Unit I

Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations

Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems.

(10 Hours)

Unit II

Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparti- cles, methods of microencapsulation, applications

Mucosal Drug Delivery system: Introduction, Principles of bioadhesion / mucoadhesion, concepts, ad- vantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems

Implantable Drug Delivery Systems: Introduction, advantages and disadvantages, concept of implants and osmotic pump

(10 Hours)

Unit III

Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting perme- ation, permeation enhancers, basic components of TDDS, formulation approaches

Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications

Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

(10 Hours)

Unit IV

Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications

(08 Hours)

Unit V

Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome –Prelimi- nary study, ocular formulations and ocuserts

Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications

(07 Hours)

‘Novel Drug Delivery System -Theory’ is a course offered in the seventh semester of B. Pharm program at School of Pharmacy, Health Sciences campus, Amrita Vishwa Vidyapeetham.

Course Duration: 45 Hours

Scope:

This subject is designed to impart basic knowledge on the area of novel drug delivery systems.

Objectives:

Upon completion of the course student shall be able

1. To understand various approaches for development of novel drug delivery systems.
2. To understand the criteria for selection of drugs and polymers for the development of Novel drug delivery systems, their formulation and evaluation

Recommended Books (Latest Editions)

1. Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992.
2. Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York, 1992.
3. Encyclopedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley Interscience Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim
4. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, First edi- tion 1997 (reprint in 2001).
5. S.P. Vyas and R.K. Khar, Controlled Drug Delivery -concepts and advances, Vallabh Prakashan, New Delhi, First edition 2002.

Journals

1. Indian Journal of Pharmaceutical Sciences (IPA)
2. Indian Drugs (IDMA)
3. Journal of Controlled Release (Elsevier Sciences)
4. Drug Development and Industrial Pharmacy (Marcel & Decker)
5. International Journal of Pharmaceutics (Elsevier Sciences)