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A facile synthesis and chemoselective reactions of dihydrothiouracils

Publication Type : Journal Article

Publisher : Thieme

Source : Synlett, 2012

Url :

Campus : Amritapuri

School : School of Biotechnology

Verified : No

Year : 2012

Abstract : A highly efficient procedure was devised for the synthesis of 3-(3-arylthioureido)propanoic/butanoic acid and its cyclization to (3-aryl/3-aryl-6-methyl)-2-thioxotetrahydropyrimidin-4(1H)-one derivatives. Carbonyl diimidazole proved to be a very effective coupling reagent for the cyclization. Studies carried out to examine the ambident nature of the thioamide moiety towards substitution reactions demonstrated the preference for alkylation at sulfur, and acylation and 1,4-addition at nitrogen.

Cite this Research Publication : Varun Kumar, Gopal L. Khatik, Anang Pal, Mohan R. Praneeth, Sanjay Bhattarai and Vipin A. Nair, "A facile synthesis and chemoselective reactions of dihydrothiouracils", Synlett 2012, 23, 2357-2362

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