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Publication Type : Journal Article
Publisher : Wiley
Source : Chemistry Select, 2016
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2017
Abstract : An efficient protocol was developed for the Friedel Crafts type thioarylation for the synthesis of aromatic/heteroaromaticthioamide derivatives from aryl isothiocyanates and electron rich aromatic/heteroaromatic molecules by employing the Lewis acid AlCl3 and the less hazardous solvent cyclohexane at 70°C. The developed protocol offers advantages over the previous methods such as use of stoichiometric amount of reactants/reagent, less toxic solvent, shorter reaction time and higher yields.
Cite this Research Publication : Kapil Kumar, Debabrata Konar, Sandeep Goyal, Mukesh Gangar, Mangilal Chouhan, Ravindra K. Rawal and Vipin A. Nair, "AlCl3/Cyclohexane Mediated Electrophilic Activation of Isothiocyanates: An Efficient Synthesis of Thioamides", Chemistry Select 2016, 1, 3228-3231