As an initiative to increase awareness on global Antimicrobial Resistance (AMR), as well as to encourage best practices among the general public, and health workers to stop the further emergence and spread of drug-resistant infections, *WHO has declared November 18-24 as the Antimicrobial Awareness Week (WAAW). 

The Amrita School of Biotechnology (ASBT) made its initial foray into the Antimicrobial research arena in 2014 after having been selected by the Bill and Melinda Gates Foundation and Department of Biotechnology, Government of India for the Reinvent the Toilet Grand Challenge Award, to address the problems of infection and smell in waste water.

Amrita Vishwa Vidyapeetham has become the first Indian University to partner with European Union's Human Brain Project that has 143 University institutes in Europe working together to understand brain function and develop solutions to better understand and cure brain diseases.

Faculty and research scholars from Amrita School of Biotechnology attended a two day International Conference on Bacteriophage Research and Antimicrobial Resistance (ICBRAMR) from  December 12-13, 2019, organized by the School of Biosciences and Technology, VIT, Vellore. 

Year of Publication Publication Type Title

2021

Journal Article

Dr. Bipin G. Nair, M, V., and J, N., “Anacardic acid-mediated regulation of osteoblast differentiation involves mitigation of inflammasome activation pathways”, Molecular and Cellular Biochemistry, vol. 476(2):1-11, 2021.[Abstract]


Disruption of the finely tuned osteoblast–osteoclast balance is the underlying basis of several inflammatory bone diseases, such as osteomyelitis, osteoporosis, and septic arthritis. Prolonged and unrestrained exposure to inflammatory environment results in reduction of bone mineral density by downregulating osteoblast differentiation. Earlier studies from our laboratory have identified that Anacardic acid (AA), a constituent of Cashew nut shell liquid that is used widely in traditional medicine, has potential inhibitory effect on gelatinases (MMP2 and MMP9) which are over-expressed in numerous inflammatory conditions (Omanakuttan et al. in Mol Pharmacol, 2012 and Nambiar et al. in Exp Cell Res, 2016). The study demonstrated for the first time that AA promotes osteoblast differentiation in lipopolysaccharide-treated osteosarcoma cells (MG63) by upregulating specific markers, like osteocalcin, receptor activator of NF-κB ligand, and alkaline phosphatase. Furthermore, expression of the negative regulators, such as nuclear factor-κB, matrix metalloproteinases (MMPs), namely MMP13, and MMP1, along with several inflammatory markers, such as Interleukin-1β and Nod-like receptor protein 3 were downregulated by AA. Taken together, AA expounds as a novel template for development of potential pharmacological therapeutics for inflammatory bone diseases

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2021

Journal Article

Dr. Bipin G. Nair, Gondkar, K., Gajanan Sathe, Joshi, N., Akhilesh Pandey, and Kumar, P., “Integrated Proteomic and Phosphoproteomics Analysis of DKK3 Signaling Reveals Activated Kinase in the Most Aggressive Gallbladder Cancer”, Cells, vol. 10(3), 511, 2021.[Abstract]


DKK3 is a secreted protein, which belongs to a family of Wnt antagonists and acts as a potential tumor suppressor in gallbladder cancer. To further understand its tumor suppressor functions, we overexpressed DKK3 in 3 GBC cell lines. We have employed high-resolution mass spectrometry and tandem mass tag (TMT) multiplexing technology along with immobilized metal affinity chromatography to enrich phosphopeptides to check the downstream regulators. In this study, we reported for the first time the alteration in the phosphorylation of 14 kinases upon DKK3 overexpression. In addition, we observed DKK3 induced hyper phosphorylation of 2 phosphatases: PPP1R12A and PTPRA, which have not been reported previously. Canonical pathway analysis of altered molecules indicated differential enrichment of signaling cascades upon DKK3 overexpression in all the 3 cell lines. Protein kinase A signaling, Sirtuin signaling pathway, and Cell Cycle Control of Chromosomal Replication were observed to be differentially activated in the GBC cell lines. Our study revealed, DKK3 overexpression has differential effect based on the aggressive behavior of the cell lines. This study expands the understanding of DKK3-mediated signaling events and can be used as a primary factor for understanding the complex nature of this molecule.

