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Oncogenic osteomalacia diagnosed by blood pool scintigraphy

Publication Type : Journal Article

Publisher : Indian Journal of Nuclear Medicine

Source : Indian Journal of Nuclear Medicine, Volume 26, Number 4, p.188-191 (2011)

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Keywords : adult, alkaline phosphatase, alkaline phosphatase blood level, article, Biochemistry, blood pool scintiscanning, bone scintiscanning, cancer surgery, case report, colecalciferol, disease severity, erythrocyte, fibroblast growth factor 23, hemangiopericytoma, histopathology, human, human tissue, limb weakness, lumbar spine, male, medronate technetium tc 99m, metabolic bone disease, nuclear magnetic resonance imaging, oncogenic osteomalacia, osteoporosis, pelvic examination, phosphate, phosphate blood level, phosphorus, tibia shaft, vertebral canal stenosis, vitamin blood level, walking difficulty, X ray

Campus : Kochi

School : School of Medicine

Department : Department of Endocrinology

Year : 2011

Abstract : Oncogenic osteomalacia is a rare metabolic bone disease characterized by phosphaturia and hypophosphatemia. Certain tumors secrete a phosphaturic factor, which results in this metabolic abnormality; this factor called as phosphatonin, is in fact a fibroblast growth factor 23 (FGF-23) involved closely in phosphate homeostasis and skeletogenesis. Complete excision of these tumors facilitates reversal of the problem. We have reported here the case of a patient who was crippled with this disease and on thorough investigation revealed an oncogenic osteomalacia with tumor focus in the right tibia. The tumor was identified as a mesenchymal tumor, i.e., hemangiopericytoma. Tumor excision alleviated patient symptoms with rapid symptomatic and biochemical improvement.

Cite this Research Publication : S. Sa Palaniswamy, Subramanyam, Pa, and Kumar, Hb, “Oncogenic osteomalacia diagnosed by blood pool scintigraphy”, Indian Journal of Nuclear Medicine, vol. 26, pp. 188-191, 2011.

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