Dr. Shyam Diwakar, Lab Director of the Computational Neuroscience and Neurophysiology Laboratory and Associate Professor of Amrita School of Biotechnology, was invited to present at the 5th Bangalore Cognition Workshop 2018 held at IISc from June 17-29, 2018.

Amrita School of Biotechnology faculty and students recently published a journal paper in the high impact Nature publishing group’s Scientific Reports.

On March 23, 2018, Amrita's Virtual Laboratories and its deployment outcomes won the GOLC Online Lab Award 2018 for visualized experiment category.

Amrita Vishwa Vidyapeetham and Wipro Limited, a leading global information technology, consulting and business process services company, jointly won the Aegis Graham Bell Awards (AGBA) 2017 in the Innovation in mHealth category.

Year of Publication Publication Type Title

2018

Journal Article

H. S. Solanki, Babu, N., Jain, A. P., Bhat, M. Younis, Puttamallesh, V. N., Advani, J., Raja, R., Mangalaparthi, K. K., Kumar, M. M., Prasad, T. S. Keshava, Mathur, P. Prakash, Sidransky, D., Gowda, H., and Chatterjee, A., “Cigarette smoke induces mitochondrial metabolic reprogramming in lung cells.”, Mitochondrion, vol. 40, pp. 58-70, 2018.[Abstract]


Cellular transformation owing to cigarette smoking is due to chronic exposure and not acute. However, systematic studies to understand the molecular alterations in lung cells due to cigarette smoke are lacking. To understand these molecular alterations induced by chronic cigarette smoke exposure, we carried out tandem mass tag (TMT) based temporal proteomic profiling of lung cells exposed to cigarette smoke for upto 12months. We identified 2620 proteins in total, of which 671 proteins were differentially expressed (1.5-fold) after 12months of exposure. Prolonged exposure of lung cells to smoke for 12months revealed dysregulation of oxidative phosphorylation and overexpression of enzymes involved in TCA cycle. In addition, we also observed overexpression of enzymes involved in glutamine metabolism, fatty acid degradation and lactate synthesis. This could possibly explain the availability of alternative source of carbon to TCA cycle apart from glycolytic pyruvate. Our data indicates that chronic exposure to cigarette smoke induces mitochondrial metabolic reprogramming in cells to support growth and survival.

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2018

Journal Article

C. Porayath, Suresh, M. K., Dr. Raja Biswas, Dr. Bipin G. Nair, Dr. Nandita Mishra, and Dr. Sanjay Pal, “Autolysin Mediated Adherence of Staphylococcus Aureus with Fibronectin, Gelatin and Heparin”, International Journal of Biological Macromolecules, 2018.

2018

Journal Article

Priyanka Somanath, Bush, K. M., and Knoepfler, P. S., “ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells”, STEM CELLS, p. n/a–n/a, 2018.[Abstract]


Developmental Pluripotency-Associated-4 (DPPA4) is one of the few core pluripotency genes lacking clearly defined molecular and cellular functions. Here, we used a proteomics screening approach of human embryonic stem cell (hESC) nuclear extract to determine DPPA4 molecular functions through identification of novel cofactors. Unexpectedly, the signaling molecule ERBB3-binding protein 1 (EBP1) was the strongest candidate binding partner for DPPA4 in hESC. EBP1 is a growth factor signaling mediator present in two isoforms, p48 and p42. The two isoforms generally have opposing functions, however their roles in pluripotent cells have not been established. We found that DPPA4 preferentially binds p48 in pluripotent and NTERA-2 cells, but this interaction is largely absent in non-pluripotent cells and is reduced with differentiation. The DPPA4–EBP1 interaction is mediated at least in part in DPPA4 by the highly conserved SAF-A/B, Acinus and PIAS (SAP) domain. Functionally, we found that DPPA4 transcriptional repressive function in reporter assays is significantly increased by specific p48 knockdown, an effect that was abolished with an interaction-deficient DPPA4 ΔSAP mutant. Thus, DPPA4 and EBP1 may cooperate in transcriptional functions through their physical association in a pluripotent cell specific context. Our study identifies EBP1 as a novel pluripotency cofactor and provides insight into potential mechanisms used by DPPA4 in regulating pluripotency through its association with EBP1. Stem Cells 2018

