Course Title: 
Integrated Circuits for Biological Systems
Course Code: 
Year Taught: 
Undergraduate (UG)
School of Engineering

'Integrated Circuits for Biological Systems' is an elective course offered for the B. Tech. (Bachelor of Technology) in Electronics and Communication Engineering at School of Engineering, Amrita Vishwa Vidyapeetham.

Unit 1

Introduction: Bio-signals, Bio-potentials: neural, cardiac, muscular, Chemical, optical signals. Role of amplifiers - Analog and digital signals – Frequency-response band and interfacing.The basic linear feedback loop, Connections between feedback loops and circuits, Root-locus techniques, Eight root-locus rules, Thezeros of a closed-loop system.

Unit 2

Device physics (MOS), Operating regimes, Large signal model - Parasitics, Small signal model, Transconductance, Impedances, Common Source (CS) Amplifier- Gain, Biasing, Interfacing CS to Biology, Diff. Amp. for Noisy Electrodes – Common/ differential mode signals – Common-mode rejection ratio, Common drain (voltage in, current out) - Common gate (current in, voltage out), Current in, current out- Biasing circuits Op-amps-two stage, frequency compensation, sources of noises, Power spectral density,noise in op-amp, Minimum detectable signal.

Unit 3

Design and simulation of ECG Pre-amplifier, High CMRR OP-Amp design, instrumentation amplifier, design and simulation of CMOS filters for low frequency ranges. Advanced process design, fabrication and testing of transistors for analog integrated circuits.


  1. Behzad Razavi, “Design of Analog CMOS Integrated Circuits”, Tata McGraw Hill, 2003.
  2. Gary. S. May and S. M. Sze, “Fundamentalsof semiconductor fabrication”, John Wiley, First Edition, 2003.


  1. T. Chan Carusone, D. Johns, and K. Martin, “Analog Integrated Circuit Design”, 2nd edition, J. Wiley & Sons, 2011.
  2. P. Allen and D. Holberg, CMOS “Analog Circuit Design”, 2nd edition, Oxford University Press, 2002.
  3. P. Gray, P. Hurst, S. Lewis, and R. Meyer, “Analysis and Design of Analog Integrated circuits”, John Wiley and Sons, Fifth Edition, 2009.
  4. Rahul Sarpeshkar,”Ultra Low Power Bioelectronics Fundamentals, Biomedical Applications and Bio-inspired Systems”, 1st edition Cambridge University Press 2010
  5. Myer Kutz, The-Bio-Medical-Engineering and Handbook.