008 Shekhar Sharma, Vijaykumar D. K., Altaf Gauhar Haji, Jerry Paul, Transfusion-related Acute Lung Injury: A Case Report and Review of Recent Advances, Amrita Journal of Medicine, Vol. 4 (1), pp. 36-41, 2008.
2008 Nampoothiri S., Mahesh K., Hiran K. R., Sunitha V., Sly Disease: Mucopolysaccharidosis Type VII, Indian Pediatrics, Vol. 45 (10), pp. 859-861, 2008.
2008 V. V. Pillay, Current Views on Antidotal Therapy in Managing Cases of Poisoning and Overdose, Journal of the Association of Physicians of India, Vol. 56, pp. 881-892, 2008.
2008 Viswanathan S., Kumar R. K., Transcatheter Closure of the Patent Ductus Arteriosus, Indian Heart Journal, 2008.
2008 Sharma S. K., Joshy S. R., Kumar A., Unnikrishnan A. G., Hoskote S. S., Moharana A. K., Chakkarwar P. N., Vaz J. A., Efficacy- Safety and Acceptability of Biphasic Insulin Aspart 30 in Indian Patients with Type 2 Diabetes: Results from the PRESENT Study, Journal of Association of Physicians of India, Vol. 56, pp. 859-863, 2008.
2008 Shekhar Sharma, Vijaykumar D. K., A Modified Approach to Intra-thoracic Tumors, Amrita Journal of Medicine, 2008.
2008 Feroze Kaliyadan, Jayasree Manoj, Unni M., Seethlekshmy M., Langerhans Cell Histiocytosis Presenting with Hypopigmented Macules, Indian Journal of Dermatology Venereology and Leprology, Vol. 74 (6), pp. 670-672, 2008.
2008 Shekhar Sharma, Vijaykumar D. K., Altaf Gauhar Haji, Shaji A. K., Irrigation Coupled Bipolar Cautery Unit: A Practical; Economic and Simple Version, Indian Journal of Plastic Surgery, 2008.
2008 Altaf Gauhar Haji, Chitrathara K., Shekhar Sharma, Vijaykumar D. K., Gangadharan V. P., Sqamous Cell Carcinoma in Bladder Extrophy: A Case Report, Indian Journal of Pediatric Medical Oncology, 2008.
2008 Kumari Indira K. S., Sujith John Chandy, Jeyaseelan L., Rashmi Kumar, Saradha Suresh, Antimicrobial Prescription Patterns for Common Acute Infections in Few Selected Rural and Urban Health Facilities of India, Indian Journal of Medical Research, Vol. 128 (2), pp. 165-171, 2008.
2008 Balakrishnan V., What Defines Tropical Pancreatitis? Reply to Letter to Editor, Indian Journal of Gastroenterology, Vol. 27 (1), 2008.
2008 Francis P. T., Non-polio AFP and Polio Eradication, Indian Pediatrics, Vol. 45, pp. 422-423, 2008.
2008 Francis P. T., Let Sabin Guide Polio Eradication in India, Indian Pediatrics, Vol. 45, 2008.
2008 Ghongade Dhananjay Moorthy S., K. P. Sreekumar, Prabhu N. K., Radiology Quiz: Neuroradiology, Indian Journal of Radiology and Imaging, Vol. 18 (1), 2008.
2008 Dayananda L., Moorthy Srikanth, K. P. Sreekumar, Prabhu Nirmal Kumar, Chetan T. N., Infrapopliteal Angioplasties for Limb Salvage in Diabetic Patients: Does the Clinical Outcome Justify its Use?, Indian Journal of Radiology and Imaging, Vol. 18 (2), pp. 156-161, 2008.
2008 Suchithra H., Meenakshi Dhar et al, Assessment of Merits of Clear Corneal Incision over Scelral Tunnel Incision in Phaco Emulsification, Kerala Journal of Ophthalmology (3), pp. 259-262, 2008.
2008 Unnikrishnan A. G., Detroja N. M., Bharath R., Jayakumar R. V., Kumar H., The “Hemi-uncertainty of Papillary Microcarcinoma of the Thyroid, Thyroid Research and Practice, Vol. 1, pp. 3-5, 2008.
2008 Sooraj V., Pande G., Sadasivan S., Narayanan V. A., Balakrishnan V., Fulminant Hepatic Failure for Herpes Simplex Virus, Journal of the Indian Medical Association, Vol. 106 (1), pp. 42-44, 2008.
2008 Unni V. N., Membranoproliferative Glomerulonephritis with Essential Cryoglobulinaemia, Indian Journal of Nephrology, Vol. 18, pp. 87-89, 2008.
2008 Feroze Kaliyadan, Teledermatology in India: Practical Implications, Indian Journal of Medical Science, Vol. 62, pp. 208-14, 2008.
2008 Feroze Kaliyadan, Venkitakrishnan S., Manoj J., L-tryptophan and Scleroderma: Significance of Nutritional Sulements Containing L-tryptophan, Journal of Postgraduate Medicine, Vol. 54, pp. 235-6, 2008.
2008 Feroze Kaliyadan, Jayasree Manoj, S. Venkitakrishnan, Xerosis and Pityriasis Alba-like Changes Associated with Zonisamide, Indian Journal of Dermatology; Vnereology and Leprology, Vol. 74, pp. 165-6, 2008.
2008 Feroze Kaliyadan, HIV and Lupus Erythematosus: A Diagnostic Dilemma, Indian Journal of Dermatology, Vol. 53, pp. 80-2, 2008.
2008 Nampoothiri S., Lakshman L. R., Anilkumar A., Thampi M. V., Partial Trisomy 9q Due to Maternal 9q/17q Translocation, Indian Pediatrics, Vol. 45 (7), pp. 595-592, 2008.
2008 S. K. Das, Vasudevan D. M., Alcohol Induced Effects on Kidney, Indian Journal of Clinical Biochemistry, Vol. 23 (1), pp. 4-9, 2008.
2008 Balakrishnan V., Prevalence of Hepatitis A and Hepatitis E and H Pylori in a Semiurban Population in Kerala, Journal of Indian Medical Association., 2008.
2008 Anuradha S. Rao, Indudharan R., Mucormycosis - Genuinely Sight Threatening and Life Threatening-Case Reports, Kerala Journal of Ophthalmology (2), pp. 197-200, 2008.
2008 Bharat N. S., Indudharan R., Dirofilariasis as an Intra-Orbital Mass, Amrita Journal of Medicine, 2008.
2008 Umadethan B., Medicolegal Aspects of Narcoanalysis, Journal of Karnataka Medico-legal Society, Vol. 117 (2), pp. 7-15, 2008.
2008 Shailaja .T. S., Kavitha R. Dinesh, Shashikala Shivaprakasha, Shamsul Karim P. M., A Case of Mycotic Keratitis Caused by Curvularia Lunata, Journal of the Academy of Clinical Microbiologists, Vol. 10 (1), 2008.
2008 Sharat Kumar, Dettol Poisoning: Clinical Features and Management, Indian Journal of Forensic Medicine & Toxicology, Vol. 2, 2008.
2008 Sharath Kumar, L. Rajam, SoJIA or MAS or HLH: Different Names for the Same Disease?, Indian Journal of Rheumatology, Vol. 3 (3), 2008.
2008 Remadevi K. S., Vaidyanathan Balu, Francis Edwin, B. R. J. Kannan, Kumar Raman Krishna, Balloon Pulmonary Valvotomy as Interim Palliation for Symptomatic Young Infants with Tetralogy of Fallot, Annals of Pediatric Cardiology, Vol. 1 (1), pp. 2-7, 2008.
2008 Vaidyanathan Balu, Drug Therapy: Sildenafil for Post-operative Pulmonary Hypertension and Eisenmenger Syndrome - A Brief Review of Literature and Survey of Expert Opinion, Annals of Pediatric Cardiology, Vol. 1 (1), pp. 70-74, 2008.
2008 Trivedi N., Patel D., Thankan K., Iyer S., Kuriakose M., Stomaplasty – Anterior Advancement Flap and Lateral Splaying of Trachea: A Simple and Effective Technique, Journal of Postgraduate Medicine, Vol. 54 (1), pp. 21-24, 2008.
2008 K. Reshma, M. Dinesh, D. M. Vasudevan, Radioprotective Effects of Ocimum Flavanoids on Leukocyte Oxidants and Antioxidants in Oral Cancer, Indian Journal of Clinical Biochemistry, Vol. 23 (2), pp. 171-175, 2008.
2008 Vijaykumar D. K., Editorial: Chemotherapy for Cervical Cancers, Indian Journal of Surgical Oncology, Vol. 29 (4), 2008.
2008 Pavithran K., N. Prasad, Variants of Multiple Meloma, Amrita Journal of Medicine, Vol. 4 (2), pp. 8-12, July-December 2008.
2008 Nandini V., Relevance of Traditional Health care Systems Today, Amrita Journal of Medicine, Vol. 4 (2), pp. 18-22, July-December 2008.
2008 S. Sharma, S. Sudhindran, Chronic Mesenteric Ischaemia, Amrita Journal of Medicine, Vol. 4 (2), pp. 5-7, 2008.
2008 A. G. Unnikrishnan, Hyperthyroidism related muscular disease, Thyroid Research and Practice, Vol. 5 (3), pp. 70-77, 2008.
2008 P. S. Sundaram, S. Sudha, S. Padma, K. Sasikala, Cytotoxic Effects of low dose 13II Therapy – Assessment of Chromosomal Aberration and Micronucleus as Biomarkers, Thyroid Research and Practice, Vol. 5 (3), pp. 83-89, 2008.
2008 A. G. Unnikrishnan, R. Bharath, R. V. Jayakumar, H. Kumar, Obesity and the central thyrostat, Thyroid Research and Practice, Vol. 5 (2), pp. 35-36, 2008.
2008 A. G. Unnikrishnan, S. Bhat, R. Bharath, R. V. Jayakumar, H. Kumar, Glucocorticoids for Thyroid associated Orbitopathy, Thyroid Research and Practice, Vol. 5 (3), pp. 67-69, 2008.
2008 R. Kariyattil, K. Mariswamappa, N. Patel, Dilip Panikar, Ventriculosubgaleal Shunts in the Management of Post Hemorrhagic and Infective Hydrocephalus, Amrita Journal of Medicine, Vol. 4 (2), pp. 63-65, July-December 2008.
2008 A. G. Unnikrishnan, Michelangelo’s Mass, Amrita Journal of Medicine, Vol. 4 (2), pp. 28-29, July-December 2008.
2008 L. Dayananda, Moorthy S., Sreekumar K. P., Prabhu N. K., Metastasis Induced Acute Pancreatitis – A Rare Initial Manifestation of Small Cell Carcinoma Lung, Amrita Journal of Medicine, Vol. 4 (2), pp. 35-36, July-December 2008.
2008 Aparna J., K. P. Vinayan, S. Rajeev, A. Kumar, An Unusual cause for Transient Ischemic Attacks in Childhood, Amrita Journal of Medicine, Vol. 4 (2), pp. 40-42, July-December 2008.
2008 Harish Kumar, Editorial: The Evidence in Medicine, Amrita Journal of Medicine, Vol. 4 (1), January-June 2008.
2008 M. Raj, M. Paul, Obesity in Children and Adolescents, Amrita Journal of Medicine, Vol. 4 (1), pp. 5-12, January-June 2008.