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2021

Journal Article

Dr. Bipin G. Nair, Divya Nedungadi, Divya Nair, Mishra, N., and Dr. Sudarslal S., “Identification of carbonylated proteins from monocytic cells under diabetes‐induced stress conditions”, Biomedical Chromatography, vol. e5065, 2021.[Abstract]


Diabetes is a metabolic disorder characterized by the presence of elevated glucose in the blood and enhanced oxidative stress. It affects the cellular homeostasis that lead to the development of micro‐and macro‐vascular complications. Monocytes are the primary immune cells present in the circulatory system. Under high glucose conditions, the cells undergo oxidative stress and secrete reactive oxygen species. The enhanced release of reactive species are known to modify biomolecules like proteins and nucleic acids. Protein carbonylation, one of the most harmful and irreversible protein modifications, is considered as a key player in the progression of diabetes and associated complications. Hence, the present study explores the identification of carbonylated proteins from the monocytes under diabetic stress and determination of their site of modifications. Combined avidin affinity chromatography and bottom‐up proteomics experiments identified thirteen consistently expressed carbonylated proteins. Most of the identified proteins were reported to have altered functions under diabetic conditions that contribute to the development of diabetes associated inflammations and complications. We were able to determine oxidative stress‐induced modifications on Lys, Val, Ile, Cys, Thr and Asp residues.

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2021

Journal Article

Dr. Bipin G. Nair, Dr. Satheesh Babu T. G., Kumar, G., Nizet, V., Priyanka Somanath, Nair, S., Anil kumar, Haripriyan, J., Shetty, K., D’Silva, J. Rowena, Chatterjee, M., Baswe, M., Gayathri Vijayakumar, Bose, S., Megha S. Kumar, and Menon, N. D., “A Novel N4-Like Bacteriophage Isolated from a Wastewater Source in South India with Activity against Several Multidrug-Resistant Clinical Pseudomonas aeruginosa Isolates”, mSphere, vol. 6(1), 2021.[Abstract]


Multidrug-resistant community-acquired infections caused by the opportunistic human pathogen Pseudomonas aeruginosa are increasingly reported in India and other locations globally. Since this organism is ubiquitous in the environment, samples such as sewage and wastewater are rich reservoirs of P. aeruginosa bacteriophages. In this study, we report the isolation and characterization of a novel P. aeruginosa N4-like lytic bacteriophage, vB_Pae_AM.P2 (AM.P2), from wastewater in Kerala, India. AM.P2 is a double-stranded DNA podovirus that efficiently lyses the model strain, PAO1, at a multiplicity of infection as low as 0.1 phage per bacterium and resistance frequency of 6.59 × 10 ⁻⁴ . Synergy in bactericidal activity was observed between AM.P2 and subinhibitory concentrations of the antibiotic ciprofloxacin. Genome sequencing of AM.P2 revealed features similar to those of the N4-like P. aeruginosa phages LUZ7 and KPP21. As judged by two independent assay methods, spot tests and growth inhibition, AM.P2 successfully inhibited the growth of almost 30% of strains from a contemporary collection of multidrug-resistant P. aeruginosa clinical isolates from South India. Thus, AM.P2 may represent an intriguing candidate for inclusion in bacteriophage cocktails developed for various applications, including water decontamination and clinical bacteriophage therapy. IMPORTANCE In India, multidrug resistance determinants are much more abundant in community-associated bacterial pathogens due to the improper treatment of domestic and industrial effluents. In particular, a high bacterial load of the opportunistic pathogen P. aeruginosa in sewage and water bodies in India is well documented. The isolation and characterization of bacteriophages that could target emerging P. aeruginosa strains, representing possible epicenters for community-acquired infections, could serve as a useful alternative tool for various applications, such as phage therapy and environmental treatment. Continuing to supplement the repertoire of broad-spectrum bacteriophages is an essential tool in confronting this problem.

