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Dr. Chandrakant Bagul

Assistant Professor, Department of Pharmaceutical Chemistry, School of Pharmacy, Kochi

Qualification: MS, Ph.D
Research Interest: Anticancer Agents, Drug Design, Machine Learning, Molecular Docking, Molecular dynamics, Organic Synthesis

Bio

Dr. Chandrakant Bagul, is an Assistant Professor in the Department of Pharmaceutical Chemistry Amrita School of Pharmacy, Kochi, India. He completed his B. Pharm from Sharadchandra Pawar College of Pharmacy, Pune University, Pune, Maharashtra. He obtained MS (Pharm.) in Medicinal Chemistry from National Institute of Pharmaceutical Education & Research (NIPER), Mohali in 2011 and Ph.D. in Medicinal Chemistry from National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad in 2018. He worked as an assistant professor in BVDU-Poona College of Pharmacy, Pune (2016-22). He has published total 22 papers in International Journals [h-index = 14; i10-index = 17; the number of citations: 535 in Google scholar (March 2022)]. His primary areas of interest are anticancer agents, EGFR inhibitors, Computer Aided Drug Design, Machine Learning, Artificial Intelligence organic synthesis.

Publications

Journal Article

Year : 2021

Cyclic adenosine monophosphate: Recent and future perspectives on various diseases

Cite this Research Publication : A, Muthal,; R, Kulkarni,; D, Sharma,; C, Bagul,; A, Kandhare,; S, Ambavade,; V, Wagh,; S, Bodhankar. Cyclic adenosine monophosphate: Recent and future perspectives on various diseases. J. App. Pharm. Sci. vol. 12, pp. 1-15..

Publisher : J. App. Pharm. Sci

Year : 2021

Artificial Intelligence: Drug Discovery and Development Prospective in Medicinal Chemistry

Cite this Research Publication : V, Walhekar,; P, Birajdar,; C, Bagul,; D, Sharma,; A, Muthal,; R, Kulkarni. Artificial Intelligence: Drug Discovery and Development Prospective in Medicinal Chemistry. EC Pharmacol. Toxicol Vol 9, pp. 77-92, 2021

Publisher : EC Pharmacol. Toxicol

Year : 2021

Molecular Hybridization Based Design and Synthesis of New benzo[5,6]chromeno[2,3-b]- quinolin-13(14H)-one Analogues as Cholinesterase Inhibitors

Cite this Research Publication : B, Macha,; R, Kulkarni,; C, Bagul,; A, Garige,; R, Akkinepally,; A, Garlapati, Molecular Hybridization Based Design and Synthesis of New benzo[5,6]chromeno[2,3-b]- quinolin-13(14H)-one Analogues as Cholinesterase Inhibitors, Med. Chem. Res,Vol. 30, pp. 685-701 2021

Publisher : Med. Chem. Res,Vol. 30, pp.

Year : 2017

2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway

Cite this Research Publication : Nayak, V. L.; Nagesh, N.; Ravikumar, A.; Bagul, C.; Vishnuvardhan, M.; Srinivasulu, V.; Kamal, A. 2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway. Apoptosis. Vol. 22, pp. 118-134 2017

Publisher : Apoptosis

Year : 2017

Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers

Cite this Research Publication : Rao, A. S.; Swapna, K.; Shaik, S. P.; Nayak, V. L.; Reddy, T. S.; Sunkari, S.; Shaik, T. B.; Bagul, C.; Kamal, A. Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers. Bioorganic & medicinal chemistry Vol. 25, pp. 977-999, 2017

Publisher : Bioorganic & medicinal chemistry

Year : 2017

Synthesis and biological evaluation of chalcone-linked pyrazolo [1, 5-a] pyrimidines as potential anticancer agents

Cite this Research Publication : Bagul, C.; Rao, G. K.; Makani, V. K. K.; Tamboli, J. R.; Pal-Bhadra, M.; Kamal, A. Synthesis and biological evaluation of chalcone-linked pyrazolo [1, 5-a] pyrimidines as potential anticancer agents. MedChemComm, Vol. 8, pp. 1810-1816, 2017

Publisher : MedChemComm

Year : 2017

Design and synthesis of 1,2,3-triazolo linked-3-benzo[d]imidazo[2, 1-b]thiazole conjugates as tubulin polymerization inhibitors

Cite this Research Publication : Shaik, S. P.; Vishnuvardhan, M.; Sultana, F.; Rao, A. S.; Bagul, C.; Bhattacharjee, D.; Kapure, J. S.; Jain, N.; Kamal, A. Design and synthesis of 1,2,3-triazolo linked-3-benzo[d]imidazo[2, 1-b]thiazole conjugates as tubulin polymerization inhibitors. Bioorganic & medicinal chemistry, Vol. 25, pp, 3285-3297.2017

