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1,2,4-Oxadiazoles: a new class of anti-prostate cancer agents

Publication Type : Journal Article

Publisher : Elsevier

Source : Bioorganic and Medicinal Chemistry Letters, 2012

Url :

Campus : Amritapuri

School : School of Biotechnology

Verified : No

Year : 2012

Abstract : Sulfide and sulfonyl derivatives of 1,2,4-oxadiazoles were synthesized and screened by MTT assay on the prostate cancer cells, DU-145. Six compounds were identified as potential anti-prostate cancer agents with IC50 values ranging from 0.5 to 5.1μM. These compounds exhibited good activity on the androgen independent cells PC-3, while the results were moderate on androgen dependent LNCaP cells, suggesting the possibility of a mechanism of action different from that of the bioisosteric bicalutamide. Also a very low cytotoxicity was observed on non-cancerous cells MCF-10A.

Cite this Research Publication : Gopal L. Khatik, Jasmine Kaur, Varun Kumar, Kulbhushan Tikoo and Vipin A. Nair "1,2,4-Oxadiazoles: a new class of anti-prostate cancer agents", Bioorganic and Medicinal Chemistry Letters 2012, 22, 1912-1916

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