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Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Indian Journal of Physiology and Pharmacology

Source : Indian Journal of Physiology and Pharmacology, Volume 50, Number 3, p.291-296 (2006)

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Keywords : adult, alcohol, Alcohol abuse, Alcoholism, antioxidant, Antioxidants, article, ascorbic acid, catalase, Central Nervous System Depressants, controlled study, Ethanol, Follicle Stimulating Hormone, follitropin, glutathione, glutathione peroxidase, glutathione reductase, glutathione transferase, gonad dysfunction, hormone blood level, human, human experiment, Humans, hypothalamus hypophysis adrenal system, Leydig Cells, luteinizing hormone, male, normal human, oxidative stress, Pituitary Gland, Sertoli Cells, Sperm Count, Sperm Motility, superoxide dismutase, testosterone, testosterone blood level, thiobarbituric acid reactive substance, Time Factors

Campus : Kochi

School : School of Medicine

Department : Biochemistry

Year : 2006

Abstract : Ethanol is a testicular toxin and it causes fertility abnormalities with low sperm count and impaired sperm motility in men. The present study was designed to investigate plasma testosterone level and hypothalamic pituitary gonadal (HPG) axis function in alcoholic men and also effect of ethanol on systemic oxidative stress. Forty six male alcohol abusers in the age group 20-40 years were selected. Fifty five, males in the same age group served as control. Alcohol abusers had significantly low plasma testosterone with low luteinizing hormone and follicle stimulating hormone. In addition they had significantly high thiobarbituric acid reactive substances (TBARS), superoxide dismutase and glutathione S-transferase, and low glutathione, ascorbic acid, catalase, glutathione reductase and glutathione peroxidase. Moreover, serum testosterone level in alcoholics negatively correlated with duration of alcohol abuse, and TBARS. Duration dependent decreased serum testosterone level in alcohol abusers might be due to 1) increased oxidative stress which can damage Leydig and supporting Sertoli cells and 2) impaired HPG axis.

Cite this Research Publication : D. M. Vasudevan, Maneesh, M., Dutta, S., and Chakrabarti, A., “Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males”, Indian Journal of Physiology and Pharmacology, vol. 50, pp. 291-296, 2006.

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