Publisher : Bioorganic & medicinal chemistry

Year : 2016

Synthesis and biological evaluation of imidazopyridinyl-1, 3, 4-oxadiazole conjugates as apoptosis inducers and topoisomerase IIα inhibitors

Cite this Research Publication : Rao, A. S.; Vardhan, M. V.; Reddy, N. S.; Reddy, T. S.; Shaik, S. P.; Bagul, C.; Kamal, A. Synthesis and biological evaluation of imidazopyridinyl-1, 3, 4-oxadiazole conjugates as apoptosis inducers and topoisomerase IIα inhibitors. Bioorganic chemistry, Vol. 69, pp. 7-19. 2016

Publisher : Bioorganic chemistry

Year : 2015

Synthesis and Biological Evaluation of Benzo [d][1, 3] Dioxol‐5‐yl Chalcones as Antiproliferating Agents

Cite this Research Publication : Kamal, A.; Balakrishna, M.; Loka Reddy, V.; Riyaz, S.; Bagul, C.; Satyanarayana, B. M.; Venkateswar Rao, J. Synthesis and Biological Evaluation of Benzo [d][1, 3] Dioxol‐5‐yl Chalcones as Antiproliferating Agents. Chemical biology & drug design, Vol. 86, pp. 1267-1284, 2015

Publisher : Chemical biology & drug design

Year : 2015

Synthesis of 2-anilinopyridyl–triazole conjugates as antimitotic agents

Cite this Research Publication : Kamal, A.; Rao, A. S.; Vishnuvardhan, M.; Reddy, T. S.; Swapna, K.; Bagul, C.; Reddy, N. S.; Srinivasulu, V. Synthesis of 2-anilinopyridyl–triazole conjugates as antimitotic agents. Organic & biomolecular chemistry, Vol. 13,pp. 4879-4895, 2015.

Publisher : Organic & biomolecular chemistry

Year : 2015

Aryl-imidazothiadiazole analogues as microtubule disrupting agents.

Cite this Research Publication : Kamal, A.; Rao, A. S.; Reddy, T. S.; Polepalli, S.; Shaik, S. P.; Bagul, C.; Vishnuvardhan, M.; Jain, N. Aryl-imidazothiadiazole analogues as microtubule disrupting agents. MedChemComm, Vol. 6, pp. 1842-1856, 2015.

Publisher : MedChemComm

Year : 2015

Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549

Cite this Research Publication : Kamal, A.; Nayak, V. L.; Bagul, C.; Vishnuvardhan, M.; Mallareddy, A. Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549. Apoptosis, Vol. 20, pp. 1518-1529, 2015.

Publisher : Apoptosis

Year : 2015

Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability

Cite this Research Publication : Kamal, A.; Sathish, M.; Nayak, V. L.; Srinivasulu, V.; Kavitha, B.; Tangella, Y.; Thummuri, D.; Bagul, C.; Shankaraiah, N.; Nagesh, N. Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability. Bioorganic & medicinal chemistry, Vol. 23, pp. 5511-5526, 2015.

Publisher : Bioorganic & medicinal chemistry

Year : 2014

Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents

Cite this Research Publication : Kamal, A.; Hussaini, S. A.; Nayak, V. L.; Malik, M. S.; Sucharitha, M. L.; Shaik, T. B.; Ashraf, M.; Bagul, C. Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. Bioorganic & medicinal chemistry, Vol. 22, pp. 6755-6767, 2014.

Publisher : Bioorganic & medicinal chemistry

Year : 2014

Synthesis of imidazothiadiazole–benzimidazole conjugates as mitochondrial apoptosis inducers

Cite this Research Publication : Kamal, A.; Ponnampalli, S.; Vishnuvardhan, M.; Rao, M. N.; Mullagiri, K.; Nayak, V. L.; Bagul, C;. Synthesis of imidazothiadiazole–benzimidazole conjugates as mitochondrial apoptosis inducers. MedChemComm, Vol. 5, pp. 1644-1650, 2014.

Publisher : MedChemComm

Year : 2014

Synthesis of β-carboline– benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation

Cite this Research Publication : Kamal, A.; Rao, M. N.; Swapna, P.; Srinivasulu, V.; Bagul, C.; Shaik, A. B.; Mullagiri, K.; Kovvuri, J.; Reddy, V. S.; Vidyasagar, a. K. Synthesis of β-carboline– benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation. Organic & biomolecular chemistry, Vol. 12, pp. 2370-2387.

