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Disseminated Tuberculosis with autoimmune hemolytic anemia

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Pulmon

Source : Pulmon, Volume 18, Issue 1, p.38-40 (2016)

Campus : Kochi

School : School of Medicine

Center : Amrita Institute of Medical Science

Department : Respiratory Medicine

Verified : Yes

Year : 2016

Abstract : Background Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports. Methods PubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia. PRISMA statement was used for systematic review. Quality assessment of the selected reports was done using the CARE guidelines. Results Twenty-one articles out of 135 search results were included. Thirty-three percent of patients were reported from India. More than half had fever and pallor. The mean haemoglobin was 5.77 g/dl (SD 2.2). Positive direct coombs test was seen in all patients. Pulmonary tuberculosis (43%) was most prevalent. Twenty-nine percent of patients needed a combination of anti-tuberculosis medicines, blood transfusion and steroids. Higher percentage of disseminated TB induced AIHA (67%) needed steroids in comparison to the other types of TB induced AIHA (13%). Conclusions Rarer complications of tuberculosis such as auto-immune haemolytic anaemia should be looked for especially in disease-endemic areas. Blood transfusion and steroids are additional treatment options along with the anti-tuberculosis medicines.

Cite this Research Publication : Nithya Haridas, “Disseminated Tuberculosis with autoimmune hemolytic anemia”, Pulmon, vol. 18, no. 1, pp. 38-40, 2016.

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