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2018

Journal Article

N. Babu, Advani, J., Solanki, H. S., Patel, K., Jain, A. P., Khan, A. Ahmad, Radhakrishnan, A., Sahasrabuddhe, N. A., Mathur, P. Prakash, Dr. Bipin G. Nair, Prasad, T. S. Keshava, Chang, X., Sidransky, D., Gowda, H., and Chatterjee, A., “miRNA and proteomic dysregulation in non-small cell lung cancer in response to cigarette smoke.”, Microrna, 2018.[Abstract]


BACKGROUND: Dysregulation of miRNAs is associated with the development of non-small cell lung cancer (NSCLC). It is imperative to study the dysregulation of miRNAs by cigarette smoke which will affect their targets, either leading to the overexpression of oncoproteins or downregulation of tumor suppressor proteins.

OBJECTIVE AND METHODS: In this study, we carried out miRNA sequencing and SILAC-based proteomic analysis of H358 cells chronically exposed to cigarette smoke condensate. Using bioinformatics analysis, we mapped the dysregulated miRNAs to differentially expressed target proteins identified in our data. Gene ontology-based enrichment and pathway analysis was performed using the deregulated targets to study the role of cigarette smoke-mediated miRNA dysregulation in NSCLC cell line.

RESULTS: miRNA sequencing resulted in the identification of 208 miRNAs, of which 6 miRNAs were found to be significantly dysregulated (2 fold, Log Base 2; p-value ≤ 0.05) in H358-Smoke cells. Proteomic analysis of the smoke exposed cells compared to the untreated parental cells resulted in the quantification of 2,610 proteins, of which 690 proteins were found to be differentially expressed (fold change ≥ 2). Gene ontology based analysis of target proteins revealed enrichment of proteins driving metabolism and a decrease in expression of proteins associated with immune response in the cells exposed to cigarette smoke. Pathway study using Ingenuity Pathway Analysis (IPA) revealed activation of NRF2-mediated oxidative stress response and actin-cytoskeleton signaling, and repression of protein kinase A signaling in H358-Smoke cells. We also identified 5 novel miRNAs in H358-Smoke cells using unassigned reads of small RNA-Seq dataset.

CONCLUSION: In summary, this study indicates that chronic exposure to cigarette smoke leads to widespread dysregulation of miRNAs and their targets, resulting in signaling aberrations in NSCLC cell line. The miRNAs and their targets identified in the study need to be further investigated to explore their role as potential therapeutic targets and/or molecular markers in NSCLC especially in smokers.

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2018

Journal Article

P. Rajagopalan, Nanjappa, V., Patel, K., Jain, A. P., Mangalaparthi, K. K., Patil, A. H., Nair, B., Mathur, P. P., Prasad, T. S. Keshava, Califano, J. A., Sidransky, D., Gowda, H., and Chatterjee, A., “Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells.”, J Cell Commun Signal, 2018.[Abstract]


Smoking is the leading cause of preventable death worldwide. Though cigarette smoke is an established cause of head and neck cancer (including oral cancer), molecular alterations associated with chronic cigarette smoke exposure are poorly studied. To understand the signaling alterations induced by chronic exposure to cigarette smoke, we developed a cell line model by exposing normal oral keratinocytes to cigarette smoke for a period of 12 months. Chronic exposure to cigarette smoke resulted in increased cellular proliferation and invasive ability of oral keratinocytes. Proteomic and phosphoproteomic analyses showed dysregulation of several proteins involved in cellular movement and cytoskeletal reorganization in smoke exposed cells. We observed overexpression and hyperphosphorylation of protein kinase N2 (PKN2) in smoke exposed cells as well as in a panel of head and neck cancer cell lines established from smokers. Silencing of PKN2 resulted in decreased colony formation, invasion and migration in both smoke exposed cells and head and neck cancer cell lines. Our results indicate that PKN2 plays an important role in oncogenic transformation of oral keratinocytes in response to cigarette smoke. The current study provides evidence that PKN2 can act as a potential therapeutic target in head and neck squamous cell carcinoma, especially in patients with a history of smoking.