2008 R. Rajat, D. S. Shaishav, K. P. Gireesh Kumar, Hypercoagulable States, Amrita Journal of Medicine, Vol. 4 (1), pp. 13-18, January-June 2008.
2008 L. Krishnan, S. Vasudevan, S. Ajitha, R. K. Kumar, Control Strategies for Rheumatic Fever and Rheumatic Heart Disease in Wayanad; Kerala, Amrita Journal of Medicine, Vol. 4 (1), pp. 24-26, January-June 2008.
2008 T. S. Mangalanandan, S. Sajith, R. Manoj, Raghavendra, N. Varma, A. Bal, H. Kumar, Adhesive Felt Offloading in the Healing of Diabetic Foot Ulcers, Amrita Journal of Medicine, Vol. 4 (1), pp. 27-31, January-June 2008.
2008 S. Sharma, O. V. Sudheer, Puneet Dhar, S. Sudhindran, Living Donor Liver Transplant in Acute Hepatic Failure is Aviable Option in Indian context, Amrita Journal of Medicine, Vol. 4 (1), pp. 33-35, January-June 2008.
2008 T. Roy, T. Rony, Ajit Babu, Cases- Evidence and Verdicts Neuroprotection, Amrita Journal of Medicine, Vol. 4 (1), pp. 42-44, January-June 2008.
2007 Minnie Pillay, Ruptured Atherosclerotic Aneurysm Masquerading as Inguinal Abscess, Journal of Indian Medical Association, 2007.
2007 Subir Kumar Das, Hiran K. R., Sukhesh Mukherjee, D. M. Vasudevan, Oxidative Stress is the Primary Event: Effects of Ethanol Consumption in Brain, Indian Journal of Clinical Biochemistry, Vol. 22 (1), pp. 99-104, 2007.
2007 M. Maneesh, Suanjiba Dutta, Amit Chakrabarti, D. M. Vasudevan, Experimental Therapeutic Intervention with Alpha Tocopherol in Ethanol Induced Testicular Injuries in Rats, Indian Journal of Clinical Biochemistry, Vol. 22 (1), pp. 138-142, 2007.
2007 Subir Kumar Das, Geetanjali Gupta, D. N. Rao, D. M. Vasudevan, Effect of Lecithin with Vitamin B. complex and Tocopheryl Acetate on Long term Effect of Ethanol Induced Immunomodulatory Activities, Indian Journal of Experimental Biology, Vol. 45, pp. 683-688, 2007.
2007 Prathapan Nair, J. C. Varghese, V. N. Unni, Rhinocerebral Mucormycosis in a Patient with Diabetic Nephropathy, Amrita Journal of Medicine, Vol. 3 (2), pp. 34-36, 2007.
2007 Jojo V. V., Rajesh R. R., V. V. Pillay, Identification of Active Principles of Manihot Esculenta and Cerbera Odallum by Thin Layer Chromatography: The Potential for Misinterpretation in Forensic Cases, Journal of the Indian Society of Toxicology, Vol. 3 (1), 2007.
2007 Indira K. S., Medical Ablation of Endobronchial Mucormyioscs with Amptiotecs B, Journal of the Association of Physicians of India, 2007.
2007 R. Indudharan, Vaishali Bafna, Prathapan Nair, Management of Laryngotracheal Stenosis, AOI Cochin newsletter, 2007.
2007 Kannan Vaidyanathan, Role of BRCA1/2 Genes in Hereditary Ovarian Cancer - IISc Experience, Indian Journal of Medical and Pediatric Oncology, Vol. 27 (1), pp. 21-22, 2007.
2007 Mini, Ahsan Moosa N. V., Unnikrishnan, Anand Kumar, Pavithran K., Serendipity at its Best: A Report of Mycoses Fungoides with Hypercalcemia and Bilateral Facial Palsy, Amrita Journal of Medicine, 2007.
2007 Shashikala shivaprakasha, Kavitha Radhakrishna, Prakash Kamath, P. M. Shamsul Karim, Late Prosthetic Valve Endocarditis Due to Carsiobacterium Hominis: An Unusual Complication, Indian Journal of Medical Microbiology, Vol. 25 (1), pp. 64-66, 2007.
2007 Shashikala shivaprakasha, Kavitha Radhakrishnan, P. M. Shamsul Karim, Non-albicans Candida: A Major Cause of Fungaemia in a Tertiary Care Hospital, Indian Journal of Medical Microbiology, Vol. 25 (4), pp. 405-407, 2007.
2007 S. K. Das, Ghosh D., Singhi A., Chattopadhyay S., Chatterjee N., Dural Biopsy – An Important Prognostic Indicator in Tuberculous Meningitis with Hydrocephalus Following Shunt Surgery, Journal of the Indian Medical Association, Vol. 105 (1), pp. 12-15, 2007.
2007 Thachathodiyl R., Cardiac CT: A Personal Clinical Perspective, Indian Journal of Radiology and Imaging, Vol. 17 (1), pp. 24-28, 2007.
2007 Meenakshi Dhar, Niranjan Pehere, Unusual Manifestations of Pituitary Tumors, Kerala Journal of Ophthalmology, Vol. 19 (2), pp. 147-155, 2007.
2007 Rajshree Nambiar, Meenakshi Dhar, Dirofilaria Masquerading as a Cyst in the Muscle, Kerala Journal of Ophthalmology, Vol. 19 (2), pp. 147-157, 2007.
2007 Deepa Janardhanan, Sajitha Nair, T. S. Subramanian, Recurrent Abdominal Pain Due to Hereditary Angioedima, Indian Journal of Paediatrics, Vol. 74, pp. 83-84, 2007.
2007 Vinitha Prasad, Case Report ‘Rabies Encephalitis', Indian Journal of Paediatrics, Vol. 44, 2007.
2007 Sharma S., Vijayakumar D. K., Chithrathara K., Haji A. G., George R. C., K. Pavithran, Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer: A Retrospective Study, Indian Journal of Medical and Pediatric Oncology, Vol. 28 (1), pp. 7-13, 2007.
2007 Sumitra K., Rajesh P. C., Kannan Vaidyanathan, Metabolic Disorders – An AIMS experience, Indian Journal of Clinical Biochemistry, Vol. 22, pp. 226-7, 2007.
2007 Ambady P., Ahsan Moosa N., Anand Kumar A., Syndrome of Spontaneous Cerebrospinal Fluid Hypovolemia: Report of Six Cases, Neurology India, Vol. 55 (4), pp. 382-384, 2007.
2007 Raj M., Sundaram K. R., Paul M., Deepa A. S., Kumar R. K., Obesity in Children – Time Trends and Relationship with Hypertension, National Medical Journal of India, Vol. 20, pp. 288-93, 2007.
2007 Chauhan D. S., Sharma V. D., Parashar D., Chauhan A., Singh D., Singh H.B, Das R., Katoch V. M., Molecular Typing of Mycobacterium Tuberculosis Isolates from Different Parts of India Based on IS6110 Element Polymorphism Using RFLP Analysis, Indian Journal of Medical Research, Vol. 125 (4), pp. 577-581, 2007.
2007 Kamath P., Pacemaker Followup Guidelines for Physicians, The Journal of the Association of Physicians of India, Vol. 55, pp. 66-70, 2007.
2007 Chandrika B. K., Non-neoplastic Renal Diseases in Kerala (India) - Analysis of 1592 Cases: A Two Year Retrospective Study, Indian Journal of Pathology and Microbiology, Vol. 50 (2), pp. 300-302, 2007.
2007 Seema Nair P., Peter Sam, V. V. Pillay, Remya V. M., Krishnaprasad R., Rajammal B., Screening of YSTR Markers in Male Fetal DNA From Maternal Circulation, Indian Journal of Human Genetics (2), pp. 69-72, 2007.
2007 Vijaykumar D. K., Vijayaraghavan Sundeep, Reconstruction of Chest and Abdominal Walls, Indian Journal of Plastic Surgery, Vol. 40 (12), pp. 90-98, 2007.
2007 Manoj Babu, Chitrathara K., Vijaykumar D. K., Haji A. G., Sentinel Node Biopsy in Cervical Cancer - A Pilot Study, Indian Journal of Pediatric and Medical Oncology, Vol. 28 (4), pp. 8-13, 2007.
2007 Chitrathara K., Ovarian Malignancy - Surgical Management, Amrita Journal of Medicine, pp. 5-8, 2007.
2007 Robin George C., Shekhar Sharma, Vijaykumar D. K., Altaf Gauhar Haji, Coexisting Carcinoma Cervix and Hydatidiform Mole-A Case Report, Indian Journal of Pediatric and Medical Oncology, Vol. 28 (4), pp. 29-31, 2007.
2007 Saha A., Kumar S., D. M. Vasudevan, Occupational Injury Surveillance: A Study in a Metal Smelting Industry, Indian Journal of Occupational and Environmental Medicine, Vol. 11 (3), pp. 103-107, 2007.
2007 Panicker J., Acute Disseminated Encephalomyelitis, Annals of Indian Academy of Neurology, Vol. 10 (3), 2007.
2007 Indira K. S., Rajesh V., Darsana V., Ranjit U., John J., Vengada Krishnaraj S. P., Dharmadhikari S. A., Whole Lung Lavage; The Salvage Therapy for Pulmonary Alveolar Proteinosis, Indian Journal of Chest Diseased and Allied Sciences, Vol. 49 (1), pp. 31-34, 2007.
2007 Patel D., Kuriakose M., Iyer S., Reconstruction of the Laryngopharynx, Indian Journal of Plastic Surgery, Vol. 40 (12), pp. 44-51, 2007.
2007 Kuriakose M., Sharma M., Iyer S., Recent Advances and Controversies in Head and Neck Reconstructive Surgery, Indian Journal of Plastic Surgery, Vol. 40 (12), pp. 3-12, 2007.
2007 Rajesh G., Siyad I., Moorthy S., Sooraj V., Saleemhusain S., Bohari, Geetha M., Sadasivan S., Narayanan V. A. & Balakrishnan V., Arterioportal Fistula Presenting as Ascites, Indian Journal of Gastroenterology, Vol. 26 (4), pp. 197-8, 2007.
2007 Balakrishnan V., Gastroenterology in India--A Retrospect, Indian Journal of Gastroenterology, Vol. 26 (1), pp. 13-7, 2007.
2007 Chatni S., Shine S. & Balakrishnan V., Sooraj V., Pande G., Rajesh G., Hussain B., Geetha M., Siyad I., Narayanan V. A., Esophageal Pseudo-tattoo from Ingested Capsule, Indian Journal of Gastroenterology, Vol. 26 (4), 2007.
2007 Unnikrishnan A. G., Buva C. N., Detroja N. M., Kumar H., Jayakumar R. V., Thyroid Autoimmunity in Euthyroid and Hypothyroid Pregnancies, Thyroid Research and Practice, Vol. 3, pp. 3-4, 2007.
2007 Unnikrishnan A. G., Detroja N. M., The Artist and the Goiter: A Tale of Michelangelo’s Angst, Thyroid Research and Practice, Vol. 4, pp. 67-69, 2007.
