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β-Chitin hydrogel/nano hydroxyapatite composite scaffolds for tissue engineering applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 85, Number 3, p.584-591 (2011)

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Keywords : adsorption, Apatite, biodegradation, biomineralization, Cell attachments, cell viability, chitin, Chitin hydrogel, Composite scaffolds, Cytocompatibility, degradation, Hydroxyapatite, Hydroxyapatite composite, In-vitro, Interconnected porous structure, Nanocomposites, Ocean habitats, Protein adsorption, Scaffolds (biology), Swelling ratio, Wound tissue

Campus : Kochi

School : Center for Nanosciences, School of Dentistry

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Periodontics, Nanosciences and Molecular Medicine

Year : 2011

Abstract : β-Chitin hydrogel/nano hydroxyapatite (nHAp) nanocomposite scaffolds were prepared by freeze-drying approach from the mixture of β-chitin hydrogel and nHAp in different concentrations such as 0.5 and 1%, respectively. The prepared nHAp and nanocomposite scaffolds were characterized using various modalities. Porosity, swelling ability, in vitro degradation, protein adsorption and biomineralization of the prepared composite scaffolds were evaluated. The composite scaffolds were found to have 70-80% porosity with well defined interconnected porous structure. The scaffolds also showed a swelling ratio of 15-20, controlled biodegradation of about 30-40% with enhanced protein adsorption. In addition, the cell viability, attachment and proliferation using MG 63, Vero, NIH3T3 and nHDF cells confirmed the cytocompatibility nature of the nanocomposite scaffolds with well improved cell attachment and proliferation. All these results essentially signify that this material can be a potential candidate for bone and wound tissue engineering applications.

Cite this Research Publication : P. T. Sudheesh Kumar, Sowmya Srinivasan, Lakshmanan, V. - K., Tamura, H., Nair, S. V., and Dr. Jayakumar Rangasamy, “β-Chitin hydrogel/nano hydroxyapatite composite scaffolds for tissue engineering applications”, Carbohydrate Polymers, vol. 85, pp. 584-591, 2011.

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