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A Systematic Evaluation of Hydroxyethyl Starch as a Potential Nanocarrier for Parenteral Drug Delivery

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 74, p.575-584 (2015)

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Keywords : Crosslinking-precipitation, Hemocompatibility, Hydroxyethyl starch, Nanoparticles, Parenteral drug delivery

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences

Year : 2015

Abstract : Development of parenteral nanoformulations is highly challenging due to the stringent demands on stability, reproducibility and high drug loading with minimal excipients. This study focuses on the development of a pharmaceutically acceptable nanomatrix system for parenteral delivery based on Hydroxyethyl Starch (HES), a FDA approved polymer that is relatively unexplored in drug delivery research. HES nanoparticles were prepared through a simple, two-step crosslinking-precipitation route, yielding 160. ±. 5. nm, nearly monodispersed spherical particles with high colloidal stability. The utility of this nanocarrier for parenteral delivery was verified by a panel of hemo/cytocompatibility assays at high concentrations (0.05-1. mg/ml) in vitro and in vivo. HES nanomatrix was found effective in encapsulating two chemically distinct drugs having varying hydrophobicities, with the release behavior being influenced by their chemical nature and drug-matrix interactions. Better in vitro efficacy was measured for the nanoencapsulated drug than its bare form, establishing the potential of HES nanocarriers for controlled drug delivery. © 2014 Elsevier B.V.

Cite this Research Publication : D. Narayanan, Shantikumar V Nair, and Dr. Deepthy Menon, “A Systematic Evaluation of Hydroxyethyl Starch as a Potential Nanocarrier for Parenteral Drug Delivery”, International Journal of Biological Macromolecules, vol. 74, pp. 575-584, 2015.

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