2007 Unnikrishnan A. G., Pillai M. R., Analysis of GSTM1 and CYP1A1 Genes in Tropical Chronic Pancreatitis, Amrita Journal of Medicine, Vol. 2, pp. 18-22, 2007.
2007 Kumaravel V., Unnikrishnan A. G., Sestamibi Scanning in the Differential Diagnosis of Thyroid Nodules, Indian Journal of Endocrinlogy and Metabolism, pp. 38-42, 2007.
2007 Detroja N. M., Nisha B., Unnikrishnan A. G., Multiple Endocrine Neoplasia-2B, Amrita Journal of Medicine, Vol. 2, pp. 37-40, 2007.
2007 Trivedi N., Kuriakose M., Iyer S., Reconstruction in Skull Base Surgery: Review of Current Concepts, Indian Journal of Plastic Surgery, Vol. 40 (12), pp. 52-59, 2007.
2007 G. Lakshminarayana, R. Rajesh, N. V. Seethalekshmy, Unni V. N., G. Kurian, Atheroembolic Renal Disease Following Thrombolysis, Indian Journal of Nephrology, Vol. 17 (1), pp. 14-17, 2007.
2007 J. C. Varghese, A. Mathew, N. V. Seethalekshmy, Unni V. N., G. Kurian, Isolated Portal Vein Thrombosis in Nephrotic Syndrome, Indian Journal of Nephrology, Vol. 17 (1), pp. 26-28, 2007.
2007 A. Mathew, J. C. Garghese, Unni V. N., G. Kurian, Hereditary Spherocytosis with Nephrotic Syndrome, Indian Journal of Nephrology, Vol. 17 (2), pp. 77-78, 2007.
2007 Feroze Kaliyadan, Sundeep V., Hiran K. R., Fouzia, Late Onset Eccrine Angiomatous Hamartoma Treated with Intralesional Sclerosant, Indian Journal of Dermatalogy, Vol. 52, pp. 99-101, 2007.
2007 Rao A. N., Varma P., Sumitra, Dhanya S., Hyperammonemia: Diagnostic Experience at the Metabolism Laboratory, Perinatology, Vol. 9 (1), pp. 9-13, 2007.
2007 Reshma K., Rao A. V., Dinesh M., D. M. Vasudevan, Effect of Withaferin- A Radiosensitizer; On the Erythrocyte Antioxidants in Carcinoma of Uterine Cervix, Biomedical Research, Vol. 18 (3), pp. 175-178, 2007.
2007 A. G. Unnikrishnan, N.M. Detroja, R.V. Jayakumar, H. Kumar, Predicting Thyroid Disease in type 1 a Diabetes: who will play Nostradamus?, Thyroid Research and Practice, Vol. 4 (2), pp. 35-36, 2007.
2007 Ajith Nambiar, A. Vijayalakshmi, Mixed Medullary and Follicular Carcinoma of the Thyroid: a Citadel Unconquered, Thyroid Research and Practice, Vol. 4 (1), pp. 5-9, 2007.
2007 S. Sumathy, M. G. Usha, N. K. Prabhu, B. Rajammal, Diagnosis of a Rdimentary Horn Pregnancy and its Laproscopic Resection, Amrita Journal of Medicine, Vol. 3 (1), pp. 37-38, Jan-June 2007.
2007 R. Thomas, Ajit Babu, Cases-Evidence and Verdicts – Management issues in COPD and Asthma, Amrita Journal of Medicine, Vol. 3 (1), pp. 41-44, Jan-June 2007.
2007 K. V. Menon, Pyogenic Discitis of the L5-S1 Disk following Inadvertant Placement of Colpopexy Screw, Amrita Journal of Medicine, Vol. 3 (1), pp. 33-36, Jan-June 2007.
2007 J. N. Panicker, Hiran K. R., A. Anand Kumar, Diagnosis Incognito, Amrita Journal of Medicine, Vol. 3 (1), pp. 28-31, Jan-June 2007.
2007 G. S. Pillai, Rajashree Nambiar, Niranjan Pehere, L. Bhat, A. Rao, Meenakshi Dhar, Monoclonal Antibodies in the Eye – A Pilot Study in Diabetic Retinopathy, Amrita Journal of Medicine, Vol. 3 (1), pp. 25-27, Jan-June 2007.
2007 N. P. Trivedi, D. Patel, K. Thankappan, S. Iyer, M. A. Kuriakose, Stomaplasty –Simple amd Effective Technique for Post Laryngectomy Stomal Stenosis, Amrita Journal of Medicine, Vol. 3 (1), pp. 21-24, Jan-June 2007.
2007 J. N. Panicker, Comprehensive Rehabilitation: A New Dawn for the Disabled, Amrita Journal of Medicine, Vol. 3 (2), pp. 9-12, July-December 2007.
2007 B. P. Rao, Caution! Counterfeit Medicines are on the Rise, Amrita Journal of Medicine, Vol. 3 (2), pp. 13-17, July-December 2007.
2007 S. S. Chatni, R. Sharan, S. Iyer, M. A. Kuriakose, Extended Maxillectomy by Transmandibular Approach, Amrita Journal of Medicine, Vol. 3 (2), pp. 23-28, July-December 2007.
2007 Siby G., Syam U. K., Anandkumar A., Hiran, Aneesh G., Nasal Cure for a Myopathy – a Neuroendocrine Puzzle, Amrita Journal of Medicine, Vol. 3 (2), pp. 29-32, July-December 2007.
2007 T. Roy, T. Rony, Ajit Babu, Cases Evidence and Verdicts – The Glitazone Controversy, Amrita Journal of Medicine, Vol. 3 (2), pp. 41-44, July-December 2007.
2007 Harish Kumar, Editorial: Death and Organ Donation, Amrita Journal of Medicine, Vol. 3 (1), Jan-June 2007.
2007 Pavithran K., Adjuvant Systemic Therapy for Breast Cancer, Amrita Journal of Medicine, Vol. 3 (1), pp. 5-7, Jan-June 2007.
2007 Shaishav, Gireesh T., FAQs about Hypomagnesemia, Amrita Journal of Medicine, Vol. 3 (1), pp. 8-12, Jan-June 2007.
2007 S. Sudhindran, Living Donor Liver Transplant in Kerala: Risky not to take the Risk, Amrita Journal of Medicine, Vol. 3 (1), pp. 13-16, Jan-June 2007.
2007 S. K. Ramachandran Nair, Thanatological Thoughts, Amrita Journal of Medicine, Vol. 3 (1), pp. 13-16, Jan-June 2007.
2007 Chithrathara K., Carcinoma of the Ovary, Amrita Journal of Medicine, Vol. 3 (2), pp. 5-8, July-December 2007.
2007 Harish Kumar, Editorial: Commercialization of Medicine, Amrita Journal of Medicine, Vol. 3 (2), July-December 2007.
2007 V. V. Pillay, Paraquat The Underestimated Lethal Pesticide, Journal of the Indian Society of Toxicology, Vol. 3 (2), pp. 11-14, July - December 2007.
2006 Renjit Kumar, K. V. Menon, Jayachandran D., Vertebral Osteochondroma – An Unusual Cause of Compressive Myelopathy – A Case Report of Failed Decompressive Laminectomy, Journal of Orthopedics Association of South Indian States (2), pp. 44-46, 2006.
2006 Subir Kumar Das, D. M. Vasudevan, Effect of Ursodeoxycholic Acid On Ethanol Induced Oxidative Stress in Liver, SFRR-India Bulletin, Vol. 4 (2), pp. 16-20, 2006.
2006 Subir Kumar Das, D. M. Vasudevan, Effect of Lecithin in the Treatment of Ethanol Medicated Free Radical Induced Hepatotoxicity, Indian Journal of Clinical Biochemistry, Vol. 21 (1), pp. 62-69, 2006.
2006 M. Maneesh, Sanjiba Dutta, Amit Chakrabarti, D. M. Vasudevan, Alcohol Abuse-Duration Dependent Decrease in Plasma Testosterone and Antioxidants in Males, Indian Journal of Physiology and Pharmacology, Vol. 50 (3), pp. 291-296, 2006.
2006 Subir Kumar Das, V. Balakrishnan, D. M. Vasudevan, Alcohol: Its Health and Social Impact in India, National Medical Journal of India, Vol. 19 (2), pp. 94-99, 2006.
2006 Ananth N. Rao, Beena V Shetty, D. M. Vasudevan, Positive Influence of Methotrexate - Hydroxy Chloroquine Combination on the Expression of GM-CSF Receptor on Neutrophils of Synovial Fluid in Rheumatoid Arthritis, Indian Journal of Clinical Biochemistry, Vol. 21 (2), pp. 49-52, 2006.
2006 Prasunpriya Nayak, Subir Kumar Das, D. M. Vasudevan, Role of Ethanol on Aluminum Induced Biochemical Changes On Rat Brain, Indian Journal of Clinical Biochemistry, Vol. 21 (2), pp. 53-57, 2006.
2006 S. K. Das, D. M. Vasudevan, Drugs and Non-alcoholic Steatohepatitis, Indian Journal of Pharmacology, Vol. 38, pp. 238-242, 2006.
2006 S. K. Das, D. M. Vasudevan, Modulation of Lecithin Activity by Vitamin-B. complex to Treat Long -term Consumption of Ethanol Induced Oxidative Stress in Liver, Indian Journal of Experimental Biology, Vol. 44, pp. 791-801, 2006.
2006 S. K. Das, D. M. Vasudevan, Protective Effects of Silymarin: A Milk Thistle (Silybium Marianum) Derivative on Ethanol-induced Oxidative Stress in Liver, Indian Journal of Biochemistry & Biophysics, Vol. 43, pp. 306-311, 2006.
2006 S. K. Das, Dey S. S., D. M. Vasudevan, Effect of Fluoride on Thyroid Functions: Myths and Facts, Thyroid Research and Practice, Vol. 3 (1), pp. 16-21, 2006.
2006 Prathapan Nair, Bini Faizal, Madhumita, Intratympanic Gentamycin for Intractable Vertigo in Minieres Disease, Amrita Journal of Medicine, Vol. 2, pp. 3-4, 2006.
2006 V. V. Pillay, How to Set Up a Low-cost Analytical Toxicology Laboratory, Journal of Indian Society for Toxicology, Vol. 2, 2006.
2006 V. V. Pillay, Death Due to Ant Bite – A Case Report, Journal of Indian Society for Toxicology, Vol. 2, pp. 48-50, 2006.
2006 Kuruvila A., V. V. Pillay, Venkitesh T., Adhikari P., Chakrapani M., Rao H. T., Bastia B. K., Rajeev A., Saralaya K. M. & Rai M., Clinical Manifestations of Workers of Mangalore (India), Toxicology and Indian Health (9), pp. 405-13, 2006.
2006 Menezes R. G., Karanth A., Manipady, V. V. Pillay, Jatropha Curcas Poisoning, Indian Journal of Pediatrics, Vol. 73 (7), pp. 634-635, 2006.
2006 Shashikala S., Haarish R., Kavitha R. Dinesh, P. M. Shamsul Karim, Aerobic Bacterial Isolates from Choledochal Bile at Tertiary Hospital, Indian Journal of Pathology & Microbiology, Vol. 49 (3), pp. 464-467, 2006.
