Publication Type : Journal Article
Publisher : Thieme
Source : Synlett, 2012
Url : https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1317133
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2012
Abstract : A highly efficient procedure was devised for the synthesis of 3-(3-arylthioureido)propanoic/butanoic acid and its cyclization to (3-aryl/3-aryl-6-methyl)-2-thioxotetrahydropyrimidin-4(1H)-one derivatives. Carbonyl diimidazole proved to be a very effective coupling reagent for the cyclization. Studies carried out to examine the ambident nature of the thioamide moiety towards substitution reactions demonstrated the preference for alkylation at sulfur, and acylation and 1,4-addition at nitrogen.
Cite this Research Publication : Varun Kumar, Gopal L. Khatik, Anang Pal, Mohan R. Praneeth, Sanjay Bhattarai and Vipin A. Nair, "A facile synthesis and chemoselective reactions of dihydrothiouracils", Synlett 2012, 23, 2357-2362