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Course Detail

Course Name Biopharmaceutics and Pharmacokinetics – Theory
Program Pharm. D.
Semester Seven & Eight
Year Taught 2014 , 2015 , 2016 , 2017 , 2018


‘Biopharmaceutics and Pharmacokinetics – Theory’ is a course offered in the fourth year of Pharm. D. program at School of Pharmacy, Health Sciences campus, Amrita Vishwa Vidyapeetham.

Lecture wise Program

Course Duration: 3 Hrs./Week

  1. Biopharmaceutics
    1. Introduction to Biopharmaceutics
      1. Absorption of drugs from gastrointestinal tract.
      2. Drug Distribution.
      3. Drug Elimination.
    2. Pharmacokinetics
      1. Introduction to Pharmacokinetics.
        1. Mathematical model
        2. Drug levels in blood.
        3. Pharmacokinetic model
        4. Compartment models
        5. Pharmacokinetic study.
  2. One compartment open model.
    1. Intravenous Injection (Bolus)
    2. Intravenous infusion.
  3. Multicompartment models.
    1. Two compartment open model.
    2. IV bolus, IV infusion and oral administration
  4. Multiple – Dosage Regimens.
    1. Repititive Intravenous injections – One Compartment Open Model
    2. Repititive Extravascular dosing – One Compartment Open model
    3. Multiple Dose Regimen – Two Compartment Open Model
  5. Nonlinear Pharmacokinetics.
    1. Introduction
    2. Factors causing Non-linearity.
    3. Michaelis-menton method of estimating parameters.
  6. Noncompartmental Pharmacokinetics.
    1. Statistical Moment Theory.
    2. MRT for various compartment models.
    3. Physiological Pharmacokinetic model.
  7. Bioavailability and Bioequivalence.
    1. Introduction.
    2. Bioavailability study protocol.
    3. Methods of Assessment of Bioavailability

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