Publication Type : Journal Article
Publisher : Elsevier
Source : Carbohydrate Polymers 2020, 250, 116952. https://doi.org/10.1016/j.carbpol.2020.116952.
Url : https://www.sciencedirect.com/science/article/abs/pii/S0144861720311255
Campus : Amritapuri
School : School for Sustainable Futures
Year : 2020
Abstract : Graphene-based bionanocomposites are employed in several ailments, such as cancers and infectious diseases, due to their large surface area (to carry drugs), photothermal properties, and ease of their functionalization (owing to their active groups). Modification of graphene-derivatives with polysaccharides is a promising strategy to decrease their toxicity and improve target ability, which consequently enhances their biotherapeutic efficacy. Herein, functionalization of graphene-based materials with carbohydrate polymers (e.g., chitosan, starch, alginate, hyaluronic acid, and cellulose) are presented. Subsequently, recent advances in graphene nanomaterial/polysaccharide-based bionanocomposites in infection treatment and cancer therapy are comprehensively discussed. Pharmacogenomic and toxicity assessments for these bionanocomposites are also highlighted to provide insight for future optimized and smart investigations and researches.
Cite this Research Publication : Makvandi, P.; Ghomi, M.; Ashrafizadeh, M.; Tafazoli, A.; Agarwal, T.; Delfi, M.; Akhtari, J.; Zare, E. N.; Padil, V. V.T .; Zarrabi, A.; Pourreza, N.; Miltyk, W.; Maiti, T. K., "A Review on Advances in Graphene-Derivative/Polysaccharide Bionanocomposites: Therapeutics, Pharmacogenomics and Toxicity," Carbohydrate Polymers 2020, 250, 116952. https://doi.org/10.1016/j.carbpol.2020.116952.