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2018

Journal Article

D. Nedungadi, Binoy, A., Nanjan Pandurangan, Pal, S., Dr. Bipin G. Nair, and Dr. Nandita Mishra, “6-Shogaol Induces Caspase-independent Paraptosis in Cancer Cells Via Proteasomal Inhibition”, Exp Cell Res, vol. 364, no. 2, pp. 243-251, 2018.[Abstract]


An α, β-unsaturated carbonyl compound of ginger, 6-Shogaol (6S), induced extensive cytoplasmic vacuolation and cell death in breast cancer cell (MDA-MB-231) and non-small lung cancer (A549) cells. In the presence of autophagic inhibitors the cells continued to exhibit cytoplasmic vacuolation and cell death clearly distinguishing it from the classic autophagic process. 6S induced death did not exhibit the characteristic apoptotic features like caspase cleavage, phosphatidyl serine exposure and DNA fragmentation. The immunofluorescence with the Endoplasmic Reticulum (ER) resident protein, calreticulin indicated that the vacuoles were of ER origin, typical of paraptosis. This was supported by the increase in level of microtubule associated protein light chain 3B (LC3 I and LC3 II) and polyubiquitin binding protein, p62. The level of ER stress markers like polyubiquitinated proteins, Bip and CHOP also consistently increased. We have found that 6S inhibits the 26S proteasome. The proteasomal inhibitory activity was elucidated by a) molecular docking of 6S onto the active site of β5 subunit and b) reduced fluorescence by the fluorogenic substrate of the chymotrypsin-like subunit. In conclusion these studies demonstrate for the first time that proteasomal inhibition by 6S induces cell death via paraptosis. So 6-shogaol may act as a template for anti-cancer lead discovery against the apoptosis resistant cancer cells.

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2018

Journal Article

V. Ozdemir and Springer, S., “What does "Diversity" Mean for Public Engagement in Science? A New Metric for Innovation Ecosystem Diversity.”, OMICS, 2018.[Abstract]


Diversity is increasingly at stake in early 21st century. Diversity is often conceptualized across ethnicity, gender, socioeconomic status, sexual preference, and professional credentials, among other categories of difference. These are important and relevant considerations and yet, they are incomplete. Diversity also rests in the way we frame questions long before answers are sought. Such diversity in the framing (epistemology) of scientific and societal questions is important for they influence the types of data, results, and impacts produced by research. Errors in the framing of a research question, whether in technical science or social science, are known as type III errors, as opposed to the better known type I (false positives) and type II errors (false negatives). Kimball defined "error of the third kind" as giving the right answer to the wrong problem. Raiffa described the type III error as correctly solving the wrong problem. Type III errors are upstream or design flaws, often driven by unchecked human values and power, and can adversely impact an entire innovation ecosystem, waste money, time, careers, and precious resources by focusing on the wrong or incorrectly framed question and hypothesis. Decades may pass while technology experts, scientists, social scientists, funding agencies and management consultants continue to tackle questions that suffer from type III errors. We propose a new diversity metric based on the hitherto neglected diversities in knowledge framing for robust, responsible, and inclusive design of innovation ecosystems with foresight. The FDI would be positively correlated with epistemological diversity and technological democracy, and inversely correlated with prevalence of type III errors in innovation ecosystems, consortia, and knowledge networks. We suggest that the FDI can usefully measure (and prevent) type III error risks in innovation ecosystems, and help broaden the concepts and practices of diversity and inclusion in science, technology, innovation and society.