2006 Shashikala S., Kavitha Radhakrishnan, P. M. Shamsul Karim, Fatal Trichosporon Asahil Fungemia, Journal of Academy of Clinical Microbiologists, Vol. 8 (1), pp. 41-43, 2006.
2006 Shashikala S., Kavitha Radhakrishnan, P. M. Shamsul Karim, Detection of Methicillin Resistant Staphylococci with Cefoxitin, Journal of Academy of Clinical Microbiologists, Vol. 8 (2), pp. 69-71, 2006.
2006 Venkateswaran C., Kumar T. M., Psycho-Oncology in India: Emerging Trends from Kerala, Indian Journal of Palliative Care, Vol. 12 (1), pp. 34-38, 2006.
2006 Shrivatsava S., Saxena A., Iyer K. S., Radhakrishnan S., Kumar K., Maheswari S., Pediatric Cardiac Society of India Recommendations for Timing of Surgery/Catheter Intervention in Left-to-rRght Shunts, Indian Heart Journal, Vol. 58 (2), pp. 169-171, 2006.
2006 Ghongade D., Kannan R., K. P. Sreekumar, Prabhu N. K., Radiological Quiz - Pediatric Neuroradiology, Indian Journal of Radiology and Imaging, Vol. 16 (3), pp. 399-400, 2006.
2006 Niranjan Pehere, Use of Bevacizumab in Proliferative Diabetic Retinopathy, Amrita Journal of Medicine, 2006.
2006 Dayananda L., Moorthy S., Prabhu N. K., K. P. Sreekumar, Diagnostic Value of Gall Bladder Wall Thickness in Patients with Ascites, Indian Journal of Gastroenterology, Vol. 25 (1), pp. 44-45, 2006.
2006 Dayananda L., Sreekumar K., Prabhu N., Radiological Quiz – Abdomen, Indian Journal of Radiology and Imaging, Vol. 16 (4), pp. 961-962, 2006.
2006 Rajeshkannan R., Moorthy S., Sreekumar K., Rupa R., Prabhu N., Clinical Alications of Diffusion Weighted MR Imaging: A Review, Indian Journal of Radiology and Imaging, Vol. 16 (4), pp. 705-710, 2006.
2006 Dayananda L., Sreekumar K., Moorthy S., Prabhu N., Para Duodenal Hernias – A Pictorial Essay, Indian Journal of Radiology and Imaging, Vol. 16 (4), pp. 469-471, 2006.
2006 Meenakshi Dhar, Book Review on Strabismus Simplified, Kerala Journal of Ophthalmology, Vol. 18, 2006.
2006 Meenakshi Dhar, Fulminant Tribacterial Traumatic Endophthalmitis, Kerala Journal of Ophthalmology, Vol. 8 (4), pp. 346-348, 2006.
2006 Meenakshi Dhar, Outcome of Vigilant Management of Early Stevens Johnson Syndrome, Kerala Journal of Ophthalmology, Vol. 18 (1), 2006.
2006 Meenakshi Dhar, Book Review on Eyelid Tumors –Clinical Diagnosis & Surgical Treatment, Kerala Journal of Ophthalmology, Vol. 18 (3), 2006.
2006 Vinayan K. P., Epilepsy; Antiepileptic Drugs and Educational Problems, Indian Pediatrics, pp. 786-94, 2006.
2006 K. Ramakrishnan, P. S. Harish, Hemoglobin Level as a Risk Factor for Lower Respiratory Tract Infections, Indian Journal of Pediatrics, Vol. 73, pp. 881-883, 2006.
2006 Kurup R. P., Kumar R. K., Cardiogenic Shock in Children, Indian Journal of Practical Pediatrics, Vol. 8, pp. 63-75, 2006.
2006 Ajith Nambiar, Concurrent Medullary and Papillary Carcinoma of the Thyroid: A Rare Combination, Thyroid Practice and Research, Vol. 3 (1), pp. 20-23, 2006.
2006 S. Bhaskaran, V. Nair, H. Kumar, Jayakumar R. V., PCOS in South Indian Women-Prevalence of Abnormal Glucose Tolerance and Insulin Resistance, Amrita Journal of Medicine, Vol. 2 (1), 2006.
2006 S. Bhaskaran, V. Nair, H. Kumar, Jayakumar R. V., Audit of Care in 21- Hydroxylase Patients, Indian Pediatrics, Vol. 43 (5), pp. 419-423, 2006.
2006 Ashok Pillai, Rajeev K., Unnikrishnan M., Surgical Management of a Pial Arteriovenous Fistula with Giant Varix in an Infant, Neurology India, Vol. 54 (4), pp. 434-436, 2006.
2006 Ajit Nambiar, Acute Radiation Colitis in Patients Treated with Short Temper – Operative Radiotherapy for Rectal Cancers, Indian Experience in Modern Pathology, Vol. 19 (3), pp. 66-67, 2006.
2006 A. V. Ghosh, N. Rao, Jai Thilak, J. Varhese, Management of Infected TKR, Journal of Kerala Orthopedic Association, Vol. 20 (1), 2006.
2006 U. Pawar, Jai Thilak, J. Varughese, Early Results of Uncemented Revision Hip Arthroplasty, Journal of Kerala Orthopedic Association, Vol. 20 (1), 2006.
2006 K. N. Rao, J. Varughese, Jai Thilak, Shanmughasundaram, Scintigraphic Assessment of Patellar Viability in TKR Following Lateral Release, Journal of Kerala Orthopedic Association, Vol. 20 (1), 2006.
2006 Ramakrishnan K., Harish P. S., Hemoglobin Level as a Risk Factor for Lower Respiratory Tract Infections, Indian Journal of Pediatrics, Vol. 73 (10), pp. 881-883, 2006.
2006 Shekhar Sharma, Vijaykumar D. K., Chithrathara K., Steroid Cell Tumor of the Ovary: A Case Report of an Acute Presentation with Virilisation & Review of Literature, Indian Journal of Gynecology and Oncology, Vol. 6 (1), pp. 56-59, 2006.
2006 Balakrishnan V., Prem Nair, Lakshmi Radhakrishnan, Narayanan V. A., Tropical Pancreatitis is not a Distinct Entity But is Part of a Spectrum of Chronic Pancreatitis, Indian Journal of Gastroenterology, 2006.
2006 Rajesh G. & Sadasivan S., Hiran K. R., Nandakumar R., Balakrishnan V., Acute Myeloid Leukemia Presenting as obstructive Jaundice, Indian Journal of Gastroenterology, Vol. 25, pp. 93-94, 2006.
2006 Balakrishnan V., Exploring Indian Medicinal Plants for Anti-ulcer Activity, Indian Journal of Pharmacology, pp. 38-216, 2006.
2006 Musthafa C. P., Moosa A., Chandrashekharan P. A., Nandakumar R., Narayanan C. A., Balakrishnan V., Intestinal Pseudo-obstruction as Initial Presentation of Thymoma, Indian Journal of Gastroenterology, Vol. 25 (5), pp. 264-5, 2006.
2006 Chatni S., Nair P., Nandakumar R., Geetha M., Sooraj V., Narayanan V. A., Balakrishnan V., Polyp within Gastric Diverticulum, Indian Journal of Gastroenterology (4), 2006.
2006 Sudhir S., Bhat H. S., Laparoscopic Partial Nephrectomy for RCC, Indian Journal of Urology, pp. 22-21, 2006.
2006 Sudhir S., Balagopal N., Ginil Kumar P., Bhat H. S., Laparoscopic Adrenalectomy: A Single Centre Experience with the Lateral Transabdominal Approach, Indian Journal of Urology, pp. 22-51, 2006.
2006 Saheed M. C. S., Bhat Sanjay H., Fulminant Biliary Peritonitis Complicating Percutaneous Nephrostolithotomy, Indian Journal of Urology, Vol. 22 (1), pp. 77-78, 2006.
2006 Sudhir S., Balagopal N., Ginil Kumar P., Bhat H. S., Laparoscopic Adrenalectomy: A Single Centre Experience Over 5 Years, Indian Journal of Urology, pp. 90-97, 2006.
2006 Vinayan K. P., Nisha B., Epilepsy; Antiepileptic Drugs and Bone Health, Annals of the Indian Academy of Neurology, Vol. 9, 2006.
2006 Bhadada S., Bhansali A., Unnikrishnan A. G., Does Paget’s Disease Exist in India: A Case Series, Journal of the Associations of Physicians of India, Vol. 54, pp. 530-4, 2006.
2006 Unnikrishnan A. G., Kumar H., Jayakumar R. V., Bone Age in a Minute: A Simple Algorithm, Amrita Journal of Medicine, Vol. 2, pp. 39-41, 2006.
2006 Nisha B., Unnikrishnan A. G., Nair. V, Fighting Fire with Fire, Amrita Journal of Medicine, Vol. 2, pp. 26-28, 2006.
2006 Pillai M. G., Unnikrishnan A. G., Hemorrhage in Nodule Following Ethanol Sclerotherapy (Thyroid Images), Thyroid Research and Practice, Vol. 3 (2), pp. 58-59, 2006.
2006 Unnikrishnan A. G., Thyrotoxic Myopathy: A Disease in Search of a Diagnosis, Thyroid Research and Practice, Vol. 3 (1), pp. 3-4, 2006.
2006 Unnikrishnan A. G., Medullary Thyroid Carcinoma: Concerns and Controversies for the Endocrinologist, Thyroid Research and Practice, Vol. 3 (2), pp. 35-39, 2006.
2006 Unnikrishnan A. G., Thyrotropin and the Ever-narrowing Reference Ranges, Thyroid Research and Practice, Vol. 3 (2), pp. 50-55, 2006.
2006 U. Rajnikanth, Utility of 99m Tc Scanning in Mc Cune Albright Syndrome, Indian Journal of Endocrinology and Metabolism, Vol. 1, pp. 31-33, 2006.
2006 Subir Kumar Das, Sukhes Mukherjee, D. M. Vasudevan, Non-alcoholic Fatty Liver Disease: An Underrecognized Cause with Emerging Importance, Current Science, Vol. 90 (5), pp. 659-665, 2006.
2006 Guruprasad U., Harish Kumar, Genetics of Type 2 Diabetes Mellitus, Journal of Metabolism and Genetics, Vol. 1 (2), pp. 97-108, 2006.
2006 Jayakumar R. V., Hypothyroidism, Journal of the Indian Medical Association, Vol. 104, pp. 557-562, 2006.
2006 Suresh G. Rao, Twists Travails and Triumphs of Pediatric & Congenital Heart Surgery in India, Indian Journal of Thoracic Cardiovascular Surgery, Vol. 22, pp. 108-110, 2006.
2006 Sundaram K. R., Statistics: How does it ally?, Amrita Journal of Medicine, Vol. 2 (2), pp. 21-23, 2006.
2006 Unnikrishnan A. G., Pillai M. R., Nandakumar R., Thomas Joseph, Indhu Hariharan, Surya Ramachandran, Jayakumar R. V., Harish Kumar, Prem Nair &Balakrishnan V., Analysis of XRCCI Genes in Tropical Chronic Pancreatitis: A Pilot Study, Journal of Metabolism and Genetics, Vol. 3, pp. 191-195, 2006.
