Course

DNA replication – genome – hidden messages in the genome – Python Programming and packages for Bioinformatics – Finding Replication Origins – DnaA boxes – Counting words – The Frequent Words Problem – Frequent words in Vibrio cholera – encodings in DNA to maintain circadian rhythm – Hunting for Regulatory Motifs – Motif Finding – Scoring Motifs – Greedy Motif Search – Randomized Motif Search – Gibbs Sampling.

Course Objectives

The course will aim at introducing the concepts pertaining to DNA replication and will equip the students to explore the question where in the genome does the DNA replication will begin. Further it will motivate the students to investigate the origin of various rhythms observed in human body such as circadian rhythm and how they are encoded in the DNA

Course Outcomes

Course Evaluation Pattern:

Internal – 75%

• Assignments – 50% (20 assignments with equal credit)
• Quiz- 25% (5 Quizzes with equal credit)

External – 25%

• Project – 25%

1. Philip Compeau and PavelPevzener, Finding Hidden Messages in DNA, Active Learning Publishers 2015.