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Course Detail

Course Name Biochemical Engineering
Course Code 15CHE431
Program B. Tech. in Chemical Engineering
Year Taught 2019


Unit 1

Introduction: History and need for biochemical Engineering; Essential life sciences: Biomolecules; Microbial world; Metabolism and Bioenergitics; Cell and their function; Enzymes and enzyme kinetics: Enzymes fundamental concepts, Classification of enzymes; Industrial application of enzymes; Industrially important enzymes; Mechanism of enzymatic reactions; Kinetics: Michaelis-Menten and Briggs Haldane equation; Evaluation of kinetic parameters; Enzymes inhibition; Factors affecting the reaction rates;

Unit 2

Immobilized enzyme: Medical and analytical application of immobilized enzyme; Techniques; Immobilized Enzyme kinetics: Effect of mass transfer resistance. Microbial kinetics: Typical growth characteristics of microbial cells, factors affecting growth; Monod’s equation; Transport in microbial system: Newtonian and NonNewtonian behaviour of broths; Agitation and Mixing; Power consumption; Gas– Liquid transport in cells; Transfer resistances; Mass transfer coefficients and their role in scale–up of equipments.

Unit 3

Bioreactors: Batch and continuous types; High performance bioreactors; Downstream processes and effluent treatment: Recovery and purification of products, different unit operations in down streaming with special reference to membrane separations; Extractive fermentation; Anaerobic treatment of effluents; Typical industrial examples for downstream processing and effluent disposal.

Text Books

  • J. E Bailey and D. F. Ollis, “Biochemical Engineering Fundamentals”, McGraw Hill, International Edition, 2nd Edition, New York, 1986.


  • J. M. Lee, “Biochemical Engineering”, 1st Edition, Prentice Hall, 1992
  • H. W. Blanch and D. S. Clark, “Biochemical Engineering”, 2nd Edition, CRC Press, 1997.
  • M. L.Shuler and F. Kargi, “Bioprocess Engineering Basic Concepts”, Prentice Hall of India, 2002.
  • D. Mukesh and N. G. Sathyanarayana, “Biochemical Engineering”, PHI Learning Pvt. Ltd., 2007

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