2006 Padmalakshmi G., Krishnaprasad R., Unnikrishnan A. G., Uric Acid Levels in Subjects with Type 2 Diabetes: A Biochemical Study, Journal of Metabolism and Genetics, Vol. 2, pp. 34-36, 2006.
2006 Subir Kumar Das, D. M. Vasudevan, Tulsi: The Indian Holy Power Plant, Natural Product Radiance, Vol. 5 (4), pp. 279-283, 2006.
2006 Unnikrishnan G., Gandhi V., Balakrishnan D., Sudheer O. V., Dhar P., Sudhindran S., Kliel Trenaunay Syndrome: A Rare Cause of Lower Gastrointestinal Bleeding, Amrita Journal of Medicine, Vol. 2 (2), pp. 40-41, 2006.
2006 Balakrishnan D., Dhar P., Praseedom R. K., Kumar L., Sudhindran S., Giant Polyp of the Oesophagus, Amrita Journal of Medicine, Vol. 2 (1), pp. 36-7, 2006.
2006 Chithra Jayaprakash, Kavitha R., Dinesh, Sudheer O. V., P. M. Shamsul Karim, A Case of Subcapsular Fungal Liver Abscess, The Journal of Academy of Clinical Microbiologists, pp. 8-2, 2006.
2006 Rao A. N., Awareness of Inborn Errors of Metabolism Among Parents - A Questionnaire Based Survey, Perinatology, Vol. 8 (2), pp. 49-53, 2006.
2006 Guruprasad U., Harish Kumar, Genetics of Type 2 Diabetes Mellitus, Perinatology, Vol. 8 (2), pp. 83-94, 2006.
2006 Raju Gopal, Arun Warrier, Ajit Babu, Cases Evidence and Verdicts – Endocrinology, Amrita Journal of Medicine, Vol. 2 (1), pp. 42-44, January-June 2006.
2006 N. V. A. Moosa, P.K. Rajiv, A. John, S. Moorthy, Paraneoplastic Diarrhea in an Infant, Amrita Journal of Medicine, Vol. 2 (1), pp. 30-32, January-June 2006.
2006 P. Subash, S. Peter, Moni Abraham Kuriakose, Distraction Osteogenesis for Airway Management in Treacher Collins Syndrome, Amrita Journal of Medicine, Vol. 2 (1), pp. 33-35, January-June 2006.
2006 V. U. Menon, A. Gilchrist, K. V. Kumar, V. Nair, H. Kumar, Iodine Status and Goitre Prevalence of a South Indian Adult Population: Amrita Diabetes and Endocrine Population Survey (ADEPS), Thyroid Research and Practice, Vol. 3 (2), pp. 40-44, 2006.
2006 Harish Kumar, Editorial: An Indian Definition of Health, Amrita Journal of Medicine, Vol. 2 (2), July-December 2006.
2006 L. Joseph, N. V. A. Moosa, A. A. Kumar, Hyponatremia, Amrita Journal of Medicine, Vol. 2 (2), pp. 5-12, July-December 2006.
2006 K. P. G. Kumar, Post Exposure Prophylaxis for Healthcare Workers for Accidental Exposure to HIV, Amrita Journal of Medicine, Vol. 2 (2), pp. 13-15, July-December 2006.
2006 P. Shanmuga Sundaram, S. Padma, H. Kumar, V. Nair, S. Kumar, U. Rajanikanth, Role of 99m Tc MDP Bone and 67 Gallium Imaging in Evaluation of Diabetic Osteopathy, Amrita Journal of Medicine, Vol. 2 (2), pp. 24-27, July-December 2006.
2006 A. G. Unnikrishnan, N. Detroja, R. Sarbani, Harish Kumar, Mercury Rising, Amrita Journal of Medicine, Vol. 2 (2), pp. 30-32, 2006.
2006 T. S. Subramanian, S. Nair, V. Sreeja, A. Nambiar, A Syndromic Wilm’s Tumor, Amrita Journal of Medicine, Vol. 2 (2), pp. 33-34, July-December 2006.
2006 J. N. Panicker, J. Philip, Two Cases pf the Bardet-Biedl Syndrome and a Review of Literature, Amrita Journal of Medicine, Vol. 2 (2), pp. 35-37, July-December 2006.
2006 T. Babu, A. G. Unnikrishnan, U. Rajanikant, R. V. Jayakumar, V. Nair, An Unusual Case of Cushing Syndrome, Amrita Journal of Medicine, Vol. 2 (2), pp. 38-39, July-December 2006.
2006 A. A. Haris, C. S. Chethan, Ajit Babu, Cases Evidence and Verdicts – Pre-Hypertension, Amrita Journal of Medicine, Vol. 2 (2), pp. 43-44, July-December 2006.
2006 Harish Kumar, Editorial: A Balanced Doctor, Amrita Journal of Medicine, Vol. 2 (1), January-June 2006.
2006 S. Vaidyanathan, V. V. Gandhi, P. Mukherjee, Parotid Surgery-Basic Principles, Amrita Journal of Medicine, Vol. 2 (1), pp. 5-7, January-June 2006.
2006 K. P. G. Kumar, V. P. Gopinath, V. P. Dhage, An Approach to the Management of Tuberculosis Associated with HIV Infection, Amrita Journal of Medicine, Vol. 2 (1), pp. 12-15, January-June 2006.
2006 G. S. Narayanan, S. S. Narayanan, M. A. Kuriakose, S. Iyer et al, Brachytherapy for Head and Neck Surgery: Our Initial Experience at AIMS, Amrita Journal of Medicine, Vol. 2 (1), pp. 20-23, January-June 2006.
2005 K. K. Krishnamma, V. Vathsala, A Study on Obturator Internus Muscle, Anatomical Adjuncts, Vol. 4 (2), 2005.
2005 Vaidya A. D. B, Raut A. A., Vaidya R. A., V. V. Pillay, Abrus Precatorius Gaertin - An Ayurvedic Potent Phytomedicine, Journal of Association of Physicians of India, Vol. 53, pp. 739-740, 2005.
2005 M. Maneesh, H. Jayalakshmi, Sanjiba Dutta, Amit Chakrabarti, D. M. Vasudevan, Experimental Therapeutic Intervention with Ascorbic Acid in Ethanol Induced Testicular Injuries in Rats, Indian Journal of Experimental Biology, Vol. 43, pp. 172-176, 2005.
2005 Subir Kumar Das, Shyam Sudar Dey, D. M. Vasudevan, Influence of Thyroid Hormone on Brain Development, Thyroid Research and Practice, Vol. 2, pp. 19-23, 2005.
2005 M. Maneesh, H. Jayalekshmi, Sanjiba Dutta, Amit Chakrabarti, D. M. Vasudevan, Effect of Chronic Ethanol Administration on Testicular Antioxidant System and Steroidogenic Enzymes in Rats, Indian Journal of Experimental Biology, Vol. 43, pp. 445-449, 2005.
2005 Subir Kumar Das, D. M. Vasudevan, Biochemical Diagnosis of Alcoholism, Indian Journal of Clinical Biochemistry, Vol. 20, pp. 35-42, 2005.
2005 Subir Kumar Das, D. M. Vasudevan, Effect of Ethanol on Liver Antioxidant Defense Systems: A Dose Dependent Study, Indian Journal of Clinical Biochemistry, Vol. 20, pp. 80-84, 2005.
2005 Krishnanda Prabhu P., Gopalakrishna Bhat and D. M. Vasudevan, Can Serum Glutathione S Transferase Levels in Carcinoma Cervix Be a Predictor of Radiation Response?, Indian Journal of Clinical Biochemistry, Vol. 20, pp. 95-97, 2005.
2005 Reshma K., Ashalatha V. Rao, Dinesh M., D. M. Vasudevan, Effect of Ocimum Flavonoids as a Radioprotector on the Erythrocyte Antioxidants in Oral Cancer, Indian Journal of Clinical Biochemistry, Vol. 20, pp. 160-164, 2005.
2005 S. K. Das, Dey S. S., D. M. Vasudevan, Neuronal Connections and Thyroid Hormones, Thyroid Research and Practice, Vol. 2 (3), pp. 9-13, 2005.
2005 Subir Kumar Das, D. M. Vasudevan, Monitoring Oxidative Stress in Patients with Non-alcoholic and Alcoholic Liver Diseases, Indian Journal of Clinical Biochemistry, Vol. 20 (2), pp. 24-28, 2005.
2005 S. K. Das, P. Nayak and D. M. Vasudevan, Consequences of Ethanol Consumption, Journal of Indian Society of Toxicology, Vol. 1 (1), pp. 1-10, 2005.
2005 M. Maneesh, H. Jayalekshmi, Sanjiba Dutta, Amit Chakrabarti, D. M. Vasudevan, Effect of Exogenous Lecithin on Ethanol Induced Testicular Injuries in wistar Rats, Indian Journal of Physiology and Pharmacology, Vol. 49 (3), pp. 297-304, 2005.
2005 M. Maneesh, H. Jayalekshmi, Sanjiba Dutta, Amit Chakrabarti, D. M. Vasudevan, Role of Oxidative Stress in Ethanol Induced Germ Cell Apoptosis – An Experimental Study in Rats, Indian Journal of Clinical Biochemistry, Vol. 20 (2), pp. 62-67, 2005.
2005 D. M. Vasudevan, N. Ananth Rao, Coronary Artery Disease: An Overview and the Role of Coconut Oil in Hypercholesterolemia, Indian Coconut Journal, Vol. 36 (4), pp. 3-7, 2005.
2005 Nayak P., Das S. K., D. M. Vasudevan, Biochemical Toxicity Study on Rat Brain Upon Co-exposure to Aluminum and Ethanol, Journal of Indian Society of Toxicology, Vol. 1 (2), pp. 13-17, 2005.
2005 Raghavan B., Palat G., Rajagopal M. R., Are Our Patients Getting Palliative Care too Late? An Audit, Indian Journal of Palliative Care, Vol. 11 (2), pp. 108-110, 2005.
2005 V. V. Pillay, Ptosis Following Wasp Sting, Journal of Association of Physicians in India, pp. 53-162, 2005.
2005 VV Pillay, Bhagyanathan P. V., Krishnaprasad R., Rajesh R. R., Vishnupriya N., Poisoning Due to White Seed Variety of Abrus Precatorius, Journal of Association of Physicians in India, Vol. 53, pp. 317-9, 2005.
2005 V. V. Pillay, Adulteration and Contamination of Ayurvedic Herbal Medications, Journal of Indian Society of Toxicology, Vol. 1, pp. 20-22, 2005.
2005 V. V. Pillay, Toxicology: An Ignored Specialty?, National Medical Journal of India, Vol. 18 (2), pp. 98-9, 2005.
2005 Shashikala Shivaprakasha, Kavitha Radhakrishnan, Shamsul Karim, Chromobacterium Violaceum: An Emerging Pathogen, Journal of Academy Clinical Microbiologists, Vol. 7 (1), pp. 41-42, 2005.
2005 Mehta R., Suvarna D., Mustafa C. P., Sadasivan S., Role of Soluble Transferring Receptors Study in Hepatocellular Carcinoma with Underlying Cirrhosis, Indian Journal of Cancer, Vol. 42 (4), 2005.
