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A Comprehensive Curated Reaction Map of Leptin Signaling Pathway

Publication Type : Journal Article

Publisher : Journal of Proteomics and Bioinformatics

Source : Journal of Proteomics and Bioinformatics, Volume 4, Number 9, p.184-189 (2011)

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Keywords : article, enzyme substrate complex, gene control, hydroxymethylglutaryl coenzyme A reductase kinase, insulin receptor substrate, Janus kinase, leptin, mitogen activated protein kinase, molecular dynamics, phosphatidylinositol 3 kinase, phospholipase C gamma, protein homeostasis, protein protein interaction, protein transport, Raf protein, Ras protein, signal transduction, STAT protein, transcription regulation

Campus : Bengaluru

School : School of Biotechnology

Department : Bioinformatics

Year : 2011

Abstract : Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (, a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations. © 2011 Nanjappa V, et al.

Cite this Research Publication : Va Nanjappa, R. Raju, Muthusamy, Bab, Sharma, Jac, J. K. Thomas, Nidhina, P. A. HdHaridas, H. C. Harsha, Pandey, Aef g h, Anilkumar, Gd, and Prasad, T. Sab c Keshav, “A Comprehensive Curated Reaction Map of Leptin Signaling Pathway”, Journal of Proteomics and Bioinformatics, vol. 4, pp. 184-189, 2011.

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