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Amphotericin B loaded sulfonated chitosan nanoparticles for targeting macrophages to treat intracellular Candida glabrata infections.

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : International Journal of Biological Macromolecules

Source : International Journal of Biological Macromolecules, Volume 110, p.133 - 139 (2018)

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Keywords : amphotericin B, Macrophages, Nanoparticles, Sulfated chitosan, Targeted drug delivery

Campus : Kochi

School : Center for Nanosciences, School of Pharmacy

Center : Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2018

Abstract : The current study assesses the potential of functionalised chitosan nanoparticles (CNPs) for proficient macrophage delivery of amphotericin B (AmpB) for the management of Candida glabrata fungemia. Chitosan was functionalised by the method of sulfation by using chlorosulfonic acid and the developed compound was confirmed by FTIR, H NMR and degree of sulfation and CHNS analysis. Amphotericin B encapsulated sulfated chitosan (AmpB-SCNPs), when characterized showed a hydrodynamic diameter of 310 ± 14 nm and zeta potential of 41.5 ± 2 mV. The safety of AmpB-SCNPs was established by the alamar cytotoxicity assay in nanoparticle treated macrophages following 24 h incubation. The AmpB-SCNPs showed a significant increase in the reduction of C. glabrata in comparison with the bare AmpB and AmpB-CNPs (55.2 and 42.7 vs 11.12 cfu/ml) indicating that AmpB-SCNPs could be a promising carrier for specific delivery of AmpB to macrophages for effective treatment of Candida glabrata fungemia.

Cite this Research Publication : M. Sandhya, V., A., K., S. Maneesha, Raja, B., Dr. Jayakumar Rangasamy, and S., S., “Amphotericin B Loaded Sulfonated Chitosan Nanoparticles for Targeting Macrophages to Treat Intracellular Candida Glabrata Infections”, International Journal of Biological Macromolecules, vol. 110, pp. 133 - 139, 2018.

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