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2018

Journal Article

P. Mol, Kannegundla, U., Dey, G., Gopalakrishnan, L., Dammalli, M., Kumar, M., Patil, A. H., Basavaraju, M., Rao, A., Ramesha, K. P., and Prasad, T. Subrahmany, “Bovine Milk Comparative Proteome Analysis from Early, Mid, and Late Lactation in the Cattle Breed, Malnad Gidda (Bos indicus).”, OMICS, 2018.[Abstract]


Bovine milk is important for both veterinary medicine and human nutrition. Understanding the bovine milk proteome at different stages of lactation has therefore broad significance for integrative biology and clinical medicine as well. Indeed, different lactation stages have marked influence on the milk yield, milk constituents, and nourishment of the neonates. We performed a comparative proteome analysis of the bovine milk obtained at different stages of lactation from the Indian indigenous cattle Malnad Gidda (Bos indicus), a widely available breed. The milk differential proteome during the lactation stages in B. indicus has not been investigated to date. Using high-resolution mass spectrometry-based quantitative proteomics of the bovine whey proteins at early, mid, and late lactation stages, we identified a total of 564 proteins, out of which 403 proteins were found to be differentially abundant at different lactation stages. As is expected of any body fluid proteome, 51% of the proteins identified in the milk were found to have signal peptides. Gene ontology analyses were carried out to categorize proteins altered across different lactation stages based on biological process and molecular function, which enabled us to correlate their significance in each lactation stage. We also investigated the potential pathways enriched in different lactation stages using bioinformatics pathway analysis tools. To the best of our knowledge, this study represents the first and largest inventory of milk proteins identified to date for an Indian cattle breed. We believe that the current study broadly informs both veterinary omics research and the emerging field of nutriproteomics during lactation stages.

More »»

Process Development for Isolation and Characterization of Phytochemicals

In the Phytochemistry laboratory, development, analysis, and optimization of technical processes for target dependent bioactive compound isolations and assays are carried out. A brief account is given below.

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Computational Neuroscience and Cognitive Modeling

In contrast to other fields in biology, mathematical thinking and methodology have become entrenched in neuroscience since its very beginning, as witnessed by the classical work of Hodgkin and Huxley.

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Inventory of Vegetation with special reference to Medicinal and Aromatic Plants and Documentation...

A tropical forest, with its varied life forms, provides an array of resources and services, making life possible on earth. The major beneficial components include food, medicine, clothing and

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Synthesis and characterization of lead salt based linear heterostructures for photovoltaic...

Quantum dots, also known as nanocrystals, are a special class of materials known as semiconductors, which are crystals composed of periodic groups of II-VI, III-V, or IV-VI materials. Their size ranges from 2-10 nanaometers.

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Regulation of Inflammation by Natural Product extracts: Role in osteoclastogenesis

Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.  It is one of the major steps in normal wound healing process with

Read More


Synthesis of Modified Benzophenanthridine – a Preliminary Anti-Cancer Study

Benzophenanthridines, naturally occurring isoquinoline alkaloids with various biological activities, are known to exist in five plant families, namely, the Fumariaceae (Genera Corydalis, Dicentra and Fumaria), the Papaveraceae, and the Rutaceae

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Role of miRNAs in cancer and modulation of oncogenes by natural products

Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth.

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Studies On Antagonistic Effects Of Partially Purified Bacteriocins From Microflora Of Fermented...

Bacteriocins are antimicrobial peptides produced by bacteria that kill or inhibit the growth of other bacteria.

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Organic Bulk Heterojunction Devices for Photovoltaic Solar Cell Applications

This study proposes the investigation of “Bulk Heterojunction” solar cells consisting of different types of p-type (donor) and n-type (acceptor) network. The various chemicals proposed to be used in this study are metal phthalocyanines,

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Identification of Natural Product Lead molecules as Potential Modulators of Wound Healing and...

Wound healing is the result of a complex interplay between various cell types wherein macrophages and fibroblasts play a crucial role during various phases of the process.

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Marine Algae - An Important Source for Lectins

The role of various sugars on the surface glycans in bacterial /fungal pathogenesis of plants and animals is well known. The focus of our research group is to hit upon proteins which are capable of interacting with these sugars. A class of

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Diversity Oriented Synthesis Applications to Flavonols, Flavones, Isoflavones and Biflavones

Divergent oriented synthesis is a strategy which aims to the synthesis of compounds with diverse chemical structures. It is often an alternative to convergent synthesis or linear synthesis.

