Publication Type : Journal Article
Publisher : Elsevier
Source : Tetrahedron Letters, 2015
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2015
Abstract : An efficient strategy for the synthesis of syn 1,3-diol has been developed, employing an imidazolidinone based chiral auxiliary via stereoselective and sequential double acetate aldol reactions. The syn 1,3-diol subunit was modified to obtain the C-7 carboxylic acid side chain and further subjected to reaction with a suitable 1,4-diketone under Paal-Knorr conditions to obtain atorvastatin lactone.
Cite this Research Publication : Sandeep Goyal, Bhautikkumar Patel, Ratnesh Sharma, Mangilal Chouhan, Kapil Kumar, Mukesh Gangar and Vipin A. Nair, "An efficient strategy for the synthesis of syn 1,3-diols via iterative acetate aldol reactions and synthesis of atorvastatin lactone", Tetrahedron Letters 2015, 56, 5409-5412