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Furfuryl Derivatives of Meldrum’s Acid: Synthesis, Characterisation and Biological Studies

Start Date: Thursday, Jan 01,2015

End Date: Tuesday, May 12,2015

School: School of Biotechnology

Project Incharge:Dr. Sobha V. Nair
Co-Project Incharge:Aiswarya Soman Ashwin Perumal Athiralakshmi S. Kalyani Ajayan Ramya Raj
Furfuryl Derivatives of Meldrum’s Acid: Synthesis, Characterisation and Biological Studies

Meldrum’s acid has been reported to undergo a condensation reaction with aromatic aldehydes to afford adducts with a host of interesting chemical, physical as well as biological properties. In the present work we have prepared the Meldrum’s acid adduct of furfural which has been screened for antifungal activity. It has been reported that the Furfuryl adduct of Meldrum’s acid undergoes a ring opening reaction with secondary amines at room temperature to afford a new class of  donor-acceptor Stenhouse adducts (DASAs). Our group is trying to explore this property of the prepared derivative for trying out various biological applications.

Furfural             Meldrum’s acid                Meldrum’s acid adduct of furfural
FTIR spectrum of Meldrum’s acid adduct of furfural

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