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A Novel Chitosan/polyoxometalate Nano-complex for Anti-cancer Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 84, Number 3, p.887-893 (2011)

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Keywords : AFM, Anticancer, Anticancer activities, apoptosis, Cancer cell lines, Cell culture, Cell death, Cesium, chitin, chitosan, Coagulation, Crosslinker, Cytotoxicity assays, Diseases, Europium, flow cytometry, Fluorescence spectroscopy, gelation, Ionotropic gelation, Material science, Molecular diversity, Nanocomplexes, Oxides, Oxygen, pH, Physiological pH, Plausible mechanisms, Polyanions, Polyoxometalates, Reactive Oxygen Species, Release profiles, SEM

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : Polyoxometalates (POMs) show great molecular diversity and have significant applications in material science as well as in medicine. In this study, nano-complexation of a novel europium containing polyanion [Cs⊂Eu 6As 6W 63O 218(H 2O) 14(OH) 4] 25- (EuWAs) with biocompatible chitosan was achieved through ionotropic gelation technique without the aid of any cross-linker. Thus obtained chitosan/EuWAs nano-complex was characterized using DLS and Zeta analysis, FT-IR, SEM, AFM, TG/DTA, EDAX and fluorescence spectroscopy. The cross-linking efficiency of EuWAs with chitosan was calculated to be 81% and the release profile recorded at physiological pH was slow and sustained. Cytotoxicity assays performed on a host of cancer cell lines, viz., KB, MCF-7, PC-3 and A549 proved the anticancer activity of the nanocomplex and flow cytometry studies revealed that reactive oxygen species generation can be the plausible mechanism for the apoptosis induced by this material. Our study has thus indicated the feasibility of using chitosan/EuWAs nano-complex for anticancer applications.

Cite this Research Publication : Dr. Deepthy Menon, Thomas, R. T., Narayanan, S., Maya, S., Dr. Jayakumar Rangasamy, Hussain, F., Lakshmanan, V. K., and Nair, S. V., “A Novel Chitosan/polyoxometalate Nano-complex for Anti-cancer Applications”, Carbohydrate Polymers, vol. 84, pp. 887-893, 2011.

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