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Biocompatible, Biodegradable and Thermo-Sensitive Chitosan-g-poly (N-isopropylacrylamide) Nanocarrier for Curcumin Drug Delivery

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 49, Number 2, p.161-172 (2011)

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Keywords : 3 (4, 5 dimethyl 2 thiazolyl) 2, 5 diphenyltetrazolium bromide, Acrylamides, Animals, apoptosis, article, biocompatibility, Biocompatible Materials, biodegradability, cancer cell culture, cell assay, Cell Line, Cell Survival, chitosan, controlled study, cross linking, curcumin, cytotoxicity, Drug Carriers, drug delivery system, Drug Delivery Systems, drug release, drug uptake, flow cytometry, fluorescence microscopy, Hemolysis, human, human cell, Humans, in vitro study, Mice, nanoparticle, Nanoparticles, particle size, poly(n isopropylacrylamide), temperature sensitivity, zeta potential

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : A nano formulation of curcumin loaded biodegradable thermoresponsive chitosan-g-poly (N-isopropylacrylamide) co-polymeric nanoparticles (TRC-NPs) (150. nm) were prepared by ionic cross-linking method and characterized. The in vitro drug release was prominent at above LCST. Cytocompatibility of TRC-NPs (100-1000 μg/ml) on an array of cell line is proved by MTT assay. The drug loaded TRC-NPs showed specific toxicity on cancer cells. The cell uptake studies were confirmed by fluorescent microscopy. Flowcytometric analysis of curcumin loaded TRC-NPs showed increased apoptosis on PC3 cells. These results indicated that TRC-NPs could be a potential nanovehicle for curcumin drug delivery. © 2011 Elsevier B.V.

Cite this Research Publication : S. N. Rejinold, Sreerekha, P. R., Chennazhi, K. P., Shantikumar V Nair, and Dr. Jayakumar Rangasamy, “Biocompatible, Biodegradable and Thermo-Sensitive Chitosan-g-poly (N-isopropylacrylamide) Nanocarrier for Curcumin Drug Delivery”, International Journal of Biological Macromolecules, vol. 49, pp. 161-172, 2011.

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