2005 Rajashree Nambiar, Antibodies in the Eye – A Pilot Study in Diabetic Retinopathy, Amrita Journal of Medicine, 2005.
2005 Niranjan K. Pehere, Rajshree Nambiar, Dilated Nonreactive Pupils in a Case of Surprise Phaeochromocytoma, Kerala Journal of Ophthalmology, 2005.
2005 K. Ramakrishnan, Sathyajith G. Nair, Role of Clonidine in Organophosphate Poisoning Children, Journal of Indian Society of Toxicology, Vol. 1, pp. 30-31, 2005.
2005 Pavithran K., Thomas M., Imatinib Induced Stevens- Johnson Syndrome: Lack of Recurrence Following Rechallenge with a Lower Dose, Indian Journal of Dermatology Venereology and Leprology, Vol. 71 (4), pp. 288-289, 2005.
2005 Pai S., Mehta R., Rao G., Thyrotoxicosis Co-existing with Ulcerative Colitis, Indian Journal of Gastroenterology, Vol. 24 (6), pp. 263-264, 2005.
2005 Jyothi Kusnur, M. Vijayakumar, C. Rajiv, K. U. Natarajan, T. Rajesh, Prakash Kamath, K. K. Haridas, Nine Month Clinical Follow-up in Patients Receiving a Combination of Drug-Eluting Stents Along with Bare Metal Stents During the Same Intervention, Indian Heart Journal, Vol. 57 (5), pp. 441-442, 2005.
2005 M. Vijayakumar, C. Rajiv, Mahesh Krisnakumar, K. K. Haridas, Predictors of Poor Outcomes After Amplatzer Device Closure of Post-myocardial Infarction Ventricular Septal Repture, Indian Heart Journal, Vol. 57 (5), 2005.
2005 Ramdas Nayak, Georgie Thomas, K. K. Mahesh, Praveen G. Pai, M. Vijayakumar, T. Rajesh, C. Rajiv, K. U. Natarajan, Prakash Kamath & K. K. Haridas, A Follow-up Study of Permanent Atrial Sensed Ventricular Pacing Mode, Indian Heart Journal, Vol. 57 (5), 2005.
2005 Anil Vatwani, Prasannakumar, K. K. Mahesh, M. Vijayakumar, T. Rajesh, C. Rajiv, K. U. Natarajan, Prakash Kamath, K. K. Haridas, Trends in Pharmacotherapy Pattern of Patient undergoing Percutaneous Transluminal Coronary Angioplasty: A 5 Year Review at a Tertiary Cardiovascular Centre, Indian Heart Journal, Vol. 57 (5), 2005.
2005 Vaidyanathan B., B. R. J. Kannan, Kumar R. K., Device Closure of Residual Ventricular Septal Defect after Repair of Tetralogy of Fallot Using the Amplatzer Duct Occluder, Indian Heart Journal, Vol. 57, pp. 64-6, 2005.
2005 B. R. J. Kannan, Ananthan K., Kumar R. K., Unusual Spasm of the Patent Arterial Duct; Images in Cardiology, Indian Heart Journal, Vol. 57, 2005.
2005 Mahesh K., B. R. J. Kannan, Anil S. R., P. Kamath, Kumar R. K., Stenting of the Patent Arterial Duct to Improve Pulmonary Blood Flow, Indian Heart Journal, Vol. 57, pp. 704-8, 2005.
2005 Subramania K. I., Mohit S., Sasidharan P. R., Abraham M. K., Arun P., Kekatpure V., Sure Closure' – Skin Stretching System: Our Clinical Experience, Indian Journal of Plastic Surgery, Vol. 38 (2), pp. 132-137, 2005.
2005 Ahsan Moosa N. V., Minal D., Rao A. N., Kumar A., Recurrent Stupor Due to lysinuric Protein Intolerance, Neurology India, Vol. 53 (3), pp. 333-334, 2005.
2009 K. V. Kumar, V. U. Menon, V. Nair., H. Kumar, Silent Myocardial Infarction in Diabetic Men, Amrita Journal of Medicine, Vol. 1 (1), 2005.
2005 S. Bhaskaran, H. Kumar, V. Nair, Unnikrishnan A. G, Jayakumar R. V., Subclinical Hypothyroidism – Indications for Thyroxine Therapy, Thyroid Research and Practice, Vol. 1 (3), pp. 10-13, 2005.
2005 Jayachandran, Jai Thilak, Jacob Varghese, Arthroscopic Management of TFCC Injuries, Journal of Orthopaedic Association of South Indian States, Vol. 2, pp. 53-55, 2005.
2005 Jai Thilak, Jacob Varughese, Fracture Fragment Removal from the Hip, Indian Journal of Orthopaedics, Vol. 39 (3), pp. 191-192, 2005.
2005 Kumar Renjit J., K. V. Menon, Bhaskaran V. K., Jayachandran D., Vertebral Osteochondroma – An Unusual Cause of Compressive Myelopathy – A Case Report of Failed Decompressive Laminectomy, Journal of Orthopaedic Association of South Indian States, Vol. 2, pp. 44-46, 2005.
2005 Rajesh G., Mehta R., Nandakumar R., Sadasivan S., John A., Balakrishnan V., Skeletal Infections in Cirrhotics, Indian Journal of Gastroenterology, Vol. 24 (4), pp. 174-5, 2005.
2005 Suvarna D., Mehta R., Sadasivan S., Raj V. V., Balakrishnan V., Infiltrating Strongyloides Stercoralis Presenting as Duodenal Obstruction, Indian Journal of Gastroenterology, Vol. 24 (4), pp. 173-4, 2005.
2005 Mehta R., Mustafa C. P., Sadasivan S., John A., Raj V. V., Narayanan V. V., Balakrishnan V., Eosinophilic Ascites, Indian Journal of Surgery, Vol. 67, pp. 227-228, 2005.
2005 Mehta R, John A., Sadasivsn S., Musthafa C. P., Nandakumar R., Raj V. V., Balakrishnan V., Factors Determining Outcome Following Pneumatic Balloon Dilation in Achalasia Cardia, Indian Journal of Gastroenterology, Vol. 24 (6), pp. 243-5, 2005.
2005 S. Ray, M. G. K. Pillai, G. Kurian, V. N. Unni, Latent Systemic Lupus Erythematosus Presenting as Hypokalemic Paralysis, Indian Journal of Nephrology, Vol. 15, pp. 98-100, 2005.
2005 S. Ray, G. Ganapathi Rao, A. Kumar, A Strange Case of Facial Nerve Palsy, Journal of Association of Physicians of India, pp. 53-614, 2005.
2005 A. K. Rafiq, S. Rajagopal, J. Sureshkumar, M. Bafna, S. G. Nair, S. K. Nair, Coronary Artery Bypass Grafting in Female Patients on Thyroxine Replacement, Indian Journal of Thoracic & Cardiovascular Surgery, Vol. 21, 2005.
2005 Unnikrishnan A. G., Nisha B., Jayakumar R. V., Levothyroxine and the Issue of Bioequivalence, Thyroid Research and Practice, Vol. 2 (2), pp. 3-5, 2005.
2005 Unnikrishnan A. G., Jayakumar R. V., Consensus Guidelines for the Management of Hypothyroidism: A Summary of the Evidence for Primary Care Practitioners, Thyroid Research and Practice, Vol. 2 (2), pp. 5-10, 2005.
2005 Unnikrishnan A. G., Cholestyramine in Thyrotoxicosis: The Eternal Twelfth Player?, Thyroid Research and Practice, Vol. 2 (3), pp. 3-4, 2005.
2005 Ashawad Kumar R., D. K. Vijaykumar, Pavithran K., Annie Jojo, Primary Fallopian Tube Carcinoma Presenting as Supraclavicular Mass, Amrita Journal of Medicine, pp. 39-40, 2005.
2005 Unni V. N., Acute Renal Failure Following Multiple Wasp Stings, Indian Journal of Nephrology, Vol. 15 (1), pp. 30-32, 2005.
2005 Joy M. G., Abraham M. K., Bilateral communicating Intralobar Pulmonary Sequestration, Indian Pediatrics, Vol. 42 (7), pp. 729-730, 2005.
2005 Krishnan P., Chandrika K., Sudheer O. V., Dhar P., Sudhindran S., Is sentinel Node Mapping Useful in Colorectal Carcinoma?, Indian Journal of Gastroenterology, Vol. 24 (3), pp. 129-30, 2005.
2005 Mahesh K., Balu Vaidyanathan, Disease – An Unusual Cause of Metabolic Cardiomyopathy in Infants, Pediatric Cardiac Society of India Newsletter, 2005.
2005 Balu Vaidyanathan, Metabolic Cardiomyopathy: A practical Approach to Diagnosis and Management, Journal of Metabolism and Genetics, Vol. 1 (2), pp. 75-83, 2005.
2005 D. M. Vasudevan, The Concept of Metabolism; A Historical Perspective (Lead Article), Journal of Metabolism and Genetics, Vol. 1 (1), pp. 3-7, 2005.
2005 Rao A. N., Prenatal Diagnosis of Inborn Errors of Metabolism – Necessity and Limitations - A Tough Balancing Act, Perinatology, Vol. 7 (1), pp. 16-21, 2005.
2005 Riju R., P. V. Pradeep, G. Unnikrishnan, C. G. Nair, Follicular carcinoma of Thyroid with Macro Angioinvasion, Thyroid Research and Practice, Vol. 2 (2), pp. 20-24, 2005.
2005 Unnikrishnan A. G., Jayakumar R. V., H. Kumar, Thyroid Disorders and Women’s Health: a Growing Concern Practitioners, Thyroid Research and Practice, Vol. 1, pp. 1-3, September 2005.
2005 Unnikrishnan A. G., Pregnancy and Thyroid Disorders, Thyroid Research and Practice, Vol. 2 (2), pp. 5-10, September 2005.
2005 Seema Nair, Ammu Thomas, Neema Job, Girija D. S ., A. K. K . Unni, Luminescent Bacteria as Biosensor for Mercury Toxicity, Journal of Indian Society of Toxicology, Vol. 1 (2), pp. 18-22, 2005.
2004 Subir Kumar Das, D. M. Vasudevan, Should We Use Carbohydrate Deficient Transferring as a Marker for Alcohol Abusers?, Indian Journal of Clinical Biochemistry, Vol. 19, pp. 36-44, 2004.
2004 Kuruvilla A., V. V. Pillay & Nayak N., Venkatesh T., Adhikari P., Charapani M., Clark C. S., D’Souza H., Clark R., Sinha S., Portable Lead Analyser to Locate Source of Lead, Indian Pediatric Journal, Vol. 71 (6), pp. 495-9, 2004.
2004 V. V. Pillai, Terrorism and Homicides by Poisoning: Why Indian Police Should Know More about Toxicology?, Indian Police Journal, Vol. L1 (3), pp. 111-115, 2004.
2004 Rajiv M., Deepak S., Rajesh G., Sadasivan S., Splenic Artery Aneurysm with Arteriovenous Fistula as a Cause of Portal Hypertension, Indian Journal of Gastroenterology, Vol. 23 (1), pp. 36-37, 2004.