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Development of Non-enzymatic Electrochemical Glucose Biosensors and Glucometer

Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which

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Amrita Insulin Pump and Low-cost, Automated Biomedical Devices

Diabetes is a chronic disorder characterized by abnormal blood glucose levels due to problems associated with insulin production and action. When glucose levels rise too high, diabetes becomes dangerous. Without medical care, it can increase the

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MIMIC – A Unique approach to wound healing assays

Nowadays researchers are interested in cell patterning and here is a method used for patterning mammalian cells that does not require access to photolithographic capabilities. This work describes a versatile process for forming microstructures of

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Isolation and Characterization of Primary Tumor Cells

 The lack of effective “in vitro” models to predict success of pharmacological therapy for patients with variety of cancer cell types demands the development of better experimental models to understand the pathophysiology of the disease and

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Synthesis of Intermediate Analogues for Biologically Active Molecules

Berberine, an isoquinoline alkaloid with a bright yellow color, is easily seen in most of the herb materials when found in significant amounts. Among Chinese herbs, the primary sources for

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Development of a Lab-on-a-Chip (LoC) for detection of Glucose, Cholesterol and Kidney Function

The proposed work involves the fabrication of lab-on-a-chip (LOC) diagnostic device that incorporates non-enzymatic sensors for detection of glucose, cholesterol and creatinine. The device consists of a disposable microfluidic component that

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In vitro studies on pharmacological potential of mycoendophyte of Simarouba glauca

The exploration of endophytes is still an emerging field. Almost all plants seem to deliver endophytes with promising contents and activities. Simarouba glauca has a long history in herbal medicine as antiparasitic, antidysentric, antipyretic and

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Paraptosis: a Newer Approach to Target Cancer

The focus of the project is to screen molecules with anti-cancer properties and understand their mode of action with respect to cell death.

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Anacardic acid - a novel template for cancer therapy

Traditional Indian medicine has always captivated Indian researchers and medical practitioners for its application in various pathological conditions.

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Identification of Endophytes from Marine Algae by 16S rRNA sequencing

Endophytes/ endosymbionts from marine micro algae have recently gained attention as potential sources of bioactive secondary metabolites. Our aim is to isolate and identify the endophytes by molecular biology methods. 

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Computational Chemistry & Molecular Docking Studies

Docking studies are computational techniques for the exploration of the possible binding modes of a substrate to a given receptor, enzyme or other binding site. The application of computational methods to study the formation of intermolecular

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Modulation of MicroRNA and Protein Signatures in Hepatocellular Carcinoma by Chemopreventive...

The current study will enable the elucidation of global miRNA expression profiles and identification of miRNA targets in response to intervention with chemopreventive phytochemicals in liver cancer.

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Mass Spectrometric Characterization of Bioactive Peptides and Proteins

Plant diseases caused by bacteria and fungi are the major reasons for significant loss in crop yields. To address this issue, many strategies have been developed and new bioanalytical tools have been utilized with an aim to control microbe

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Natural Dyes as Efficient Candidate for Enhancing the Photovoltaic Properties of Dye Sensitized...

The requirement of energy in India has been growing exponentially over the years. Since conventional energy options are futile to tackle this raise, the needs for non-conventional energy sources have become essential.

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Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care

In a unique partnership, Amrita Vishwa Vidyapeetham joined hands with Wipro Technologies, Bangalore to work on an end-to-end diabetes solution. The project entitled "Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care" is funded by

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Benchtop Nanoscale patterning using soft lithography for the printing of DNA molecules

DNA microarrays have rapidly evolved to become one of the essential tools to examine expression or mutation of thousands of genes simultaneously.

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Neurophysiological Recording and Modeling Fast-response Timing of Granule and Golgi Cell Responses...

One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems.

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Computational Modelling and Prediction of Cerebellar Input Layer function, Timing and Plasticity...

Investigating the organized activity of neuron ensembles is critical to understand how brain circuits work and is one main target of the project. Reconstruction of network activity has proved to be a hard task. This project will study cellular

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Chemically Modified Biopolymers : Synthesis, Characterization & Applications

The research activity in our laboratory aims at the development of novel biopolymer matrices with potential applications in waste water management, drug delivery etc. For instance, the β-oxothioamide derivative of chitosan biopolymer was found to

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Design and Validation of Point of Care Disposable Sensor Strips for Diagnosis of Tuberculosis from...