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2021

Journal Article

Dr. Bipin G. Nair, Arathi G. Rajendran, Asha Vijayan, Chaitanya Medini, and Dr. Shyam Diwakar, “Computational modelling of cerebellum granule neuron temporal responses for auditory and visual stimuli”, International Journal of Advanced Intelligence Paradigms, vol. Vol.18 No.3, pp.356 - 372, 2021.[Abstract]


Sensorimotor signals from the cerebral cortex modulate the pattern generating metaheuristic capabilities of cerebellum. To better understand the functional integration of multisensory information by the single granule neurons and the role of multimodal information in motor guidance of cerebellum, we have modelled granular layer microcircuit in the cerebellum and analysed the encoding of information during the auditory and visual stimuli. A multi-compartmental granule neuron model comprising of excitatory and inhibitory synapses was used and in vivo like behaviour was modelled with the short and long bursts. The change in intrinsic parameters in the model helped to quantify the effect of spike-time dependent plasticity in the firing of granule neurons. Computer simulations implicate coding correlation of output patterns to temporal excitatory stimuli. We observed the role of induced plasticity and granular layer role in sparse recoding of auditory and visual inputs and the model predict how plasticity mechanisms affect the average amount of information transmitted through the single granule neurons during multimodal stimuli.

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2021

Patent

J. Raveendran, Raj, V. S., Aarathi Pradeep, Dr. Suneesh P. V., John Stanley, Dr. Bipin G. Nair, Thiagarajan, R., and Dr. Satheesh Babu T. G., “Lab on Chip Device for Multi Analyte Detection and Method of Fabrication Thereof”, 2021.[Abstract]


The disclosure provides for a lab-on-a-chip (LOC) device and a method of fabrication thereof. Additionally, a system and a method for point of care testing of multiple biomarkers such as glucose, cholesterol, creatinine, uric acid, and bilirubin is provided. The microfluidic assembly consists of three layers in which the top and the middle layers are made up of polydimethylsiloxane (PDMS) and the bottom layer with polyethylene terephthalate (PET). The device integrates screen printed non-enzymatic electrochemical sensors in the bottom layer for simultaneous detection of glucose, cholesterol, creatinine, uric acid, and bilirubin. A hand held potentiostat with readout enables readout for the point of care application of integrated sensing device. The device developed has potential to revamp healthcare by providing access to affordable technology for better management a diabetes and related complications at every door step.

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2021

Journal Article

Shaji Sanu K., G. Drishya, Damu Sunilkumar, Nanjan Pandurangan, Geetha B. Kumar, and Nair, B. G., “Nuclear factor-κB plays an important role in Tamarixetin-mediated inhibition of matrix metalloproteinase-9 expression.”, Eur J Pharmacol, vol. 893, p. 173808, 2021.[Abstract]


Flavonoids possess a broad spectrum of pharmacological properties, including anti-cancer, anti-oxidant and immunomodulatory activities. The current study explored the potential of some less-studied flavonoids in inhibiting Matrix Metalloproteinase-9 (MMP-9), a prominent biomarker, upregulated in a variety of cancers and known to promote migration and invasion of cancer cells. Amongst these, Tamarixetin, a naturally occurring flavonoid derivative of Quercetin, demonstrated significant dose-dependent inhibition of MMP-9 expression. Furthermore, a substantial inhibition of migration, invasion and clonogenic potential of HT1080 cells was also observed in the presence of Tamarixetin, which further suggests its role as a potential anti-cancer agent. It is noteworthy that Tamarixetin inhibits nuclear translocation as well the activity of nuclear factor kappa B (NFκB), both of which are functions essential for the activation of MMP-9 in promoting tumorigenesis. Additionally, the endogenous regulators of MMP-9 that tightly control its activity were also modulated by Tamarixetin, as evident from the 1.9 fold increase in the expression of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1), with a concomitant 2.2 fold decrease in Matrix Metalloproteinase-14 (MMP-14) expression. The results obtained were further corroborated in three dimensional (3D) tumor models, which showed significant inhibition of MMP-9 activity as well as reduced invasive potential in the presence of Tamarixetin. Taken together, our observations demonstrate for the first time, the anti-invasive potential of Tamarixetin in cancer cells, indicating its possible use as a template for novel therapeutic applications.

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2020

Journal Article

A. Sreekumar, Navaneeth, P., Suneesh, P. Vasu, Dr. Bipin G. Nair, and Dr. Satheesh Babu T. G., “A graphite pencil electrode with electrodeposited Pt-CuO for nonenzymatic amperometric sensing of glucose over a wide linear response range”, Microchimica Acta, vol. 187, p. 113, 2020.[Abstract]


A disposable nonenzymatic glucose sensor was obtained by pulsed electrodeposition of Pt-CuO on a graphite pencil electrode (GPE). The morphology of the modified GPE was studied using SEM, and the chemical composition of the coating was examined by EDAX and XRD. The electrochemical response of the modified GPE was compared with individual copper- and platinum-modified GPEs. The electrodeposition parameters were optimized with respect to the electrocatalytic activity of the deposits towards glucose oxidation. Best operated at a working potential of 0.6 V vs. Ag/AgCl, the sensor has a sensitivity of 2035 μA mM−1 cm−2, a 0.1 μM detection limit and a wide linear response range that extends up to 25 mM. It is highly selective for glucose in the presence of various exogenous and endogenous interfering species. Eventhough the requirement of alkaline medium for sensing is a limitation, easy fabrication procedure, very high sensitivity and selectivity, wide analytical range, and disposable sensor characteristics show potential application towards blood glucose determination.

More »»

Theoretical and Empirical Investigations on the Interaction of Asymmetric Migration and Intrinsic...

The dynamics of spatially structured populations (metapopulations) have been widely studied over the last few decades.

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Anacardic acid - a novel template for cancer therapy

Traditional Indian medicine has always captivated Indian researchers and medical practitioners for its application in various pathological conditions.

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Identification of Endophytes from Marine Algae by 16S rRNA sequencing

Endophytes/ endosymbionts from marine micro algae have recently gained attention as potential sources of bioactive secondary metabolites. Our aim is to isolate and identify the endophytes by molecular biology methods. 

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In vitro studies on pharmacological potential of mycoendophyte of Simarouba glauca

The exploration of endophytes is still an emerging field. Almost all plants seem to deliver endophytes with promising contents and activities. Simarouba glauca has a long history in herbal medicine as antiparasitic, antidysentric, antipyretic and

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Seabuckthorn – A Repository of Bioactive Phytochemicals

Seabuckthorn (SBT), (Hippophae L.) are deciduous shrubs in the genus Hippophae, family Elaeagnaceae.

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Cerebellum Inspired Approach for Pattern Classification in Robots

This project proposes to develop a cerebellum inspired pattern recognition algorithm for robotic data classification.

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Natural Dyes as Efficient Candidate for Enhancing the Photovoltaic Properties of Dye Sensitized...

The requirement of energy in India has been growing exponentially over the years. Since conventional energy options are futile to tackle this raise, the needs for non-conventional energy sources have become essential.

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Computational Chemistry & Molecular Docking Studies

Docking studies are computational techniques for the exploration of the possible binding modes of a substrate to a given receptor, enzyme or other binding site. The application of computational methods to study the formation of intermolecular

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Benchtop Nanoscale patterning using soft lithography for the printing of DNA molecules

DNA microarrays have rapidly evolved to become one of the essential tools to examine expression or mutation of thousands of genes simultaneously.

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Amrita Insulin Pump and Low-cost, Automated Biomedical Devices

Diabetes is a chronic disorder characterized by abnormal blood glucose levels due to problems associated with insulin production and action. When glucose levels rise too high, diabetes becomes dangerous. Without medical care, it can increase the

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Computational Modelling and Prediction of Cerebellar Input Layer function, Timing and Plasticity...

Investigating the organized activity of neuron ensembles is critical to understand how brain circuits work and is one main target of the project. Reconstruction of network activity has proved to be a hard task. This project will study cellular

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Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care

In a unique partnership, Amrita Vishwa Vidyapeetham joined hands with Wipro Technologies, Bangalore to work on an end-to-end diabetes solution. The project entitled "Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care" is funded by

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Proteomics and Antivenomics of Snake Venom

Through this project we aim at to characterize the protein components from the venom of medically important snake species found in the Western Ghats region in Kerala through mass spectrometry-assisted proteomic experiments

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Synthesis of Modified Benzophenanthridine – a Preliminary Anti-Cancer Study

Benzophenanthridines, naturally occurring isoquinoline alkaloids with various biological activities, are known to exist in five plant families, namely, the Fumariaceae (Genera Corydalis, Dicentra and Fumaria), the Papaveraceae, and the Rutaceae

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Elucidating the Molecular Mechanisms of Anacardic Acid and Biacacetin Mediated Regulation of Matrix...

Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries like India.

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Chemically Modified Biopolymers : Synthesis, Characterization & Applications

The research activity in our laboratory aims at the development of novel biopolymer matrices with potential applications in waste water management, drug delivery etc. For instance, the β-oxothioamide derivative of chitosan biopolymer was found to

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Design and Validation of Point of Care Disposable Sensor Strips for Diagnosis of Tuberculosis from...

Tuberculosis (TB) is believed to affect nearly one third of the world population with approximately 9 million new cases detected every year. Current methods of diagnosis includes sputum smear microscopy, chest X-Ray and biopsy which are time

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Organic Bulk Heterojunction Devices for Photovoltaic Solar Cell Applications

This study proposes the investigation of “Bulk Heterojunction” solar cells consisting of different types of p-type (donor) and n-type (acceptor) network. The various chemicals proposed to be used in this study are metal phthalocyanines,

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Bio-inspired Processor Design for Cognitive Functions via Detailed Computational Modeling of...

This project aims at understanding cognitive functioning of cerebellar input layer and implement signal processing abilities into neural hardware using cerebellar architecture.

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Regulation of Inflammasomes by Natural Product extracts:Role in metabolic disorders

Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.

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Development of Heterotrophic and Phototrophic Microbial Fuel Cell

Apart from the various alternatives of conventional energy sources, electricity generated by microorganisms can be an important source of renewable energy. The Microbial Fuel Cell (MFC) which harnesses this potential, offers possibilities of

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Identification of Molecular Mechanisms of Action of the Cardioprotective Compound Arjunolic Acid

Anthracyclines are among the most effective anti-cancer treatments ever developed, but their clinical use is limited by their cumulative dose-related cardio-toxicity which may ultimately lead to a severe form of cardiomyopathy.

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Mass Spectrometric Characterization of Bioactive Peptides and Proteins

Plant diseases caused by bacteria and fungi are the major reasons for significant loss in crop yields. To address this issue, many strategies have been developed and new bioanalytical tools have been utilized with an aim to control microbe

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Viral agents to target and kill pathogens and odour-producing bacteria in fecal waste

Viruses infecting the bacteria, called bacteriophage (phage), have been used for over 90 years as an alternative to antibiotics in Russia, east Europe and France.  They are currently being tried as a possible therapy against multi-drug-resistant

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Designing a BMI-based robotic arm using EEG and motor articulation control

In this project, we will use EEG recordings to control robotic arm by extracting left and right side motor imagery movement patterns. We will develop and use feature extraction methods to extract the required features from the pre-processed

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VALUE Virtual Simulation Labs

Virtual Lab: Amrita Vishwa Vidyapeetham is transforming the face of higher education and research, through a revolutionary new educational tool – virtual labs. The VALUE Initiative is a project dedicated to developing these virtual labs in

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Synthesis of Intermediate Analogues for Biologically Active Molecules

Berberine, an isoquinoline alkaloid with a bright yellow color, is easily seen in most of the herb materials when found in significant amounts. Among Chinese herbs, the primary sources for

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Quorum Sensing and Biofilm Formation in Microbial Pathogenesis

When encountering a new host, every potential microbial pathogen can stay, acquire nutrients, colonize and then seek another host.  Alternatively the pathogen could express its full battery of virulence factors, and invade the host.

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An innovative green technology for treating municipal and industrial wastewater entering rivers and...

This research project seeks to bring together biomass based biochars and hydrochars from rice husk waste product to remove heavy metals and other contaminants from industrial and domestic wastewater that makes its way untreated or only partially

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Development and Fabrication of non-enzymatic Electrochemical Glucose Biosensor and Fabrication of...

iabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has serious drawbacks like insufficient long-term stability, which originates from the intrinsic

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Paraptosis: a Newer Approach to Target Cancer

The focus of the project is to screen molecules with anti-cancer properties and understand their mode of action with respect to cell death.

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Natural products as modulators of diabetes associated endothelial dysfunctions

Endothelium helps in maintaining vascular tone by regulating the vascular permeability. It selectively allows only certain molecules to cross the endothelial barrier.

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Development of chromatographic separation and detection techniques for natural products, as plant...

The separation and characterization of bioactive compounds from plant extract is the crucial step in the study of phytochemicals.

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Affordable paper based microfluidics point of care testing device for liver function

It is seen that therapies for diabetes and heart disease affects liver and these diseases are increasing in prevalence especially in developing countries. The liver metabolises and detoxifies drugs and substances that are harmful to the body as

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Development of Non-enzymatic Electrochemical Glucose Biosensors and Glucometer

Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which

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Virtual Amrita Laboratories in Biotechnology

Amrita Virtual Biotechnology laboratory is a new kind of experimental science that is being established as a virtual simulation based laboratory.

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Escherichia Coli based microfluidic whole-cell glucose biosensor

Diabetes is a long term prevailing disease which affects millions of people worldwide. It is a condition where the body fails to utilize the ingested glucose. There has been a dire need for the development of low cost yet effective glucose

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Value Addition to Underutilized Biosources

There are a wide range of underutilized plants with well known nutritional and medicinal properties. They have the potential for further promotion as they are locally available or are byproducts or waste materials.

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Molecular Mechanisms in Impaired Wound-Healing

Diabetic wound healing is a challenging problem to solve as it requires the integration of interdependent processes that involve signal transduction input from inflammation, cell migration, cell proliferation,

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Cyclooxygenase-2 in Cancer and Inflammatory Diseases

Cancer, which results from altered tissue growth regulation, is one of the leading causes of death worldwide.  Inflammation is the response of the immune system to infection and injury and has been implicated in the pathogeneses of arthritis and

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Matrix Binding microbes and bacteriophages to counter infection

Matrix binding proteins from probiotics and viruses:

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WeNet: The Internet of Us

WeNet will create a platform to enable people to support each other transcending geographical and cultural backgrounds.It is funded by Horizon 2020 (the biggest EU Research and Innovation program) and was launched at the Department of Information

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Peptide-Based Anti-Snake Venom Therapy

Typically, a snake bite is treated with polyclonal antibody preparations obtained from immunized animals.

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Mass spectrometry based proteomic characterization of carbonylated proteins as indicators of...

Oxidative stress refers to the physiological stress caused by an imbalance between the systemic production of reactive oxygen species and the biological system's ability to detoxify the reactive intermediates.

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Identification and characterization of the role of Allium sativum-microbiome on the production of...

A wide range of plants have been harnessed for the development of remedies under the Ayurvedic system of medicine.

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Cost Effective Device and Cloud Enabled Smart Solution for Diabetes Care

The joint effort by Amrita and Wipro has the goal of making diabetes care available, accessible and affordable for the Indian masses. Amrita and Wipro has envisaged a patient-centric solution wherein low cost diabetes care devices (glucose strips

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Modulation of MicroRNA and Protein Signatures in Hepatocellular Carcinoma by Chemopreventive...

The current study will enable the elucidation of global miRNA expression profiles and identification of miRNA targets in response to intervention with chemopreventive phytochemicals in liver cancer.

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Neurophysiological Recording and Modeling Fast-response Timing of Granule and Golgi Cell Responses...

One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems.

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Synthesis and characterization of lead salt based linear heterostructures for photovoltaic...

Quantum dots, also known as nanocrystals, are a special class of materials known as semiconductors, which are crystals composed of periodic groups of II-VI, III-V, or IV-VI materials. Their size ranges from 2-10 nanaometers.

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Process Development for Isolation and Characterization of Phytochemicals

In the Phytochemistry laboratory, development, analysis, and optimization of technical processes for target dependent bioactive compound isolations and assays are carried out. A brief account is given below.

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Lentiviral Vectors for the Creation of Transgenic Organisms

Lentiviral vectors are powerful tools to deliver genetic material into almost any cell or tissue, and are useful even in the creation of transgenic animals. They have been shown to deliver foreign genes not only to mammalian cells, but also in

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Role of miRNAs in cancer and modulation of oncogenes by natural products

Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth.

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Regulation of Inflammation by Natural Product extracts: Role in osteoclastogenesis

Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.  It is one of the major steps in normal wound healing process with

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Modeling fMRI BOLD Correlates of Neural Circuit Activity

Blood Oxygen Level Dependent (BOLD) signals are the responses of functional magnetic resonance imaging techniques used to understand brain state and function in neurology.

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The Discovery of MicroRNAs (miRNAs) that Regulate the Expression of Gelatinase A (Matrix...

MicroRNAs (miRNAs) are short double stranded RNAs that are produced endogenously in mammalian cells, and control the regulation of many target genes at the post-transcriptional level. There are many reports of the misregulation of these miRNAs in

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Identification of Natural Product Lead molecules as Potential Modulators of Wound Healing and...

Wound healing is the result of a complex interplay between various cell types wherein macrophages and fibroblasts play a crucial role during various phases of the process.

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Marine Algae - An Important Source for Lectins

The role of various sugars on the surface glycans in bacterial /fungal pathogenesis of plants and animals is well known. The focus of our research group is to hit upon proteins which are capable of interacting with these sugars. A class of

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Studies On Antagonistic Effects Of Partially Purified Bacteriocins From Microflora Of Fermented...

Bacteriocins are antimicrobial peptides produced by bacteria that kill or inhibit the growth of other bacteria.

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Modulation of MicroRNA and Transcriptional Regulation of MMP-2 by Natural Products in Human Breast...

India is rich in plant biodiversity, and that has been utilized extensively in traditional medicine. In collaboration with Dr.

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Computational Neuroscience and Cognitive Modeling

In contrast to other fields in biology, mathematical thinking and methodology have become entrenched in neuroscience since its very beginning, as witnessed by the classical work of Hodgkin and Huxley.

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MIMIC – A Unique approach to wound healing assays

Nowadays researchers are interested in cell patterning and here is a method used for patterning mammalian cells that does not require access to photolithographic capabilities. This work describes a versatile process for forming microstructures of

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Diversity Oriented Synthesis Applications to Flavonols, Flavones, Isoflavones and Biflavones

Divergent oriented synthesis is a strategy which aims to the synthesis of compounds with diverse chemical structures. It is often an alternative to convergent synthesis or linear synthesis.

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Inventory of Vegetation with special reference to Medicinal and Aromatic Plants and Documentation...

A tropical forest, with its varied life forms, provides an array of resources and services, making life possible on earth. The major beneficial components include food, medicine, clothing and

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Development of a Lab-on-a-Chip (LoC) for detection of Glucose, Cholesterol and Kidney Function

The proposed work envisages the fabrication of microfluidic lab-on-a-chip (LOC) module for non-enzymatic sensing of glucose, cholesterol and creatinine using a single device.

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Isolation and Characterization of Primary Tumor Cells

 The lack of effective “in vitro” models to predict success of pharmacological therapy for patients with variety of cancer cell types demands the development of better experimental models to understand the pathophysiology of the disease and

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Development of Endogenous H2S Triggered Fluorescence Modulated Theranostic in Cancer Therapy and...

The Project entitled "Development of Endogenous H2S Triggered Fluorescence Modulated Theranostic in Cancer Therapy and Imaging" is funded by CSIR (02(0386)/1 9/EMR-ll).

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Studies On Antagonistic Effects Of Partially Purified Bacteriocins From Microflora Of Fermented Vegetables Against Enteric Pathogens

Bacteriocins are antimicrobial peptides produced by bacteria that kill or inhibit the growth of other bacteria. Bacteriocins differ from most therapeutic antibiotics in being proteinaceous and generally express a narrow specificity of action

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Label - Free Quantitative Proteomics Analysis to Study the Effect of Triclosan on Delta-Haemolysin: A Haemolytic Factor of Methicillin - Resistant Staphylococcus Aureus

Triclosan is a widely used biocide to prevent Methicillin-resistant Staphylococcus aureus (MRSA) outbreaks in hospitals. Lately, long term exposure to triclosan has resulted in certain strains showing susceptibility and thereby resistance and

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Electrospun TiO2 Nanofibers as a matrix to enhance the drug loading

The technique of Electrospinning has been considered as the most promising approach for the large scale production of nanofibers of varying diameter. It is quite a simple and efficient method for the nanofiber production.

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Mar
18
2018
A research study carried by researchers from Amrita School of Biotechnology, Osmania University’s Microbiology Department and SLS Cell Cure Technologies, revealed that mutton, chicken, beef and fish sold in Hyderabad markets are highly bacterial contaminant due to bad handling by meat sellers.   
Mar
18
2018
A research study carried by researchers from Amrita School of Biotechnology, Osmania University’s Microbiology Department and SLS Cell Cure Technologies, revealed that mutton, chicken, beef and fish sold in Hyderabad markets are highly bacterial contaminant due to bad handling by meat sellers.   
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.
Apr
9
2016
Amrita Center for Computational Neurosciences and Neurophysiology at School of Biotechnology, Amritapuri campus has developed a computer model to understand the brain disorders. Besides neurological disorders, the approach based on accelerated computing platform can be extended to understand cancer, its origin and functional misbehavior and even infections spread through viruses.