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Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Oral Surg Oral Med Oral Pathol Oral Radiol
Source : Oral Surg Oral Med Oral Pathol Oral Radiol, Volume 124, Issue 1, p.24-31 (2017)
Keywords : Carcinoma, Squamous Cell, Combined Modality Therapy, Humans, Lymphatic Metastasis, Mouth Neoplasms, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Risk Factors
Campus : Kochi
School : School of Medicine
Department : Head & Neck Surgery
Year : 2017
Abstract : The use of postoperative radiotherapy (PORT) in early stage oral cancer with adverse pathologic features (APFs) is controversial. Prognostically relevant APFs reviewed were perineural invasion, lymphovascular invasion, depth of invasion, worst pattern of invasion, and margin status. The current literature remains divided with regard to the benefit of treatment escalation in these patients; although these patients are at high risk for recurrence, the morbidity of PORT needs to be balanced against the likely benefit in disease control. A wide heterogeneity in the literature exists, likely as a result of differences in treatment protocols. We performed a literature review of the role of PORT in early-stage oral cancer with APFs. Based on the current evidence, the decision to administer adjuvant therapy needs to be made on an individual basis; patients with 1 APF are likely to benefit from PORT, and the use of risk-scoring systems may help in decision making.
Cite this Research Publication : Narayana Subramaniam, Deepak Balasubramanian, Murthy, S., Limbachiya, S., Krishnakumar Thankappan, and Dr. Subramania Iyer K., “Adverse pathologic features in early oral squamous cell carcinoma and the role of postoperative radiotherapy-a review.”, Oral Surg Oral Med Oral Pathol Oral Radiol, vol. 124, no. 1, pp. 24-31, 2017.