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Genes that control epithelial growth and morphogenesis play an important role in normal development and disease. For example, an epithelial- mesenchymal transition (EMT) allows a polarized epithelial cell to undergo biochemical changes that allow it to assume a mesenchymal phenotype. EMT occurs during normal development and during tumor progression. We aim to understand the signaling machinery within the epithelial cells that coordinates polarity through studying the function of certain genes involved in epithelial growth and polarity in normal and disease conditions.
amrita
Tissue architecture lab

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The Neurobiology and Reproductive Biology Research Group investigates the molecular mechanisms underlying neurodegenerative and reproductive disorders through integrated molecular, cellular, computational and organismal approaches. In neurobiology, our research focuses on oxidative stress, synaptic dysfunction, mitochondrial impairment and neuroinflammation in Alzheimer’s and Parkinson’s diseases. We combine bioinformatics, medicinal chemistry, cell culture, 3D disease models and Drosophila melanogaster to identify novel therapeutic targets and evaluate neuroprotective phytochemicals and synthetic compounds. In reproductive biology, we investigate cell adhesion and inflammatory signaling at the maternal–fetal interface to understand pregnancy-associated disorders.

research themes

Bioinformatics-guided drug repurposing and discovery of neuroprotective phytochemicals and synthetic compounds for Alzheimer’s and Parkinson’s diseases

Synaptic dysfunction and cell adhesion signaling (DLG5–cadherin–catenin axis) in neurodegeneration
Mechanisms of oxidative stress, redox imbalance and mitochondrial dysfunction in Alzheimer’s and Parkinson’s disease
Development of cellular, 3D spheroid and Drosophila disease models for therapeutic screening
Oxidative stress as a central mechanism driving neurodegeneration. Graphical summary illustrating the role of oxidative stress, mitochondrial dysfunction and redox signaling pathways in neurodegenerative diseases.

Current Research

  • Discovery and evaluation of neuroprotective phytochemicals and synthetic small molecules targeting oxidative stress and glutathione metabolism in Alzheimer’s disease
  • Elucidating the role of DLG5 in neurodegeneration and screening of neuroprotective compounds using cellular, 3D and Drosophila models

  • A deglycation-based therapeutic approach for Alzheimer’s disease: Restoring the sensitivity of amyloid-β aggregates to natural clearance pathways using advanced glycation end product (AGE) breakers

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Current Research

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Developmental Biology
School of Biotechnology
Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P.O.
Kollam – 690525, Keralam, India

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