2004 Kavitha R. Dinesh, Harish R., Shashikala S., P. M. Shamsul Karim, Isolation Rates of Microorganisms by BACTE 9240, The Journal of the Academy of Clinical Microbiologists, Vol. 6 (1), 2004.
2004 Rajashree Nambiar, Vogt Koyanagi Harada Syndrome – A Case Report, Kerala Journal of Opthalmology, 2004.
2004 Bhatt M., Anil S. R., Kumar R. K., Kawasaki Disease in the Newborn, Indian Pediatric Journal, Vol. 71, pp. 353-4, 2004.
2004 B. R. J. Kannan, Anil S. R., Padhi S. S., Kumar R. K., Catheter Closure of the Patent Ductus Arteriosus in Sick Ventilated Infants, Indian Heart Journal, Vol. 56, pp. 232-234, 2004.
2004 K. P. Sreekumar, Prabhu N. K., Moorthy S., Bilateral Persistent Sciatic Artery: Demonstration of the Anomaly and its Complications with Intra Arterial Contrast Enhanced Spiral CT, Indian Journal of Radiology and Imaging, Vol. 14 (2), pp. 205-207, 2004.
2004 Vaidyanathan B., Kumar R. K., Neurological Complications and Neuro Developmental Sequelae after Congenital Heart Surgery, Indian Heart Journal, Vol. 56, pp. 286-92, 2004.
2004 Kumar K., Progress in Pediatric Cardiology, Indian Academy of Pediatrics, 2004.
2004 Georgies Thomas, Mahesh Krishnakumar, Prasanna Kumar, M. Vijayakumar, T. Rajesh, K. U. Natarajan, Balakrishna V. Pai, K. K. Haridas, Effect of Upstream Eptifibatide on Angiogrpahic and Clinical In-Hospital Outcomes During Primary Angiogplasty and Stenting for Acute Myocardial Infarction, Indian Heart Journal, Vol. 56, pp. 415-446, 2004.
2004 Nayak Ramdas, Practice Pattern and Intermediate Follow-up Results with Paclitaxel-Eluting Stents for Coronary Artery Disease, Indian Heart Journal, Vol. 56, pp. 415-446, 2004.
2004 Cherian Koshy, R. Krishnakumar, Aranya Anirudhan, Intermediate-term Hemodynamic Peroformance of the TTK Chitra Tilting Disc Valve, Indian Heart Journal, Vol. 56, 2004.
2004 Anoop Soman, Balu Vaidyanathan, C. Rajiv, Mahesh Krishnakumar, M. Vijayakumar, K. K. Haridas, Does Hemodynamic Testing at Cardiac Catheterisation Predict Clinical Response on Follo-up in Patients in Primary Pulmonary Hypertension Receiving Oral Sildenafil?, Indian Heart Journal, Vol. 56, pp. 474-489, 2004.
2004 Anil Vatwani, Prasanna Kumar, M. Vijaya Kumar, T. Rajesh, C. Rajiv, K. U. Natarajan, Balakrishna Pai, K. K. Haridas, Clinical Angiographic Profile and Procedural Results of Patients Undergoing Renal Angioplasty and Stenting – AIMS Renal Registry, Indian Heart Journal, Vol. 56, pp. 518-524, 2004.
2004 Jyoti Kusnur, M. Vijaya Kumar, Venkatesh T., P. G. Pai, Prasanna Kumar, Mahesh Krishna Kumar, K. U. Natarajan, Prakash Kamath, B. V. Pai & K. K. Haridas, Clinical Profile and Early Outcomes after Thrombolytic Therapy for Acute Pulmonary Embolism, Indian Heart Journal, Vol. 56, pp. 560-591, 2004.
2004 Mehta R., Suvarna D., Sadasivan S., Rajesh G., John A., Acute Colonic Pseudo Obstruction (Ogilvie's Syndrome) in Critical Care Unit, Indian Journal of Critical Care Medicine, Vol. 8 (1), pp. 43-45, 2004.
2004 Harish Kumar, An Approach to Euthyroid Thyroid Nodules, Thyroid Research and Practice, Vol. 1 (21), 2004.
2004 Rajiv Mehta, Deepak S., Anil John, Balakrishnan V., Idiopathic Colonic Varices, Indian Journal of Gastroenterology, Vol. 23 (1), pp. 30-1, 2004.
2004 Rajiv Mehta, Deepak S., Anil John, V. V. Raj, Shine Sadasivan, Balakrishnan V., Takayasu’s Arteritis Presenting as Chronic Mesenteric Ischaemia, Indian Journal of Gastroenterology, Vol. 24 (1), 2004.
2004 Mehta Rajiv, Suvarna Deepak, Sadasivan S., John Anil, Raj V., Prem Nair, Balakrishnan V., Natural Course of Asymptomatic Pancreatic : A Prospective Study, Indian Journal of Gastroenterology, Vol. 24 (4), pp. 140-142, 2004.
2004 Rajiv Mehta, Unnikrishnan G., Sudheer O. V., Anil John, Puneet Dhar, Sudhindran S., Balakrishnan V., Incidental Detection of Tubular Esophageal Duplication in Gastric Cardia Malignancy, Indian Journal of Gastroenterology, Vol. 24 (5), 2004.
2004 Sanjeevan K. V., Sudhir S., Ginilkumar P., Bhat H. S., Laparoscopic Simultaneous Bilateral Pre-transplant Nephrectomy for Uncontrolled Hypertension, Indian Journal of Urology, Vol. 20, pp. 69-70, 2004.
2004 S. Moorthy, Prabhu N. K., K. P. Sreekumar, A. K. Pillai, P. V. Nair, Hilar Cholangiocarcinoma: Results of Percutaneous Stenting with Self-Expandable Metal Stents, Indian Journal of Radiology and Imaging, Vol. 14 (1), pp. 45-51, 2004.
2004 Suresh G. Nair, Rakhee Balachandran, Perioperative Fluid and Electrolyte Management in Children, Indian Journal of Anesthesia, Vol. 48, pp. 355-364, 2004.
2004 Unnikrishnan G., Dhar P., Vijayakumar D. K., Bhat S., Abdominoperineal Resection and Pelvic Exenteration for Carcinoma Rectum (How i do it), GI Surgery Annual, Vol. 10, 2004.
2004 Unnikrishnan A. G., Tom Babu, H. Kumar, Selected Summaries: A New Marker of the Metabolic Syndrome is Closer to the Heart, National Medical Journal of India, Vol. 17 (1), pp. 27-28, 2004.
2004 Gopinathan V. P., Trivedi T. H., Chawla V., Yeolekar M. E., Epidemic of Leptospirosis: An ICU Experience, Journal of Association of Physicians of India, Vol. 52, pp. 1010-1011, 2004.
2004 Singh S. K., Reddy D. V. S., Unnikrishnan A. G., Lipoprotein (a) and Lipid Levels in Thyroid Dysfunction, Thyroid research and Practice, Vol. 1, pp. 7-13, 2004.
2004 Jayakumar R. V., Unsolved Issues in the Natural History of Subclinical Hyperthyroidism, Thyroid Research and Practice, Vol. 1 (2), pp. 3-5, 2004.
2004 Unnikrishnan A. G., Nisha B., Jayakumar R. V., Undetected Maternal Hypothyroidism in Pregnancy: To Treat Or Not?, Thyroid Research and Practice, Vol. 1 (3), pp. 3-5, 2004.
2004 Unnikrishnan A. G., R. V. Jayakumar, A New Forum for the Study of Thyroid Disorders in India, Thyroid Research and Practice, Vol. 1 (1), 2004.
2004 Bhaskaran H., Unnikrishnan A. G., Jayakumar R. V., Subclinical Hypothyroidism: Indications for Therapy, Thyroid Research and Practice, Vol. 1 (3), pp. 10-13, 2004.
2004 Unnikrishnan A. G., Jayakumar R. V., The ITS Working Committee Consensus Guidelines on the Management of Differentiated Thyroid Cancer, Thyroid Research and Practice, Vol. 1 (1), pp. 5-8, 2004.
2004 Girish Warrier, Baiju S. Dharan, Sajan Koshy, Shenoj Kumar, Shivaprakasha K., Suresh G. Rao, Repair of Total Anomalous Pulmonary Venous Connection in Neonates, Indian Journal of Thoracic and Cardiovascular Surgery, Vol. 20, pp. 155-158, 2004.
2004 Girish Warrier, Baiju S. Dharan, Sajan Koshy, Shenoj Kumar, Shivaprakasha K., Suresh G. Rao, Bidirectional Glenn Operation in Infancy, Indian Journal of Thoracic and Cardiovascular Surgery, Vol. 20, pp. 159-163, 2004.
2004 S. Vaidyanathan, P. Jacob, V. Pushapangathan, R. Dayananda Babu, Recurrent Laryngeal Nerve Injury in Thyroid Surgery, Thyroid Research & Practice, Vol. 1 (2), pp. 6-9, 2004.
2003 K. K. Krishnamma, K. Gopinathan, Parietal Thinning in a Human Skull, Anatomical Adjuncts, Vol. 3 (3), 2003.
2003 K. Gopinathan, Krishnamma K. K., Sundarapandian S., Incidence of Posterior Condylar Canal in South Indian Human skull, Anatomical Adjuncts, Vol. 3 (3), pp. 1-5, 2003.
2003 K. K. Krishnamma, K. Gopinathan, Parietal Thinning in a Human Skull, Anatomical Adjuncts, Vol. 3 (3), pp. 43-46, 2003.
2003 Sharmila Upadhya, Subramanya Udadhya, D. M. Vasudevan, Tissue Polypeptide Specific Antigen in the Post Therapeutic Evaluation of Patients with Ovarian and Colorectal Cancer, Indian Journal of Clinical Biochemistry, Vol. 18, pp. 46-51, 2003.
2003 Ananth N., Beena V. Shetty, D. M. Vasudevan, Possible Role of Granulocyte Macrophage Colony Stimulating Factor Receptor (GM-CSF R) in Malaria 41, Indian Journal of Experimental Biology, pp. 161-168, 2003.
2003 Winston Costa Pereira, Muddanna S. Rao, D. M. Vasudevan, Secondary Immunization Inhibits Drug Induced Apoptosis in Vivo, Indian Journal of Clinical Biochemistry, Vol. 18, 2003.
2003 Subir Kumar Das, Nayak, D. M. Vasudevan, Biochemical Markers for Alcohol Consumption, Indian Journal of Clinical Biochemistry, Vol. 18 (2), pp. 111-118, 2003.
2003 Ananth N., Beena V. Shetty, D. M. Vasudevan, Vitamin E- Levels during Chemotherapy for Ovarian Carcinoma, National Medical Journal of India, Vol. 16, pp. 231-232, 2003.
2003 Mohan Abraham, Sunil S. Meono, Bindu Mol, Thoracoscopic Repair of Eventration of Diaphragam, Indian Pediatric Journal – Case Reports, Vol. 40, pp. 1088-1089, 2003.
2003 Namboothiri S., Renjit Kumar, K. V. Menon, Scoliosis – An Update, Kerala Medical Journal, 2003.
2003 Jayakumar R. V., Hypertension and Diabetes Mellitus, Journal of the Indian Medical Association, Vol. 101 (4), pp. 254-256, 2003.