Tuberculosis (TB) is believed to affect nearly one third of the world population with approximately 9 million new cases detected every year. Current methods of diagnosis includes sputum smear microscopy, chest X-Ray and biopsy which are time

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Peptide-Based Anti-Snake Venom Therapy

Typically, a snake bite is treated with polyclonal antibody preparations obtained from immunized animals.

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Elucidating the Molecular Mechanisms of Anacardic Acid and Biacacetin Mediated Regulation of Matrix...

Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries like India.

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Development of Heterotrophic and Phototrophic Microbial Fuel Cell

Apart from the various alternatives of conventional energy sources, electricity generated by microorganisms can be an important source of renewable energy. The Microbial Fuel Cell (MFC) which harnesses this potential, offers possibilities of

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Modulation of MicroRNA and Transcriptional Regulation of MMP-2 by Natural Products in Human Breast...

India is rich in plant biodiversity, and that has been utilized extensively in traditional medicine. In collaboration with Dr.

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Virtual Amrita Laboratories in Biotechnology

Amrita Virtual Biotechnology laboratory is a new kind of experimental science that is being established as a virtual simulation based laboratory.

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Regulation of Inflammasomes by Natural Product extracts:Role in metabolic disorders

Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.

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Designing a BMI-based robotic arm using EEG and motor articulation control

In this project, we will use EEG recordings to control robotic arm by extracting left and right side motor imagery movement patterns. We will develop and use feature extraction methods to extract the required features from the pre-processed

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Identification of Molecular Mechanisms of Action of the Cardioprotective Compound Arjunolic Acid

Anthracyclines are among the most effective anti-cancer treatments ever developed, but their clinical use is limited by their cumulative dose-related cardio-toxicity which may ultimately lead to a severe form of cardiomyopathy.

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Molecular Mechanisms in Impaired Wound-Healing

Diabetic wound healing is a challenging problem to solve as it requires the integration of interdependent processes that involve signal transduction input from inflammation, cell migration, cell proliferation,

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Viral agents to target and kill pathogens and odour-producing bacteria in fecal waste

Viruses infecting the bacteria, called bacteriophage (phage), have been used for over 90 years as an alternative to antibiotics in Russia, east Europe and France.  They are currently being tried as a possible therapy against multi-drug-resistant

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An innovative green technology for treating municipal and industrial wastewater entering rivers and...

This research project seeks to bring together biomass based biochars and hydrochars from rice husk waste product to remove heavy metals and other contaminants from industrial and domestic wastewater that makes its way untreated or only partially

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Development and Fabrication of non-enzymatic Electrochemical Glucose Biosensor and Fabrication of...

Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has serious drawbacks like insufficient long-term stability, which originates from the intrinsic

Read More


The Discovery of MicroRNAs (miRNAs) that Regulate the Expression of Gelatinase A (Matrix...

MicroRNAs (miRNAs) are short double stranded RNAs that are produced endogenously in mammalian cells, and control the regulation of many target genes at the post-transcriptional level. There are many reports of the misregulation of these miRNAs in

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Quorum Sensing and Biofilm Formation in Microbial Pathogenesis

When encountering a new host, every potential microbial pathogen can stay, acquire nutrients, colonize and then seek another host.  Alternatively the pathogen could express its full battery of virulence factors, and invade the host.

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Affordable paper based microfluidics point of care testing device for liver function

Liver function test is one of the commonly performed blood analyses. Colorimetric test for the estimation of liver enzymes and total proteins are well established. The objective of this project is to integrate all the colorimetric tests into a

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Seabuckthorn – A Repository of Bioactive Phytochemicals

Seabuckthorn (SBT), (Hippophae L.) are deciduous shrubs in the genus Hippophae, family Elaeagnaceae.

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Natural products as modulators of diabetes associated endothelial dysfunctions

Endothelium helps in maintaining vascular tone by regulating the vascular permeability. It selectively allows only certain molecules to cross the endothelial barrier.

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Development of chromatographic separation and detection techniques for natural products, as plant...

The separation and characterization of bioactive compounds from plant extract is the crucial step in the study of phytochemicals.

