Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Pulmon
Source : Pulmon, Volume 18, Issue 1, p.38-40 (2016)
Campus : Kochi
School : School of Medicine
Center : Amrita Institute of Medical Science
Department : Respiratory Medicine
Verified : Yes
Year : 2016
Abstract : Background
Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports.
PubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia. PRISMA statement was used for systematic review. Quality assessment of the selected reports was done using the CARE guidelines.
Twenty-one articles out of 135 search results were included. Thirty-three percent of patients were reported from India. More than half had fever and pallor. The mean haemoglobin was 5.77 g/dl (SD 2.2). Positive direct coombs test was seen in all patients. Pulmonary tuberculosis (43%) was most prevalent. Twenty-nine percent of patients needed a combination of anti-tuberculosis medicines, blood transfusion and steroids. Higher percentage of disseminated TB induced AIHA (67%) needed steroids in comparison to the other types of TB induced AIHA (13%).
Rarer complications of tuberculosis such as auto-immune haemolytic anaemia should be looked for especially in disease-endemic areas. Blood transfusion and steroids are additional treatment options along with the anti-tuberculosis medicines.
Cite this Research Publication : Nithya Haridas, “Disseminated Tuberculosis with autoimmune hemolytic anemia”, Pulmon, vol. 18, no. 1, pp. 38-40, 2016.