2003 B. R. J. Kannan, Kannan, B. R. J. Kannan, Long-term Outcome of Patients Operated for Large Ventricular Septal Defects with Increased Pulmonary Vascular Resistance, Indian Heart Journal, Vol. 55 (2), pp. 161-166, 2003.
2003 Kumar S. N., K. P. Sreekumar, Prabhu N. K., Moorthy S., Images: Wegener's Granulomatosis, Indian Journal of Radiology and Imaging, Vol. 13 (2), pp. 151-153, 2003.
2003 Moosa A., Joy M. A., Kumar A., Pseudotumour Cerebri and Guillain-Barre Syndrome: Cause or Effect?, Neurology India, Vol. 51 (2), 2003.
2003 Shashikala Shivapraksha, Robin George, Shamsul Karim, A Case Report: Meningococcemia in a Splenectomy Patient, Journal of the Academy of Clinical Microbiologists, Vol. 5 (1), pp. 47-48, 2003.
2003 Kar A. K., Rath P. C., Sinha N., Haridas K. K., Dasbiswas A., Kerkar P., Kumar R., Noncoronary Cardiac Interventions. The 3rd Report of the Non-Coronary Cardiac Interventions Registry of India for the Cardiological Society of India, Indian Heart Journal, Vol. 55 (6), pp. 658-62, 2003.
2003 Praveen Pai, C. Rajiv, T. Rajesh, Vijayakumar, K. U. Natarajan, Prakash Kamath, Balakrishna Pai, K. K. Haridas, Percutaneous Transvenous Mitral Commissurotomy in Older Patients: Is their Procedural and Late Outcome Different from Younger Patients?, Indian Heart Journal, Vol. 55, 2003.
2003 A. B. Mehta, M. Vijayakumar, H. M. Madrikar, M. S. Hiramath, Brian Pinto, Atul Abhyankar, Parvindar Singh, K. K. Haridas, Immediate Outcome and 30-Day Major Adverse Coronary Events After Implantation of Pro-Nova Sirolimus-Eluting Stent in De Novo Coronary Lesions - Initial Results from a Multocenter Indian Registry, Indian Heart Journal, Vol. 55, 2003.
2003 Prasanna Kumar, Mahesh Krishna Kumar, C. Rajiv, Vijayakumar, T. Rajesh, K. U. Natarajan, P. Kamath, B. V. Pai, K. K. Haridas, Acute and Intermediate Results of Percutaneous Coronary Angioplasty in Young Patients (<40 Years of Age): A Retrospective Analysis, Indian Heart Journal, Vol. 55, 2003.
2003 Mahesh Krishna Kumar, Prasanna Kumar, C. Rajiv, Vijayakumar, T. Rajesh, K. U. Natarajan, P. Kamath, B. V. Pai, K. K. Haridas, Clinical Profile: Procedural Results and Late Follow-up of Women Undergoing Stenting in Coronary Artery Disease, Indian Heart Journal, Vol. 55, 2003.
2003 Anil S. R. & B. R. J. Kannan, Kumar R. K., Transcatheter Closure of Native Pulmonary Artery for Elimination of Accessory Pulmonary Blood Flow after Bidirectional Glenn Shunt, Indian Heart Journal, Vol. 55, pp. 373-375, 2003.
2003 Prem Nair, Anil John, Praseedom R. K., Balakrishnan V., Coloenteroscopy: A Novel Method for Endoscopic Evaluation of Distal Small Bowel, Indian Journal of Gastroenterology, Vol. 22, 2003.
2003 Subir Kumar Das, Prasunpriya Nayak and D. M. Vasudevan, Biochemical Parameters in Alcoholic Liver Injury, Trends in Clinical and Biochemical Laboratory Medicine, pp. 227-233, 2003.
2003 S Moorthy, K. P. Sreekumar & Prabhu N. K., MRI Findings in Occult Spinal Dysraphisms, Indian Journal of Radiology and Imaging, Vol. 13 (1), pp. 67-74, 2003.
2003 Dhar P., Prasad K., Pelvic Exenteration, GI Surgery Annual, Vol. 10, 2003.
2003 V. V. Pillai, Alications of DNA Markers for Human Identity, Journal of Forensic Medical Toxicology, Vol. 20, pp. 54-56, 2003.
2003 Dayananda L., Moorthy S., Prabhu N. K., K. P. Sreekumar, Pulmonary Langerhan`s Cell Histiocytosis X: A Case Report., Indian Journal of Radiology and Imaging, Vol. 13 (3), pp. 275-276, 2003.
2003 Mohan K. Abraham, Thoracoscopic Repair of Eventration of Diaphragm, Indian Pediatrics, Vol. 40, pp. 1088-1089, 2003.
2003 Rao A. N., Inborn Errors of Metabolism, Perinatology, Vol. 5 (4), pp. 191-192, 2003.
2003 Rao A. N., Inborn Errors of Metabolism in the Pathophysiology of Brain Dysgenesis, Perinatology, Vol. 5 (6), pp. 272-274, 2003.
2002 Isaac Ramesh Kumar, Suresh G. Nair, Shivaprakasha, Suresh G. Rao, pH Stat Establishment During Deep Hypothermic Circulatory Arrest CPB – Our Experience at AIMS, Indian Journal of Extra-Corporeal Technology, Vol. 11 (3), pp. 95-99, 2002.
2002 N. K. Prabhu, S. Moorthy, K. P. Sreekumar, V. Nair, H. Kumar, A. K. Pillai, Rationale and Technique of Inferior Petrosal Venous Sinus Sampling in ACTH Dependent Cushings Syndrome - A Pictorial Essay, Indian Journal of Radiological and Imaging, Vol. 12 (1), pp. 13-20, 2002.
2002 S. Kandasamy, K. P. Jojo, S. Alpana, V. N. Unni, Antiglomerular Basement Disease in a Case of Chronic Unresolved Pneumonia, Indian Journal of Nephrology, Vol. 12 (3), pp. 90-91, 2002.
2002 K. K. Haridas, Neurovascular Rescue for Embolic Stroke Following Atrial Septal Defect Closure, Indian Heart Journal, Vol. 54 (3), pp. 309-311, 2002.
2002 Anil S. R., Sivakumar K., Kumar R. K., Bioptome Assisted Closure of Coronary Artery Fistula, Indian Heart Journal, Vol. 54, pp. 189-192, 2002.
2002 Anil S. R., Manoj P., Kumar R. K., Massive Primary Chylopericardium in an Infant, Indian Heart Journal, Vol. 54, pp. 295-6, 2002.
2002 Kumar R. K., A Practical Approach to Treatment of Cardiomyopathy in Children, Indian Journal of Pediatrics, Vol. 69, pp. 341-350, 2002.
2002 S. Moorthy, T. S. Subramanian et al, Posterior Reversible Encephalopathy in a Child with Phaecochromacytoma, Indian Journal of Radiology and Imaging, Vol. 12 (3), pp. 321-324, 2002.
2002 Nirmal Prabhu, S. Moorthy, K. P. Sreekumar et al, Rationale and Technique of Inferior Petrosal Venous Sampling in ACTH Dependant Cushing`s Syndrome- A Pictorial Essay, Indian Journal of Radiology and Imaging, Vol. 12 (1), pp. 13-20, 2002.
2002 A. K. Pillai, K. P. Sreekumar, N. K. Prabhu, S. Moorthy, Utility of MR Cholangiography in Planning Transhepatic Biliary Interventions in Malignant Hilar Obstructions, Indian Journal of Radiology and Imaging, Vol. 12 (1), pp. 37-42, 2002.
2002 B. S. Arunbabu, S. N. Kumar, S. Moorthy, A Giant Abdominal CSF Pseudocyst, Indian Journal of Radiology and Imaging, Vol. 12 (3), pp. 445-446, 2002.
2002 Kumar N. S., Arun Babu B. S., Moorthy S., Prabhu N. K., K. P. Sreekumar, A. K. Pillai, Radiology Quiz-Chest (Mounier Kuhn Syndrome), Indian Journal of Radiology and Imaging, Vol. 12 (1), pp. 123-124, 2002.
2002 Kumar N. S., Arun Babu B. S., Moorthy S., Prabhu N. K., K. P. Sreekumar, A. K. Pillai, Radiology Quiz- Chest (Bronchial Atresia), Indian Journal of Radiology and Imaging, Vol. 12 (4), pp. 574-575, 2002.
2002 Arun Babu B. S., S. N. Kumar, Moorthy S., Prabhu N. K., K. P. Sreekumar, A. K. Pillai, Radiology Quiz-Brain (Congenital Pituitary Hypoplasia), Indian Journal of Radiology and Imaging, Vol. 12 (3), pp. 427-428, 2002.
2002 A. K. Pillai, K. P. Sreekumar, N. K. Prabhu, S. Moorthy, Popliteal Artery Entrapment Syndrome: Diagnosis by MRI, Indian Journal of Radiology and Imaging, Vol. 12 (1), pp. 91-93, 2002.
2002 S. Moorthy, K. P. Sreekumar, N. K. Prabhu, Intraductal Papillary Mucinous Tumour of Pancreas. – Images, Indian Journal of Radiology and Imaging, Vol. 12 (4), pp. 501-502, 2002.
2002 S. Moorthy, Prabhu N. K., Sreekumar K. P., Radiology Quiz – Spine (Idiopathic Epidural Lipomatosis), Indian Journal of Radiology and Imaging, Vol. 12, pp. 566-567, 2002.
2002 S. Moorthy, K. P. Sreekumar, N. K. Prabhu, Von Hippel Lindau Disease- Images, Indian Journal of Radiology and Imaging, Vol. 12 (3), pp. 325-327, 2002.
2002 Nirmal Prabhu, S. Moorthy, K. P. Sreekumar, Recurrence of Complex Congenital Hepato-Portal Fistula after Coil Embolisation- A Case Report, Indian Journal of Radiology and Imaging, Vol. 12 (2), pp. 233-236, 2002.
2002 S. Moorthy, K. P. Sreekumar, N. K. Prabhu, Posterior Reversible Encephalopathy Syndrome in a Child with Phaechromocytoma- A Case Report, Indian Journal of Radiology and Imaging, Vol. 12 (3), pp. 321-324, 2002.
2002 Nirmal Prabhu, S. Moorthy, K. P. Sreekumar, Post Traumatic High-flow Priapism Treated by Transarterial Embolisation- A Case Report, Indian Journal of Radiology and Imaging, Vol. 12 (2), pp. 257-260, 2002.
2002 K. P. Sreekumar, S. Moorthy, N. K. Prabhu, Intra-Arterial Contrast Enhanced Spiral CT: Adjunct to Angiography for Localisisng Obscure Gastrointestinal Bleed, Indian Journal of Gastroenterology, Vol. 21 (6), pp. 230-231, 2002.
2002 Sivasankaran, B. R. J. Kannan, Kumar A., Tharakan J. A., Coexistence of Congenital Subaortic and Sinus of Valsalva Aneurysms, Indian Heart Journal, Vol. 54 (4), pp. 432-434, 2002.
2002 Kumar R. K., A Practical Approach for the Diagnosis and Management of Dilated Cardiomyopathy, Indian Journal of Pediatrics, Vol. 69 (4), pp. 341-350, 2002.
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