Course

Unit 1:

Cells and their long-term structure-control mechanisms (basic molecular biology: genes, exons, introns, histones, chromatin accessibility, transcription factors, etc.)

Unit 2

Overall metabolic crossovers (Biological gates and switches, Transcription Regulation, Feed-forward and Feedback loops, Biological Networks, Introduction to Systems biology)

Unit 3

Cellular/systemic short-term powering & homeostasis & coherence, murburn concept (including xenobiotics and their modes of interaction), Cell-cell, cell-matrix, cell-environment interactions, etc.

Course Objectives:

• Develop a fundamental understanding of basic molecular biology concepts, including genes, exons, introns, histones, chromatin accessibility, and transcription factors.
• Explore overall metabolic crossovers, including biological gates and switches, transcription regulation, feed-forward and feedback loops
• Understand cellular and systemic powering, homeostasis, coherence, and murburn concept.

Course Outcomes:

After completing this course, students should be able to
CO1: Analyze and interpret fundamental molecular biology concepts, including the structure and control mechanisms of cells.
CO2: Demonstrate and apply concepts related to metabolic crossovers, biological gates, switches, transcription regulation, and the principles of systems biology.
CO3: Develop an understanding of cellular and systemic powering, homeostasis, coherence, and the murburn concept, including the interactions of cells with xenobiotics and their roles in cell-cell, cell-matrix, and cell-environment interactions.

CO-PO Mapping

1. Nelson, D.L. and Cox, M.M. (2017) Lehninger Principles of Biochemistry. 7th Edition, W.H. Freeman, New York, 1328.
2. Basic concepts in biochemistry: A student’s survival guide by Hiram F Gilbert. pp 298. McGraw-Hill, NY. 1992.
3. Bruce Alberts … [and others]. Molecular Biology of the Cell. New York :Garland Pub., 1989.
4. Pelczar, M.J., Chan, E.C.S. and Kreig, N.R. (2002) Microbiology. 5th Edition, Tata McGraw-Hill, New Delhi.
5. Mescher A.L.(Ed.), [publicationyear2] Junqueira’s Basic Histology: Text and Atlas, 15e. McGraw-Hill Education. https://accessmedicine.mhmedical.com/content.aspx?bookid=2430&sectionid=190220001
6. Richard L. Drake, A. Wayne Vogl, Adam W. M. Mitchell. Gray’s anatomy for students. Elsevier. ISBN : 9780323934237
7. Gloria Doran, Cell physiology. Callisto Reference. ISBN-10:163239815X
8. Stuart Ira Fox Dr and Krista Rompolski Human physiology by Fox & Rompolsk
9. Dunecan Massey & Imran Noorani. Carpenter’s Neurophysiology: A Conceptual Approach.  ISBN-10 ‏ : ‎ 0367340607
   Neurophysiology by Carpenter
10. Murburn concept in cellular function and bioenergetics: Part 1: Understanding murzymes at the molecular level. https://doi.org/10.1063/5.0171857 Manoj etal.
11. Murburn concept in cellular function and bioenergetics: Part 1: Understanding integrations-translations from molecular to macroscopic levels. https://doi.org/10.1063/5.0171860 Manoj etal.