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Value Addition to Underutilized Biosources

There are a wide range of underutilized plants with well known nutritional and medicinal properties. They have the potential for further promotion as they are locally available or are byproducts or waste materials.

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Cerebellum Inspired Approach for Pattern Classification in Robots

This project proposes to develop a cerebellum inspired pattern recognition algorithm for robotic data classification.

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Lentiviral Vectors for the Creation of Transgenic Organisms

Lentiviral vectors are powerful tools to deliver genetic material into almost any cell or tissue, and are useful even in the creation of transgenic animals. They have been shown to deliver foreign genes not only to mammalian cells, but also in

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Escherichia Coli based microfluidic whole-cell glucose biosensor

Diabetes is a long term prevailing disease which affects millions of people worldwide. It is a condition where the body fails to utilize the ingested glucose. There has been a dire need for the development of low cost yet effective glucose

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Matrix Binding microbes and bacteriophages to counter infection

Matrix binding proteins from probiotics and viruses:

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VALUE Virtual Simulation Labs

Virtual Lab: Amrita Vishwa Vidyapeetham is transforming the face of higher education and research, through a revolutionary new educational tool – virtual labs. The VALUE Initiative is a project dedicated to developing these virtual labs in

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Theoretical and Empirical Investigations on the Interaction of Asymmetric Migration and Intrinsic...

The dynamics of spatially structured populations (metapopulations) have been widely studied over the last few decades.

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Cyclooxygenase-2 in Cancer and Inflammatory Diseases

Cancer, which results from altered tissue growth regulation, is one of the leading causes of death worldwide.  Inflammation is the response of the immune system to infection and injury and has been implicated in the pathogeneses of arthritis and

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Cost effective device and cloud enabled smart solution for diabetes care

The joint effort by Amrita and Wipro has the goal of making diabetes care available, accessible and affordable for the Indian masses. Amrita and Wipro has envisaged a patient-centric solution wherein low cost diabetes care devices (glucose strips

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Bio-inspired Processor Design for Cognitive Functions via Detailed Computational Modeling of...

This project aims at understanding cognitive functioning of cerebellar input layer and implement signal processing abilities into neural hardware using cerebellar architecture.

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Mass spectrometry based proteomic characterization of carbonylated proteins as indicators of...

Oxidative stress refers to the physiological stress caused by an imbalance between the systemic production of reactive oxygen species and the biological system's ability to detoxify the reactive intermediates.

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Identification and characterization of the role of Allium sativum-microbiome on the production of...

A wide range of plants have been harnessed for the development of remedies under the Ayurvedic system of medicine.

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Studies On Antagonistic Effects Of Partially Purified Bacteriocins From Microflora Of Fermented Vegetables Against Enteric Pathogens

Bacteriocins are antimicrobial peptides produced by bacteria that kill or inhibit the growth of other bacteria. Bacteriocins differ from most therapeutic antibiotics in being proteinaceous and generally express a narrow specificity of action

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Label - Free Quantitative Proteomics Analysis to Study the Effect of Triclosan on Delta-Haemolysin: A Haemolytic Factor of Methicillin - Resistant Staphylococcus Aureus

Triclosan is a widely used biocide to prevent Methicillin-resistant Staphylococcus aureus (MRSA) outbreaks in hospitals. Lately, long term exposure to triclosan has resulted in certain strains showing susceptibility and thereby resistance and

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Electrospun TiO2 Nanofibers as a matrix to enhance the drug loading

The technique of Electrospinning has been considered as the most promising approach for the large scale production of nanofibers of varying diameter. It is quite a simple and efficient method for the nanofiber production.

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Mar
18
2018
A research study carried by researchers from Amrita School of Biotechnology, Osmania University’s Microbiology Department and SLS Cell Cure Technologies, revealed that mutton, chicken, beef and fish sold in Hyderabad markets are highly bacterial contaminant due to bad handling by meat sellers.   
Mar
18
2018
A research study carried by researchers from Amrita School of Biotechnology, Osmania University’s Microbiology Department and SLS Cell Cure Technologies, revealed that mutton, chicken, beef and fish sold in Hyderabad markets are highly bacterial contaminant due to bad handling by meat sellers.   
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.
207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS