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Cardiovascular Disease Biology


Cardiac hypertrophy is the first and foremost element in cardiac remodeling that occurs due to sustained hemodynamic load imposed by hypertension. In 2019, hypertensive heart disease was the main cause of 1.16 million deaths globally (Roth et al., 2020). Hypertrophy is an adaptive response of the heart which is characterized by an increase in wall thickness of the left ventricle. Even though an initial adaptive response to sustain cardiac output, hypertrophy leads to heart failure in the long run. Since therapeutic options for cardiac failure are limited, it is appropriate to prevent the progression of hypertrophy to failure. Being a societal challenge, the projects are aimed to deliver possible solutions to address the issue. Preliminary work carried out by the PI indicates that efforts to target autophagy will be a logical approach in the treatment of cardiac hypertrophy.


Therapeutic Targeting of Autophagy in Hypertrophied Myocardium: Potential Effects of Compounds from Desmodium Gangeticum
Funded by SERB, Government of India under the SERB Power Grant, (30 lakhs)


Cardiovascular Disease Biology
Dr. Vandana Shankar

Research Scientist, School of Biotechnology

Cardiovascular Disease Biology
Dr. Chinchu Bose

Assistant Professor, School of Biotechnology

Cardiovascular Disease Biology
Dr Nandita Misra

Associate Professor, School of Biotechnology,

Cardiovascular Disease Biology
Ms. Varsha R

Research Fellow, School of Biotechnology


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Cardiovascular Disease Biology

Amrita Vishwa Vidyapeetham,
School of Biotechnology,

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