Publisher : Organic & biomolecular chemistry

Year : 2014

Design and Synthesis of C3‐Pyrazole/Chalcone‐Linked Beta‐Carboline Hybrids: Antitopoisomerase I, DNA‐Interactive, and Apoptosis‐Inducing Anticancer Agents

Cite this Research Publication : Kamal, A.; Srinivasulu, V.; Nayak, V. L.; Sathish, M.; Shankaraiah, N.; Bagul, C.; Reddy, N. S.; Rangaraj, N.; Nagesh, N. Design and Synthesis of C3‐Pyrazole/Chalcone‐Linked Beta‐Carboline Hybrids: Antitopoisomerase I, DNA‐Interactive, and Apoptosis‐Inducing Anticancer Agents. ChemMedChem, Vol. 9, pp. 2084-2098, 2014.

Publisher : ChemMedChem

Year : 2014

Synthesis and biological evaluation of new epalrestat analogues as aldose reductase inhibitors (ARIs).

Cite this Research Publication : Reddy, T. N.; Ravinder, M.; Bagul, P.; Ravikanti, K.; Bagul, C.; Nanubolu, J. B.; Srinivas, K.; Banerjee, S. K.; Rao, V. J. Synthesis and biological evaluation of new epalrestat analogues as aldose reductase inhibitors (ARIs). European journal of medicinal chemistry, Vol. 71, pp. 53-66, 2014.

Publisher : European journal of medicinal chemistry

Year : 2013

Design, synthesis and biological evaluation of imidazo [1, 5-a] pyridine–PBD conjugates as potential DNA-directed alkylating agents

Cite this Research Publication : Kamal, A.; Ramakrishna, G.; Ramaiah, M. J.; Viswanath, A.; Rao, A. S.; Bagul, C.; Mukhopadyay, D.; Pushpavalli, S.; Pal-Bhadra, M. Design, synthesis and biological evaluation of imidazo [1, 5-a] pyridine–PBD conjugates as potential DNA-directed alkylating agents. MedChemComm, Vol. 4, pp. 697-703, 2013.

Publisher : MedChemComm

Year : 2013

Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents

Cite this Research Publication : Kamal, A.; Swapna, P.; Shetti, R. V.; Shaik, A. B.; Rao, M. N.; Sultana, F.; Khan, I. A.; Sharma, S.; Kalia, N. P.; Kumar, S.; Bagul, C. Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents. European journal of medicinal chemistry, Vol. 64, pp. 239-251, 2013.

Publisher : European journal of medicinal chemistry

Year : 2013

Synthesis of 1, 5- Diarylpyrazoles as Potential COX-2 Inhibitors with Nitric Oxide Releasing Ability

Cite this Research Publication : Rao, B. N.; Muthuppalaniappan, M.; Dinavahi, S. S.; Viswanadha, S.; Bagul, C.; Srinivas, K.; Vakkalanka, S. K. V.; Atcha, K. R.; Kamal, A. Synthesis of 1, 5- Diarylpyrazoles as Potential COX-2 Inhibitors with Nitric Oxide Releasing Ability. Letters in Drug Design & Discovery, Vol. 10, pp. 594-603, 2013.

Publisher : Letters in Drug Design & Discovery

Year : 2012

Divalent N (I) character in 2-(thiazol-2-yl) guanidine: an electronic structure analysis

Cite this Research Publication : Bhatia, S.; Bagul, C.; Kasetti, Y.; Patel, D. S.; Bharatam, P. V. Divalent N (I) character in 2-(thiazol-2-yl) guanidine: an electronic structure analysis. The Journal of Physical Chemistry A, Vol. 116, pp. 9071-9079, 2012.

Publisher : The Journal of Physical Chemistry A

Education

2011-2016 PhD in Medicinal Chemistry
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India
Title: “Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidines and Triaryl Olefins as EGFR Inhibitors” Under the supervision of Dr. Ahmed Kamal.
2009-2011 M.S. (Pharm.) in Medicinal Chemistry
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) Mohali, (Punjab), India.
Title: “Computational Studies on the Stability of Thiazole-2-ylidene” Under the supervision Prof. P. V. Bharatam

Areas of Interest

Drug Design
Anticancer agents
Molecular Docking
Molecular Dynamics
Machine Learning
Organic Synthesis

Awards and Fellowships

NIPER Fellowship for PhD in Medicinal Chemistry, Department of Chemical and fertilizers, Govt. Of India, New Delhi (2011-2015)
NIPER Fellowship for MS (Pharm.) by Department of Chemical and fertilizers, Govt. Of India, New Delhi (2011-2016)
GATE Scholarship by IIT Roorkee (2009)

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